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Department
  • Clinical Biochemistry
    • Institute
  • Wellcome – MRC Institute of Metabolic Science
    • Research Theme Neurons, Circuits and Networks
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    Professor Fiona Gribble

    University Position
    Professor

    Interests

    Endocrine communication between the gut and brain, relaying food-related signals that control appetite and metabolism.

    Key Publications

    Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis.

    DOI: http://doi.org/10.1016/j.molmet.2018.08.006
    Journal: Mol Metab
    E-pub date: 1 Nov 2018
    Authors: P Kirwan, RG Kay, B Brouwers, V Herranz-Pérez, M Jura, P Larraufie, J Jerber, J Pembroke, T Bartels, A White, FM Gribble, F Reimann, IS Farooqi, S O'Rahilly, FT Merkle

    Transcriptomic profiling of pancreatic alpha, beta and delta cell populations identifies delta cells as a principal target for ghrelin in mouse islets.

    DOI: http://doi.org/10.1007/s00125-016-4033-1
    Journal: Diabetologia
    E-pub date: 1 Oct 2016
    Authors: AE Adriaenssens, B Svendsen, BYH Lam, GSH Yeo, JJ Holst, F Reimann, FM Gribble

    Publications

    Obesity medication lorcaserin requires brainstem GLP-1 neurons to reduce food intake in mice

    DOI: http://doi.org/10.1101/2022.05.06.490598
    Journal:
    E-pub date: 1 Aug 2022
    Authors: S Wagner, D Brierley, A Leeson-Payne, W Jiang, R Chianese, B Lam, G Dowsett, C Cristiano, D Lyons, F Reimann, F Gribble, GSH Yeo, S Trapp, L Heisler

    Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice – Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells.

    DOI: http://doi.org/10.1016/j.molmet.2019.09.001
    Journal: Mol Metab
    E-pub date: 1 Nov 2019
    Authors: LJ Billing, P Larraufie, J Lewis, A Leiter, J Li, B Lam, GS Yeo, DA Goldspink, RG Kay, FM Gribble, F Reimann

    Comparison of Human and Murine Enteroendocrine Cells by Transcriptomic and Peptidomic Profiling.

    DOI: http://doi.org/10.2337/db18-0883
    Journal: Diabetes
    E-pub date: 1 May 2019
    Authors: GP Roberts, P Larraufie, P Richards, RG Kay, SG Galvin, EL Miedzybrodzka, A Leiter, HJ Li, LL Glass, MKL Ma, B Lam, GSH Yeo, R Scharfmann, D Chiarugi, RH Hardwick, F Reimann, FM Gribble

    Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons.

    DOI: http://doi.org/10.1038/s41467-019-09045-9
    Journal: Nat Commun
    E-pub date: 4 Mar 2019
    Authors: VB Lu, J Rievaj, EA O'Flaherty, CA Smith, R Pais, LA Pattison, G Tolhurst, AB Leiter, DC Bulmer, FM Gribble, F Reimann

    Comparison of human and murine enteroendocrine cells by transcriptomic and peptidomic profiling

    DOI: http://doi.org/10.1101/374579
    Journal:
    E-pub date: 1 Aug 2018
    Authors: G Roberts, P Larraufie, P Richards, R Kay, S Galvin, E Miedzybrodzka, A Leiter, H Joyce Li, L Glass, MKL Ma, B Lam, GSH Yeo, R Scharfmann, D Chiarugi, R Hardwick, F Reimann, F Gribble

    A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium.

    DOI: http://doi.org/10.1210/en.2015-1301
    Journal: Endocrinology
    E-pub date: 1 Nov 2015
    Authors: A Adriaenssens, BYH Lam, L Billing, K Skeffington, S Sewing, F Reimann, F Gribble