• Haematology
  • Research Focus


  • Neural Stem Cells
  • Brain
  • Neural Regeneration
  • Remyelination
  • Oligodendrocyte Progenitor Cells
  • Niche
  • Clinical Conditions

  • Dementia
  • Stroke
  • Multiple sclerosis
  • Traumatic brain injury
  • Equipment & Techniques

  • Cell culture
  • Immunohistochemistry
  • Confocal microscopy
  • Science Culture

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    University Position
    Visiting Scientist
    Dr ILIAS KAZANIS is pleased to consider applications from prospective PhD students.


    My research focuses on the regulation of adult brain cytogenesis, especilly on the biology of the subependymal zone neurogenic/gliogenic niche. I am interested in the role of components of the extracellular matrix (ECM/ such as integrins, laminins and tenascin-C), as well as of structural elements of the niche (such as ependymal cells and blood vessels) in the regulation of adult stem cell behaviour. When and how the neural stem cell transforms from a very active progenitor into a relatively quiescent cell? What is the contribution of ECM molecules in this process? How is the niche microenvironment altered when stem cells become activated in order to regenerate the neural tissue? Recently I have started exploring more intensively the oligodendrogenic properties of the subependymal zone, especially in the context of the ageing brain, as well as the potential to develop new methods to isolate neural progenitors from the niche.

    Investigating the role of Platelets in regulating Neural Stem Cells

    Key Publications

    Subependymal Zone-Derived Oligodendroblasts Respond to Focal Demyelination but Fail to Generate Myelin in Young and Aged Mice.

    Journal: Stem Cell Reports
    E-pub date: 14 Mar 2017
    Authors: I Kazanis, KA Evans, E Andreopoulou, C Dimitriou, C Koutsakis, RT Karadottir, RJM Franklin

    Lesion-induced accumulation of platelets promotes survival of adult neural stem / progenitor cells.

    Journal: Exp Neurol
    E-pub date: 1 Jul 2015
    Authors: I Kazanis, M Feichtner, S Lange, P Rotheneichner, S Hainzl, M Öller, K Schallmoser, E Rohde, HA Reitsamer, S Couillard-Despres, H-C Bauer, RJM Franklin, L Aigner, FJ Rivera

    Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals.

    Journal: J Neurosci
    E-pub date: 21 Jul 2010
    Authors: I Kazanis, JD Lathia, TJ Vadakkan, E Raborn, R Wan, MR Mughal, DM Eckley, T Sasaki, B Patton, MP Mattson, KK Hirschi, ME Dickinson, C ffrench-Constant


    Being a Neural Stem Cell: A Matter of Character But Defined by the Microenvironment.

    Journal: Adv Exp Med Biol
    E-pub date: 1 Aug 2017
    Authors: E Andreopoulou, A Arampatzis, M Patsoni, I Kazanis

    Oligodendrocyte progenitor cells: the ever mitotic cells of the CNS.

    Journal: Front Biosci (Schol Ed)
    E-pub date: 1 Jan 2016
    Authors: B Neumann, I Kazanis

    Beyond Clotting: A Role of Platelets in CNS Repair?

    Journal: Front Cell Neurosci
    E-pub date: 1 Aug 2015
    Authors: FJ Rivera, I Kazanis, C Ghevaert, L Aigner

    Disc1 variation leads to specific alterations in adult neurogenesis.

    Journal: PLoS One
    E-pub date: 1 Aug 2014
    Authors: JS Chandran, I Kazanis, SJ Clapcote, F Ogawa, JK Millar, DJ Porteous, C Ffrench-Constant

    The late response of rat subependymal zone stem and progenitor cells to stroke is restricted to directly affected areas of their niche.

    Journal: Exp Neurol
    E-pub date: 1 Oct 2013
    Authors: I Kazanis, N Gorenkova, J-W Zhao, RJM Franklin, M Modo, C Ffrench-Constant

    Neurogenesis in the adult mammalian brain: how much do we need, how much do we have?

    Journal: Curr Top Behav Neurosci
    E-pub date: 1 Aug 2013
    Authors: I Kazanis

    Niche derived oligodendrocyte progenitors: a source of rejuvenation or complementation for local oligodendrogenesis?

    Journal: Front Cell Neurosci
    E-pub date: 1 Aug 2013
    Authors: S Agathou, RT Káradóttir, I Kazanis

    Extracellular matrix and the neural stem cell niche.

    Journal: Dev Neurobiol
    E-pub date: 1 Nov 2011
    Authors: I Kazanis, C ffrench-Constant

    Adhesion molecules in the stem cell niche–more than just staying in shape?

    Journal: J Cell Sci
    E-pub date: 15 May 2010
    Authors: V Marthiens, I Kazanis, L Moss, K Long, C Ffrench-Constant

    The adult mouse subependymal zone regenerates efficiently in the absence of tenascin-C.

    Journal: J Neurosci
    E-pub date: 19 Dec 2007
    Authors: I Kazanis, A Belhadi, A Faissner, C Ffrench-Constant

    Dual function of Sox1 in telencephalic progenitor cells.

    Journal: Dev Biol
    E-pub date: 1 Oct 2007
    Authors: L Kan, A Jalali, L-R Zhao, X Zhou, T McGuire, I Kazanis, V Episkopou, AG Bassuk, JA Kessler

    Neuronal migration and ventral subtype identity in the telencephalon depend on SOX1.

    Journal: PLoS Biol
    E-pub date: 1 Jun 2005
    Authors: A Ekonomou, I Kazanis, S Malas, H Wood, P Alifragis, M Denaxa, D Karagogeos, A Constanti, R Lovell-Badge, V Episkopou

    Alterations in IGF-I, BDNF and NT-3 levels following experimental brain trauma and the effect of IGF-I administration.

    Journal: Exp Neurol
    E-pub date: 1 Apr 2004
    Authors: I Kazanis, M Giannakopoulou, H Philippidis, F Stylianopoulou

    Neuroprotective effects of insulin-like growth factor-I (IGF-I) following a penetrating brain injury in rats.

    Journal: Brain Res
    E-pub date: 21 Nov 2003
    Authors: I Kazanis, E Bozas, H Philippidis, F Stylianopoulou

    Control of neuronal nitric oxide synthase and brain-derived neurotrophic factor levels by GABA-A receptors in the developing rat cortex.

    Journal: Brain Res Dev Brain Res
    E-pub date: 12 Nov 2003
    Authors: A Mantelas, A Stamatakis, I Kazanis, H Philippidis, F Stylianopoulou

    In utero radiation-induced changes in growth factor levels in the developing rat brain.

    Journal: Int J Radiat Biol
    E-pub date: 1 Jan 2001
    Authors: A Benekou, S Bolaris, E Kazanis, E Bozas, H Philippidis, F Stylianopoulou

    NMDA receptor mediated changes in IGF-II gene expression in the rat brain after injury and the possible role of nitric oxide.

    Journal: Neuropathol Appl Neurobiol
    E-pub date: 1 Dec 2000
    Authors: M Giannakopoulou, M Mansour, E Kazanis, E Bozas, H Philpipidis, F Stylianopoulou