• Neurology Unit
  • Research Focus


  • Remyelination
  • Children
  • Clinical Conditions

  • Multiple sclerosis
  • Equipment & Techniques

  • Magnetic resonance imaging (MRI)
  • Electrophysiological recording techniques
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    Dr Jonathon Holland MA(Cantab) MRCPCH

    University Position
    PhD student


    I am studying the repair of myelin (the fatty substance protecting the projections of nerve cells) in children with multiple sclerosis (MS) - re-myelination - using complementary electrophysiological, neuroimaging and optometric outcome measures over time. This is in collaboration with Dr Nick Cunniffe and Gioia Riboni-Verri on the ARMOUR-One study in Professor Alasdair Coles' lab. This research will explore the relationship between ageing in humans and re-myelination, as well as the feasibility of introducing these measures in to clinical practice. My research is kindly supported by an Action Medical Research and British Paediatric Neurology Association Research Training Fellowship, which began in November 2022. By background I am a junior doctor nearing the completion of my national sub-specialist training in Paediatric Neurology. I continue to work closely with the Paediatric Neuroinflammatory service at Addenbrooke's Hospital.


    Multimodal Assessment of ReMyelination And Light-chain neurofilament Assay following Demyelinating Events in Children

    Key Publications


    Evaluation of the feasibility, diagnostic yield, and clinical utility of rapid genome sequencing in infantile epilepsy (Gene-STEPS): an international, multicentre, pilot cohort study

    Journal: Lancet Neurol
    Year: 2023
    Authors: D'Gama AM, Mulhern S, Sheidley BR, Boodhoo F, Buts S, Chandler NJ, Cobb J, Curtis M, Higginbotham EJ, Holland J, Khan T, Koh J , Liang NSY, McRae L, Nesbitt SE, Oby BT, Paternoster B, Patton A, Rose G, Scotchman E, Valentine R, Wiltrout, KN, Gene-STEPS Study Group, IPCHiP Executive Committee, Hayeems RZ, Jain P, Lunke S, Marshall CR, Rockowitz S, Sebire NJ, Stark Z, White SM, Chitty LS, Cross JH, Scheffer IE, Chau V, Costain G, Poduri A, Howell KB, McTague A