Research Focus


  • Remyelination
  • Visual System
  • Clinical Trials
  • Multiple Sclerosis
  • Clinical Conditions

  • Multiple sclerosis
  • Equipment & Techniques

  • Electrophysiological recording techniques
  • Magnetic resonance imaging (MRI)
  • Randomised control trials
  • Back

    Dr Nick Cunniffe

    University Position
    Clinical Lecturer
    Dr Nick Cunniffe is pleased to consider applications from prospective PhD students.


    I am an Academic Clinical Lecturer in Neurology. My research is centred on the different ways of promoting and measuring remyelination in people living with multiple sclerosis; it is anticipated that through enhancing remyelination of damaged nerves we can delay, prevent, or reverse the progression of disability. I work on clinical trials, in particular the Cambridge Centre for Myelin Repair remyelination trials and, at the Cambridge Clinical Vision Laboratory, I use visual evoked potentials (VEP), optical coherence tomography (OCT), and tests of eye movements and visual function to measure the effects of remyelinating and neuroprotective therapies. I am also working to integrate these measures of remyelination and axonal health into routine clinical practice, alongside MRI-based measures. Outside of the lab, I am committed to medical education. I supervise neuroscience to medical students at Gonville and Caius College and am co-author of an undergraduate neuroscience textbook.

    Cambridge Clinical Vision Laboratory

    Professor Coles, Dr Brown and Dr Cunniffe in the Cambridge Clinical Vision Laboratory

    Key Publications

    Early non-disabling relapses are important predictors of disability accumulation in people with relapsing-remitting multiple sclerosis.

    Journal: Mult Scler
    E-pub date: 1 Jun 2023
    Authors: C Daruwalla, V Shaygannejad, S Ozakbas, EK Havrdova, D Horakova, R Alroughani, C Boz, F Patti, M Onofrj, A Lugaresi, S Eichau, M Girard, A Prat, P Duquette, B Yamout, SJ Khoury, SA Sajedi, R Turkoglu, A Altintas, O Skibina, K Buzzard, P Grammond, R Karabudak, A van der Walt, H Butzkueven, D Maimone, J Lechner-Scott, A Soysal, N John, J Prevost, D Spitaleri, C Ramo-Tello, O Gerlach, G Iuliano, M Foschi, R Ampapa, V van Pesch, M Barnett, N Shalaby, M D'hooghe, J Kuhle, MJ Sa, M Fabis-Pedrini, A Kermode, S Mrabet, R Gouider, S Hodgkinson, G Laureys, L Van Hijfte, R Macdonell, C Oreja-Guevara, E Cristiano, P McCombe, JL Sanchez-Menoyo, B Singhal, Y Blanco, S Hughes, J Garber, C Solaro, C McGuigan, B Taylor, K de Gans, M Habek, A Al-Asmi, S Mihaela, T Castillo Triviño, T Al-Harbi, JI Rojas, O Gray, D Khurana, B Van Wijmeersch, N Grigoriadis, J Inshasi, J Oh, E Aguera-Morales, Y Fragoso, F Moore, C Shaw, SM Baghbanian, N Shuey, B Willekens, TA Hardy, D Decoo, AP Sempere, D Field, R Wynford-Thomas, NG Cunniffe, I Roos, CB Malpas, AJ Coles, T Kalincik, JWL Brown

    Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study.

    Journal: Lancet Neurol
    E-pub date: 1 Sep 2021
    Authors: JWL Brown, NG Cunniffe, F Prados, B Kanber, JL Jones, E Needham, Z Georgieva, D Rog, OR Pearson, J Overell, D MacManus, RS Samson, J Stutters, C Ffrench-Constant, CAM Gandini Wheeler-Kingshott, C Moran, PD Flynn, AW Michell, RJM Franklin, S Chandran, DR Altmann, DT Chard, P Connick, AJ Coles

    The MS Remyelinating Drug Bexarotene (an RXR Agonist) Promotes Induction of Human Tregs and Suppresses Th17 Differentiation In Vitro.

    Journal: Front Immunol
    E-pub date: 1 Aug 2021
    Authors: CM Gaunt, DB Rainbow, RJ Mackenzie, LB Jarvis, HS Mousa, N Cunniffe, Z Georgieva, JW Brown, AJ Coles, JL Jones

    Promoting remyelination in multiple sclerosis.

    Journal: J Neurol
    E-pub date: 1 Jan 2021
    Authors: N Cunniffe, A Coles


    Remyelination varies between and within lesions in multiple sclerosis following bexarotene.

    Journal: Ann Clin Transl Neurol
    E-pub date: 1 Oct 2022
    Authors: JWL Brown, F Prados, DR Altmann, B Kanber, J Stutters, NG Cunniffe, JL Jones, ZG Georgieva, EJ Needham, C Daruwalla, CG Wheeler-Kingshott, P Connick, S Chandran, R Franklin, D MacManus, R Samson, A Coles, D Chard

    Remyelination in humans due to a retinoid-X receptor agonist is age-dependent.

    Journal: Ann Clin Transl Neurol
    E-pub date: 1 Jul 2022
    Authors: CE McMurran, T Mukherjee, JWL Brown, AW Michell, DT Chard, RJM Franklin, AJ Coles, NG Cunniffe

    Systematic approach to selecting licensed drugs for repurposing in the treatment of progressive multiple sclerosis.

    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Mar 2021
    Authors: N Cunniffe, KA Vuong, D Ainslie, D Baker, J Beveridge, S Bickley, P Camilleri, M Craner, D Fitzgerald, AG de la Fuente, G Giovannoni, E Gray, L Hazlehurst, R Kapoor, R Kaur, D Kozlowski, B Lumicisi, D Mahad, B Neumann, A Palmer, L Peruzzotti-Jametti, S Pluchino, J Robertson, A Rothaul, L Shellard, KJ Smith, A Wilkins, A Williams, A Coles

    How achievable are COVID-19 clinical trial recruitment targets? A UK observational cohort study and trials registry analysis.

    Journal: BMJ Open
    E-pub date: 5 Oct 2020
    Authors: NG Cunniffe, SJ Gunter, M Brown, SW Burge, C Coyle, A De Soyza, T Dymond, H Esmail, DP Francis, J Galloway, JB Galloway, E Gkrania-Klotsas, J Greenaway, G Katritsis, P Kanagaratnam, MD Knolle, K Leonard, ZC McIntyre, B Prudon, T Rampling, ME Torok, B Warne, M Yates, NJ Matheson, L Su, S Villar, GD Stewart, M Toshner

    Using saccades to diagnose covert hepatic encephalopathy.

    Journal: Metab Brain Dis
    E-pub date: 1 Jun 2015
    Authors: N Cunniffe, H Munby, S Chan, D Saatci, E Edison, RHS Carpenter, D Massey

    Clinical examination does not assist in the detection of systemic relapse of testicular germ cell tumour.

    Journal: Clin Oncol (R Coll Radiol)
    E-pub date: 1 Feb 2012
    Authors: NG Cunniffe, J Robson, D Mazhar, MV Williams

    Dynamic imaging of calcium and STIM1 in the same cell using wide-field and TIRF microscopy.

    Journal: Biotechniques
    E-pub date: 1 Sep 2008
    Authors: S Walker, N Cunniffe, M Bootman, HL Roderick