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I am a Visiting Researcher in Pharmacology interested in the interaction between novel inflammatory mediators and sensory neurons, with the aim of better understanding nociceptive signalling during inflammatory disease. My PhD and post-doctoral research with Dr David Bulmer was primarily focussed on investigating the interaction between Angiotensin II and sensory neurons in vitro, using genetically engineered neurons (in collaboration with Prof John Wood and Prof James Cox, UCL) and pharmacological tools in tandem with calcium imaging, patch-clamp electrophysiology and immunofluorescence. Before moving to Cambridge, I worked on trying to understand the neurophysiological changes which underpin behavioural deficits in Alzheimer's disease (using Drosophila), and on characterising the pharmacological and biophysical properties of a novel heteromeric calcium-activated potassium channel.
Single-channel activity of recombinant human IKCa channels in an inside-out patch at a holding potential of -30 (top), -50 (middle) and -70 mV (bottom; isotonic potassium; 1 uM free calcium).
