Professor Jonathan Coles

University Position

Professor

Interests

As a clinician specialising within Neurointensive care my research interests are focused on describing the pathophysiology of head injury and optimising patient outcome. Using the combined facilities of the Wolfson Brain Imaging and Neurosciences Critical Care Unit at Addenbrooke's Hospital patients undergo structural and functional imaging studies using positron emission tomography and magnetic resonance imaging. I have used such imaging tools to define the incidence, temporal evolution and impact on outcome of cerebral ischaemia following head injury. Other work has addressed the impact of clinical interventions aimed at controlling intracranial pressure such as hyperventilation and elevation of cerebral perfusion pressure. Current research is aimed at using imaging techniques to define the temporal pattern and metabolic correlates of neuronal loss after human head injury. Such data will be crucial in the development and implementation of successful neuroprotective therapies.

Key Publications

Serum biomarkers identify critically ill traumatic brain injury patients for MRI

DOI: http://doi.org/10.1186/s13054-022-04250-3
Journal: Crit Care
E-pub date: 29 Nov 2022
Authors: S Richter, S Winzeck, E Czeiter, K Amrein, EN Kornaropoulos, J Verheyden, G Sugar, Z Yang, K Wang, AIR Maas, E Steyerberg, A Büki, VFJ Newcombe, DK Menon, K Amrein, N Andelic, L Andreassen, A Anke, P Azouvi, B Bellander, H Benali, A Buki, A Caccioppola, E Calappi, M Carbonara, G Citerio, H Clusmann, M Coburn, J Coles, M Correia, E Czeiter, V De Keyser, V Degos, B Depreitere, L Eikenes, E Ezer, K Foks, S Frisvold, D Galanaud, A Ghuysen, B Glocker, A Haberg, I Haitsma, E Helseth, PJ Hutchinson, E Kornaropoulos, N Kovács, A Kowark, S Laureys, D Ledoux, H Lingsma, AIR Maas, G Manley, DK Menon, T Menovsky, B Misset, V Muraleedharan, I Nakken, V Newcombe, W Nordhøy, J Nyirádi, F Ortolano, PM Parizel, V Perlbarg, P Persona, W Peul, JP Posti, L Puybasset, S Richter, C Roe, O Roise, R Rossaint, S Rossi, D Rueckert, T Skandsen, A Sorinola, E Stamatakis, EW Steyerberg, N Stocchetti, R Takala, V Tamás, O Tenovuo, Z Vámos, G Van der Steen, W Van Hecke, TV Vyvere, J Verheyden, A Vik, V Volovici, LT Westlye, G Williams, S Winzeck, P Ylén, T Zoerle

Metabolic derangements are associated with impaired glucose delivery following traumatic brain injury.

DOI: http://doi.org/10.1093/brain/awab255
Journal: Brain
E-pub date: 16 Dec 2021
Authors: J Hermanides, YT Hong, M Trivedi, J Outtrim, F Aigbirhio, PJ Nestor, M Guilfoyle, S Winzeck, VFJ Newcombe, T Das, MM Correia, KLH Carpenter, PJA Hutchinson, AK Gupta, TD Fryer, JD Pickard, DK Menon, JP Coles

Spatial and Temporal Pattern of Ischemia and Abnormal Vascular Function Following Traumatic Brain Injury.

DOI: http://doi.org/10.1001/jamaneurol.2019.3854
Journal: JAMA Neurol
E-pub date: 1 Mar 2020
Authors: Y Launey, TD Fryer, YT Hong, LA Steiner, J Nortje, TV Veenith, PJ Hutchinson, A Ercole, AK Gupta, FI Aigbirhio, JD Pickard, JP Coles, DK Menon

Pathophysiologic Mechanisms of Cerebral Ischemia and Diffusion Hypoxia in Traumatic Brain Injury.

DOI: http://doi.org/10.1001/jamaneurol.2016.0091
Journal: JAMA Neurol
E-pub date: 1 May 2016
Authors: TV Veenith, EL Carter, T Geeraerts, J Grossac, VFJ Newcombe, J Outtrim, GS Gee, V Lupson, R Smith, FI Aigbirhio, TD Fryer, YT Hong, DK Menon, JP Coles

Incidence and mechanisms of cerebral ischemia in early clinical head injury.

DOI: http://doi.org/10.1097/01.WCB.0000103022.98348.24
Journal: J Cereb Blood Flow Metab
E-pub date: 1 Feb 2004
Authors: JP Coles, TD Fryer, P Smielewski, DA Chatfield, LA Steiner, AJ Johnston, SPMJ Downey, GB Williams, F Aigbirhio, PJ Hutchinson, K Rice, TA Carpenter, JC Clark, JD Pickard, DK Menon

Publications

Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses.

DOI: http://doi.org/10.1093/brain/awac321
Journal: Brain
E-pub date: 21 Nov 2022
Authors: EJ Needham, AL Ren, RJ Digby, EJ Norton, S Ebrahimi, JG Outtrim, DA Chatfield, AE Manktelow, MM Leibowitz, VFJ Newcombe, R Doffinger, G Barcenas-Morales, C Fonseca, MJ Taussig, RM Burnstein, RJ Samanta, C Dunai, N Sithole, NJ Ashton, H Zetterberg, M Gisslén, A Edén, E Marklund, PJM Openshaw, J Dunning, MJ Griffiths, J Cavanagh, G Breen, SR Irani, A Elmer, N Kingston, C Summers, JR Bradley, LS Taams, BD Michael, ET Bullmore, KGC Smith, PA Lyons, AJ Coles, DK Menon, Cambridge NeuroCOVID Group, CITIID-NIHR COVID-19 BioResource Collaboration, Cambridge NIHR Clinical Research Facility

Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome: associations with amyloid burden and longitudinal cognitive decline.

DOI: http://doi.org/10.1093/braincomms/fcaa198
Journal: Brain Commun
E-pub date: 1 Aug 2021
Authors: E Mak, M Grigorova, J Beresford-Webb, M Malpetti, M Walpert, S Brown, E Jones, I Clare, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DK Menon, PJ Nestor, AJ Holland, SH Zaman

Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study.

DOI: http://doi.org/10.1016/S2215-0366(20)30287-X
Journal: Lancet Psychiatry
E-pub date: 1 Oct 2020
Authors: A Varatharaj, N Thomas, MA Ellul, NWS Davies, TA Pollak, EL Tenorio, M Sultan, A Easton, G Breen, M Zandi, JP Coles, H Manji, R Al-Shahi Salman, DK Menon, TR Nicholson, LA Benjamin, A Carson, C Smith, MR Turner, T Solomon, R Kneen, SL Pett, I Galea, RH Thomas, BD Michael, CoroNerve Study Group

Synaptic loss in primary tauopathies revealed by [11C]UCB-J positron emission tomography

DOI: http://doi.org/10.1101/2020.01.24.20018697
Journal:
E-pub date: 1 Aug 2020
Authors: N Holland, S Jones, G Savulich, J Wiggins, Y Hong, T Fryer, R Manavaki, SM Sephton, I Boros, M Malpetti, F Hezemans, F Aigbirhio, J Coles, J O’Brien, J Rowe

Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.

DOI: http://doi.org/10.1093/brain/awaa033
Journal: Brain
E-pub date: 1 Mar 2020
Authors: WR Bevan-Jones, TE Cope, PS Jones, SS Kaalund, L Passamonti, K Allinson, O Green, YT Hong, TD Fryer, R Arnold, JP Coles, FI Aigbirhio, AJ Larner, K Patterson, JT O'Brien, JB Rowe

Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.: weak correlations were observed between our cohorts of controls for each ligand (supplementary figure 1)

DOI: http://doi.org/10.1101/525642
Journal:
E-pub date: 1 Aug 2019
Authors: WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, Y Hong, T Fryer, R Arnold, J Coles, F Aigbirhio, A Larner, K Patterson, J O'Brien, J Rowe

In vivo evidence for pre-symptomatic neuroinflammation in a MAPT mutation carrier.

DOI: http://doi.org/10.1002/acn3.683
Journal: Ann Clin Transl Neurol
E-pub date: 1 Feb 2019
Authors: WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, YT Hong, T Fryer, R Arnold, JP Coles, FI Aigbirhio, JT O'Brien, JB Rowe

[18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia.

DOI: http://doi.org/10.1136/jnnp-2017-316402
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Oct 2018
Authors: WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, YT Hong, TD Fryer, R Arnold, KSJ Allinson, JP Coles, FI Aigbirhio, K Patterson, JT O'Brien, JB Rowe

[18F]AV-1451 binding is increased in frontotemporal dementia due to C9orf72 expansion.

DOI: http://doi.org/10.1002/acn3.631
Journal: Ann Clin Transl Neurol
E-pub date: 1 Oct 2018
Authors: RW Bevan-Jones, TE Cope, SP Jones, L Passamonti, YT Hong, T Fryer, R Arnold, JP Coles, FA Aigbirhio, K Patterson, JT O'Brien, JB Rowe

[18F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation.

DOI: http://doi.org/10.1002/acn3.366
Journal: Ann Clin Transl Neurol
E-pub date: 1 Dec 2016
Authors: WR Bevan Jones, TE Cope, L Passamonti, TD Fryer, YT Hong, F Aigbirhio, JJ Kril, SL Forrest, K Allinson, JP Coles, P Simon Jones, MG Spillantini, JR Hodges, JT O'Brien, JB Rowe

Dynamic Changes in White Matter Abnormalities Correlate With Late Improvement and Deterioration Following TBI: A Diffusion Tensor Imaging Study.

DOI: http://doi.org/10.1177/1545968315584004
Journal: Neurorehabil Neural Repair
E-pub date: 1 Jan 2016
Authors: VFJ Newcombe, MM Correia, C Ledig, MG Abate, JG Outtrim, D Chatfield, T Geeraerts, AE Manktelow, E Garyfallidis, JD Pickard, BJ Sahakian, PJA Hutchinson, D Rueckert, JP Coles, GB Williams, DK Menon

Microstructural basis of contusion expansion in traumatic brain injury: insights from diffusion tensor imaging.

DOI: http://doi.org/10.1038/jcbfm.2013.11
Journal: Journal of Cerebral Blood Flow and Metabolism
E-pub date: 1 Jun 2013
Authors: VFJ Newcombe, GB Williams, JG Outtrim, D Chatfield, M Gulia Abate, T Geeraerts, A Manktelow, H Room, L Mariappen, PJ Hutchinson, JP Coles, DK Menon