Department

School

Institute

Division of Anaesthesia

Research Theme Neurons, Circuits and Networks Brains and Machines Beyond the Neuron

Research Focus

Keywords

Positron Emission Tomography

Magnetic Resonance Imaging

TBI

Neurocritical Care

Clinical Conditions

Traumatic brain injury

Equipment & Techniques

Positron Emission Tomography (PET)

Magnetic resonance imaging (MRI)

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Professor Jonathan Coles

University Position

Professor

Interests

As a clinician specialising within Neurointensive care my research interests are focused on describing the pathophysiology of head injury and optimising patient outcome. Using the combined facilities of the Wolfson Brain Imaging and Neurosciences Critical Care Unit at Addenbrooke's Hospital patients undergo structural and functional imaging studies using positron emission tomography and magnetic resonance imaging. I have used such imaging tools to define the incidence, temporal evolution and impact on outcome of cerebral ischaemia following head injury. Other work has addressed the impact of clinical interventions aimed at controlling intracranial pressure such as hyperventilation and elevation of cerebral perfusion pressure. Current research is aimed at using imaging techniques to define the temporal pattern and metabolic correlates of neuronal loss after human head injury. Such data will be crucial in the development and implementation of successful neuroprotective therapies.

Key Publications

Acute thalamic connectivity precedes chronic post-concussive symptoms in mild traumatic brain injury.

DOI: http://doi.org/10.1093/brain/awad056
Journal: Brain
E-pub date: 1 Aug 2023
Authors: RE Woodrow, S Winzeck, AI Luppi, IR Kelleher-Unger, LRB Spindler, JTL Wilson, VFJ Newcombe, JP Coles, CENTER-TBI MRI Substudy Participants and Investigators, DK Menon, EA Stamatakis

Serum biomarkers identify critically ill traumatic brain injury patients for MRI

DOI: http://doi.org/10.1186/s13054-022-04250-3
Journal: Crit Care
E-pub date: 29 Nov 2022
Authors: S Richter, S Winzeck, E Czeiter, K Amrein, EN Kornaropoulos, J Verheyden, G Sugar, Z Yang, K Wang, AIR Maas, E Steyerberg, A Büki, VFJ Newcombe, DK Menon, K Amrein, N Andelic, L Andreassen, A Anke, P Azouvi, B Bellander, H Benali, A Buki, A Caccioppola, E Calappi, M Carbonara, G Citerio, H Clusmann, M Coburn, J Coles, M Correia, E Czeiter, V De Keyser, V Degos, B Depreitere, L Eikenes, E Ezer, K Foks, S Frisvold, D Galanaud, A Ghuysen, B Glocker, A Haberg, I Haitsma, E Helseth, PJ Hutchinson, E Kornaropoulos, N Kovács, A Kowark, S Laureys, D Ledoux, H Lingsma, AIR Maas, G Manley, DK Menon, T Menovsky, B Misset, V Muraleedharan, I Nakken, V Newcombe, W Nordhøy, J Nyirádi, F Ortolano, PM Parizel, V Perlbarg, P Persona, W Peul, JP Posti, L Puybasset, S Richter, C Roe, O Roise, R Rossaint, S Rossi, D Rueckert, T Skandsen, A Sorinola, E Stamatakis, EW Steyerberg, N Stocchetti, R Takala, V Tamás, O Tenovuo, Z Vámos, G Van der Steen, W Van Hecke, TV Vyvere, J Verheyden, A Vik, V Volovici, LT Westlye, G Williams, S Winzeck, P Ylén, T Zoerle

Metabolic derangements are associated with impaired glucose delivery following traumatic brain injury.

DOI: http://doi.org/10.1093/brain/awab255
Journal: Brain
E-pub date: 16 Dec 2021
Authors: J Hermanides, YT Hong, M Trivedi, J Outtrim, F Aigbirhio, PJ Nestor, M Guilfoyle, S Winzeck, VFJ Newcombe, T Das, MM Correia, KLH Carpenter, PJA Hutchinson, AK Gupta, TD Fryer, JD Pickard, DK Menon, JP Coles

Spatial and Temporal Pattern of Ischemia and Abnormal Vascular Function Following Traumatic Brain Injury.

DOI: http://doi.org/10.1001/jamaneurol.2019.3854
Journal: JAMA Neurol
E-pub date: 1 Mar 2020
Authors: Y Launey, TD Fryer, YT Hong, LA Steiner, J Nortje, TV Veenith, PJ Hutchinson, A Ercole, AK Gupta, FI Aigbirhio, JD Pickard, JP Coles, DK Menon

Pathophysiologic Mechanisms of Cerebral Ischemia and Diffusion Hypoxia in Traumatic Brain Injury.

DOI: http://doi.org/10.1001/jamaneurol.2016.0091
Journal: JAMA Neurol
E-pub date: 1 May 2016
Authors: TV Veenith, EL Carter, T Geeraerts, J Grossac, VFJ Newcombe, J Outtrim, GS Gee, V Lupson, R Smith, FI Aigbirhio, TD Fryer, YT Hong, DK Menon, JP Coles

Diffusion limited oxygen delivery following head injury.

DOI: http://doi.org/10.1097/01.ccm.0000127777.16609.08
Journal: Crit Care Med
E-pub date: 1 Jun 2004
Authors: DK Menon, JP Coles, AK Gupta, TD Fryer, P Smielewski, DA Chatfield, F Aigbirhio, JN Skepper, PS Minhas, PJ Hutchinson, TA Carpenter, JC Clark, JD Pickard

Incidence and mechanisms of cerebral ischemia in early clinical head injury.

DOI: http://doi.org/10.1097/01.WCB.0000103022.98348.24
Journal: J Cereb Blood Flow Metab
E-pub date: 1 Feb 2004
Authors: JP Coles, TD Fryer, P Smielewski, DA Chatfield, LA Steiner, AJ Johnston, SPMJ Downey, GB Williams, F Aigbirhio, PJ Hutchinson, K Rice, TA Carpenter, JC Clark, JD Pickard, DK Menon

Publications

Repeat traumatic brain injury exacerbates acute thalamic hyperconnectivity in humans

DOI: http://doi.org/10.1093/braincomms/fcae223
Journal: Brain Commun
E-pub date: 1 Aug 2024
Authors: RE Woodrow, K Amrein, N Andelic, L Andreassen, A Anke, P Azouvi, B Bellander, H Benali, A Buki, A Caccioppola, E Calappi, M Carbonara, G Citerio, H Clusmann, M Coburn, J Coles, M Correia, E Czeiter, V De Keyser, V Degos, B Depreitere, L Eikenes, E Ezer, K Foks, S Frisvold, D Galanaud, A Ghuysen, B Glocker, A Haberg, I Haitsma, E Helseth, PJ Hutchinson, E Kornaropoulos, N Kovács, A Kowark, S Laureys, D Ledoux, H Lingsma, AIR Maas, G Manley, DK Menon, T Menovsky, B Misset, V Muraleedharan, I Nakken, V Newcombe, W Nordhøy, J Nyirádi, F Ortolano, PM Parizel, V Perlbarg, P Persona, W Peul, JP Posti, L Puybasset, S Richter, C Roe, O Roise, R Rossaint, S Ross, D Rueckert, RD Singh, T Skandsen, A Sorinola, E Stamatakis, EW Steyerberg, N Stocchetti, R Takala, V Tamás, O Tenovuo, A Thibaut, Z Vámos, G Van der Steen, IA van Erp, W Van Hecke, T Vande Vyvere, J Verheyden, A Vik, V Volovici, LT Westlye, D Whitehouse, G Williams, S Winzeck, P Ylén, T Zoerle, DK Menon, EA Stamatakis

Amyloid and tau deposition influences cognitive and functional decline in Down Syndrome

DOI: http://doi.org/10.1002/alz.062617
Journal: Alzheimer's & Dementia
E-pub date: 1 Jun 2023
Authors: M Grigorova, E Mak, SSG Brown, J Beresford‐Webb, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DL Tudorascu, AD Cohen, BT Christian, B Ances, BL Handen, CM Laymon, WE Klunk, I Clare, AJ Holland, S Zaman

Amyloid- β and tau deposition influences cognitive and functional decline in Down syndrome.

DOI: http://doi.org/10.1016/j.neurobiolaging.2022.07.003
Journal: Neurobiol Aging
E-pub date: 1 Nov 2022
Authors: M Grigorova, E Mak, SSG Brown, J Beresford-Webb, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, D Tudorascu, A Cohen, BT Christian, B Ances, BL Handen, CM Laymon, WE Klunk, ICH Clare, AJ Holland, SH Zaman

Mapping neurotransmitter systems to the structural and functional organization of the human neocortex.

DOI: http://doi.org/10.1038/s41593-022-01186-3
Journal: Nat Neurosci
E-pub date: 1 Nov 2022
Authors: JY Hansen, G Shafiei, RD Markello, K Smart, SML Cox, M Nørgaard, V Beliveau, Y Wu, J-D Gallezot, É Aumont, S Servaes, SG Scala, JM DuBois, G Wainstein, G Bezgin, T Funck, TW Schmitz, RN Spreng, M Galovic, MJ Koepp, JS Duncan, JP Coles, TD Fryer, FI Aigbirhio, CJ McGinnity, A Hammers, J-P Soucy, S Baillet, S Guimond, J Hietala, M-A Bedard, M Leyton, E Kobayashi, P Rosa-Neto, M Ganz, GM Knudsen, N Palomero-Gallagher, JM Shine, RE Carson, L Tuominen, A Dagher, B Misic

Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses.

DOI: http://doi.org/10.1093/brain/awac321
Journal: Brain
E-pub date: 6 Sep 2022
Authors: EJ Needham, AL Ren, RJ Digby, EJ Norton, S Ebrahimi, JG Outtrim, DA Chatfield, AE Manktelow, MM Leibowitz, VFJ Newcombe, R Doffinger, G Barcenas-Morales, C Fonseca, MJ Taussig, RM Burnstein, RJ Samanta, C Dunai, N Sithole, NJ Ashton, H Zetterberg, M Gisslén, A Edén, E Marklund, PJM Openshaw, J Dunning, MJ Griffiths, J Cavanagh, G Breen, SR Irani, A Elmer, N Kingston, C Summers, JR Bradley, LS Taams, BD Michael, ET Bullmore, KGC Smith, PA Lyons, AJ Coles, DK Menon, Cambridge NeuroCOVID Group, CITIID-NIHR COVID-19 BioResource Collaboration, Cambridge NIHR Clinical Research Facility

Support vector machine learning and diffusion-derived structural networks predict amyloid quantity and cognition in adults with Down’s syndrome.

DOI: http://doi.org/10.1016/j.neurobiolaging.2022.02.013
Journal: Neurobiol Aging
E-pub date: 1 Jul 2022
Authors: SSG Brown, E Mak, I Clare, M Grigorova, J Beresford-Webb, M Walpert, E Jones, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, D Tudorascu, A Cohen, BT Christian, BL Handen, WE Klunk, DK Menon, PJ Nestor, AJ Holland, SH Zaman

Cortical atrophy and amyloid and tau deposition in Down syndrome: A longitudinal study.

DOI: http://doi.org/10.1002/dad2.12288
Journal: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
E-pub date: 1 Jan 2022
Authors: C Padilla, V Montal, MJ Walpert, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, SL Hartley, AD Cohen, DL Tudorascu, BT Christian, BL Handen, WE Klunk, AJ Holland, SH Zaman

Amyloid and tau deposition influences cognitive decline in Down syndrome

DOI: http://doi.org/10.1002/alz.056384
Journal: Alzheimer's & Dementia
E-pub date: 1 Dec 2021
Authors: M Grigorova, E Mak, J Beresford‐Webb, SSG Brown, E Jones, I Clare, T Holland, YT Hong, TD Fryer, JP Coles, GB Williams, FI Aigbirhio, BM Ances, BT Christian, BL Handen, WE Klunk, CM Laymon, DL Tudorascu, S Zaman

Validation of a combined image derived input function and venous sampling approach for the quantification of [18F]GE-179 PET binding in the brain.

DOI: http://doi.org/10.1016/j.neuroimage.2021.118194
Journal: Neuroimage
E-pub date: 15 Aug 2021
Authors: M Galovic, K Erlandsson, TD Fryer, YT Hong, R Manavaki, H Sari, S Chetcuti, BA Thomas, M Fisher, S Sephton, R Canales, JJ Russell, K Sander, E Årstad, FI Aigbirhio, AM Groves, JS Duncan, K Thielemans, BF Hutton, JP Coles, MJ Koepp, NEST investigators

Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome: associations with amyloid burden and longitudinal cognitive decline.

DOI: http://doi.org/10.1093/braincomms/fcaa198
Journal: Brain Commun
E-pub date: 1 Aug 2021
Authors: E Mak, M Grigorova, J Beresford-Webb, M Malpetti, M Walpert, S Brown, E Jones, I Clare, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DK Menon, PJ Nestor, AJ Holland, SH Zaman

Outcome Prediction after Moderate and Severe Traumatic Brain Injury: External Validation of Two Established Prognostic Models in 1742 European Patients.

DOI: http://doi.org/10.1089/neu.2020.7300
Journal: J Neurotrauma
E-pub date: 15 May 2021
Authors: SA Dijkland, IRAR Helmrich, D Nieboer, M van der Jagt, DWJ Dippel, DK Menon, N Stocchetti, AIR Maas, HF Lingsma, EW Steyerberg, CENTER-TBI Participants and Investigators

Neuroanatomical substrates of generalized brain dysfunction in COVID-19.

DOI: http://doi.org/10.1007/s00134-020-06241-w
Journal: Intensive Care Med
E-pub date: 1 Jan 2021
Authors: VFJ Newcombe, LRB Spindler, T Das, S Winzeck, K Allinson, EA Stamatakis, DK Menon, Cambridge NeuroCovid Imaging Collaborators

Understanding the relationship between cognitive performance and function in daily life after traumatic brain injury.

DOI: http://doi.org/10.1136/jnnp-2020-324492
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 2 Dec 2020
Authors: L Wilson, L Horton, K Kunzmann, BJ Sahakian, VF Newcombe, EA Stamatakis, N von Steinbuechel, K Cunitz, A Covic, A Maas, D Van Praag, D Menon, CENTER-TBI participants and investigators

Diffusion structural network metrics as a predictor for Alzheimer’s disease diagnosis in Down syndrome using support vector machine classification

DOI: http://doi.org/10.1002/alz.040261
Journal: Alzheimer's & Dementia
E-pub date: 1 Dec 2020
Authors: SSG Brown, E Mak, M Grigorova, J Beresford‐Webb, MJ Walpert, E Jones, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, BL Handen, BT Christian, WE Klunk, DK Menon, PJ Nestor, AJ Holland, S Zaman

Neurological and neuropsychiatric complications of COVID-19 in 153 patients: a UK-wide surveillance study.

DOI: http://doi.org/10.1016/S2215-0366(20)30287-X
Journal: Lancet Psychiatry
E-pub date: 1 Oct 2020
Authors: A Varatharaj, N Thomas, MA Ellul, NWS Davies, TA Pollak, EL Tenorio, M Sultan, A Easton, G Breen, M Zandi, JP Coles, H Manji, R Al-Shahi Salman, DK Menon, TR Nicholson, LA Benjamin, A Carson, C Smith, MR Turner, T Solomon, R Kneen, SL Pett, I Galea, RH Thomas, BD Michael, CoroNerve Study Group

Synaptic Loss in Primary Tauopathies Revealed by [11 C]UCB-J Positron Emission Tomography.

DOI: http://doi.org/10.1002/mds.28188
Journal: Mov Disord
E-pub date: 1 Oct 2020
Authors: N Holland, PS Jones, G Savulich, JK Wiggins, YT Hong, TD Fryer, R Manavaki, SM Sephton, I Boros, M Malpetti, FH Hezemans, FI Aigbirhio, JP Coles, J O'Brien, JB Rowe

Depression following traumatic brain injury is characterised by dominant and recurring brain loops in self-referential areas

DOI: http://doi.org/10.1101/2020.08.14.20175000
Journal:
E-pub date: 1 Aug 2020
Authors: I Pappas, L Moreno-López, E Carroll, A Manktelow, J Outtrim, J Coles, V Newcombe, B Sahakian, D Menon, E Stamatakis

Synaptic loss in primary tauopathies revealed by [11C]UCB-J positron emission tomography

DOI: http://doi.org/10.1101/2020.01.24.20018697
Journal:
E-pub date: 1 Aug 2020
Authors: N Holland, S Jones, G Savulich, J Wiggins, Y Hong, T Fryer, R Manavaki, SM Sephton, I Boros, M Malpetti, F Hezemans, F Aigbirhio, J Coles, J O’Brien, J Rowe

Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.

DOI: http://doi.org/10.1093/brain/awaa033
Journal: Brain
E-pub date: 1 Mar 2020
Authors: WR Bevan-Jones, TE Cope, PS Jones, SS Kaalund, L Passamonti, K Allinson, O Green, YT Hong, TD Fryer, R Arnold, JP Coles, FI Aigbirhio, AJ Larner, K Patterson, JT O'Brien, JB Rowe

Longitudinal trajectories of amyloid deposition, cortical thickness, and tau in Down syndrome: A deep-phenotyping case report.

DOI: http://doi.org/10.1016/j.dadm.2019.04.006
Journal: Alzheimers Dement (Amst)
E-pub date: 1 Dec 2019
Authors: E Mak, A Bickerton, C Padilla, MJ Walpert, T Annus, LR Wilson, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, BT Christian, BL Handen, WE Klunk, DK Menon, PJ Nestor, SH Zaman, AJ Holland

Delineating the topography of amyloid-associated cortical atrophy in Down syndrome.

DOI: http://doi.org/10.1016/j.neurobiolaging.2019.02.018
Journal: Neurobiol Aging
E-pub date: 31 Aug 2019
Authors: E Mak, C Padilla, T Annus, LR Wilson, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DK Menon, PJ Nestor, SH Zaman, AJ Holland

Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.: weak correlations were observed between our cohorts of controls for each ligand (supplementary figure 1)

DOI: http://doi.org/10.1101/525642
Journal:
E-pub date: 1 Aug 2019
Authors: WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, Y Hong, T Fryer, R Arnold, J Coles, F Aigbirhio, A Larner, K Patterson, J O'Brien, J Rowe

In vivo evidence for pre-symptomatic neuroinflammation in a MAPT mutation carrier.

DOI: http://doi.org/10.1002/acn3.683
Journal: Ann Clin Transl Neurol
E-pub date: 1 Feb 2019
Authors: WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, YT Hong, T Fryer, R Arnold, JP Coles, FI Aigbirhio, JT O'Brien, JB Rowe

[18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia.

DOI: http://doi.org/10.1136/jnnp-2017-316402
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Oct 2018
Authors: WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, YT Hong, TD Fryer, R Arnold, KSJ Allinson, JP Coles, FI Aigbirhio, K Patterson, JT O'Brien, JB Rowe

[18F]AV-1451 binding is increased in frontotemporal dementia due to C9orf72 expansion.

DOI: http://doi.org/10.1002/acn3.631
Journal: Ann Clin Transl Neurol
E-pub date: 1 Oct 2018
Authors: RW Bevan-Jones, TE Cope, SP Jones, L Passamonti, YT Hong, T Fryer, R Arnold, JP Coles, FA Aigbirhio, K Patterson, JT O'Brien, JB Rowe

Neural correlates of visual memory in patients with diffuse axonal injury.

DOI: http://doi.org/10.1080/02699052.2017.1341998
Journal: Brain Inj
E-pub date: 1 Aug 2017
Authors: J Lauer, L Moreno-López, A Manktelow, EL Carroll, JG Outtrim, JP Coles, VF Newcombe, BJ Sahakian, DK Menon, EA Stamatakis

The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis.

DOI: http://doi.org/10.1016/j.neurobiolaging.2017.01.009
Journal: Neurobiol Aging
E-pub date: 1 May 2017
Authors: T Annus, LR Wilson, J Acosta-Cabronero, A Cardenas-Blanco, YT Hong, TD Fryer, JP Coles, DK Menon, SH Zaman, AJ Holland, PJ Nestor

Neuroimaging of Inflammation in Memory and Related Other Disorders (NIMROD) study protocol: a deep phenotyping cohort study of the role of brain inflammation in dementia, depression and other neurological illnesses.

DOI: http://doi.org/10.1136/bmjopen-2016-013187
Journal: BMJ Open
E-pub date: 7 Jan 2017
Authors: WR Bevan-Jones, A Surendranathan, L Passamonti, P Vázquez Rodríguez, R Arnold, E Mak, L Su, JP Coles, TD Fryer, YT Hong, G Williams, F Aigbirhio, JB Rowe, JT O'Brien

Neuroinflammatory and morphological changes in late-life depression: the NIMROD study.

DOI: http://doi.org/10.1192/bjp.bp.116.190165
Journal: BRITISH JOURNAL OF PSYCHIATRY
E-pub date: 1 Dec 2016
Authors: L Su, YO Faluyi, YT Hong, TD Fryer, E Mak, S Gabel, L Hayes, S Soteriades, GB Williams, R Arnold, L Passamonti, PV Rodríguez, A Surendranathan, RW Bevan-Jones, J Coles, F Aigbirhio, JB Rowe, JT O'Brien

[18F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation.

DOI: http://doi.org/10.1002/acn3.366
Journal: Ann Clin Transl Neurol
E-pub date: 1 Dec 2016
Authors: WR Bevan Jones, TE Cope, L Passamonti, TD Fryer, YT Hong, F Aigbirhio, JJ Kril, SL Forrest, K Allinson, JP Coles, P Simon Jones, MG Spillantini, JR Hodges, JT O'Brien, JB Rowe

The pattern of amyloid accumulation in the brains of adults with Down syndrome.

DOI: http://doi.org/10.1016/j.jalz.2015.07.490
Journal: Alzheimers Dement
E-pub date: 1 May 2016
Authors: T Annus, LR Wilson, YT Hong, J Acosta-Cabronero, TD Fryer, A Cardenas-Blanco, R Smith, I Boros, JP Coles, FI Aigbirhio, DK Menon, SH Zaman, PJ Nestor, AJ Holland

Dynamic Changes in White Matter Abnormalities Correlate With Late Improvement and Deterioration Following TBI: A Diffusion Tensor Imaging Study.

DOI: http://doi.org/10.1177/1545968315584004
Journal: Neurorehabil Neural Repair
E-pub date: 1 Jan 2016
Authors: VFJ Newcombe, MM Correia, C Ledig, MG Abate, JG Outtrim, D Chatfield, T Geeraerts, AE Manktelow, E Garyfallidis, JD Pickard, BJ Sahakian, PJA Hutchinson, D Rueckert, JP Coles, GB Williams, DK Menon

Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): a prospective longitudinal observational study.

DOI: http://doi.org/10.1227/NEU.0000000000000575
Journal: Neurosurgery
E-pub date: 1 Jan 2015
Authors: AIR Maas, DK Menon, EW Steyerberg, G Citerio, F Lecky, GT Manley, S Hill, V Legrand, A Sorgner, CENTER-TBI Participants and Investigators

Comparison of 15oxygen positron emission tomography and near-infrared spectroscopy for measurement of cerebral physiology

DOI: http://doi.org/10.1186/cc14525
Journal: Critical care (London, England)
E-pub date: 1 Jan 2015
Authors: J Simpson, N Sudhan, H Hare, J Donnelly, X Liu, F Aigbirhio, T Fryer, G Stocks-Gee, P Smielewski, D Bulte, J Coles

Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury.

DOI: http://doi.org/10.1001/jamaneurol.2013.4847
Journal: JAMA Neurol
E-pub date: 1 Jan 2014
Authors: YT Hong, T Veenith, D Dewar, JG Outtrim, V Mani, C Williams, S Pimlott, PJA Hutchinson, A Tavares, R Canales, CA Mathis, WE Klunk, FI Aigbirhio, JP Coles, J-C Baron, JD Pickard, TD Fryer, W Stewart, DK Menon

Microstructural basis of contusion expansion in traumatic brain injury: insights from diffusion tensor imaging.

DOI: http://doi.org/10.1038/jcbfm.2013.11
Journal: J Cereb Blood Flow Metab
E-pub date: 1 Jun 2013
Authors: VFJ Newcombe, GB Williams, JG Outtrim, D Chatfield, M Gulia Abate, T Geeraerts, A Manktelow, H Room, L Mariappen, PJ Hutchinson, JP Coles, DK Menon

Validation of reference tissue modelling for [11C]flumazenil positron emission tomography following head injury.

DOI: http://doi.org/10.1007/s12149-011-0480-4
Journal: Annals of Nuclear Medicine
E-pub date: 1 Jul 2011
Authors: T Geeraerts, JP Coles, FI Aigbirhio, JD Pickard, DK Menon, TD Fryer, YT Hong

A combined microdialysis and FDG-PET study of glucose metabolism in head injury.

DOI: http://doi.org/10.1007/s00701-008-0169-1
Journal: ACTA NEUROCHIR
E-pub date: 1 Jan 2009
Authors: PJ Hutchinson, MT O'Connell, A Seal, J Nortje, I Timofeev, PG Al-Rawi, JP Coles, TD Fryer, DK Menon, JD Pickard, KLH Carpenter

Early derangements in oxygen and glucose metabolism following head injury: the ischemic penumbra and pathophysiological heterogeneity.

DOI: http://doi.org/10.1007/s12028-008-9119-2
Journal: Neurocrit Care
E-pub date: 1 Aug 2008
Authors: MG Abate, M Trivedi, TD Fryer, P Smielewski, DA Chatfield, GB Williams, F Aigbirhio, TA Carpenter, JD Pickard, DK Menon, JP Coles

Effect of hyperoxia on regional oxygenation and metabolism after severe traumatic brain injury: preliminary findings.

DOI: http://doi.org/10.1097/01.CCM.0000292014.60835.15
Journal: Crit Care Med
E-pub date: 1 Jan 2008
Authors: J Nortje, JP Coles, I Timofeev, TD Fryer, FI Aigbirhio, P Smielewski, JG Outtrim, DA Chatfield, JD Pickard, PJ Hutchinson, AK Gupta, DK Menon

Hyperventilation following head injury: effect on ischemic burden and cerebral oxidative metabolism.

DOI: http://doi.org/10.1097/01.CCM.0000254066.37187.88
Journal: Crit Care Med
E-pub date: 1 Feb 2007
Authors: JP Coles, TD Fryer, MR Coleman, P Smielewski, AK Gupta, PS Minhas, F Aigbirhio, DA Chatfield, GB Williams, S Boniface, TA Carpenter, JC Clark, JD Pickard, DK Menon

Intersubject variability and reproducibility of 15O PET studies.

DOI: http://doi.org/10.1038/sj.jcbfm.9600179
Journal: J Cereb Blood Flow Metab
E-pub date: 1 Jan 2006
Authors: JP Coles, TD Fryer, PG Bradley, J Nortje, P Smielewski, K Rice, JC Clark, JD Pickard, DK Menon

Coexisting low cerebral blood flow and volume in head injury is due to microvascular ischaemia, not hypometabolism

DOI: http://doi.org/10.1097/00003643-200509001-00072
Journal: European Journal of Anaesthesiology
E-pub date: 1 Sep 2005
Authors: JP Coles, DK Menon, TD Fryer, DA Chatfield, AK Gupta, LA Steiner, AJ Johnston, J Nortje, PJA Hutchinson, FI Aigbirhio, JC Clark, JD Pickard

Physiological thresholds for irreversible tissue damage in contusional regions following traumatic brain injury.

DOI: http://doi.org/10.1093/brain/awh536
Journal: Brain
E-pub date: 31 Aug 2005
Authors: AS Cunningham, R Salvador, JP Coles, DA Chatfield, PG Bradley, AJ Johnston, LA Steiner, TD Fryer, FI Aigbirhio, P Smielewski, GB Williams, TA Carpenter, JH Gillard, JD Pickard, DK Menon

Sources of variability in oxygen-15 PET studies in acute brain injury – impact on sample size estimation

DOI: http://doi.org/10.1038/sj.jcbfm.9591524.0675
Journal: Journal of Cerebral Blood Flow & Metabolism
E-pub date: 31 Aug 2005
Authors: JP Coles, TD Fryer, PG Bradley, J Nortje, P Smielewski, K Rice, JC Clark, JD Pickard, DK Menon

15O-PET shows that cerebral blood volume is increased in head injury, but may still not be the dominant cause of intracranial hypertension

DOI: http://doi.org/10.1038/sj.jcbfm.9591524.0317
Journal: Journal of Cerebral Blood Flow & Metabolism
E-pub date: 31 Aug 2005
Authors: DK Menon, JP Coles, TD Fryer, DA Chatfield, LA Steiner, AJ Johnston, FI Aigbirhio, JC Clark, JD Pickard

Effect of cerebral perfusion pressure augmentation on regional oxygenation and metabolism after head injury.

DOI: http://doi.org/10.1097/01.ccm.0000149837.09225.bd
Journal: Crit Care Med
E-pub date: 1 Jan 2005
Authors: AJ Johnston, LA Steiner, JP Coles, DA Chatfield, TD Fryer, P Smielewski, PJ Hutchinson, MT O'Connell, PG Al-Rawi, FI Aigbirihio, JC Clark, JD Pickard, AK Gupta, DK Menon

Imaging of cerebral blood flow and metabolism in brain injury in the ICU.

DOI: http://doi.org/10.1007/3-211-32318-X_94
Journal: Acta Neurochirurgica, Supplementum
E-pub date: 1 Jan 2005
Authors: JD Pickard, PJ Hutchinson, JP Coles, LA Steiner, AJ Johnston, TD Fryer, MR Coleman, P Smielewski, DA Chatfield, F Aigbirhio, GB Williams, K Rice, JC Clark, CH Salmond, BJ Sahakian, PG Bradley, TA Carpenter, R Salvador, A Pena, JH Gillard, AS Cunningham, S Piechnik, M Czosnyka, DK Menon

Glucose metabolism in traumatic brain injury: a combined microdialysis and [18F]-2-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) study.

DOI: http://doi.org/10.1007/3-211-32318-X_35
Journal: Acta Neurochirurgica, Supplementum
E-pub date: 1 Jan 2005
Authors: MT O'Connell, A Seal, J Nortje, PG Al-Rawi, JP Coles, TD Fryer, DK Menon, JD Pickard, PJ Hutchinson

Does induced hypertension reduce cerebral ischaemia within the traumatized human brain?

DOI: http://doi.org/10.1093/brain/awh268
Journal: Brain
E-pub date: 1 Nov 2004
Authors: JP Coles, LA Steiner, AJ Johnston, TD Fryer, MR Coleman, P Smieleweski, DA Chatfield, F Aigbirhio, GB Williams, S Boniface, K Rice, JC Clark, JD Pickard, DK Menon

Defining ischemic burden after traumatic brain injury using 15O PET imaging of cerebral physiology.

DOI: http://doi.org/10.1097/01.WCB.0000100045.07481.DE
Journal: J Cereb Blood Flow Metab
E-pub date: 1 Feb 2004
Authors: JP Coles, TD Fryer, P Smielewski, K Rice, JC Clark, JD Pickard, DK Menon

Normal pressure hydrocephalus and cerebral blood flow: a PET study of baseline values.

DOI: http://doi.org/10.1097/01.WCB.0000093326.88757.49
Journal: J Cereb Blood Flow Metab
E-pub date: 1 Jan 2004
Authors: BK Owler, S Momjian, Z Czosnyka, M Czosnyka, A Péna, NG Harris, P Smielewski, T Fryer, T Donovan, J Coles, A Carpenter, JD Pickard

Responses of posttraumatic pericontusional cerebral blood flow and blood volume to an increase in cerebral perfusion pressure.

DOI: http://doi.org/10.1097/01.WCB.0000090861.67713.10
Journal: J Cereb Blood Flow Metab
E-pub date: 1 Nov 2003
Authors: LA Steiner, JP Coles, AJ Johnston, M Czosnyka, TD Fryer, P Smielewski, DA Chatfield, R Salvador, FI Aigbirhio, JC Clark, DK Menon, JD Pickard

Assessment of cerebrovascular autoregulation in head-injured patients: a validation study.

DOI: http://doi.org/10.1161/01.STR.0000089014.59668.04
Journal: Stroke
E-pub date: 1 Oct 2003
Authors: LA Steiner, JP Coles, AJ Johnston, DA Chatfield, P Smielewski, TD Fryer, FI Aigbirhio, JC Clark, JD Pickard, DK Menon, M Czosnyka

Cerebrovascular pressure reactivity is related to global cerebral oxygen metabolism after head injury.

DOI: http://doi.org/10.1136/jnnp.74.6.765
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Jun 2003
Authors: LA Steiner, JP Coles, M Czosnyka, PS Minhas, TD Fryer, FI Aigbirhio, JC Clark, P Smielewski, DA Chatfield, T Donovan, JD Pickard, DK Menon

Integrated image analysis solutions for PET datasets in damaged brain.

DOI: http://doi.org/10.1023/a:1026293611455
Journal: J Clin Monit Comput
E-pub date: 1 Dec 2002
Authors: P Smielewski, JP Coles, TD Fryer, PS Minhas, DK Menon, JD Pickard

Effect of hyperventilation on cerebral blood flow in traumatic head injury: clinical relevance and monitoring correlates.

DOI: http://doi.org/10.1097/00003246-200209000-00002
Journal: Crit Care Med
E-pub date: 1 Sep 2002
Authors: JP Coles, PS Minhas, TD Fryer, P Smielewski, F Aigbirihio, T Donovan, SPMJ Downey, G Williams, D Chatfield, JC Matthews, AK Gupta, TA Carpenter, JC Clark, JD Pickard, DK Menon

Ischaemic Burden following Traumatic Brain Injury: Monitoring Correlates and Relevance to Outcome

DOI: http://doi.org/10.1042/cs103062p
Journal: Clinical Science
E-pub date: 1 Jul 2002
Authors: JP Coles, TD Fryer, DA Parry, P Smieleswiksi, J Matthews, T Donovan, D Day, F Aigbrhio, JC Clark, JD Pickard, DK Menon

Correlation between cerebral blood flow, substrate delivery, and metabolism in head injury: a combined microdialysis and triple oxygen positron emission tomography study.

DOI: http://doi.org/10.1097/00004647-200206000-00012
Journal: J Cereb Blood Flow Metab
E-pub date: 1 Jun 2002
Authors: PJ Hutchinson, AK Gupta, TF Fryer, PG Al-Rawi, DA Chatfield, JP Coles, MT O'Connell, R Kett-White, PS Minhas, FI Aigbirhio, JC Clark, PJ Kirkpatrick, DK Menon, JD Pickard