Department

Institute

Research Theme Beyond the Neuron Neurons, Circuits and Networks

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Dr Elizabeth Warburton

University Position

Consultant

Interests

Research interests are as follows 1. Molecular imaging of atheroma - particularly carotid plaque imaging using PET/CT and MRI techniques. Both Clinical and microPET imaging. Proof of principle trials of novel atheroma drugs with imaging biomarkers. 2. Imaging mechanisms of damage in both ischemic and heamorrhagic stroke using PET, CTperfusion and MRI imaging 3. Imaging mechanisms of recovery from aphasic stroke and behavioural interventions

Key Publications

Imaging of the carotid artery.

DOI: http://doi.org/10.1016/S1474-4422(22)00223-X
Journal: Lancet Neurol
E-pub date: 1 Jul 2022
Authors: NR Evans, JHF Rudd, EA Warburton

Frailty and cerebrovascular disease: Concepts and clinical implications for stroke medicine.

DOI: http://doi.org/10.1177/17474930211034331
Journal: Int J Stroke
E-pub date: 1 Mar 2022
Authors: NR Evans, OM Todd, JS Minhas, P Fearon, GW Harston, J Mant, G Mead, J Hewitt, TJ Quinn, EA Warburton

Carotid Atheroinflammation Is Associated With Cerebral Small Vessel Disease Severity.

DOI: http://doi.org/10.3389/fneur.2021.690935
Journal: Front Neurol
E-pub date: 1 Aug 2021
Authors: NR Evans, JM Tarkin, J Walsh, MM Chowdhury, AJ Patterson, MJ Graves, JHF Rudd, EA Warburton

Clinical frailty independently predicts early mortality after ischaemic stroke.

DOI: http://doi.org/10.1093/ageing/afaa004
Journal: Age Ageing
E-pub date: 1 Jul 2020
Authors: NR Evans, J Wall, B To, SJ Wallis, R Romero-Ortuno, EA Warburton

Dual-Tracer Positron-Emission Tomography for Identification of Culprit Carotid Plaques and Pathophysiology In Vivo.

DOI: http://doi.org/10.1161/CIRCIMAGING.119.009539
Journal: Circ Cardiovasc Imaging
E-pub date: 1 Mar 2020
Authors: NR Evans, JM Tarkin, MM Chowdhury, EPV Le, PA Coughlin, JHF Rudd, EA Warburton

PET imaging of the neurovascular interface in cerebrovascular disease.

DOI: http://doi.org/10.1038/nrneurol.2017.129
Journal: Nat Rev Neurol
E-pub date: 1 Nov 2017
Authors: NR Evans, JM Tarkin, JR Buscombe, HS Markus, JHF Rudd, EA Warburton

PET Imaging of Atherosclerotic Disease: Advancing Plaque Assessment from Anatomy to Pathophysiology.

DOI: http://doi.org/10.1007/s11883-016-0584-3
Journal: Curr Atheroscler Rep
E-pub date: 1 Jun 2016
Authors: NR Evans, JM Tarkin, MM Chowdhury, EA Warburton, JHF Rudd

Imaging atherosclerotic plaque inflammation with [18F]- fluorodeoxyglucose positron emission tomography

DOI: http://doi.org/10.17863/CAM.16643
Journal:
E-pub date: 1 Jan 2003
Authors: J Rudd

Publications

The contribution of competing mechanisms in stroke despite anticoagulation in patients with atrial fibrillation.

DOI: http://doi.org/10.1177/23969873231168367
Journal: Eur Stroke J
E-pub date: 1 Jun 2023
Authors: R Herlekar, A Sur Roy, S Hajiev, I Induruwa, S Agarwal, NR Evans, K Khadjooi, H Markus, E O'Brien, E Warburton, G Zachariah, JJ McCabe

Hyperacute stroke thrombolysis via telemedicine: a multicentre study of performance, safety and clinical efficacy.

DOI: http://doi.org/10.1136/bmjopen-2021-057372
Journal: BMJ Open
E-pub date: 17 Jan 2022
Authors: NR Evans, L Sibson, DJ Day, S Agarwal, R Shekhar, EA Warburton

Assessing robustness of carotid artery CT angiography radiomics in the identification of culprit lesions in cerebrovascular events.

DOI: http://doi.org/10.1038/s41598-021-82760-w
Journal: Sci Rep
E-pub date: 10 Feb 2021
Authors: EPV Le, L Rundo, JM Tarkin, NR Evans, MM Chowdhury, PA Coughlin, H Pavey, C Wall, F Zaccagna, FA Gallagher, Y Huang, R Sriranjan, A Le, JR Weir-McCall, M Roberts, FJ Gilbert, EA Warburton, C-B Schönlieb, E Sala, JHF Rudd

Integrated cardiovascular assessment of atherosclerosis using PET/MRI.

DOI: http://doi.org/10.1259/bjr.20190921
Journal: Br J Radiol
E-pub date: 1 Sep 2020
Authors: NR Evans, JM Tarkin, EP Le, RS Sriranjan, A Corovic, EA Warburton, JH Rudd

Vascular Positron Emission Tomography and Restenosis in Symptomatic Peripheral Arterial Disease: A Prospective Clinical Study.

DOI: http://doi.org/10.1016/j.jcmg.2019.03.031
Journal: JACC Cardiovasc Imaging
E-pub date: 1 Apr 2020
Authors: MM Chowdhury, JM Tarkin, MS Albaghdadi, NR Evans, EPV Le, TB Berrett, U Sadat, FR Joshi, EA Warburton, JR Buscombe, PD Hayes, MR Dweck, DE Newby, JHF Rudd, PA Coughlin

18F-FDG Uptake on PET/CT in Symptomatic versus Asymptomatic Carotid Disease: a Meta-Analysis.

DOI: http://doi.org/10.1016/j.ejvs.2018.03.028
Journal: Eur J Vasc Endovasc Surg
E-pub date: 31 Aug 2018
Authors: MM Chowdhury, JM Tarkin, NR Evans, E Le, EA Warburton, PD Hayes, JHF Rudd, PA Coughlin

Relationships between selective neuronal loss and microglial activation after ischaemic stroke in man.

DOI: http://doi.org/10.1093/brain/awy121
Journal: Brain
E-pub date: 1 Jul 2018
Authors: RS Morris, P Simon Jones, JA Alawneh, YT Hong, TD Fryer, FI Aigbirhio, EA Warburton, J-C Baron

Vascular Imaging With 18F-Fluorodeoxyglucose Positron Emission Tomography Is Influenced by Hypoxia.

DOI: http://doi.org/10.1016/j.jacc.2017.01.050
Journal: J Am Coll Cardiol
E-pub date: 11 Apr 2017
Authors: FR Joshi, R Manavaki, TD Fryer, NL Figg, JC Sluimer, FI Aigbirhio, AP Davenport, PJ Kirkpatrick, EA Warburton, JHF Rudd

Detection of Atherosclerotic Inflammation by 68Ga-DOTATATE PET Compared to [18F]FDG PET Imaging.

DOI: http://doi.org/10.1016/j.jacc.2017.01.060
Journal: J Am Coll Cardiol
E-pub date: 11 Apr 2017
Authors: JM Tarkin, FR Joshi, NR Evans, MM Chowdhury, NL Figg, AV Shah, LT Starks, A Martin-Garrido, R Manavaki, E Yu, RE Kuc, L Grassi, R Kreuzhuber, MA Kostadima, M Frontini, PJ Kirkpatrick, PA Coughlin, D Gopalan, TD Fryer, JR Buscombe, AM Groves, WH Ouwehand, MR Bennett, EA Warburton, AP Davenport, JHF Rudd

Internal carotid artery dissection.

DOI: http://doi.org/10.12968/hmed.2016.77.12.708
Journal: Br J Hosp Med (Lond)
E-pub date: 2 Dec 2016
Authors: TB Stoker, NR Evans, EA Warburton

Dominant hemisphere functional networks compensate for structural connectivity loss to preserve phonological retrieval with aging.

DOI: http://doi.org/10.1002/brb3.495
Journal: Brain Behav
E-pub date: 1 Sep 2016
Authors: S Agarwal, EA Stamatakis, S Geva, EA Warburton

Running, ischaemic stroke and carotid artery dissection.

DOI: http://doi.org/10.1093/qjmed/hcv089
Journal: QJM
E-pub date: 1 Dec 2015
Authors: NR Evans, V Harper, DJ Scoffings, EA Warburton

Early-Phase 11C-PiB PET in Amyloid Angiopathy-Related Symptomatic Cerebral Hemorrhage: Potential Diagnostic Value?

DOI: http://doi.org/10.1371/journal.pone.0139926
Journal: PLoS One
E-pub date: 1 Aug 2015
Authors: K Farid, YT Hong, FI Aigbirhio, TD Fryer, DK Menon, EA Warburton, J-C Baron

Is CT-Based Perfusion and Collateral Imaging Sensitive to Time Since Stroke Onset?

DOI: http://doi.org/10.3389/fneur.2015.00070
Journal: Front Neurol
E-pub date: 1 Aug 2015
Authors: S Agarwal, T Matys, ST Marrapu, DJ Scoffings, J Mitchell, PS Jones, J-C Baron, EA Warburton

White matter perivascular spaces on magnetic resonance imaging: marker of cerebrovascular amyloid burden?

DOI: http://doi.org/10.1161/STROKEAHA.115.009090
Journal: Stroke
E-pub date: 1 Jun 2015
Authors: A Charidimou, YT Hong, HR Jäger, Z Fox, FI Aigbirhio, TD Fryer, DK Menon, EA Warburton, DJ Werring, J-C Baron

Diffusion and perfusion correlates of the 18F-MISO PET lesion in acute stroke: pilot study.

DOI: http://doi.org/10.1007/s00259-013-2581-x
Journal: Eur J Nucl Med Mol Imaging
E-pub date: 1 Apr 2014
Authors: JA Alawneh, RR Moustafa, ST Marrapu, U Jensen-Kondering, RS Morris, PS Jones, FI Aigbirhio, TD Fryer, TA Carpenter, EA Warburton, J-C Baron

Diagnostic utility of amyloid PET in cerebral amyloid angiopathy-related symptomatic intracerebral hemorrhage.

DOI: http://doi.org/10.1038/jcbfm.2014.43
Journal: Journal of Cerebral Blood Flow and Metabolism
E-pub date: 1 Jan 2014
Authors: J-C Baron, K Farid, E Dolan, G Turc, ST Marrapu, E O'Brien, FI Aigbirhio, TD Fryer, DK Menon, EA Warburton, YT Hong

Is neural activation within the rescued penumbra impeded by selective neuronal loss?

DOI: http://doi.org/10.1093/brain/awt112
Journal: Brain
E-pub date: 1 Jun 2013
Authors: E Carrera, PS Jones, RS Morris, J Alawneh, YT Hong, FI Aigbirhio, TD Fryer, TA Carpenter, EA Warburton, J-C Baron

A comparison of VLSM and VBM in a cohort of patients with post-stroke aphasia.

DOI: http://doi.org/10.1016/j.nicl.2012.08.003
Journal: Neuroimage Clin
E-pub date: 1 Aug 2012
Authors: S Geva, J-C Baron, PS Jones, CJ Price, EA Warburton

Microembolism versus hemodynamic impairment in rosary-like deep watershed infarcts: a combined positron emission tomography and transcranial Doppler study.

DOI: http://doi.org/10.1161/STROKEAHA.111.616334
Journal: Stroke
E-pub date: 1 Nov 2011
Authors: RR Moustafa, I Momjian-Mayor, PS Jones, S Morbelli, DJ Day, FI Aigbirhio, TD Fryer, EA Warburton, J-C Baron

The neural correlates of inner speech defined by voxel-based lesion-symptom mapping.

DOI: http://doi.org/10.1093/brain/awr232
Journal: Brain
E-pub date: 1 Oct 2011
Authors: S Geva, PS Jones, JT Crinion, CJ Price, J-C Baron, EA Warburton

Predicting infarction within the diffusion-weighted imaging lesion: does the mean transit time have added value?

DOI: http://doi.org/10.1161/STROKEAHA.110.606970
Journal: Stroke
E-pub date: 1 Jun 2011
Authors: E Carrera, PS Jones, JA Alawneh, I Klærke Mikkelsen, T-H Cho, S Siemonsen, JV Guadagno, K Mouridsen, L Ribe, N Hjort, TD Fryer, TA Carpenter, FI Aigbirhio, J Fiehler, N Nighoghossian, EA Warburton, L Ostergaard, J-C Baron

The vascular mean transit time: a surrogate for the penumbra flow threshold?

DOI: http://doi.org/10.1038/jcbfm.2010.197
Journal: Journal of Cerebral Blood Flow and Metabolism
E-pub date: 1 Apr 2011
Authors: E Carrera, PS Jones, S Iglesias, JV Guadagno, EA Warburton, TD Fryer, FI Aigbirhio, J-C Baron

Carotid plaque inflammation is associated with cerebral microembolism in patients with recent transient ischemic attack or stroke: a pilot study.

DOI: http://doi.org/10.1161/CIRCIMAGING.110.938225
Journal: Circ Cardiovasc Imaging
E-pub date: 1 Sep 2010
Authors: RR Moustafa, D Izquierdo-Garcia, TD Fryer, MJ Graves, JHF Rudd, JH Gillard, PL Weissberg, J-C Baron, EA Warburton

Watershed infarcts in transient ischemic attack/minor stroke with > or = 50% carotid stenosis: hemodynamic or embolic?

DOI: http://doi.org/10.1161/STROKEAHA.110.580415
Journal: Stroke
E-pub date: 1 Jul 2010
Authors: RR Moustafa, D Izquierdo-Garcia, PS Jones, MJ Graves, TD Fryer, JH Gillard, EA Warburton, J-C Baron

FDG-PET can distinguish inflamed from non-inflamed plaque in an animal model of atherosclerosis.

DOI: http://doi.org/10.1007/s10554-009-9506-6
Journal: Int J Cardiovasc Imaging
E-pub date: 1 Jan 2010
Authors: JR Davies, D Izquierdo-Garcia, JHF Rudd, N Figg, HK Richards, JLE Bird, FI Aigbirhio, AP Davenport, PL Weissberg, TD Fryer, EA Warburton

T2*-weighted MRI versus oxygen extraction fraction PET in acute stroke.

DOI: http://doi.org/10.1159/000229017
Journal: Cerebrovasc Dis
E-pub date: 1 Aug 2009
Authors: ML Donswijk, PS Jones, JV Guadagno, TA Carpenter, RR Moustafa, TD Fryer, FI Aigbirhio, EA Warburton, JC Baron

Comparison of methods for magnetic resonance-guided [18-F]fluorodeoxyglucose positron emission tomography in human carotid arteries: reproducibility, partial volume correction, and correlation between methods.

DOI: http://doi.org/10.1161/STROKEAHA.108.521393
Journal: Stroke
E-pub date: 1 Jan 2009
Authors: D Izquierdo-Garcia, JR Davies, MJ Graves, JHF Rudd, JH Gillard, PL Weissberg, TD Fryer, EA Warburton

Selective neuronal loss in rescued penumbra relates to initial hypoperfusion.

DOI: http://doi.org/10.1093/brain/awn175
Journal: Brain
E-pub date: 1 Oct 2008
Authors: JV Guadagno, PS Jones, FI Aigbirhio, D Wang, TD Fryer, DJ Day, N Antoun, I Nimmo-Smith, EA Warburton, JC Baron

How reliable is perfusion MR in acute stroke? Validation and determination of the penumbra threshold against quantitative PET.

DOI: http://doi.org/10.1161/STROKEAHA.107.500090
Journal: Stroke
E-pub date: 1 Mar 2008
Authors: M Takasawa, PS Jones, JV Guadagno, S Christensen, TD Fryer, S Harding, JH Gillard, GB Williams, FI Aigbirhio, EA Warburton, L Østergaard, J-C Baron

Strategy for improved [(11)C]DAA1106 radiosynthesis and in vivo peripheral benzodiazepine receptor imaging using microPET, evaluation of [(11)C]DAA1106.

DOI: http://doi.org/10.1016/j.nucmedbio.2007.02.009
Journal: Nucl Med Biol
E-pub date: 1 May 2007
Authors: KC Probst, D Izquierdo, JLE Bird, L Brichard, D Franck, JR Davies, TD Fryer, HK Richards, JC Clark, AP Davenport, PL Weissberg, EA Warburton

Synthesis and evaluation of fluorine-18 and copper-64 labelled PBR radioligands

DOI: http://doi.org/10.1002/jlcr.1274
Journal: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
E-pub date: 1 Apr 2007
Authors: KC Probst, D Izquierdo, JR Davies, JLE Bird, TD Fryer, HK Richards, JC Clark, EA Warburton, PL Weissberg, FI Aigbirhio

How affected is oxygen metabolism in DWI lesions?: A combined acute stroke PET-MR study.

DOI: http://doi.org/10.1212/01.wnl.0000233984.66907.db
Journal: Neurology
E-pub date: 12 Sep 2006
Authors: JV Guadagno, EA Warburton, PS Jones, DJ Day, FI Aigbirhio, TD Fryer, S Harding, CJ Price, HA Green, O Barret, JH Gillard, J-C Baron

Intrinsic activated microglia map to the peri-infarct zone in the subacute phase of ischemic stroke.

DOI: http://doi.org/10.1161/01.STR.0000226980.95389.0b
Journal: Stroke
E-pub date: 1 Jul 2006
Authors: CJS Price, D Wang, DK Menon, JV Guadagno, M Cleij, T Fryer, F Aigbirhio, J-C Baron, EA Warburton

Local relationships between restricted water diffusion and oxygen consumption in the ischemic human brain.

DOI: http://doi.org/10.1161/01.STR.0000232437.00621.86
Journal: Stroke
E-pub date: 1 Jul 2006
Authors: JV Guadagno, PS Jones, TD Fryer, O Barret, FI Aigbirhio, TA Carpenter, CJ Price, JH Gillard, EA Warburton, J-C Baron

Identification of culprit lesions after transient ischemic attack by combined 18F fluorodeoxyglucose positron-emission tomography and high-resolution magnetic resonance imaging.

DOI: http://doi.org/10.1161/01.STR.0000190896.67743.b1
Journal: Stroke
E-pub date: 1 Dec 2005
Authors: JR Davies, JHF Rudd, TD Fryer, MJ Graves, JC Clark, PJ Kirkpatrick, JH Gillard, EA Warburton, PL Weissberg

The diffusion-weighted lesion in acute stroke: heterogeneous patterns of flow/metabolism uncoupling as assessed by quantitative positron emission tomography.

DOI: http://doi.org/10.1159/000084087
Journal: Cerebrovasc Dis
E-pub date: 1 Aug 2005
Authors: JV Guadagno, EA Warburton, PS Jones, TD Fryer, DJ Day, JH Gillard, TA Carpenter, FI Aigbirhio, CJ Price, J-C Baron

Does the acute diffusion-weighted imaging lesion represent penumbra as well as core? A combined quantitative PET/MRI voxel-based study.

DOI: http://doi.org/10.1097/01.WCB.0000141557.32867.6B
Journal: J Cereb Blood Flow Metab
E-pub date: 1 Nov 2004
Authors: JV Guadagno, EA Warburton, FI Aigbirhio, P Smielewski, TD Fryer, S Harding, CJ Price, JH Gillard, TA Carpenter, J-C Baron

Cerebral neutrophil recruitment, histology, and outcome in acute ischemic stroke: an imaging-based study.

DOI: http://doi.org/10.1161/01.STR.0000130592.71028.92
Journal: Stroke
E-pub date: 1 Jul 2004
Authors: CJS Price, DK Menon, AM Peters, JR Ballinger, RW Barber, KK Balan, A Lynch, JH Xuereb, T Fryer, JV Guadagno, EA Warburton

Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography.

DOI: http://doi.org/10.1161/01.cir.0000020548.60110.76
Journal: Circulation
E-pub date: 11 Jun 2002
Authors: JHF Rudd, EA Warburton, TD Fryer, HA Jones, JC Clark, N Antoun, P Johnström, AP Davenport, PJ Kirkpatrick, BN Arch, JD Pickard, PL Weissberg