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EMAIL mm2243@medschl.cam.ac.uk
College Sidney Sussex College
Department
  • Clinical Neurosciences
    • School
  • Clinical Medicine
    • Institute
  • Neurology Unit
    • Research Theme Lifelong Brain Development and Brain Ageing Beyond the Neuron Neurons, Circuits and Networks
    Research Focus

    Keywords

  • PET Imaging
  • Brain Inflammation
  • Dementia
  • Neurodegeneration

    • Clinical Conditions

  • Alzheimer's disease
  • Frontotemporal dementia
  • Progressive supranuclear palsy
  • Multiple sclerosis

    • Equipment & Techniques

  • Positron Emission Tomography (PET)
  • Magnetic resonance imaging (MRI)

    • Science Culture

  • Equality, Diversity, Inclusion and Wellbeing
  • Mentorship
  • Public Engagement

    • Back

    Maura Malpetti

    University Position
    Research Fellow
    Senior Research Associate
    Dr Maura Malpetti is pleased to consider applications from prospective PhD students.

    Interests

    I am a Senior Research Associate and a Race Against Dementia Alzheimer's Research UK fellow at the Cambridge Centre for Frontotemporal Dementia and Related disorders. I am interested in the study of neuropathology, biomarkers and clinical features of neurodegenerative diseases, with special interest in frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD). My work focuses on the application of neuroimaging techniques (multi-tracer PET and MRI) to investigate the pathophysiology of neurodegenerative diseases, in order to identify early diagnostic and prognostic markers. As a RAD fellow, I am studying novel clinically viable PET and other biomarkers for inflammation, tau and synaptic loss in FTLD. To this end, my lab applies longitudinal statistical models and multimodal imaging analyses, with an interdisciplinary approach that integrates imaging and clinical data with fluid markers and post-mortem pathology.

    Associated News Items

    Key Publications

    PET Imaging to Measure Neuroinflammation In Vivo.

    DOI: http://doi.org/10.1007/978-1-0716-3774-6_12
    Journal: Methods Mol Biol
    E-pub date: 1 Aug 2024
    Authors: M Malpetti, N Franzmeier, M Brendel

    Neuroinflammation is linked to dementia risk in Parkinson’s disease.

    DOI: http://doi.org/10.1093/brain/awad322
    Journal: Brain
    E-pub date: 1 Mar 2024
    Authors: A Kouli, LRB Spindler, TD Fryer, YT Hong, M Malpetti, FI Aigbirhio, SR White, M Camacho, JT O'Brien, CH Williams-Gray

    A robust harmonization approach for cognitive data from multiple aging and dementia cohorts.

    DOI: http://doi.org/10.1002/dad2.12453
    Journal: Alzheimers Dement (Amst)
    E-pub date: 1 Aug 2023
    Authors: J Giorgio, A Tanna, M Malpetti, SR White, J Wang, S Baker, S Landau, T Tanaka, C Chen, JB Rowe, J O'Brien, J Fripp, M Breakspear, W Jagust, Z Kourtzi, Alzheimer's Disease Neuroimaging Initiative, Australian Imaging Biomarkers and Lifestyle flagship study

    Differential levels of plasma biomarkers of neurodegeneration in Lewy body dementia, Alzheimer’s disease, frontotemporal dementia and progressive supranuclear palsy.

    DOI: http://doi.org/10.1136/jnnp-2021-327788
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jun 2022
    Authors: L Chouliaras, A Thomas, M Malpetti, P Donaghy, J Kane, E Mak, G Savulich, MA Prats-Sedano, AJ Heslegrave, H Zetterberg, L Su, JB Rowe, JT O'Brien

    Tau Beats Amyloid in Predicting Brain Atrophy in Alzheimer Disease: Implications for Prognosis and Clinical Trials.

    DOI: http://doi.org/10.2967/jnumed.121.263694
    Journal: J Nucl Med
    E-pub date: 1 Jun 2022
    Authors: M Malpetti, RL Joie, GD Rabinovici

    In vivo neuroinflammation and cerebral small vessel disease in mild cognitive impairment and Alzheimer’s disease.

    DOI: http://doi.org/10.1136/jnnp-2020-323894
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 11 Sep 2020
    Authors: A Low, E Mak, M Malpetti, L Passamonti, N Nicastro, JD Stefaniak, G Savulich, L Chouliaras, L Su, JB Rowe, HS Markus, JT O'Brien

    Publications

    Differential Synaptic Loss in β‐Amyloid Positive Versus β‐Amyloid Negative Corticobasal Syndrome

    DOI: http://doi.org/10.1002/mds.29814
    Journal: Mov Disord
    E-pub date: 1 Jul 2024
    Authors: N Holland, G Savulich, PS Jones, DJ Whiteside, D Street, P Swann, M Naessens, M Malpetti, YT Hong, TD Fryer, T Rittman, E Mulroy, FI Aigbirhio, KP Bhatia, JT O'Brien, JB Rowe

    Synaptic density affects clinical severity via network dysfunction in syndromes associated with frontotemporal lobar degeneration.

    DOI: http://doi.org/10.1038/s41467-023-44307-7
    Journal: Nat Commun
    E-pub date: 20 Dec 2023
    Authors: DJ Whiteside, N Holland, KA Tsvetanov, E Mak, M Malpetti, G Savulich, PS Jones, M Naessens, MA Rouse, TD Fryer, YT Hong, FI Aigbirhio, E Mulroy, KP Bhatia, T Rittman, JT O'Brien, JB Rowe

    Artificial intelligence for diagnostic and prognostic neuroimaging in dementia: A systematic review.

    DOI: http://doi.org/10.1002/alz.13412
    Journal: Alzheimers Dement
    E-pub date: 1 Dec 2023
    Authors: RJ Borchert, T Azevedo, A Badhwar, J Bernal, M Betts, R Bruffaerts, MC Burkhart, I Dewachter, HM Gellersen, A Low, I Lourida, L Machado, CR Madan, M Malpetti, J Mejia, S Michopoulou, C Muñoz-Neira, J Pepys, M Peres, V Phillips, S Ramanan, S Tamburin, HM Tantiangco, L Thakur, A Tomassini, A Vipin, E Tang, D Newby, Deep Dementia Phenotyping (DEMON) Network, JM Ranson, DJ Llewellyn, M Veldsman, T Rittman

    From Clinical Trials to Memory Clinics, tau-PET Visual Reads Can Help Diagnosis and Patient Stratification.

    DOI: http://doi.org/10.1212/WNL.0000000000207935
    Journal: Neurology
    E-pub date: 7 Nov 2023
    Authors: M Malpetti, GD Rabinovici

    Structural correlates of survival in progressive supranuclear palsy.

    DOI: http://doi.org/10.1016/j.parkreldis.2023.105866
    Journal: Parkinsonism Relat Disord
    E-pub date: 1 Nov 2023
    Authors: D Street, WR Bevan-Jones, M Malpetti, PS Jones, L Passamonti, BC Ghosh, T Rittman, IT Coyle-Gilchrist, K Allinson, CE Dawson, JB Rowe

    Locus coeruleus integrity is linked to response inhibition deficits in Parkinson’s disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1523/JNEUROSCI.0289-22.2023
    Journal: J Neurosci
    E-pub date: 18 Oct 2023
    Authors: R Ye, FH Hezemans, C O'Callaghan, KA Tsvetanov, C Rua, PS Jones, N Holland, M Malpetti, AG Murley, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

    Network connectivity and structural correlates of survival in progressive supranuclear palsy and corticobasal syndrome.

    DOI: http://doi.org/10.1002/hbm.26342
    Journal: Hum Brain Mapp
    E-pub date: 1 Aug 2023
    Authors: DJ Whiteside, D Street, AG Murley, PS Jones, M Malpetti, BCP Ghosh, I Coyle-Gilchrist, A Gerhard, MT Hu, JC Klein, PN Leigh, A Church, DJ Burn, HR Morris, JB Rowe, T Rittman

    Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia.

    DOI: http://doi.org/10.1093/brain/awad078
    Journal: Brain
    E-pub date: 1 Aug 2023
    Authors: M Malpetti, TE Cope, D Street, PS Jones, FH Hezemans, E Mak, KA Tsvetanov, T Rittman, WR Bevan-Jones, K Patterson, L Passamonti, TD Fryer, YT Hong, FI Aigbirhio, JT O'Brien, JB Rowe

    Longitudinal Synaptic Loss in Primary Tauopathies: An In Vivo [11 C]UCB-J Positron Emission Tomography Study.

    DOI: http://doi.org/10.1002/mds.29421
    Journal: Mov Disord
    E-pub date: 1 Jul 2023
    Authors: N Holland, PS Jones, G Savulich, M Naessens, M Malpetti, DJ Whiteside, D Street, P Swann, YT Hong, TD Fryer, T Rittman, E Mulroy, FI Aigbirhio, KP Bhatia, JT O'Brien, JB Rowe

    Temporal dynamics predict symptom onset and cognitive decline in familial frontotemporal dementia.

    DOI: http://doi.org/10.1002/alz.12824
    Journal: Alzheimers Dement
    E-pub date: 1 May 2023
    Authors: DJ Whiteside, M Malpetti, PS Jones, BCP Ghosh, I Coyle-Gilchrist, JC van Swieten, H Seelaar, L Jiskoot, B Borroni, R Sanchez-Valle, F Moreno, R Laforce, C Graff, M Synofzik, D Galimberti, M Masellis, MC Tartaglia, E Finger, R Vandenberghe, A de Mendonça, F Tagliavini, CR Butler, I Santana, IL Ber, A Gerhard, S Ducharme, J Levin, A Danek, M Otto, S Sorbi, F Pasquier, A Bouzigues, LL Russell, JD Rohrer, JB Rowe, T Rittman, GENFI consortium

    APOEε4 associates with microglial activation independently of Aβ plaques and tau tangles.

    DOI: http://doi.org/10.1126/sciadv.ade1474
    Journal: Sci Adv
    E-pub date: 5 Apr 2023
    Authors: JP Ferrari-Souza, FZ Lussier, DT Leffa, J Therriault, C Tissot, B Bellaver, PCL Ferreira, M Malpetti, Y-T Wang, G Povala, AL Benedet, NJ Ashton, M Chamoun, S Servaes, G Bezgin, MS Kang, J Stevenson, N Rahmouni, V Pallen, NM Poltronetti, JT O'Brien, JB Rowe, AD Cohen, OL Lopez, DL Tudorascu, TK Karikari, WE Klunk, VL Villemagne, J-P Soucy, S Gauthier, DO Souza, H Zetterberg, K Blennow, ER Zimmer, P Rosa-Neto, TA Pascoal

    Synaptic Loss in Frontotemporal Dementia Revealed by [11 C]UCB-J Positron Emission Tomography.

    DOI: http://doi.org/10.1002/ana.26543
    Journal: Ann Neurol
    E-pub date: 1 Jan 2023
    Authors: M Malpetti, PS Jones, TE Cope, N Holland, M Naessens, MA Rouse, T Rittman, G Savulich, DJ Whiteside, D Street, TD Fryer, YT Hong, S Milicevic Sephton, FI Aigbirhio, JT O Brien, JB Rowe

    Amyloid, tau and metabolic PET correlates of cognition in early and late-onset Alzheimer’s disease.

    DOI: http://doi.org/10.1093/brain/awac229
    Journal: Brain
    E-pub date: 19 Dec 2022
    Authors: JA Tanner, L Iaccarino, L Edwards, BM Asken, ML Gorno-Tempini, JH Kramer, J Pham, DC Perry, K Possin, M Malpetti, T Mellinger, BL Miller, Z Miller, NS Mundada, HJ Rosen, DN Soleimani-Meigooni, A Strom, R La Joie, GD Rabinovici

    Locus Coeruleus Integrity from 7 T MRI Relates to Apathy and Cognition in Parkinsonian Disorders.

    DOI: http://doi.org/10.1002/mds.29072
    Journal: Mov Disord
    E-pub date: 31 Aug 2022
    Authors: R Ye, C O'Callaghan, C Rua, FH Hezemans, N Holland, M Malpetti, PS Jones, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, J Rowe

    Synaptic loss in behavioural variant frontotemporal dementia revealed by [11C]UCB-J PET

    DOI: http://doi.org/10.1101/2022.01.30.22270123
    Journal:
    E-pub date: 1 Aug 2022
    Authors: M Malpetti, S Jones, T Cope, N Holland, M Naessens, M Rouse, G Savulich, T Fryer, Y Hong, SM Sephton, F Aigbirhio, J O’Brien, J Rowe

    In Vivo 18F-Flortaucipir PET Does Not Accurately Support the Staging of Progressive Supranuclear Palsy.

    DOI: http://doi.org/10.2967/jnumed.121.262985
    Journal: J Nucl Med
    E-pub date: 1 Jul 2022
    Authors: M Malpetti, SS Kaalund, KA Tsvetanov, T Rittman, M Briggs, KSJ Allinson, L Passamonti, N Holland, PS Jones, TD Fryer, YT Hong, A Kouli, WR Bevan-Jones, E Mak, G Savulich, MG Spillantini, FI Aigbirhio, CH Williams-Gray, JT O'Brien, JB Rowe

    Imaging Alzheimer’s pathology stage by stage.

    DOI: http://doi.org/10.1038/s43587-022-00236-6
    Journal: Nat Aging
    E-pub date: 1 Jun 2022
    Authors: M Malpetti, R La Joie

    Molecular pathology and synaptic loss in primary tauopathies: A [18F]AV-1451 and [11C]UCB-J PET study

    DOI: http://doi.org/10.1093/brain/awab282
    Journal: Brain
    E-pub date: 29 Mar 2022
    Authors: N Holland, M Malpetti, T Rittman, E Mak, L Passamonti, S Kaalund, F Hezemans, P Jones, G Savulich, Y Hong, T Fryer, F Aigbirhio, J O'Brien, J Rowe

    Lifelong bilingualism and mechanisms of neuroprotection in Alzheimer dementia.

    DOI: http://doi.org/10.1002/hbm.25605
    Journal: Hum Brain Mapp
    E-pub date: 1 Feb 2022
    Authors: A Sala, M Malpetti, M Farsad, F Lubian, G Magnani, G Frasca Polara, J-B Epiney, J Abutalebi, F Assal, V Garibotto, D Perani

    Microglial activation and atrophy in frontal cortex predict executive dysfunction in frontotemporal dementia

    DOI: http://doi.org/10.1002/alz.055456
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2021
    Authors: M Malpetti, PS Jones, FH Hezemans, E Mak, D Street, L Passamonti, T Rittman, TE Cope, WR Bevan‐Jones, K Patterson, TD Fryer, YT Hong, FI Aigbirho, JT O'Brien, JB Rowe

    A morphometric double dissociation: cortical thickness is more related to aging; surface area is more related to cognition

    DOI: http://doi.org/10.1101/2021.09.30.462545
    Journal:
    E-pub date: 1 Oct 2021
    Authors: GS Borgeest, RN Henson, TC Kietzmann, CR Madan, T Fox, M Malpetti, D Fuhrmann, E Knights, JD Carlin, RA Kievit

    Clinical progression of progressive supranuclear palsy: impact of trials bias and phenotype variants.

    DOI: http://doi.org/10.1093/braincomms/fcab206
    Journal: Brain Commun
    E-pub date: 1 Aug 2021
    Authors: D Street, M Malpetti, T Rittman, BCP Ghosh, AG Murley, I Coyle-Gilchrist, L Passamonti, JB Rowe

    Reduced locus coeruleus integrity linked to response inhibition deficits in parkinsonian disorders

    DOI: http://doi.org/10.1101/2021.10.14.21264996
    Journal:
    E-pub date: 1 Aug 2021
    Authors: R Ye, F Hezemans, C O’Callaghan, K Tsvetanov, C Rua, S Jones, N Holland, M Malpetti, A Murley, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

    Locus Coeruleus Integrity from 7T MRI Relates to Apathy and Cognition in Parkinson’s Disease and Progressive Supranuclear Palsy

    DOI: http://doi.org/10.1101/2021.04.19.21255762
    Journal:
    E-pub date: 1 Aug 2021
    Authors: R Ye, C O’Callaghan, C Rua, F Hezemans, N Holland, M Malpetti, S Jones, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

    Artificial intelligence for diagnosis and prognosis in neuroimaging for dementia; a systematic review

    DOI: http://doi.org/10.1101/2021.12.12.21267677
    Journal:
    E-pub date: 1 Aug 2021
    Authors: R Borchert, T Azevedo, A Badhwar, J Bernal, M Betts, R Bruffaerts, MC Burkhart, I Dewachter, HM Gellersen, A Low, L Machado, CR Madan, M Malpetti, J Mejia, S Michopoulou, C Muñoz-Neira, M Peres, V Phillips, S Ramanan, S Tamburin, H Tantiangco, L Thakur, A Tomassini, A Vipin, E Tang, D Newby, J Ranson, DJ Llewellyn, M Veldsman, T Rittman

    [18F]-AV-1451 binding in the substantia nigra as a marker of neuromelanin in Lewy body diseases.

    DOI: http://doi.org/10.1093/braincomms/fcab177
    Journal: Brain Commun
    E-pub date: 1 Aug 2021
    Authors: E Mak, A Kouli, N Holland, N Nicastro, G Savulich, A Surendranathan, M Malpetti, R Manavaki, YT Hong, TD Fryer, F Aigbirhio, JB Rowe, JT O'Brien, CH Williams-Gray

    Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome: associations with amyloid burden and longitudinal cognitive decline.

    DOI: http://doi.org/10.1093/braincomms/fcaa198
    Journal: Brain Commun
    E-pub date: 1 Aug 2021
    Authors: E Mak, M Grigorova, J Beresford-Webb, M Malpetti, M Walpert, S Brown, E Jones, I Clare, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DK Menon, PJ Nestor, AJ Holland, SH Zaman

    Validation of the new pathology staging system for progressive supranuclear palsy

    DOI: http://doi.org/10.1101/2021.01.18.21250017
    Journal:
    E-pub date: 1 Aug 2021
    Authors: M Briggs, KSJ Allinson, M Malpetti, MG Spillantini, JB Rowe, SS Kaalund

    Looking beneath the surface: the importance of subcortical structures in frontotemporal dementia.

    DOI: http://doi.org/10.1093/braincomms/fcab158
    Journal: Brain Commun
    E-pub date: 1 Aug 2021
    Authors: M Bocchetta, M Malpetti, EG Todd, JB Rowe, JD Rohrer

    Neuroinflammation predicts disease progression in progressive supranuclear palsy.

    DOI: http://doi.org/10.1136/jnnp-2020-325549
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jul 2021
    Authors: M Malpetti, L Passamonti, PS Jones, D Street, T Rittman, TD Fryer, YT Hong, P Vàsquez Rodriguez, WR Bevan-Jones, FI Aigbirhio, JT O'Brien, JB Rowe

    Synaptic density in carriers of C9orf72 mutations: a [11 C]UCB-J PET study.

    DOI: http://doi.org/10.1002/acn3.51407
    Journal: Ann Clin Transl Neurol
    E-pub date: 1 Jul 2021
    Authors: M Malpetti, N Holland, PS Jones, R Ye, TE Cope, TD Fryer, YT Hong, G Savulich, T Rittman, L Passamonti, E Mak, FI Aigbirhio, JT O'Brien, JB Rowe

    Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes.

    DOI: http://doi.org/10.1002/alz.12252
    Journal: Alzheimers Dement
    E-pub date: 1 Jun 2021
    Authors: M Malpetti, PS Jones, KA Tsvetanov, T Rittman, JC van Swieten, B Borroni, R Sanchez-Valle, F Moreno, R Laforce, C Graff, M Synofzik, D Galimberti, M Masellis, MC Tartaglia, E Finger, R Vandenberghe, A de Mendonça, F Tagliavini, I Santana, S Ducharme, CR Butler, A Gerhard, J Levin, A Danek, M Otto, GB Frisoni, R Ghidoni, S Sorbi, C Heller, EG Todd, M Bocchetta, DM Cash, RS Convery, G Peakman, KM Moore, JD Rohrer, RA Kievit, JB Rowe, Genetic FTD Initiative (GENFI)

    In vivo coupling of dendritic complexity with presynaptic density in primary tauopathies.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2021.01.016
    Journal: Neurobiol Aging
    E-pub date: 1 May 2021
    Authors: E Mak, N Holland, PS Jones, G Savulich, A Low, M Malpetti, SS Kaalund, L Passamonti, T Rittman, R Romero-Garcia, R Manavaki, GB Williams, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2020.11.006
    Journal: Neurobiol Aging
    E-pub date: 1 May 2021
    Authors: E Mak, N Nicastro, M Malpetti, G Savulich, A Surendranathan, N Holland, L Passamonti, PS Jones, SF Carter, L Su, YT Hong, TD Fryer, GB Williams, F Aigbirhio, JB Rowe, JT O'Brien

    Validation of the new pathology staging system for progressive supranuclear palsy.

    DOI: http://doi.org/10.1007/s00401-021-02298-z
    Journal: Acta Neuropathol
    E-pub date: 1 May 2021
    Authors: M Briggs, KSJ Allinson, M Malpetti, MG Spillantini, JB Rowe, SS Kaalund

    In vivo PET imaging of neuroinflammation in familial frontotemporal dementia.

    DOI: http://doi.org/10.1136/jnnp-2020-323698
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Mar 2021
    Authors: M Malpetti, T Rittman, PS Jones, TE Cope, L Passamonti, WR Bevan-Jones, K Patterson, TD Fryer, YT Hong, FI Aigbirhio, JT O'Brien, JB Rowe

    Neuroinflammation and Tau Colocalize in vivo in Progressive Supranuclear Palsy.

    DOI: http://doi.org/10.1002/ana.25911
    Journal: Ann Neurol
    E-pub date: 1 Dec 2020
    Authors: M Malpetti, L Passamonti, T Rittman, PS Jones, P Vázquez Rodríguez, WR Bevan-Jones, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Multimodal imaging markers of tau, neuroinflammation and atrophy to predict clinical progression in progressive supranuclear palsy

    DOI: http://doi.org/10.1002/alz.044724
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2020
    Authors: M Malpetti, L Passamonti, PS Jones, T Rittman, TD Fryer, YT Hong, D Street, PV Rodríguez, WR Bevan‐Jones, FI Aigbirhio, JT O'Brien, JB Rowe

    The prognostic role of microglia and tau PET in Alzheimer’s disease

    DOI: http://doi.org/10.1002/alz.039817
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2020
    Authors: M Malpetti, RA Kievit, L Passamonti, PS Jones, KA Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan‐Jones, L Su, YT Hong, TD Fryer, FI Aigbirho, JT O'Brien, JB Rowe

    A cross‐cohort cognitive composite for tracking changes in pre‐clinical and prodromal Alzheimer’s disease

    DOI: http://doi.org/10.1002/alz.037928
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2020
    Authors: J Giorgio, A Tanna, WJ Jagust, SL Baker, SM Landau, T Tanaka, CP Chen, A Reilhac, M Malpetti, JB Rowe, JT O'Brien, Z Kourtzi

    Trajectory of apathy, cognition and neural correlates in the decades before symptoms in frontotemporal dementia

    DOI: http://doi.org/10.1002/alz.041821
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2020
    Authors: M Malpetti, RA Kievit, PS Jones, T Rittman, KA Tsvetanov, JC van Swieten, B Borroni, D Galimberti, R Sanchez‐Valle, R Laforce, F Moreno, M Synofzik, C Graff, M Masellis, C Tartaglia, R Vandenberghe, E Finger, F Tagliavini, A de Mendonca, I Santana, C Butler, S Ducharme, A Gerhard, A Danek, J Levin, M Otto, GB Frisoni, R Ghidoni, C Heller, E Todd, M Bocchetta, RS Convery, G Peakman, KM Moore, JD Rohrer, JB Rowe

    Synaptic Loss in Primary Tauopathies Revealed by [11 C]UCB-J Positron Emission Tomography.

    DOI: http://doi.org/10.1002/mds.28188
    Journal: Mov Disord
    E-pub date: 1 Oct 2020
    Authors: N Holland, PS Jones, G Savulich, JK Wiggins, YT Hong, TD Fryer, R Manavaki, SM Sephton, I Boros, M Malpetti, FH Hezemans, FI Aigbirhio, JP Coles, J O'Brien, JB Rowe

    Gray matter changes related to microglial activation in Alzheimer’s disease.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2020.06.010
    Journal: Neurobiol Aging
    E-pub date: 1 Oct 2020
    Authors: N Nicastro, M Malpetti, E Mak, GB Williams, WR Bevan-Jones, SF Carter, L Passamonti, TD Fryer, YT Hong, FI Aigbirhio, JB Rowe, JT O'Brien

    Peak Width of Skeletonized Mean Diffusivity as a Marker of Diffuse Cerebrovascular Damage.

    DOI: http://doi.org/10.3389/fnins.2020.00238
    Journal: Front Neurosci
    E-pub date: 1 Aug 2020
    Authors: A Low, E Mak, JD Stefaniak, M Malpetti, N Nicastro, G Savulich, L Chouliaras, HS Markus, JB Rowe, JT O'Brien

    Synaptic loss in primary tauopathies revealed by [11C]UCB-J positron emission tomography

    DOI: http://doi.org/10.1101/2020.01.24.20018697
    Journal:
    E-pub date: 1 Aug 2020
    Authors: N Holland, S Jones, G Savulich, J Wiggins, Y Hong, T Fryer, R Manavaki, SM Sephton, I Boros, M Malpetti, F Hezemans, F Aigbirhio, J Coles, J O’Brien, J Rowe

    In vivo PET imaging of neuroinflammation in familial frontotemporal dementia

    DOI: http://doi.org/10.1101/2020.05.11.20098046
    Journal:
    E-pub date: 1 Aug 2020
    Authors: M Malpetti, T Rittman, S Jones, T Cope, L Passamonti, R Bevan-Jones, K Patterson, T Fryer, Y Hong, F Aigbirhio, J O’Brien, J Rowe

    Neuroinflammation predicts disease progression in progressive supranuclear palsy

    DOI: http://doi.org/10.1101/2020.05.19.20106393
    Journal:
    E-pub date: 1 Aug 2020
    Authors: M Malpetti, L Passamonti, S Jones, D Street, T Rittman, T Fryer, Y Hong, P Vasquez-Rodriguez, WR Bevan-Jones, F Aigbirhio, J O'Brien, J Rowe

    Cortical Complexity Analyses and Their Cognitive Correlate in Alzheimer’s Disease and Frontotemporal Dementia.

    DOI: http://doi.org/10.3233/JAD-200246
    Journal: J Alzheimers Dis
    E-pub date: 1 Aug 2020
    Authors: N Nicastro, M Malpetti, TE Cope, WR Bevan-Jones, E Mak, L Passamonti, JB Rowe, JT O'Brien

    Microglial activation and tau burden predict cognitive decline in Alzheimer’s disease.

    DOI: http://doi.org/10.1093/brain/awaa088
    Journal: Brain
    E-pub date: 1 May 2020
    Authors: M Malpetti, RA Kievit, L Passamonti, PS Jones, KA Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    18F-AV1451 PET imaging and multimodal MRI changes in progressive supranuclear palsy.

    DOI: http://doi.org/10.1007/s00415-019-09566-9
    Journal: J Neurol
    E-pub date: 1 Feb 2020
    Authors: N Nicastro, PV Rodriguez, M Malpetti, WR Bevan-Jones, P Simon Jones, L Passamonti, FI Aigbirhio, JT O'Brien, JB Rowe

    Asymmetrical atrophy of thalamic subnuclei in Alzheimer’s disease and amyloid-positive mild cognitive impairment is associated with key clinical features.

    DOI: http://doi.org/10.1016/j.dadm.2019.08.001
    Journal: Alzheimers Dement (Amst)
    E-pub date: 1 Dec 2019
    Authors: A Low, E Mak, M Malpetti, L Chouliaras, N Nicastro, L Su, N Holland, T Rittman, PV Rodríguez, L Passamonti, WR Bevan-Jones, PS Jones, JB Rowe, JT O'Brien

    Variant-specific vulnerability in metabolic connectivity and resting-state networks in behavioural variant of frontotemporal dementia.

    DOI: http://doi.org/10.1016/j.cortex.2019.07.018
    Journal: Cortex
    E-pub date: 1 Nov 2019
    Authors: M Malpetti, G Carli, A Sala, C Cerami, A Marcone, S Iannaccone, G Magnani, D Perani

    High body mass index, brain metabolism and connectivity: an unfavorable effect in elderly females.

    DOI: http://doi.org/10.18632/aging.102347
    Journal: Aging (Albany NY)
    E-pub date: 9 Oct 2019
    Authors: A Sala, M Malpetti, A Ferrulli, L Gianolli, L Luzi, D Perani, Alzheimer’s Disease Neuroimaging Initiative (ADNI) database

    Microglial activation and tau burden predict cognitive decline in Alzheimer’s Disease

    DOI: http://doi.org/10.1101/19011189
    Journal:
    E-pub date: 1 Aug 2019
    Authors: M Malpetti, R Kievit, L Passamonti, S Jones, K Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, Y Hong, T Fryer, F Aigbirhio, J O'Brien, J Rowe

    PET markers of tau and neuroinflammation are co-localized in progressive supranuclear palsy

    DOI: http://doi.org/10.1101/19010702
    Journal:
    E-pub date: 1 Aug 2019
    Authors: M Malpetti, L Passamonti, T Rittman, S Jones, P Vázquez Rodríguez, R Bevan-Jones, Y Hong, T Fryer, F Aigbirhio, J O’Brien, J Rowe

    Cortical complexity analyses and their cognitive correlate in Alzheimer’s disease and frontotemporal dementia

    DOI: http://doi.org/10.1101/19013466
    Journal:
    E-pub date: 1 Aug 2019
    Authors: N Nicastro, M Malpetti, T Cope, WR Bevan-Jones, E Mak, L Passamonti, J Rowe, J O’brien

    18F-AV1451 PET imaging and white matter changes in progressive supranuclear palsy

    DOI: http://doi.org/10.1101/19000596
    Journal:
    E-pub date: 1 Aug 2019
    Authors: N Nicastro, P Vazquez Rodriguez, M Malpetti, WR Bevan-Jones, S Jones, L Passamonti, F Aigbirhio, J O’brien, J Rowe

    O4‐03‐06: LONGITUDINAL ASSOCIATION BETWEEN APATHY AND COGNITIVE DECLINE IN PRE‐ AND POST‐SYMPTOMATIC GENETIC FRONTOTEMPORAL DEMENTIA

    DOI: http://doi.org/10.1016/j.jalz.2019.06.4757
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Jul 2019
    Authors: M Malpetti, RA Kievit, PS Jones, T Rittman, KA Tsvetanov, JC van Swieten, B Borroni, D Galimberti, R Sanchez-Valle, R Laforce, F Moreno, M Synofzik, C Graff, M Masellis, C Tartaglia, R Vandenberghe, E Finger, F Tagliavini, A Mendonca, I Santana, CR Butler, S Ducharme, A Gerhard, A Danek, J Levin, M Otto, GB Frisoni, S Cappa, C Heller, RS Convery, KM Dick, JD Rohrer, JB Rowe

    Unfavourable gender effect of high body mass index on brain metabolism and connectivity.

    DOI: http://doi.org/10.1038/s41598-018-30883-y
    Journal: Sci Rep
    E-pub date: 22 Aug 2018
    Authors: M Malpetti, A Sala, EG Vanoli, L Gianolli, L Luzi, D Perani

    Effects of High BMI on Synaptic Function and Metabolic Connectivity in the Brain-Evidence of Gender Difference

    DOI: http://doi.org/10.2337/db18-363-OR
    Journal: DIABETES
    E-pub date: 1 Aug 2018
    Authors: A Sala, M Malpetti, A Ferrulli, L Gianolli, L Luzi, D Perani

    Gender differences in healthy aging and Alzheimer’s Dementia: A 18 F-FDG-PET study of brain and cognitive reserve.

    DOI: http://doi.org/10.1002/hbm.23659
    Journal: Hum Brain Mapp
    E-pub date: 31 Aug 2017
    Authors: M Malpetti, T Ballarini, L Presotto, V Garibotto, M Tettamanti, D Perani, Alzheimer's Disease Neuroimaging Initiative (ADNI) database;, Network for Efficiency and Standardization of Dementia Diagnosis (NEST-DD) database

    The impact of bilingualism on brain reserve and metabolic connectivity in Alzheimer’s dementia.

    DOI: http://doi.org/10.1073/pnas.1610909114
    Journal: Proc Natl Acad Sci U S A
    E-pub date: 14 Feb 2017
    Authors: D Perani, M Farsad, T Ballarini, F Lubian, M Malpetti, A Fracchetti, G Magnani, A March, J Abutalebi