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Department
  • Psychiatry
  • Research Focus

    Keywords

  • Motivation
  • Reward
  • Computational Modelling
  • Transdiagnostic Approaches to Mental Health
  • Apathy
  • Ageing
  • Neurodegenerative Brain Disorders
  • Clinical Conditions

  • Depressive disorders
  • Schizophrenia
  • Dementia
  • Equipment & Techniques

  • Magnetic resonance imaging (MRI)
  • Computational modelling
  • Electroencephalography (EEG)
  • Behavioural analysis
  • Neuropsychological testing
  • Science Culture

  • Reproducibility in Science
  • Open Access
  • Mentorship
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    Dr Noham Wolpe

    (he/him/his)
    University Position
    Other

    Interests

    I am currently a Visiting Researcher in the Department of Psychiatry. Our research focuses on linking subjective experiences to objective, performance-based measures and exploring the physiological mechanisms that mediate this relationship. In more recent years, we have examined the computational mechanisms of human motivation—a key transdiagnostic construct that is disrupted across many neuropsychiatric conditions, including depression and schizophrenia, and one that remains poorly treated. Our overarching goal is to integrate a transdiagnostic framework with advanced neuroscience methods—computational modelling, neuroimaging and real-time symptom tracking—to develop or repurpose treatments targeting specific motivational symptoms across patient populations.

    Key Publications

    What Is Mental Effort: A Clinical Perspective

    DOI: https://doi.org/10.1016/j.biopsych.2024.01.022
    Journal: Biological Psychiatry
    Year: 2024
    Authors: Wolpe , Holton , Fletcher

    Depression and anxiety symptom networks across the lifespan

    DOI: https://doi.org/10.1093/ageing/afaf153
    Journal: Age and Ageing
    Year: 2025
    Authors: Harlev , Vituri , Shahar , Wolpe

    A Virtual Reality-Based Assessment Tool for Apathy

    DOI: https://doi.org/10.1101/2025.05.26.25328377
    Journal: medRxiv
    Year: 2025
    Authors: Harlev, Ravona-Springer, Koren, Zorani, Plotnik, Wolpe

    Publications