• Psychiatry
  • Research Focus


  • Schizophrenia
  • Antipsychotics
  • Clozapine
  • Aetiology
  • Clinical Trials
  • Clinical Conditions

  • Schizophrenia
  • Equipment & Techniques

  • Neuropsychological testing
  • Randomised control trials
  • Statistical analysis
  • Computational modelling
  • Science Culture

  • History of Science
  • Philosophy of Science
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    Dr Emilio Fernandez-Egea

    University Position
    Associate Professor
    Affiliated Member
    Dr Emilio Fernandez-Egea is pleased to consider applications from prospective PhD students.


    My research interests are mostly the biological and clinical aspects of chronic schizophrenia. I’m the Cambridge Psychosis Centre and Clozapine Clinic Lead for the local MH Trust (Cambridgeshire and Peterborough NHS Foundation Trust). We study treatment resistant schizophrenia from different angles, including studies on biomarkers (metabolism, immunity and inflammation), clinical epidemiology, interaction between physical and mental health and clinical trials with new interventions (both pharmacological and non-pharmacological). Our main lines of research are: 1) the link between metabolic abnormalities and schizophrenia, 2) the understanding of negative symptoms and, 3) uncommon antipsychotic-induced side effects (i.e. compulsive behaviour).

    Key Publications

    Birth weight, family history of diabetes and diabetes onset in schizophrenia.

    Journal: BMJ Open Diabetes Res Care
    E-pub date: 1 Jan 2020
    Authors: E Fernandez-Egea, R Walker, H Ziauddeen, RN Cardinal, ET Bullmore


    Relationship between severe mental illness and physical multimorbidity: a meta-analysis and call for action.

    Journal: BMJ Ment Health
    E-pub date: 1 Oct 2023
    Authors: D Pizzol, M Trott, L Butler, Y Barnett, T Ford, SA Neufeld, A Ragnhildstveit, CN Parris, BR Underwood, GF López Sánchez, M Fossey, C Brayne, E Fernandez-Egea, G Fond, L Boyer, JI Shin, S Pardhan, L Smith

    Longitudinal effect of clozapine-associated sedation on motivation in schizophrenia: naturalistic longitudinal study.

    Journal: Br J Psychiatry
    E-pub date: 1 Jul 2023
    Authors: N Wolpe, S Chen, B Kirkpatrick, PB Jones, C Jenkins, RN Cardinal, E Fernandez-Egea

    Clozapine-related obsessive-compulsive symptoms and their impact on wellbeing: a naturalistic longitudinal study.

    Journal: Psychol Med
    E-pub date: 1 May 2023
    Authors: K Parkin, S Chen, M Biria, J Plaistow, H Beckwith, I Jarratt-Barnham, N Segarra, Y Worbe, NA Fineberg, RN Cardinal, TW Robbins, E Fernandez-Egea

    The psychosis metabolic risk calculator (PsyMetRiC) for young people with psychosis: International external validation and site-specific recalibration in two independent European samples.

    Journal: Lancet Reg Health Eur
    E-pub date: 1 Nov 2022
    Authors: BI Perry, F Vandenberghe, N Garrido-Torres, EF Osimo, M Piras, J Vazquez-Bourgon, R Upthegrove, C Grosu, VO-G De La Foz, PB Jones, N Laaboub, M Ruiz-Veguilla, J Stochl, C Dubath, M Canal-Rivero, P Mallikarjun, A Delacrétaz, N Ansermot, E Fernandez-Egea, S Crettol, F Gamma, KJ Plessen, P Conus, GM Khandaker, GK Murray, CB Eap, B Crespo-Facorro

    Risk factors for excess deaths during lockdown among older users of secondary care mental health services without confirmed COVID-19: A retrospective cohort study.

    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Dec 2021
    Authors: S Chen, PB Jones, BR Underwood, E Fernandez-Egea, P Qin, JR Lewis, RN Cardinal

    Longer-term mortality following SARS-CoV-2 infection in people with severe mental illness: retrospective case-matched study.

    Journal: BJPsych Open
    E-pub date: 1 Nov 2021
    Authors: S Chen, E Fernandez-Egea, PB Jones, JR Lewis, RN Cardinal

    The Effect of Clozapine on Self-reported Duration of Sleep and Its Interaction With 23 Other Medications: A 5-Year Naturalistic Study.

    Journal: J Clin Psychopharmacol
    E-pub date: 1 Sep 2021
    Authors: E Fernandez-Egea, S Chen, C Jenkins, C Turrion, SP Mitchell, DJF Dodwell, LM Mann, JB Deakin, ZH Syed, S Hafizi, J Zimbron, AS Praseedom, RN Cardinal

    Early versus late risk factors for deficit and nondeficit schizophrenia.

    Journal: Rev Psiquiatr Salud Ment (Engl Ed)
    E-pub date: 1 Apr 2021
    Authors: S Alabaf, B Kirkpatrick, S Chen, RN Cardinal, E Fernandez-Egea

    The Medium-Term Impact of COVID-19 Lockdown on Referrals to Secondary Care Mental Health Services: A Controlled Interrupted Time Series Study.

    Journal: Front Psychiatry
    E-pub date: 1 Aug 2020
    Authors: S Chen, R She, P Qin, A Kershenbaum, E Fernandez-Egea, JR Nelder, C Ma, J Lewis, C Wang, RN Cardinal

    Risk Factors for Excess Deaths Among Older Adults Without Confirmed COVID-19 During Lockdown: A Retrospective Cohort Study

    E-pub date: 1 Aug 2020
    Authors: S Chen, P Jones, B Underwood, E Fernandez-Egea, P Qin, J Lewis, R Cardinal

    Causes of death in clozapine-treated patients in a catchment area: a 10-year retrospective case-control study.

    Journal: Eur Neuropsychopharmacol
    E-pub date: 1 Jul 2020
    Authors: E Rose, S Chen, C Turrion, C Jenkins, RN Cardinal, E Fernandez-Egea

    Reality monitoring impairment in schizophrenia reflects specific prefrontal cortex dysfunction.

    Journal: Neuroimage Clin
    E-pub date: 1 Aug 2017
    Authors: JR Garrison, E Fernandez-Egea, R Zaman, M Agius, JS Simons

    Psychosis and catatonia as a first presentation of antiphospholipid syndrome.

    Journal: Br J Psychiatry
    E-pub date: 1 Sep 2009
    Authors: RN Cardinal, DN Shah, CJ Edwards, GRV Hughes, E Fernández-Egea