• Psychiatry
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    Professor Peter Jones

    University Position


    The Cambridge ?epiCentre? group works at the interface between population-based research, neuroscience and clinical psychiatry in order to understand the causes, mechanisms and treatments for psychosis (particularly schizophrenia) dementia, depression and bipolar disorder. We investigate classical epidemiological characteristics in order to uncover causes, and have particular interests in cognition, longitudinal data and novel modelling approaches to defining life course descriptions of disorders and psychological dimensions in the population that we believe are stronger phenotypes for aetiological, genetic and treatment research than traditional approaches. We have many local and international collaborators. We have a strong partnership with the local clinical service for first episode psychosis, CAMEO ( Post-docs: Camice Revier, Anjalene Whittier, Anna Chaplin, Emma Soneson, Ben Perry, Tomas Formanek, Anna Wiedemann

    Key Publications

    Predicting treatment resistance from first-episode psychosis using routinely collected clinical information.

    Journal: Nat Ment Health
    E-pub date: 19 Jan 2023
    Authors: EF Osimo, BI Perry, P Mallikarjun, M Pritchard, J Lewis, A Katunda, GK Murray, J Perez, PB Jones, RN Cardinal, OD Howes, R Upthegrove, GM Khandaker

    Sexually divergent development of depression-related brain networks during healthy human adolescence.

    Journal: Sci Adv
    E-pub date: 27 May 2022
    Authors: L Dorfschmidt, RA Bethlehem, J Seidlitz, F Váša, SR White, R Romero-García, MG Kitzbichler, AR Aruldass, SE Morgan, IM Goodyer, P Fonagy, PB Jones, RJ Dolan, NSPN Consortium, NA Harrison, PE Vértes, ET Bullmore

    Association between lithium use and the incidence of dementia and its subtypes: A retrospective cohort study.

    Journal: PLoS Med
    E-pub date: 1 Mar 2022
    Authors: S Chen, BR Underwood, PB Jones, JR Lewis, RN Cardinal

    Development and external validation of the Psychosis Metabolic Risk Calculator (PsyMetRiC): a cardiometabolic risk prediction algorithm for young people with psychosis.

    Journal: Lancet Psychiatry
    E-pub date: 1 Jul 2021
    Authors: BI Perry, EF Osimo, R Upthegrove, PK Mallikarjun, J Yorke, J Stochl, J Perez, S Zammit, O Howes, PB Jones, GM Khandaker

    Development and Validation of a Nonremission Risk Prediction Model in First-Episode Psychosis: An Analysis of 2 Longitudinal Studies.

    Journal: Schizophr Bull Open
    E-pub date: 1 Jan 2021
    Authors: SP Leighton, R Krishnadas, R Upthegrove, S Marwaha, EW Steyerberg, GV Gkoutos, MR Broome, PF Liddle, L Everard, SP Singh, N Freemantle, D Fowler, PB Jones, V Sharma, R Murray, T Wykes, RJ Drake, I Buchan, S Rogers, J Cavanagh, SW Lewis, M Birchwood, PK Mallikarjun

    Conservative and disruptive modes of adolescent change in human brain functional connectivity.

    Journal: Proc Natl Acad Sci U S A
    E-pub date: 11 Feb 2020
    Authors: F Váša, R Romero-Garcia, MG Kitzbichler, J Seidlitz, KJ Whitaker, MM Vaghi, P Kundu, AX Patel, P Fonagy, RJ Dolan, PB Jones, IM Goodyer, NSPN Consortium, PE Vértes, ET Bullmore

    Development and validation of multivariable prediction models of remission, recovery, and quality of life outcomes in people with first episode psychosis: a machine learning approach.

    Journal: Lancet Digit Health
    E-pub date: 1 Oct 2019
    Authors: SP Leighton, R Upthegrove, R Krishnadas, ME Benros, MR Broome, GV Gkoutos, PF Liddle, SP Singh, L Everard, PB Jones, D Fowler, V Sharma, N Freemantle, RHB Christensen, N Albert, M Nordentoft, M Schwannauer, J Cavanagh, AI Gumley, M Birchwood, PK Mallikarjun

    Intravenous immunoglobulin and rituximab versus placebo treatment of antibody-associated psychosis: study protocol of a randomised phase IIa double-blinded placebo-controlled trial (SINAPPS2).

    Journal: Trials
    E-pub date: 7 Jun 2019
    Authors: B Lennox, K Yeeles, PB Jones, M Zandi, E Joyce, L-M Yu, G Tomei, R Pollard, S-A Vincent, M Shimazaki, I Cairns, F Dowling, T Kabir, TRE Barnes, A Lingford Hughes, AA Hosseini, T Harrower, C Buckley, A Coles

    Prevalence and correlates of low-grade systemic inflammation in adult psychiatric inpatients: An electronic health record-based study.

    Journal: Psychoneuroendocrinology
    E-pub date: 1 Mar 2018
    Authors: EF Osimo, RN Cardinal, PB Jones, GM Khandaker

    Reduction in adolescent depression after contact with mental health services: a longitudinal cohort study in the UK.

    Journal: Lancet Psychiatry
    E-pub date: 1 Feb 2017
    Authors: SAS Neufeld, VJ Dunn, PB Jones, TJ Croudace, IM Goodyer

    Gene transcription profiles associated with inter-modular hubs and connection distance in human functional magnetic resonance imaging networks.

    Journal: Philos Trans R Soc Lond B Biol Sci
    E-pub date: 5 Oct 2016
    Authors: PE Vértes, T Rittman, KJ Whitaker, R Romero-Garcia, F Váša, MG Kitzbichler, K Wagstyl, P Fonagy, RJ Dolan, PB Jones, IM Goodyer, NSPN Consortium, ET Bullmore

    Adolescence is associated with genomically patterned consolidation of the hubs of the human brain connectome.

    Journal: Proc Natl Acad Sci U S A
    E-pub date: 9 Aug 2016
    Authors: KJ Whitaker, PE Vértes, R Romero-Garcia, F Váša, M Moutoussis, G Prabhu, N Weiskopf, MF Callaghan, K Wagstyl, T Rittman, R Tait, C Ooi, J Suckling, B Inkster, P Fonagy, RJ Dolan, PB Jones, IM Goodyer, NSPN Consortium, ET Bullmore

    Ten-Year Outcomes of First-Episode Psychoses in the MRC ÆSOP-10 Study.

    Journal: J Nerv Ment Dis
    E-pub date: 1 May 2015
    Authors: CJ Revier, U Reininghaus, R Dutta, P Fearon, RM Murray, GA Doody, T Croudace, P Dazzan, M Heslin, A Onyejiaka, E Kravariti, J Lappin, B Lomas, JB Kirkbride, K Donoghue, C Morgan, PB Jones


    Why Is Non-suicidal Self-injury More Common in Women? Mediation and Moderation Analyses of Psychological Distress, Emotion Dysregulation, and Impulsivity.

    Journal: Arch Suicide Res
    E-pub date: 1 Aug 2023
    Authors: NM Lutz, SAS Neufeld, RW Hook, PB Jones, ET Bullmore, IM Goodyer, TJ Ford, SR Chamberlain, PO Wilkinson

    Longitudinal effect of clozapine-associated sedation on motivation in schizophrenia: naturalistic longitudinal study.

    Journal: Br J Psychiatry
    E-pub date: 1 Jul 2023
    Authors: N Wolpe, S Chen, B Kirkpatrick, PB Jones, C Jenkins, RN Cardinal, E Fernandez-Egea

    Measurement Invariance in Longitudinal Bifactor Models: Review and Application Based on the p Factor.

    Journal: Assessment
    E-pub date: 22 Jun 2023
    Authors: SAS Neufeld, M St Clair, J Brodbeck, PO Wilkinson, IM Goodyer, PB Jones

    The serum metabolomic profile of a distinct, inflammatory subtype of acute psychosis.

    Journal: Mol Psychiatry
    E-pub date: 1 Nov 2022
    Authors: B Lennox, W Xiong, P Waters, A Coles, PB Jones, T Yeo, JTM May, K Yeeles, D Anthony, F Probert

    The psychosis metabolic risk calculator (PsyMetRiC) for young people with psychosis: International external validation and site-specific recalibration in two independent European samples.

    Journal: Lancet Reg Health Eur
    E-pub date: 1 Nov 2022
    Authors: BI Perry, F Vandenberghe, N Garrido-Torres, EF Osimo, M Piras, J Vazquez-Bourgon, R Upthegrove, C Grosu, VO-G De La Foz, PB Jones, N Laaboub, M Ruiz-Veguilla, J Stochl, C Dubath, M Canal-Rivero, P Mallikarjun, A Delacrétaz, N Ansermot, E Fernandez-Egea, S Crettol, F Gamma, KJ Plessen, P Conus, GM Khandaker, GK Murray, CB Eap, B Crespo-Facorro

    Device-measured sleep onset and duration in the development of depressive symptoms in adolescence.

    Journal: J Affect Disord
    E-pub date: 1 Aug 2022
    Authors: EA Thorburn-Winsor, SAS Neufeld, H Rowthorn, EMF van Sluijs, S Brage, PB Jones, IM Goodyer, EM Winpenny

    Age and gender effects on non-suicidal self-injury, and their interplay with psychological distress.

    Journal: J Affect Disord
    E-pub date: 1 Jun 2022
    Authors: PO Wilkinson, T Qiu, C Jesmont, SAS Neufeld, SP Kaur, PB Jones, IM Goodyer

    A class-contrastive human-interpretable machine learning approach to predict mortality in severe mental illness.

    Journal: NPJ Schizophr
    E-pub date: 8 Dec 2021
    Authors: S Banerjee, P Lio, PB Jones, RN Cardinal

    Risk factors for excess deaths during lockdown among older users of secondary care mental health services without confirmed COVID-19: A retrospective cohort study.

    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Dec 2021
    Authors: S Chen, PB Jones, BR Underwood, E Fernandez-Egea, P Qin, JR Lewis, RN Cardinal

    Longer-term mortality following SARS-CoV-2 infection in people with severe mental illness: retrospective case-matched study.

    Journal: BJPsych Open
    E-pub date: 1 Nov 2021
    Authors: S Chen, E Fernandez-Egea, PB Jones, JR Lewis, RN Cardinal

    Longitudinal association between CRP levels and risk of psychosis: a meta-analysis of population-based cohort studies.

    Journal: NPJ Schizophr
    E-pub date: 28 May 2021
    Authors: EF Osimo, L Baxter, J Stochl, BI Perry, SA Metcalf, SK Kunutsor, JA Laukkanen, MK Wium-Andersen, PB Jones, GM Khandaker

    Inflammatory and cardiometabolic markers at presentation with first episode psychosis and long-term clinical outcomes: A longitudinal study using electronic health records.

    Journal: Brain Behav Immun
    E-pub date: 1 Jan 2021
    Authors: EF Osimo, BI Perry, RN Cardinal, M-E Lynall, J Lewis, A Kudchadkar, GK Murray, J Perez, PB Jones, GM Khandaker

    The early impact of COVID-19 on mental health and community physical health services and their patients’ mortality in Cambridgeshire and Peterborough, UK.

    Journal: J Psychiatr Res
    E-pub date: 1 Dec 2020
    Authors: S Chen, PB Jones, BR Underwood, A Moore, ET Bullmore, S Banerjee, EF Osimo, JB Deakin, CF Hatfield, FJ Thompson, JD Artingstall, MP Slann, JR Lewis, RN Cardinal

    Risk Factors for Excess Deaths Among Older Adults Without Confirmed COVID-19 During Lockdown: A Retrospective Cohort Study

    E-pub date: 1 Aug 2020
    Authors: S Chen, P Jones, B Underwood, E Fernandez-Egea, P Qin, J Lewis, R Cardinal

    Longitudinal population subgroups of CRP and risk of depression in the ALSPAC birth cohort.

    Journal: Compr Psychiatry
    E-pub date: 1 Jan 2020
    Authors: EF Osimo, J Stochl, S Zammit, G Lewis, PB Jones, GM Khandaker

    Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels.

    Journal: Psychol Med
    E-pub date: 1 Sep 2019
    Authors: EF Osimo, LJ Baxter, G Lewis, PB Jones, GM Khandaker

    Poor family functioning mediates the link between childhood adversity and adolescent nonsuicidal self-injury.

    Journal: J Child Psychol Psychiatry
    E-pub date: 31 Aug 2018
    Authors: M Cassels, A-L van Harmelen, S Neufeld, I Goodyer, PB Jones, P Wilkinson

    The association between pubertal status and depressive symptoms and diagnoses in adolescent females: A population-based cohort study.

    Journal: PLoS One
    E-pub date: 1 Aug 2018
    Authors: G Lewis, K Ioannidis, A-L van Harmelen, S Neufeld, J Stochl, G Lewis, PB Jones, I Goodyer

    Adolescent friendships predict later resilient functioning across psychosocial domains in a healthy community cohort.

    Journal: Psychol Med
    E-pub date: 1 Oct 2017
    Authors: A-L van Harmelen, RA Kievit, K Ioannidis, S Neufeld, PB Jones, E Bullmore, R Dolan, NSPN Consortium, P Fonagy, I Goodyer

    Characterising the latent structure and organisation of self-reported thoughts, feelings and behaviours in adolescents and young adults.

    Journal: PLoS One
    E-pub date: 1 Aug 2017
    Authors: MC St Clair, S Neufeld, PB Jones, P Fonagy, ET Bullmore, RJ Dolan, M Moutoussis, U Toseeb, IM Goodyer

    Psychosis in autism: comparison of the features of both conditions in a dually affected cohort.

    Journal: Br J Psychiatry
    E-pub date: 1 Apr 2017
    Authors: FV Larson, AP Wagner, PB Jones, D Tantam, M-C Lai, S Baron-Cohen, AJ Holland

    First-generation antipsychotics: not gone but forgotten.

    Journal: BJPsych Bull
    E-pub date: 1 Apr 2016
    Authors: CRM Dibben, GM Khandaker, BR Underwood, C O'Loughlin, C Keep, L Mann, PB Jones

    Immunotherapy for patients with acute psychosis and serum N-Methyl D-Aspartate receptor (NMDAR) antibodies: a description of a treated case series.

    Journal: Schizophr Res
    E-pub date: 1 Dec 2014
    Authors: MS Zandi, JB Deakin, K Morris, C Buckley, L Jacobson, L Scoriels, AL Cox, AJ Coles, PB Jones, A Vincent, BR Lennox