Research interests span the areas of cognitive neuroscience, behavioural neuroscience and psychopharmacology. Main work focuses on the functions of the frontal lobes of the brain and their connections with other regions. These brain systems are relevant to such psychiatric and neurological disorders as Parkinson?s and Huntington?s disease, dementia, schizophrenia, depression, drug addiction, obsessive-compulsive disorder and attention deficit/hyperactivity disorder, as well as frontal lobe injury. The lab uses a variety of methods for studying these systems, including sophisticated psychological paradigms for investigating cognitive functions and impulsivity in both normal subjects and patients; these include the computerised CANTAB battery. Also employed are MRI or PET to determine where in the human brain various cognitive operations are carried out. We are also interested in establishing how drugs work to produce changes in brain chemistry, and how these affect behaviour.