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Research Theme Adaptive Brain Computations
Research Focus

Keywords

  • Inflammation

    • Clinical Conditions

  • Schizophrenia
  • Depressive disorders

    • Equipment & Techniques

  • Computational modelling
  • Statistical analysis

    • Science Culture

  • Equality, Diversity, Inclusion and Wellbeing

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    Dr Rajeev Krishnadas MBBS, MD, PhD, FRCPsych, FRCP (EDIN)

    (he/him/his)
    University Position
    Assistant Professor
    Dr Rajeev Krishnadas is pleased to consider applications from prospective PhD students.

    Interests

    I am an assistant professor specializing in psychosis studies. My research focuses on the application of inflammatory markers and interoceptive processes to predict both physical and mental health outcomes in complex psychosis, employing machine learning and predictive modeling techniques.

    Collaborators

    Cambridge
  • Peter Jones
  • Paul Fletcher
  • Graham Murray
    • External
  • Dr Filippo Queirazza
  • Prof Lena Palaniyappan
  • Prof Peter Uhlhaas
  • Dr Sameer Jauhar
  • Dr Jongrae Kim

    • Key Publications

    Five points to consider when reading a translational machine-learning paper.

    DOI: http://doi.org/10.1192/bjp.2022.29
    Journal: Br J Psychiatry
    E-pub date: 1 Apr 2022
    Authors: D Dwyer, R Krishnadas

    Development and Validation of a Nonremission Risk Prediction Model in First-Episode Psychosis: An Analysis of 2 Longitudinal Studies.

    DOI: http://doi.org/10.1093/schizbullopen/sgab041
    Journal: Schizophr Bull Open
    E-pub date: 1 Jan 2021
    Authors: SP Leighton, R Krishnadas, R Upthegrove, S Marwaha, EW Steyerberg, GV Gkoutos, MR Broome, PF Liddle, L Everard, SP Singh, N Freemantle, D Fowler, PB Jones, V Sharma, R Murray, T Wykes, RJ Drake, I Buchan, S Rogers, J Cavanagh, SW Lewis, M Birchwood, PK Mallikarjun

    Mild Inflammation in Healthy Males Induces Fatigue Mediated by Changes in Effective Connectivity Within the Insula.

    DOI: http://doi.org/10.1016/j.bpsc.2020.04.005
    Journal: Biol Psychiatry Cogn Neurosci Neuroimaging
    E-pub date: 1 Sep 2020
    Authors: K Stefanov, J McLean, A McColl, N Basu, J Cavanagh, R Krishnadas

    Mild inflammation causes a reduction in resting-state amplitude of low-frequency fluctuation in healthy adult males.

    DOI: http://doi.org/10.1177/2398212820949353
    Journal: Brain Neurosci Adv
    E-pub date: 1 Aug 2020
    Authors: K Stefanov, J McLean, B Allan, J Cavanagh, R Krishnadas

    Development and validation of multivariable prediction models of remission, recovery, and quality of life outcomes in people with first episode psychosis: a machine learning approach.

    DOI: http://doi.org/10.1016/S2589-7500(19)30121-9
    Journal: Lancet Digit Health
    E-pub date: 1 Oct 2019
    Authors: SP Leighton, R Upthegrove, R Krishnadas, ME Benros, MR Broome, GV Gkoutos, PF Liddle, SP Singh, L Everard, PB Jones, D Fowler, V Sharma, N Freemantle, RHB Christensen, N Albert, M Nordentoft, M Schwannauer, J Cavanagh, AI Gumley, M Birchwood, PK Mallikarjun

    Predicting one-year outcome in first episode psychosis using machine learning.

    DOI: http://doi.org/10.1371/journal.pone.0212846
    Journal: PLoS One
    E-pub date: 1 Aug 2019
    Authors: SP Leighton, R Krishnadas, K Chung, A Blair, S Brown, S Clark, K Sowerbutts, M Schwannauer, J Cavanagh, AI Gumley

    Dysregulated Brain Dynamics in a Triple-Network Saliency Model of Schizophrenia and Its Relation to Psychosis.

    DOI: http://doi.org/10.1016/j.biopsych.2018.07.020
    Journal: Biol Psychiatry
    E-pub date: 1 Jan 2019
    Authors: K Supekar, W Cai, R Krishnadas, L Palaniyappan, V Menon

    Depression: an inflammatory illness?

    DOI: http://doi.org/10.1136/jnnp-2011-301779
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 May 2012
    Authors: R Krishnadas, J Cavanagh

    Publications

    Intact Mismatch Negativity Responses in Clinical High-Risk for Psychosis and First-Episode Psychosis: Evidence from Source-Reconstructed Event-Related Fields and Time-Frequency Data.

    DOI: http://doi.org/10.1016/j.bpsc.2023.09.006
    Journal: Biol Psychiatry Cogn Neurosci Neuroimaging
    E-pub date: 1 Jan 2024
    Authors: P Dheerendra, T Grent-'t-Jong, R Gajwani, J Gross, AI Gumley, R Krishnadas, SM Lawrie, M Schwannauer, F Schultze-Lutter, PJ Uhlhaas

    Functional Magnetic Resonance Imaging Signatures of Pavlovian and Instrumental Valuation Systems during a Modified Orthogonalized Go/No-go Task.

    DOI: http://doi.org/10.1162/jocn_a_02062
    Journal: J Cogn Neurosci
    E-pub date: 1 Dec 2023
    Authors: F Queirazza, JD Steele, R Krishnadas, J Cavanagh, MG Philiastides

    A systematic review of factors prolonging or reducing the duration of untreated psychosis for people with psychosis in low- and middle-income countries.

    DOI: http://doi.org/10.1111/eip.13466
    Journal: Early Interv Psychiatry
    E-pub date: 1 Nov 2023
    Authors: M Paquin-Goulet, R Krishnadas, L Beattie

    Thalamo-cortical circuits during sensory attenuation in emerging psychosis: a combined magnetoencephalography and dynamic causal modelling study.

    DOI: http://doi.org/10.1038/s41537-023-00341-4
    Journal: Schizophrenia (Heidelb)
    E-pub date: 28 Apr 2023
    Authors: L Hua, RA Adams, T Grent-'t-Jong, R Gajwani, J Gross, AI Gumley, R Krishnadas, SM Lawrie, F Schultze-Lutter, M Schwannauer, PJ Uhlhaas

    Structural and Functional Brain Changes in Acute Takotsubo Syndrome.

    DOI: http://doi.org/10.1016/j.jchf.2022.11.001
    Journal: JACC Heart Fail
    E-pub date: 1 Mar 2023
    Authors: H Khan, DT Gamble, A Rudd, AM Mezincescu, H Abbas, A Noman, A Stewart, G Horgan, R Krishnadas, C Williams, GD Waiter, DK Dawson

    Hippocampal structural alterations in early-stage psychosis: Specificity and relationship to clinical outcomes.

    DOI: http://doi.org/10.1016/j.nicl.2022.103087
    Journal: Neuroimage Clin
    E-pub date: 1 Aug 2022
    Authors: G Brunner, R Gajwani, J Gross, AI Gumley, R Krishnadas, SM Lawrie, M Schwannauer, F Schultze-Lutter, A Fracasso, PJ Uhlhaas

    Computerised cognitive training during early-stage psychosis improves cognitive deficits and gamma-band oscillations: A pilot study.

    DOI: http://doi.org/10.1016/j.schres.2022.04.001
    Journal: Schizophr Res
    E-pub date: 1 May 2022
    Authors: K Haining, T Grent-'t-Jong, B Chetcuti, R Gajwani, J Gross, C Kearns, R Krishnadas, SM Lawrie, S Molavi, C Paton, F Queirazza, E Richardson, F Schultze-Lutter, M Schwannauer, PJ Uhlhaas

    40-Hz Auditory Steady-State Responses Characterize Circuit Dysfunctions and Predict Clinical Outcomes in Clinical High-Risk for Psychosis Participants: A Magnetoencephalography Study.

    DOI: http://doi.org/10.1016/j.biopsych.2021.03.018
    Journal: Biol Psychiatry
    E-pub date: 15 Sep 2021
    Authors: T Grent-'t-Jong, R Gajwani, J Gross, AI Gumley, R Krishnadas, SM Lawrie, M Schwannauer, F Schultze-Lutter, PJ Uhlhaas

    Long range temporal correlations (LRTCs) in MEG-data during emerging psychosis: Relationship to symptoms, medication-status and clinical trajectory.

    DOI: http://doi.org/10.1016/j.nicl.2021.102722
    Journal: Neuroimage Clin
    E-pub date: 1 Aug 2021
    Authors: G Cruz, T Grent-'t-Jong, R Krishnadas, JM Palva, S Palva, PJ Uhlhaas

    Anti-NMDAR encephalitis for psychiatrists: the essentials.

    DOI: http://doi.org/10.1192/bjb.2021.35
    Journal: BJPsych Bull
    E-pub date: 2 Jun 2021
    Authors: M Beattie, J Goodfellow, M Oto, R Krishnadas

    Association of Magnetoencephalographically Measured High-Frequency Oscillations in Visual Cortex With Circuit Dysfunctions in Local and Large-scale Networks During Emerging Psychosis.

    DOI: http://doi.org/10.1001/jamapsychiatry.2020.0284
    Journal: JAMA Psychiatry
    E-pub date: 1 Aug 2020
    Authors: T Grent-'t-Jong, R Gajwani, J Gross, AI Gumley, R Krishnadas, SM Lawrie, M Schwannauer, F Schultze-Lutter, PJ Uhlhaas

    Treatment delay in early psychosis: not a linear problem.

    DOI: http://doi.org/10.1016/S2215-0366(20)30239-X
    Journal: Lancet Psychiatry
    E-pub date: 1 Jul 2020
    Authors: L Palaniyappan, R Krishnadas

    Is there a symptomatic distinction between the affective psychoses and schizophrenia? A machine learning approach.

    DOI: http://doi.org/10.1016/j.schres.2018.06.070
    Journal: Schizophr Res
    E-pub date: 1 Dec 2018
    Authors: S Jauhar, R Krishnadas, MM Nour, D Cunningham-Owens, EC Johnstone, SM Lawrie

    Brain-stem serotonin transporter availability in maternal uniparental disomy and deletion Prader-Willi syndrome.

    DOI: http://doi.org/10.1192/bjp.2017.7
    Journal: Br J Psychiatry
    E-pub date: 1 Jan 2018
    Authors: R Krishnadas, S-A Cooper, A Nicol, S Pimlott, S Soni, AJ Holland, L McArthur, J Cavanagh

    Chemokines in depression in health and in inflammatory illness: a systematic review and meta-analysis.

    DOI: http://doi.org/10.1038/mp.2017.205
    Journal: Mol Psychiatry
    E-pub date: 1 Jan 2018
    Authors: SP Leighton, L Nerurkar, R Krishnadas, C Johnman, GJ Graham, J Cavanagh

    Depression Phenotype, Inflammation, and the Brain: Implications for Future Research.

    DOI: http://doi.org/10.1097/PSY.0000000000000339
    Journal: Psychosom Med
    E-pub date: 1 May 2016
    Authors: R Krishnadas, NA Harrison

    Circulating tumour necrosis factor is highly correlated with brainstem serotonin transporter availability in humans.

    DOI: http://doi.org/10.1016/j.bbi.2015.08.005
    Journal: Brain Behav Immun
    E-pub date: 1 Jan 2016
    Authors: R Krishnadas, A Nicol, J Sassarini, N Puri, AD Burden, J Leman, E Combet, S Pimlott, D Hadley, IB McInnes, J Cavanagh

    Adjunctive aripiprazole in risperidone-induced hyperprolactinaemia: double-blind, randomised, placebo-controlled trial.

    DOI: http://doi.org/10.1192/bjpo.bp.115.001248
    Journal: BJPsych Open
    E-pub date: 1 Oct 2015
    Authors: G Raghuthaman, R Venkateswaran, R Krishnadas

    Localized connectivity in depression: a meta-analysis of resting state functional imaging studies.

    DOI: http://doi.org/10.1016/j.neubiorev.2015.01.006
    Journal: Neurosci Biobehav Rev
    E-pub date: 1 Apr 2015
    Authors: SJ Iwabuchi, R Krishnadas, C Li, DP Auer, J Radua, L Palaniyappan

    Psychoticism and salience network morphology

    DOI: http://doi.org/10.1016/j.paid.2013.09.016
    Journal: Personality and Individual Differences
    E-pub date: 1 Jan 2014
    Authors: R Krishnadas, L Palaniyappan, J Lang, J McLean, J Cavanagh

    Socioeconomic status and the cerebellar grey matter volume. Data from a well-characterised population sample.

    DOI: http://doi.org/10.1007/s12311-013-0497-4
    Journal: Cerebellum
    E-pub date: 1 Dec 2013
    Authors: J Cavanagh, R Krishnadas, GD Batty, H Burns, KA Deans, I Ford, A McConnachie, A McGinty, JS McLean, K Millar, N Sattar, PG Shiels, C Tannahill, YN Velupillai, CJ Packard, J McLean

    Socioeconomic deprivation and cortical morphology: psychological, social, and biological determinants of ill health study.

    DOI: http://doi.org/10.1097/PSY.0b013e3182a151a7
    Journal: Psychosom Med
    E-pub date: 1 Sep 2013
    Authors: R Krishnadas, J McLean, GD Batty, H Burns, KA Deans, I Ford, A McConnachie, JS McLean, K Millar, N Sattar, PG Shiels, C Tannahill, YN Velupillai, CJ Packard, J Cavanagh

    Cardio-metabolic risk factors and cortical thickness in a neurologically healthy male population: Results from the psychological, social and biological determinants of ill health (pSoBid) study.

    DOI: http://doi.org/10.1016/j.nicl.2013.04.012
    Journal: Neuroimage Clin
    E-pub date: 1 Aug 2013
    Authors: R Krishnadas, J McLean, GD Batty, H Burns, KA Deans, I Ford, A McConnachie, A McGinty, JS McLean, K Millar, N Sattar, PG Shiels, YN Velupillai, CJ Packard, J Cavanagh

    The envirome and the connectome: exploring the structural noise in the human brain associated with socioeconomic deprivation.

    DOI: http://doi.org/10.3389/fnhum.2013.00722
    Journal: Front Hum Neurosci
    E-pub date: 1 Aug 2013
    Authors: R Krishnadas, J Kim, J McLean, GD Batty, JS McLean, K Millar, CJ Packard, J Cavanagh

    Has the prevalence, clinical presentation and social functioning of schizophrenia changed over the last 25 years? Nithsdale schizophrenia survey revisited.

    DOI: http://doi.org/10.1016/j.schres.2013.02.006
    Journal: Schizophr Res
    E-pub date: 1 May 2013
    Authors: S Shivashankar, S Telfer, J Arunagiriraj, M McKinnon, S Jauhar, R Krishnadas, R McCreadie

    Macroeconomic environment during infancy as a possible risk factor for adolescent behavioral problems.

    DOI: http://doi.org/10.1001/jamapsychiatry.2013.280
    Journal: JAMA Psychiatry
    E-pub date: 1 Feb 2013
    Authors: S Ramanathan, N Balasubramanian, R Krishnadas

    Early life socioeconomic status, chronic physiological stress and hippocampal N-acetyl aspartate concentrations.

    DOI: http://doi.org/10.1016/j.bbr.2012.08.013
    Journal: Behav Brain Res
    E-pub date: 1 Dec 2012
    Authors: J McLean, R Krishnadas, GD Batty, H Burns, KA Deans, I Ford, A McConnachie, A McGinty, JS McLean, K Millar, N Sattar, PG Shiels, C Tannahill, YN Velupillai, CJ Packard, BR Condon, DM Hadley, J Cavanagh

    Nicotine dependence and illness severity in schizophrenia.

    DOI: http://doi.org/10.1192/bjp.bp.111.107953
    Journal: Br J Psychiatry
    E-pub date: 1 Oct 2012
    Authors: R Krishnadas, S Jauhar, S Telfer, S Shivashankar, RG McCreadie

    Ethnicity, deprivation and psychosis: the Glasgow experience.

    DOI: http://doi.org/10.1017/S2045796012000352
    Journal: Epidemiol Psychiatr Sci
    E-pub date: 1 Sep 2012
    Authors: P Srireddy, A Agnihotri, J Park, J Taylor, M Connolly, R Krishnadas

    Biodistribution and dosimetry of ¹²³I-mZIENT: a novel ligand for imaging serotonin transporters.

    DOI: http://doi.org/10.1007/s00259-011-2056-x
    Journal: Eur J Nucl Med Mol Imaging
    E-pub date: 1 May 2012
    Authors: A Nicol, R Krishnadas, S Champion, G Tamagnan, JS Stehouwer, MM Goodman, DM Hadley, SL Pimlott

    Tardive dyskinesia and deficit schizophrenia.

    DOI: http://doi.org/10.1111/j.1600-0447.2011.01751.x
    Journal: Acta Psychiatr Scand
    E-pub date: 1 Nov 2011
    Authors: S Telfer, S Shivashankar, R Krishnadas, RG McCreadie, B Kirkpatrick

    Relationship of cognitive function in patients with schizophrenia in remission to disability: a cross-sectional study in an Indian sample.

    DOI: http://doi.org/10.1186/1744-859X-6-19
    Journal: Ann Gen Psychiatry
    E-pub date: 30 Jul 2007
    Authors: R Krishnadas, BP Moore, A Nayak, RR Patel