Equipment & Techniques
I work on the causes, brain mechanisms and treatments of mental disorder. I utilize a variety of neuroscience techniques, including statistical genomics (and other 'omics), brain imaging, computational psychiatry, pharmacological and neuropsychological studies in patients and healthy volunteers. I study the relationship between cognitive development and mental illness across the lifespan, and on the mechanisms through which etiological factors (such as genetics) lead to pathophysiological disruptions in mental illness. I am interested in the research and clinical applications of risk scores, including polygenic risk scores and clinical informatic risk prediction models. I am working to try to improve the infrastructure for psychosis translational research in the UK, through jointly leading the early psychosis workstream of the Office of Life Sciences/NIHR Mental Health Mission.