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Department
  • Psychiatry
  • Research Focus

    Keywords

  • Genomics
  • Bioinformatics
  • Clinical Epidemiology
  • Mental Health
  • Brain
  • Mental Health Services
  • Computational Psychiatry
  • Clinical Trials
  • Clinical Conditions

  • Bipolar disorder
  • Psychotic disorders
  • Schizophrenia
  • Depressive disorders
  • Equipment & Techniques

  • Statistical analysis
  • Magnetic resonance imaging (MRI)
  • Science Culture

  • Mentorship
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    Professor Graham Murray MD PhD FRCPsych

    (he/him/his)
    University Position
    Professor
    Professor Graham Murray is pleased to consider applications from prospective PhD students.

    Interests

    I work on the causes, brain mechanisms and treatments of mental disorder. I utilize a variety of neuroscience techniques, including statistical genomics (and other 'omics), brain imaging, computational psychiatry, pharmacological and neuropsychological studies in patients and healthy volunteers. I study the relationship between cognitive development and mental illness across the lifespan, and on the mechanisms through which etiological factors (such as genetics) lead to pathophysiological disruptions in mental illness. I am interested in the research and clinical applications of risk scores, including polygenic risk scores and clinical informatic risk prediction models. I am working to try to improve the infrastructure for psychosis translational research in the UK, through jointly leading the early psychosis workstream of the Office of Life Sciences/NIHR Mental Health Mission.

    Key Publications

    Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes.

    DOI: http://doi.org/10.1038/s41588-023-01475-y
    Journal: Nat Genet
    E-pub date: 1 Sep 2023
    Authors: V Warrier, E-M Stauffer, QQ Huang, EM Wigdor, EAW Slob, J Seidlitz, L Ronan, SL Valk, TT Mallard, AD Grotzinger, R Romero-Garcia, S Baron-Cohen, DH Geschwind, MA Lancaster, GK Murray, MJ Gandal, A Alexander-Bloch, H Won, HC Martin, ET Bullmore, RAI Bethlehem

    Predicting treatment resistance from first-episode psychosis using routinely collected clinical information.

    DOI: http://doi.org/10.1038/s44220-022-00001-z
    Journal: Nat Ment Health
    E-pub date: 19 Jan 2023
    Authors: EF Osimo, BI Perry, P Mallikarjun, M Pritchard, J Lewis, A Katunda, GK Murray, J Perez, PB Jones, RN Cardinal, OD Howes, R Upthegrove, GM Khandaker

    Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population

    DOI: http://doi.org/10.1101/668939
    Journal:
    E-pub date: 1 Aug 2019
    Authors: M Montagnese, F Knolle, J Haarsma, JD Griffin, A Richards, P Vertes, B Kiddle, PC Fletcher, PB Jones, MJ Owen, P Fonagy, ET Bullmore, R Dolan, NSPN Consortium, M Moutoussis, I Goodyer, GK Murray

    Publications

    Associations of 2,922 genetically predicted plasma protein levels with mental illness and response to treatment

    DOI: http://doi.org/10.21203/rs.3.rs-4313341/v1
    Journal:
    E-pub date: 1 Aug 2024
    Authors: K Zhang, B Chidiac, V Zhao, S Noordeen, V Warrier, A Butterworth, BI Perry, GK Murray, EF Osimo

    More must be done to reduce cardiovascular risk for patients on antipsychotic medications.

    DOI: http://doi.org/10.1097/YIC.0000000000000464
    Journal: Int Clin Psychopharmacol
    E-pub date: 1 May 2023
    Authors: EF Osimo, BI Perry, GK Murray

    The psychosis metabolic risk calculator (PsyMetRiC) for young people with psychosis: International external validation and site-specific recalibration in two independent European samples.

    DOI: http://doi.org/10.1016/j.lanepe.2022.100493
    Journal: Lancet Reg Health Eur
    E-pub date: 1 Nov 2022
    Authors: BI Perry, F Vandenberghe, N Garrido-Torres, EF Osimo, M Piras, J Vazquez-Bourgon, R Upthegrove, C Grosu, VO-G De La Foz, PB Jones, N Laaboub, M Ruiz-Veguilla, J Stochl, C Dubath, M Canal-Rivero, P Mallikarjun, A Delacrétaz, N Ansermot, E Fernandez-Egea, S Crettol, F Gamma, KJ Plessen, P Conus, GM Khandaker, GK Murray, CB Eap, B Crespo-Facorro

    The genetics of cortical organisation and development: a study of 2,347 neuroimaging phenotypes

    DOI: http://doi.org/10.1101/2022.09.08.507084
    Journal:
    E-pub date: 8 Sep 2022
    Authors: V Warrier, E-M Stauffer, QQ Huang, EM Wigdor, EAW Slob, J Seidlitz, L Ronan, S Valk, TT Mallard, AD Grotzinger, R Romero-Garcia, S Baron-Cohen, DH Geschwind, M Lancaster, GK Murray, MJ Gandal, A Alexander-Bloch, H Won, HC Martin, ET Bullmore, RAI Bethlehem

    Precision weighting of cortical unsigned prediction error signals benefits learning, is mediated by dopamine, and is impaired in psychosis.

    DOI: http://doi.org/10.1038/s41380-020-0803-8
    Journal: Mol Psychiatry
    E-pub date: 1 Sep 2021
    Authors: J Haarsma, PC Fletcher, JD Griffin, HJ Taverne, H Ziauddeen, TJ Spencer, C Miller, T Katthagen, I Goodyer, KMJ Diederen, GK Murray

    Grey and white matter micro-structure is associated with polygenic risk for schizophrenia

    DOI: http://doi.org/10.1101/2021.02.06.21251073
    Journal:
    E-pub date: 1 Aug 2021
    Authors: E-M Stauffer, RAI Bethlehem, V Warrier, G Murray, R Romero-Garcia, J Seidlitz, E Bullmore

    Is the Association Between Smoking and Depression Mediated by Inflammation? A Mendelian Randomization Study

    DOI: http://doi.org/10.1101/2021.02.04.21251136
    Journal:
    E-pub date: 1 Aug 2021
    Authors: D Galan, BI Perry, V Warrier, D Easton, GM Khandaker, GK Murray

    The relationship of COVID-19 related stress and media consumption with schizotypy, depression and anxiety

    DOI: http://doi.org/10.1101/2021.11.26.21266896
    Journal:
    E-pub date: 1 Aug 2021
    Authors: S Daimer, L Mihatsch, SAS Neufeld, GK Murray, F Knolle

    Inflammatory and cardiometabolic markers at presentation with first episode psychosis and long-term clinical outcomes: A longitudinal study using electronic health records.

    DOI: http://doi.org/10.1016/j.bbi.2020.09.011
    Journal: Brain Behav Immun
    E-pub date: 1 Jan 2021
    Authors: EF Osimo, BI Perry, RN Cardinal, M-E Lynall, J Lewis, A Kudchadkar, GK Murray, J Perez, PB Jones, GM Khandaker

    Evidence in cortical folding patterns for prenatal predispositions to hallucinations in schizophrenia.

    DOI: http://doi.org/10.1038/s41398-020-01075-y
    Journal: Transl Psychiatry
    E-pub date: 6 Nov 2020
    Authors: CPE Rollins, JR Garrison, M Arribas, A Seyedsalehi, Z Li, RCK Chan, J Yang, D Wang, P Liò, C Yan, Z-H Yi, A Cachia, R Upthegrove, B Deakin, JS Simons, GK Murray, J Suckling

    Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population.

    DOI: http://doi.org/10.1016/j.schres.2020.04.022
    Journal: Schizophr Res
    E-pub date: 31 Aug 2020
    Authors: M Montagnese, F Knolle, J Haarsma, JD Griffin, A Richards, PE Vertes, B Kiddle, PC Fletcher, PB Jones, MJ Owen, P Fonagy, ET Bullmore, RJ Dolan, NSPN Consortium, M Moutoussis, IM Goodyer, GK Murray

    The neurodevelopment of anomalous perception: Evidence in cortical folding patterns for prenatal predispositions to hallucinations in schizophrenia

    DOI: http://doi.org/10.1101/2020.06.04.20122424
    Journal:
    E-pub date: 1 Aug 2020
    Authors: CPE Rollins, J Garrison, M Arribas, A Seyedsalehi, Z Li, RCK Chan, J Yang, D Wang, P Lio, C Yan, Z-H Yi, A Cachia, R Upthegrove, B Deakin, J Simons, G Murray, J Suckling

    Meta-analytic Evidence for the Plurality of Mechanisms in Transdiagnostic Structural MRI Studies of Hallucination Status.

    DOI: http://doi.org/10.1016/j.eclinm.2019.01.012
    Journal: EClinicalMedicine
    E-pub date: 1 Feb 2019
    Authors: CPE Rollins, JR Garrison, JS Simons, JB Rowe, C O'Callaghan, GK Murray, J Suckling

    Abnormal Frontostriatal Activity During Unexpected Reward Receipt in Depression and Schizophrenia: Relationship to Anhedonia.

    DOI: http://doi.org/10.1038/npp.2015.370
    Journal: Neuropsychopharmacology
    E-pub date: 1 Jul 2016
    Authors: N Segarra, A Metastasio, H Ziauddeen, J Spencer, NR Reinders, RB Dudas, G Arrondo, TW Robbins, L Clark, PC Fletcher, GK Murray

    Reduction in ventral striatal activity when anticipating a reward in depression and schizophrenia: a replicated cross-diagnostic finding.

    DOI: http://doi.org/10.3389/fpsyg.2015.01280
    Journal: Front Psychol
    E-pub date: 1 Aug 2015
    Authors: G Arrondo, N Segarra, A Metastasio, H Ziauddeen, J Spencer, NR Reinders, RB Dudas, TW Robbins, PC Fletcher, GK Murray

    Hedonic and disgust taste perception in borderline personality disorder and depression.

    DOI: http://doi.org/10.1192/bjp.bp.114.150433
    Journal: Br J Psychiatry
    E-pub date: 1 Jul 2015
    Authors: G Arrondo, GK Murray, E Hill, B Szalma, K Yathiraj, C Denman, RB Dudas

    Brain structural signatures of negative symptoms in depression and schizophrenia.

    DOI: http://doi.org/10.3389/fpsyt.2014.00116
    Journal: Front Psychiatry
    E-pub date: 1 Aug 2014
    Authors: J-Y Chuang, GK Murray, A Metastasio, N Segarra, R Tait, J Spencer, H Ziauddeen, RB Dudas, PC Fletcher, J Suckling

    The relevance of reward pathways for schizophrenia.

    DOI: http://doi.org/10.1097/YCO.0b013e328336661b
    Journal: Curr Opin Psychiatry
    E-pub date: 1 Mar 2010
    Authors: H Ziauddeen, GK Murray

    Illusions and delusions: relating experimentally-induced false memories to anomalous experiences and ideas.

    DOI: http://doi.org/10.3389/neuro.08.053.2009
    Journal: Front Behav Neurosci
    E-pub date: 1 Aug 2009
    Authors: PR Corlett, JS Simons, JS Pigott, JM Gardner, GK Murray, JH Krystal, PC Fletcher