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    Dr Emanuele Osimo MD, PhD, MRCPsych

    (he/him/his)
    University Position
    Clinical Lecturer
    Dr Emanuele Osimo is pleased to consider applications from prospective PhD students.

    Interests

    As an Academic Clinical Lecturer in psychiatry at the University of Cambridge, and a visiting researcher at Imperial College London/MRC London Institute for Medical Sciences (LMS), I focus on unraveling the immune and cardio-metabolic landscape of early psychosis and schizophrenia using diverse scientific approaches. For my research, in the past I have used clinical research methods such as Magnetic Resonance Imaging and biomarker analysis to delve into cardiac and adipose tissue changes in schizophrenia. This exploration has led to the formulation of a novel hypothesis regarding the potential causes of cardiac alterations in this condition. Through psychiatric clinical epidemiology methods, I've developed longitudinal "virtual cohorts" of psychiatric patients, utilizing large datasets to characterize immune and metabolic markers across different stages of illness. This work has culminated in the development of risk prediction models for health outcomes in psychosis, including the creation of a clinically useful risk calculator for treatment-resistant schizophrenia, named MOZART, which has earned recognition, including the Schizophrenia International Research Society Early Career Award. I have also completed a clinical PhD in bioinformatics on the genetics of schizophrenia at Imperial College London. Apart from my research, I'm deeply engaged in medical education, teaching medical students and supervising research projects. I'm also committed to mentorship, having initiated and managed a mentoring program within the Cambridge NHS Trust. Looking ahead, my aim is to further refine and validate MOZART using larger datasets and industry collaborations, with the ultimate goal of integrating it into clinical practice. I aspire to become a leading figure in the field, continuing my work as an academic clinician in psychiatry, and contributing to advancements in understanding and treating mental illness.

    MOZART: a risk prediction tool for treatment resistant schizophrenia

    Commonly recorded clinical information at psychosis onset including blood markers can help predict whether a person will develop treatment resistant schizophrenia.

    Key Publications

    Predicting treatment resistance from first-episode psychosis using routinely collected clinical information.

    DOI: http://doi.org/10.1038/s44220-022-00001-z
    Journal: Nat Ment Health
    E-pub date: 19 Jan 2023
    Authors: EF Osimo, BI Perry, P Mallikarjun, M Pritchard, J Lewis, A Katunda, GK Murray, J Perez, PB Jones, RN Cardinal, OD Howes, R Upthegrove, GM Khandaker

    Adipose tissue dysfunction, inflammation, and insulin resistance: alternative pathways to cardiac remodelling in schizophrenia. A multimodal, case-control study.

    DOI: http://doi.org/10.1038/s41398-021-01741-9
    Journal: Transl Psychiatry
    E-pub date: 6 Dec 2021
    Authors: EF Osimo, M Sweeney, A de Marvao, A Berry, B Statton, BI Perry, T Pillinger, T Whitehurst, SA Cook, DP O'Regan, EL Thomas, OD Howes

    Development and external validation of the Psychosis Metabolic Risk Calculator (PsyMetRiC): a cardiometabolic risk prediction algorithm for young people with psychosis.

    DOI: http://doi.org/10.1016/S2215-0366(21)00114-0
    Journal: Lancet Psychiatry
    E-pub date: 1 Jul 2021
    Authors: BI Perry, EF Osimo, R Upthegrove, PK Mallikarjun, J Yorke, J Stochl, J Perez, S Zammit, O Howes, PB Jones, GM Khandaker

    Cardiac structure and function in schizophrenia: cardiac magnetic resonance imaging study.

    DOI: http://doi.org/10.1192/bjp.2019.268
    Journal: Br J Psychiatry
    E-pub date: 31 Aug 2020
    Authors: EF Osimo, SP Brugger, A de Marvao, T Pillinger, T Whitehurst, B Statton, M Quinlan, A Berry, SA Cook, DP O'Regan, OD Howes

    Prevalence and correlates of low-grade systemic inflammation in adult psychiatric inpatients: An electronic health record-based study.

    DOI: http://doi.org/10.1016/j.psyneuen.2018.02.031
    Journal: Psychoneuroendocrinology
    E-pub date: 1 Mar 2018
    Authors: EF Osimo, RN Cardinal, PB Jones, GM Khandaker

    Publications

    USING ELECTRONIC HEALTH RECORDS TO FACILITATE PRECISION PSYCHIATRY.

    DOI: http://doi.org/10.1016/j.biopsych.2024.02.1006
    Journal: Biol Psychiatry
    E-pub date: 24 Feb 2024
    Authors: D Oliver, M Arribas, BI Perry, D Whiting, G Blackman, K Krakowski, A Seyedsalehi, EF Osimo, SL Griffiths, D Stahl, A Cipriani, S Fazel, P Fusar-Poli, P McGuire

    More must be done to reduce cardiovascular risk for patients on antipsychotic medications.

    DOI: http://doi.org/10.1097/YIC.0000000000000464
    Journal: Int Clin Psychopharmacol
    E-pub date: 1 May 2023
    Authors: EF Osimo, BI Perry, GK Murray

    Effect of polygenic risk for schizophrenia on cardiac structure and function: a UK Biobank observational study.

    DOI: http://doi.org/10.1016/S2215-0366(22)00403-5
    Journal: Lancet Psychiatry
    E-pub date: 1 Feb 2023
    Authors: T Pillinger, EF Osimo, A de Marvao, M Shah, C Francis, J Huang, E D'Ambrosio, J Firth, MM Nour, RA McCutcheon, AF Pardiñas, PM Matthews, DP O'Regan, OD Howes

    The psychosis metabolic risk calculator (PsyMetRiC) for young people with psychosis: International external validation and site-specific recalibration in two independent European samples.

    DOI: http://doi.org/10.1016/j.lanepe.2022.100493
    Journal: Lancet Reg Health Eur
    E-pub date: 1 Nov 2022
    Authors: BI Perry, F Vandenberghe, N Garrido-Torres, EF Osimo, M Piras, J Vazquez-Bourgon, R Upthegrove, C Grosu, VO-G De La Foz, PB Jones, N Laaboub, M Ruiz-Veguilla, J Stochl, C Dubath, M Canal-Rivero, P Mallikarjun, A Delacrétaz, N Ansermot, E Fernandez-Egea, S Crettol, F Gamma, KJ Plessen, P Conus, GM Khandaker, GK Murray, CB Eap, B Crespo-Facorro

    Clozapine treatment and risk of COVID-19.

    DOI: http://doi.org/10.1192/bjo.2022.537
    Journal: BJPsych Open
    E-pub date: 11 Jul 2022
    Authors: EF Osimo, J Lewis, RN Cardinal, GM Khandaker

    A cross-sectional MR study of body fat volumes and distribution in chronic schizophrenia.

    DOI: http://doi.org/10.1038/s41537-022-00233-z
    Journal: Schizophrenia (Heidelb)
    E-pub date: 18 Mar 2022
    Authors: EF Osimo, SP Brugger, EL Thomas, OD Howes

    Risk Prediction in Psychosis: Progress Made and Challenges Ahead.

    DOI: http://doi.org/10.1016/j.biopsych.2021.08.015
    Journal: Biol Psychiatry
    E-pub date: 1 Nov 2021
    Authors: BI Perry, EF Osimo, GM Khandaker

    Longitudinal association between CRP levels and risk of psychosis: a meta-analysis of population-based cohort studies.

    DOI: http://doi.org/10.1038/s41537-021-00161-4
    Journal: NPJ Schizophr
    E-pub date: 28 May 2021
    Authors: EF Osimo, L Baxter, J Stochl, BI Perry, SA Metcalf, SK Kunutsor, JA Laukkanen, MK Wium-Andersen, PB Jones, GM Khandaker

    Inflammatory and cardiometabolic markers at presentation with first episode psychosis and long-term clinical outcomes: A longitudinal study using electronic health records.

    DOI: http://doi.org/10.1016/j.bbi.2020.09.011
    Journal: Brain Behav Immun
    E-pub date: 1 Jan 2021
    Authors: EF Osimo, BI Perry, RN Cardinal, M-E Lynall, J Lewis, A Kudchadkar, GK Murray, J Perez, PB Jones, GM Khandaker

    The early impact of COVID-19 on mental health and community physical health services and their patients’ mortality in Cambridgeshire and Peterborough, UK.

    DOI: http://doi.org/10.1016/j.jpsychires.2020.09.020
    Journal: J Psychiatr Res
    E-pub date: 1 Dec 2020
    Authors: S Chen, PB Jones, BR Underwood, A Moore, ET Bullmore, S Banerjee, EF Osimo, JB Deakin, CF Hatfield, FJ Thompson, JD Artingstall, MP Slann, JR Lewis, RN Cardinal

    Inflammatory markers in depression: A meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls.

    DOI: http://doi.org/10.1016/j.bbi.2020.02.010
    Journal: Brain Behav Immun
    E-pub date: 1 Jul 2020
    Authors: EF Osimo, T Pillinger, IM Rodriguez, GM Khandaker, CM Pariante, OD Howes

    Longitudinal population subgroups of CRP and risk of depression in the ALSPAC birth cohort.

    DOI: http://doi.org/10.1016/j.comppsych.2019.152143
    Journal: Compr Psychiatry
    E-pub date: 1 Jan 2020
    Authors: EF Osimo, J Stochl, S Zammit, G Lewis, PB Jones, GM Khandaker

    A Meta-analysis of Immune Parameters, Variability, and Assessment of Modal Distribution in Psychosis and Test of the Immune Subgroup Hypothesis.

    DOI: http://doi.org/10.1093/schbul/sby160
    Journal: Schizophr Bull
    E-pub date: 11 Sep 2019
    Authors: T Pillinger, EF Osimo, S Brugger, V Mondelli, RA McCutcheon, OD Howes

    Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels.

    DOI: http://doi.org/10.1017/S0033291719001454
    Journal: Psychol Med
    E-pub date: 1 Sep 2019
    Authors: EF Osimo, LJ Baxter, G Lewis, PB Jones, GM Khandaker

    Longitudinal C-reactive protein (CRP) population sub-groups as predictors of depression: Findings from the ALSPAC birth cohort

    DOI: http://doi.org/10.1016/j.euroneuro.2018.11.286
    Journal: EUROPEAN NEUROPSYCHOPHARMACOLOGY
    E-pub date: 1 Aug 2019
    Authors: EF Osimo, J Stochl, GM Khandaker

    Cardiac structure and function in patients with schizophrenia taking antipsychotic drugs: an MRI study.

    DOI: http://doi.org/10.1038/s41398-019-0502-x
    Journal: Transl Psychiatry
    E-pub date: 7 Jun 2019
    Authors: T Pillinger, EF Osimo, A de Marvao, MA Berry, T Whitehurst, B Statton, M Quinlan, S Brugger, A Vazir, SA Cook, DP O'Regan, OD Howes

    Synaptic loss in schizophrenia: a meta-analysis and systematic review of synaptic protein and mRNA measures.

    DOI: http://doi.org/10.1038/s41380-018-0041-5
    Journal: Mol Psychiatry
    E-pub date: 1 Apr 2019
    Authors: EF Osimo, K Beck, T Reis Marques, OD Howes