• Psychiatry
  • Research Theme Beyond the Neuron

    Other Interdiciplinary Incentives

  • Neuroscience
  • Research Focus


  • Psychosis
  • Early Interventions
  • Mood Disorders
  • Depression
  • Bipolar Disorder
  • Genetics
  • Genetic Epidemiology
  • Cardiometabolic Disorders
  • Inflammation & Immunity
  • Epidemiology
  • Risk Prediction
  • Bioinformatics
  • Antipsychotics
  • Body Weight
  • Psychiatry
  • Clinical Conditions

  • Psychotic disorders
  • Depressive disorders
  • Bipolar disorder
  • Schizophrenia
  • Equipment & Techniques

  • Computational modelling
  • Cross-sectional and cohort studies
  • Statistical analysis
  • Science Culture

  • CamBRAIN
  • Mentorship
  • Public Outreach
  • Reproducibility in Science
  • Teaching
  • Science Writing
  • Back

    Dr Emanuele Osimo

    University Position
    Clinical Lecturer
    Dr Emanuele Osimo is pleased to consider applications from prospective PhD students.


    I’m Emanuele, an Academic Clinical Lecturer in psychiatry in Cambridge. My research to date has aimed at characterising the immune and cardio-metabolic landscape of early psychosis and of schizophrenia using clinical research methods (e.g., MRI and biomarkers), as well as data science methods (e.g., electronic-health-record and cohort data). Together with my clinical experience as a psychiatrist, my data science and clinical informatics background have led me towards risk prediction modelling. Today, my research is mostly computational and aims to uncover the correlates and predictors for common clinical outcomes, both psychiatric (e.g., psychiatric clinical course and treatment responsiveness), and cardiometabolic (e.g., metabolic syndrome/diabetes) in people with serious mental illness, such as schizophrenia, depression and bipolar disorder.

    MOZART: a risk prediction tool for treatment resistant schizophrenia

    Commonly recorded clinical information at psychosis onset including blood markers can help predict whether a person will develop treatment resistant schizophrenia.

    Key Publications

    Predicting treatment resistance from first-episode psychosis using routinely collected clinical information.

    Journal: Nat Ment Health
    E-pub date: 19 Jan 2023
    Authors: EF Osimo, BI Perry, P Mallikarjun, M Pritchard, J Lewis, A Katunda, GK Murray, J Perez, PB Jones, RN Cardinal, OD Howes, R Upthegrove, GM Khandaker

    Adipose tissue dysfunction, inflammation, and insulin resistance: alternative pathways to cardiac remodelling in schizophrenia. A multimodal, case-control study.

    Journal: Transl Psychiatry
    E-pub date: 6 Dec 2021
    Authors: EF Osimo, M Sweeney, A de Marvao, A Berry, B Statton, BI Perry, T Pillinger, T Whitehurst, SA Cook, DP O'Regan, EL Thomas, OD Howes

    Development and external validation of the Psychosis Metabolic Risk Calculator (PsyMetRiC): a cardiometabolic risk prediction algorithm for young people with psychosis.

    Journal: Lancet Psychiatry
    E-pub date: 1 Jul 2021
    Authors: BI Perry, EF Osimo, R Upthegrove, PK Mallikarjun, J Yorke, J Stochl, J Perez, S Zammit, O Howes, PB Jones, GM Khandaker

    Cardiac structure and function in schizophrenia: cardiac magnetic resonance imaging study.

    Journal: Br J Psychiatry
    E-pub date: 31 Aug 2020
    Authors: EF Osimo, SP Brugger, A de Marvao, T Pillinger, T Whitehurst, B Statton, M Quinlan, A Berry, SA Cook, DP O'Regan, OD Howes

    Prevalence and correlates of low-grade systemic inflammation in adult psychiatric inpatients: An electronic health record-based study.

    Journal: Psychoneuroendocrinology
    E-pub date: 1 Mar 2018
    Authors: EF Osimo, RN Cardinal, PB Jones, GM Khandaker


    More must be done to reduce cardiovascular risk for patients on antipsychotic medications.

    Journal: Int Clin Psychopharmacol
    E-pub date: 1 May 2023
    Authors: EF Osimo, BI Perry, GK Murray

    Effect of polygenic risk for schizophrenia on cardiac structure and function: a UK Biobank observational study.

    Journal: Lancet Psychiatry
    E-pub date: 1 Feb 2023
    Authors: T Pillinger, EF Osimo, A de Marvao, M Shah, C Francis, J Huang, E D'Ambrosio, J Firth, MM Nour, RA McCutcheon, AF Pardiñas, PM Matthews, DP O'Regan, OD Howes

    The psychosis metabolic risk calculator (PsyMetRiC) for young people with psychosis: International external validation and site-specific recalibration in two independent European samples.

    Journal: Lancet Reg Health Eur
    E-pub date: 1 Nov 2022
    Authors: BI Perry, F Vandenberghe, N Garrido-Torres, EF Osimo, M Piras, J Vazquez-Bourgon, R Upthegrove, C Grosu, VO-G De La Foz, PB Jones, N Laaboub, M Ruiz-Veguilla, J Stochl, C Dubath, M Canal-Rivero, P Mallikarjun, A Delacrétaz, N Ansermot, E Fernandez-Egea, S Crettol, F Gamma, KJ Plessen, P Conus, GM Khandaker, GK Murray, CB Eap, B Crespo-Facorro

    Clozapine treatment and risk of COVID-19.

    Journal: BJPsych Open
    E-pub date: 11 Jul 2022
    Authors: EF Osimo, J Lewis, RN Cardinal, GM Khandaker

    A cross-sectional MR study of body fat volumes and distribution in chronic schizophrenia.

    Journal: Schizophrenia (Heidelb)
    E-pub date: 18 Mar 2022
    Authors: EF Osimo, SP Brugger, EL Thomas, OD Howes

    Risk Prediction in Psychosis: Progress Made and Challenges Ahead.

    Journal: Biol Psychiatry
    E-pub date: 1 Nov 2021
    Authors: BI Perry, EF Osimo, GM Khandaker

    Longitudinal association between CRP levels and risk of psychosis: a meta-analysis of population-based cohort studies.

    Journal: NPJ Schizophr
    E-pub date: 28 May 2021
    Authors: EF Osimo, L Baxter, J Stochl, BI Perry, SA Metcalf, SK Kunutsor, JA Laukkanen, MK Wium-Andersen, PB Jones, GM Khandaker

    Inflammatory and cardiometabolic markers at presentation with first episode psychosis and long-term clinical outcomes: A longitudinal study using electronic health records.

    Journal: Brain Behav Immun
    E-pub date: 1 Jan 2021
    Authors: EF Osimo, BI Perry, RN Cardinal, M-E Lynall, J Lewis, A Kudchadkar, GK Murray, J Perez, PB Jones, GM Khandaker

    The early impact of COVID-19 on mental health and community physical health services and their patients’ mortality in Cambridgeshire and Peterborough, UK.

    Journal: J Psychiatr Res
    E-pub date: 1 Dec 2020
    Authors: S Chen, PB Jones, BR Underwood, A Moore, ET Bullmore, S Banerjee, EF Osimo, JB Deakin, CF Hatfield, FJ Thompson, JD Artingstall, MP Slann, JR Lewis, RN Cardinal

    Inflammatory markers in depression: A meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls.

    Journal: Brain Behav Immun
    E-pub date: 1 Jul 2020
    Authors: EF Osimo, T Pillinger, IM Rodriguez, GM Khandaker, CM Pariante, OD Howes

    Longitudinal population subgroups of CRP and risk of depression in the ALSPAC birth cohort.

    Journal: Compr Psychiatry
    E-pub date: 1 Jan 2020
    Authors: EF Osimo, J Stochl, S Zammit, G Lewis, PB Jones, GM Khandaker

    A Meta-analysis of Immune Parameters, Variability, and Assessment of Modal Distribution in Psychosis and Test of the Immune Subgroup Hypothesis.

    Journal: Schizophr Bull
    E-pub date: 11 Sep 2019
    Authors: T Pillinger, EF Osimo, S Brugger, V Mondelli, RA McCutcheon, OD Howes

    Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels.

    Journal: Psychol Med
    E-pub date: 1 Sep 2019
    Authors: EF Osimo, LJ Baxter, G Lewis, PB Jones, GM Khandaker

    Longitudinal C-reactive protein (CRP) population sub-groups as predictors of depression: Findings from the ALSPAC birth cohort

    E-pub date: 1 Aug 2019
    Authors: EF Osimo, J Stochl, GM Khandaker

    Cardiac structure and function in patients with schizophrenia taking antipsychotic drugs: an MRI study.

    Journal: Transl Psychiatry
    E-pub date: 7 Jun 2019
    Authors: T Pillinger, EF Osimo, A de Marvao, MA Berry, T Whitehurst, B Statton, M Quinlan, S Brugger, A Vazir, SA Cook, DP O'Regan, OD Howes

    Synaptic loss in schizophrenia: a meta-analysis and systematic review of synaptic protein and mRNA measures.

    Journal: Mol Psychiatry
    E-pub date: 1 Apr 2019
    Authors: EF Osimo, K Beck, T Reis Marques, OD Howes