EMAIL efo22@cam.ac.uk

Department

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Research Theme Beyond the Neuron

Other Interdiciplinary Incentives

Neuroscience

Research Focus

Keywords

Psychosis

Early Interventions

Mood Disorders

Depression

Bipolar Disorder

Genetics

Genetic Epidemiology

Cardiometabolic Disorders

Inflammation & Immunity

Epidemiology

Risk Prediction

Bioinformatics

Antipsychotics

Body Weight

Psychiatry

Clinical Epidemiology

Clinical & Lifecourse Epidemiology

Clinical Conditions

Psychotic disorders

Depressive disorders

Bipolar disorder

Schizophrenia

Equipment & Techniques

Computational modelling

Cross-sectional and cohort studies

Statistical analysis

Science Culture

CamBRAIN

Mentorship

Public Outreach

Reproducibility in Science

Teaching

Science Writing

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Dr Emanuele Osimo MD, PhD, MRCPsych

(he/him/his)

University Position

Clinical Lecturer

Dr Emanuele Osimo is pleased to consider applications from prospective PhD students.

Interests

As an Academic Clinical Lecturer in psychiatry at the University of Cambridge, and a visiting researcher at Imperial College London/MRC London Institute for Medical Sciences (LMS), I focus on unraveling the immune and cardio-metabolic landscape of early psychosis and schizophrenia using diverse scientific approaches. For my research, in the past I have used clinical research methods such as Magnetic Resonance Imaging and biomarker analysis to delve into cardiac and adipose tissue changes in schizophrenia. This exploration has led to the formulation of a novel hypothesis regarding the potential causes of cardiac alterations in this condition. Through psychiatric clinical epidemiology methods, I've developed longitudinal "virtual cohorts" of psychiatric patients, utilizing large datasets to characterize immune and metabolic markers across different stages of illness. This work has culminated in the development of risk prediction models for health outcomes in psychosis, including the creation of a clinically useful risk calculator for treatment-resistant schizophrenia, named MOZART, which has earned recognition, including the Schizophrenia International Research Society Early Career Award. I have also completed a clinical PhD in bioinformatics on the genetics of schizophrenia at Imperial College London. Apart from my research, I'm deeply engaged in medical education, teaching medical students and supervising research projects. I'm also committed to mentorship, having initiated and managed a mentoring program within the Cambridge NHS Trust. Looking ahead, my aim is to further refine and validate MOZART using larger datasets and industry collaborations, with the ultimate goal of integrating it into clinical practice. I aspire to become a leading figure in the field, continuing my work as an academic clinician in psychiatry, and contributing to advancements in understanding and treating mental illness.

MOZART: a risk prediction tool for treatment resistant schizophrenia

Commonly recorded clinical information at psychosis onset including blood markers can help predict whether a person will develop treatment resistant schizophrenia.

Collaborators

Cambridge

External

Key Publications

Predicting treatment resistance from first-episode psychosis using routinely collected clinical information.

DOI: http://doi.org/10.1038/s44220-022-00001-z
Journal: Nat Ment Health
E-pub date: 19 Jan 2023
Authors: EF Osimo, BI Perry, P Mallikarjun, M Pritchard, J Lewis, A Katunda, GK Murray, J Perez, PB Jones, RN Cardinal, OD Howes, R Upthegrove, GM Khandaker

Adipose tissue dysfunction, inflammation, and insulin resistance: alternative pathways to cardiac remodelling in schizophrenia. A multimodal, case-control study.

DOI: http://doi.org/10.1038/s41398-021-01741-9
Journal: Transl Psychiatry
E-pub date: 6 Dec 2021
Authors: EF Osimo, M Sweeney, A de Marvao, A Berry, B Statton, BI Perry, T Pillinger, T Whitehurst, SA Cook, DP O'Regan, EL Thomas, OD Howes

Development and external validation of the Psychosis Metabolic Risk Calculator (PsyMetRiC): a cardiometabolic risk prediction algorithm for young people with psychosis.

DOI: http://doi.org/10.1016/S2215-0366(21)00114-0
Journal: Lancet Psychiatry
E-pub date: 1 Jul 2021
Authors: BI Perry, EF Osimo, R Upthegrove, PK Mallikarjun, J Yorke, J Stochl, J Perez, S Zammit, O Howes, PB Jones, GM Khandaker

Cardiac structure and function in schizophrenia: cardiac magnetic resonance imaging study.

DOI: http://doi.org/10.1192/bjp.2019.268
Journal: Br J Psychiatry
E-pub date: 31 Aug 2020
Authors: EF Osimo, SP Brugger, A de Marvao, T Pillinger, T Whitehurst, B Statton, M Quinlan, A Berry, SA Cook, DP O'Regan, OD Howes

Prevalence and correlates of low-grade systemic inflammation in adult psychiatric inpatients: An electronic health record-based study.

DOI: http://doi.org/10.1016/j.psyneuen.2018.02.031
Journal: Psychoneuroendocrinology
E-pub date: 1 Mar 2018
Authors: EF Osimo, RN Cardinal, PB Jones, GM Khandaker

Publications

More must be done to reduce cardiovascular risk for patients on antipsychotic medications.

DOI: http://doi.org/10.1097/YIC.0000000000000464
Journal: Int Clin Psychopharmacol
E-pub date: 1 May 2023
Authors: EF Osimo, BI Perry, GK Murray

Effect of polygenic risk for schizophrenia on cardiac structure and function: a UK Biobank observational study.

DOI: http://doi.org/10.1016/S2215-0366(22)00403-5
Journal: Lancet Psychiatry
E-pub date: 1 Feb 2023
Authors: T Pillinger, EF Osimo, A de Marvao, M Shah, C Francis, J Huang, E D'Ambrosio, J Firth, MM Nour, RA McCutcheon, AF Pardiñas, PM Matthews, DP O'Regan, OD Howes

The psychosis metabolic risk calculator (PsyMetRiC) for young people with psychosis: International external validation and site-specific recalibration in two independent European samples.

DOI: http://doi.org/10.1016/j.lanepe.2022.100493
Journal: Lancet Reg Health Eur
E-pub date: 1 Nov 2022
Authors: BI Perry, F Vandenberghe, N Garrido-Torres, EF Osimo, M Piras, J Vazquez-Bourgon, R Upthegrove, C Grosu, VO-G De La Foz, PB Jones, N Laaboub, M Ruiz-Veguilla, J Stochl, C Dubath, M Canal-Rivero, P Mallikarjun, A Delacrétaz, N Ansermot, E Fernandez-Egea, S Crettol, F Gamma, KJ Plessen, P Conus, GM Khandaker, GK Murray, CB Eap, B Crespo-Facorro

Clozapine treatment and risk of COVID-19.

DOI: http://doi.org/10.1192/bjo.2022.537
Journal: BJPsych Open
E-pub date: 11 Jul 2022
Authors: EF Osimo, J Lewis, RN Cardinal, GM Khandaker

A cross-sectional MR study of body fat volumes and distribution in chronic schizophrenia.

DOI: http://doi.org/10.1038/s41537-022-00233-z
Journal: Schizophrenia (Heidelb)
E-pub date: 18 Mar 2022
Authors: EF Osimo, SP Brugger, EL Thomas, OD Howes

Risk Prediction in Psychosis: Progress Made and Challenges Ahead.

DOI: http://doi.org/10.1016/j.biopsych.2021.08.015
Journal: Biol Psychiatry
E-pub date: 1 Nov 2021
Authors: BI Perry, EF Osimo, GM Khandaker

Longitudinal association between CRP levels and risk of psychosis: a meta-analysis of population-based cohort studies.

DOI: http://doi.org/10.1038/s41537-021-00161-4
Journal: NPJ Schizophr
E-pub date: 28 May 2021
Authors: EF Osimo, L Baxter, J Stochl, BI Perry, SA Metcalf, SK Kunutsor, JA Laukkanen, MK Wium-Andersen, PB Jones, GM Khandaker

Inflammatory and cardiometabolic markers at presentation with first episode psychosis and long-term clinical outcomes: A longitudinal study using electronic health records.

DOI: http://doi.org/10.1016/j.bbi.2020.09.011
Journal: Brain Behav Immun
E-pub date: 1 Jan 2021
Authors: EF Osimo, BI Perry, RN Cardinal, M-E Lynall, J Lewis, A Kudchadkar, GK Murray, J Perez, PB Jones, GM Khandaker

The early impact of COVID-19 on mental health and community physical health services and their patients’ mortality in Cambridgeshire and Peterborough, UK.

DOI: http://doi.org/10.1016/j.jpsychires.2020.09.020
Journal: J Psychiatr Res
E-pub date: 1 Dec 2020
Authors: S Chen, PB Jones, BR Underwood, A Moore, ET Bullmore, S Banerjee, EF Osimo, JB Deakin, CF Hatfield, FJ Thompson, JD Artingstall, MP Slann, JR Lewis, RN Cardinal

Inflammatory markers in depression: A meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls.

DOI: http://doi.org/10.1016/j.bbi.2020.02.010
Journal: Brain Behav Immun
E-pub date: 1 Jul 2020
Authors: EF Osimo, T Pillinger, IM Rodriguez, GM Khandaker, CM Pariante, OD Howes

Longitudinal population subgroups of CRP and risk of depression in the ALSPAC birth cohort.

DOI: http://doi.org/10.1016/j.comppsych.2019.152143
Journal: Compr Psychiatry
E-pub date: 1 Jan 2020
Authors: EF Osimo, J Stochl, S Zammit, G Lewis, PB Jones, GM Khandaker

A Meta-analysis of Immune Parameters, Variability, and Assessment of Modal Distribution in Psychosis and Test of the Immune Subgroup Hypothesis.

DOI: http://doi.org/10.1093/schbul/sby160
Journal: Schizophr Bull
E-pub date: 11 Sep 2019
Authors: T Pillinger, EF Osimo, S Brugger, V Mondelli, RA McCutcheon, OD Howes

Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels.

DOI: http://doi.org/10.1017/S0033291719001454
Journal: Psychol Med
E-pub date: 1 Sep 2019
Authors: EF Osimo, LJ Baxter, G Lewis, PB Jones, GM Khandaker

Longitudinal C-reactive protein (CRP) population sub-groups as predictors of depression: Findings from the ALSPAC birth cohort

DOI: http://doi.org/10.1016/j.euroneuro.2018.11.286
Journal: EUROPEAN NEUROPSYCHOPHARMACOLOGY
E-pub date: 1 Aug 2019
Authors: EF Osimo, J Stochl, GM Khandaker

Cardiac structure and function in patients with schizophrenia taking antipsychotic drugs: an MRI study.

DOI: http://doi.org/10.1038/s41398-019-0502-x
Journal: Transl Psychiatry
E-pub date: 7 Jun 2019
Authors: T Pillinger, EF Osimo, A de Marvao, MA Berry, T Whitehurst, B Statton, M Quinlan, S Brugger, A Vazir, SA Cook, DP O'Regan, OD Howes

Synaptic loss in schizophrenia: a meta-analysis and systematic review of synaptic protein and mRNA measures.

DOI: http://doi.org/10.1038/s41380-018-0041-5
Journal: Mol Psychiatry
E-pub date: 1 Apr 2019
Authors: EF Osimo, K Beck, T Reis Marques, OD Howes