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Key Publications

Mitochondrial complex I activity in microglia sustains neuroinflammation

DOI: http://doi.org/10.1038/s41586-024-07167-9
Journal: Nature
E-pub date: 1 Apr 2024
Authors: S Pluchino, L Peruzzotti Jametti

Metabolic Control of Smoldering Neuroinflammation.

DOI: http://doi.org/10.3389/fimmu.2021.705920
Journal: Front Immunol
E-pub date: 1 Aug 2021
Authors: L Peruzzotti-Jametti, CM Willis, R Hamel, G Krzak, S Pluchino

Neural stem cells traffic functional mitochondria via extracellular vesicles.

DOI: http://doi.org/10.1371/journal.pbio.3001166
Journal: PLoS Biol
E-pub date: 1 Apr 2021
Authors: L Peruzzotti-Jametti, JD Bernstock, CM Willis, G Manferrari, R Rogall, E Fernandez-Vizarra, JC Williamson, A Braga, A van den Bosch, T Leonardi, G Krzak, Á Kittel, C Benincá, N Vicario, S Tan, C Bastos, I Bicci, N Iraci, JA Smith, B Peacock, KH Muller, PJ Lehner, EI Buzas, N Faria, M Zeviani, C Frezza, A Brisson, NJ Matheson, C Viscomi, S Pluchino

Systematic approach to selecting licensed drugs for repurposing in the treatment of progressive multiple sclerosis.

DOI: http://doi.org/10.1136/jnnp-2020-324286
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Mar 2021
Authors: N Cunniffe, KA Vuong, D Ainslie, D Baker, J Beveridge, S Bickley, P Camilleri, M Craner, D Fitzgerald, AG de la Fuente, G Giovannoni, E Gray, L Hazlehurst, R Kapoor, R Kaur, D Kozlowski, B Lumicisi, D Mahad, B Neumann, A Palmer, L Peruzzotti-Jametti, S Pluchino, J Robertson, A Rothaul, L Shellard, KJ Smith, A Wilkins, A Williams, A Coles

Succinate Receptor 1: An Emerging Regulator of Myeloid Cell Function in Inflammation.

DOI: http://doi.org/10.1016/j.it.2020.11.004
Journal: Trends Immunol
E-pub date: 1 Jan 2021
Authors: G Krzak, CM Willis, JA Smith, S Pluchino, L Peruzzotti-Jametti

Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation

DOI: http://doi.org/10.1016/j.stem.2018.01.020
Journal: Cell Stem Cell
E-pub date: 1 Mar 2018
Authors: L Peruzzotti-Jametti, JD Bernstock, N Vicario, ASH Costa, CK Kwok, T Leonardi, LM Booty, I Bicci, B Balzarotti, G Volpe, G Mallucci, G Manferrari, M Donegà, N Iraci, A Braga, JM Hallenbeck, MP Murphy, F Edenhofer, C Frezza, S Pluchino

Extracellular vesicles are independent metabolic units with asparaginase activity.

DOI: http://doi.org/10.1038/nchembio.2422
Journal: Nat Chem Biol
E-pub date: 1 Sep 2017
Authors: N Iraci, E Gaude, T Leonardi, ASH Costa, C Cossetti, L Peruzzotti-Jametti, JD Bernstock, HK Saini, M Gelati, AL Vescovi, C Bastos, N Faria, LG Occhipinti, AJ Enright, C Frezza, S Pluchino

Metabolic determinants of the immune modulatory function of neural stem cells.

DOI: http://doi.org/10.1186/s12974-016-0667-7
Journal: J Neuroinflammation
E-pub date: 2 Sep 2016
Authors: D Drago, V Basso, E Gaude, G Volpe, L Peruzzotti-Jametti, A Bachi, G Musco, A Andolfo, C Frezza, A Mondino, S Pluchino

The role of immune cells, glia and neurons in white and gray matter pathology in multiple sclerosis.

DOI: http://doi.org/10.1016/j.pneurobio.2015.02.003
Journal: Prog Neurobiol
E-pub date: 1 Apr 2015
Authors: G Mallucci, L Peruzzotti-Jametti, JD Bernstock, S Pluchino

Publications

Time-resolved single-cell RNAseq profiling identifies a novel Fabp5+ subpopulation of inflammatory myeloid cells with delayed cytotoxic profile in chronic spinal cord injury.

DOI: http://doi.org/10.1016/j.heliyon.2023.e18339
Journal: Heliyon
E-pub date: 31 Aug 2023
Authors: R Hamel, L Peruzzotti-Jametti, K Ridley, V Testa, B Yu, D Rowitch, JC Marioni, S Pluchino

A neural stem-cell treatment for progressive multiple sclerosis.

DOI: http://doi.org/10.1038/s41591-022-02164-9
Journal: Nat Med
E-pub date: 1 Jan 2023
Authors: V Fossati, L Peruzzotti-Jametti, S Pluchino

Small Extracellular Vesicles Secreted by Nigrostriatal Astrocytes Rescue Cell Death and Preserve Mitochondrial Function in Parkinson’s Disease.

DOI: http://doi.org/10.1002/adhm.202201203
Journal: Adv Healthc Mater
E-pub date: 1 Oct 2022
Authors: L Leggio, F L'Episcopo, A Magrì, MJ Ulloa-Navas, G Paternò, S Vivarelli, CAP Bastos, C Tirolo, N Testa, S Caniglia, P Risiglione, F Pappalardo, A Serra, P García-Tárraga, N Faria, JJ Powell, L Peruzzotti-Jametti, S Pluchino, JM García-Verdugo, A Messina, B Marchetti, N Iraci

Soluble factors influencing the neural stem cell niche in brain physiology, inflammation, and aging.

DOI: http://doi.org/10.1016/j.expneurol.2022.114124
Journal: Exp Neurol
E-pub date: 1 Sep 2022
Authors: CM Willis, AM Nicaise, G Krzak, R-B Ionescu, V Pappa, A D'Angelo, R Agarwal, M Repollés-de-Dalmau, L Peruzzotti-Jametti, S Pluchino

Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73.

DOI: http://doi.org/10.1038/s42003-021-02721-x
Journal: Commun Biol
E-pub date: 14 Oct 2021
Authors: LB Jarvis, DB Rainbow, V Coppard, SK Howlett, Z Georgieva, JL Davies, HK Mullay, J Hester, T Ashmore, A Van Den Bosch, JT Grist, AJ Coles, HS Mousa, S Pluchino, KT Mahbubani, JL Griffin, K Saeb-Parsy, F Issa, L Peruzzotti-Jametti, LS Wicker, JL Jones

Stem Cell Therapies for Progressive Multiple Sclerosis.

DOI: http://doi.org/10.3389/fcell.2021.696434
Journal: Front Cell Dev Biol
E-pub date: 1 Aug 2021
Authors: JA Smith, AM Nicaise, R-B Ionescu, R Hamel, L Peruzzotti-Jametti, S Pluchino

Promises and Limitations of Neural Stem Cell Therapies for Progressive Multiple Sclerosis.

DOI: http://doi.org/10.1016/j.molmed.2020.04.005
Journal: Trends Mol Med
E-pub date: 1 Oct 2020
Authors: S Pluchino, JA Smith, L Peruzzotti-Jametti

Harnessing the Neural Stem Cell Secretome for Regenerative Neuroimmunology.

DOI: http://doi.org/10.3389/fncel.2020.590960
Journal: Front Cell Neurosci
E-pub date: 1 Aug 2020
Authors: CM Willis, AM Nicaise, R Hamel, V Pappa, L Peruzzotti-Jametti, S Pluchino

Chapter 6 The therapeutic potential of exogenous adult stem cells for the injured central nervous system

DOI: http://doi.org/10.1016/b978-0-12-818084-6.00006-4
Journal:
E-pub date: 1 Aug 2020
Authors: JA Smith, A Braga, R Hamel, C Rutigliani, B Yu, L Peruzzotti-Jametti, S Pluchino

Transplantation of induced neural stem cells (iNSCs) into chronically demyelinated corpus callosum ameliorates motor deficits.

DOI: http://doi.org/10.1186/s40478-020-00960-3
Journal: Acta Neuropathol Commun
E-pub date: 9 Jun 2020
Authors: GM Sullivan, AK Knutsen, L Peruzzotti-Jametti, A Korotcov, A Bosomtwi, BJ Dardzinski, JD Bernstock, S Rizzi, F Edenhofer, S Pluchino, RC Armstrong

The neural stem cell secretome and its role in brain repair.

DOI: http://doi.org/10.1016/j.brainres.2019.146615
Journal: Brain Res
E-pub date: 15 Feb 2020
Authors: CM Willis, AM Nicaise, L Peruzzotti-Jametti, S Pluchino

Foxg1 Antagonizes Neocortical Stem Cell Progression to Astrogenesis.

DOI: http://doi.org/10.1093/cercor/bhz031
Journal: Cereb Cortex
E-pub date: 17 Dec 2019
Authors: C Falcone, M Santo, G Liuzzi, N Cannizzaro, C Grudina, E Valencic, L Peruzzotti-Jametti, S Pluchino, A Mallamaci

SUMOylation promotes survival and integration of neural stem cell grafts in ischemic stroke.

DOI: http://doi.org/10.1016/j.ebiom.2019.03.035
Journal: EBioMedicine
E-pub date: 1 Apr 2019
Authors: JD Bernstock, L Peruzzotti-Jametti, T Leonardi, N Vicario, D Ye, Y-J Lee, D Maric, KR Johnson, Y Mou, A Van Den Bosch, M Winterbone, GK Friedman, RJM Franklin, JM Hallenbeck, S Pluchino

Neural Stem Cell Grafts Promote Astroglia-Driven Neurorestoration in the Aged Parkinsonian Brain via Wnt/β-Catenin Signaling.

DOI: http://doi.org/10.1002/stem.2827
Journal: Stem Cells
E-pub date: 31 Aug 2018
Authors: F L'Episcopo, C Tirolo, L Peruzzotti-Jametti, MF Serapide, N Testa, S Caniglia, B Balzarotti, S Pluchino, B Marchetti

Past, present and future of cell-based therapy in progressive multiple sclerosis

DOI: http://doi.org/10.1007/978-3-319-90695-9_6
Journal:
E-pub date: 27 Jun 2018
Authors: G Volpe, JD Bernstock, L Peruzzotti-Jametti, S Pluchino

RNA Nanotherapeutics for the Amelioration of Astroglial Reactivity.

DOI: http://doi.org/10.1016/j.omtn.2017.11.008
Journal: Mol Ther Nucleic Acids
E-pub date: 2 Mar 2018
Authors: JA Smith, A Braga, J Verheyen, S Basilico, S Bandiera, C Alfaro-Cervello, L Peruzzotti-Jametti, D Shu, F Haque, P Guo, S Pluchino

Evaluation of RGD functionalization in hybrid hydrogels as 3D neural stem cell culture systems.

DOI: http://doi.org/10.1039/c7bm01056g
Journal: Biomater Sci
E-pub date: 27 Feb 2018
Authors: E Mauri, A Sacchetti, N Vicario, L Peruzzotti-Jametti, F Rossi, S Pluchino

Cell-based therapeutic strategies for multiple sclerosis.

DOI: http://doi.org/10.1093/brain/awx154
Journal: Brain
E-pub date: 1 Nov 2017
Authors: NJ Scolding, M Pasquini, SC Reingold, JA Cohen, International Conference on Cell-Based Therapies for Multiple Sclerosis, International Conference on Cell-Based Therapies for Multiple Sclerosis, International Conference on Cell-Based Therapies for Multiple Sclerosis

Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming.

DOI: http://doi.org/10.1038/s41598-017-07631-9
Journal: Sci Rep
E-pub date: 7 Aug 2017
Authors: JD Bernstock, D Ye, FA Gessler, Y-J Lee, L Peruzzotti-Jametti, P Baumgarten, KR Johnson, D Maric, W Yang, D Kögel, S Pluchino, JM Hallenbeck

Neural stem cell transplantation in ischemic stroke: A role for preconditioning and cellular engineering.

DOI: http://doi.org/10.1177/0271678X17700432
Journal: J Cereb Blood Flow Metab
E-pub date: 1 Jul 2017
Authors: JD Bernstock, L Peruzzotti-Jametti, D Ye, FA Gessler, D Maric, N Vicario, Y-J Lee, S Pluchino, JM Hallenbeck

Interleukin-4 induced 1 (IL4I1) promotes central nervous system remyelination.

DOI: http://doi.org/10.1093/brain/aww266
Journal: Brain
E-pub date: 1 Dec 2016
Authors: S Pluchino, L Peruzzotti-Jametti

Astrocyte power fuels neurons during stroke.

DOI: http://doi.org/10.4414/smw.2016.14374
Journal: Swiss Med Wkly
E-pub date: 1 Aug 2016
Authors: S Pluchino, L Peruzzotti-Jametti, C Frezza

A novel quantitative high-throughput screen identifies drugs that both activate SUMO conjugation via the inhibition of microRNAs 182 and 183 and facilitate neuroprotection in a model of oxygen and glucose deprivation.

DOI: http://doi.org/10.1177/0271678X15609939
Journal: J Cereb Blood Flow Metab
E-pub date: 1 Feb 2016
Authors: JD Bernstock, Y-J Lee, L Peruzzotti-Jametti, N Southall, KR Johnson, D Maric, G Volpe, J Kouznetsova, W Zheng, S Pluchino, JM Hallenbeck

Functional Magnetic Resonance Imaging of Rats with Experimental Autoimmune Encephalomyelitis Reveals Brain Cortex Remodeling.

DOI: http://doi.org/10.1523/JNEUROSCI.0540-15.2015
Journal: J Neurosci
E-pub date: 8 Jul 2015
Authors: S Tambalo, L Peruzzotti-Jametti, R Rigolio, S Fiorini, P Bontempi, G Mallucci, B Balzarotti, P Marmiroli, A Sbarbati, G Cavaletti, S Pluchino, P Marzola

The role of the immune system in central nervous system plasticity after acute injury.

DOI: http://doi.org/10.1016/j.neuroscience.2014.04.036
Journal: Neuroscience
E-pub date: 26 Dec 2014
Authors: L Peruzzotti-Jametti, M Donegá, E Giusto, G Mallucci, B Marchetti, S Pluchino

Neural precursor cells in the ischemic brain – integration, cellular crosstalk, and consequences for stroke recovery.

DOI: http://doi.org/10.3389/fncel.2014.00291
Journal: Front Cell Neurosci
E-pub date: 1 Aug 2014
Authors: DM Hermann, L Peruzzotti-Jametti, J Schlechter, JD Bernstock, TR Doeppner, S Pluchino

Injection of next-generation directly-induced neural stem cells (iNSCs) induces recovery in a mouse model of multiple sclerosis

DOI: http://doi.org/10.1016/j.jneuroim.2014.08.520
Journal: JOURNAL OF NEUROIMMUNOLOGY
E-pub date: 1 Aug 2014
Authors: L Peruzzotti-jametti, G Mallucci, G Tannahill, B Huang, YB Lakes, E Giusto, M Donega, B Balzarotti, F Edenhofer, S Pluchino

Rewiring the ischaemic brain with human-induced pluripotent stem cell-derived cortical neurons.

DOI: http://doi.org/10.1093/brain/awt330
Journal: Brain
E-pub date: 1 Dec 2013
Authors: S Pluchino, L Peruzzotti-Jametti

Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms. (vol 132, pg 2239, 2009)

DOI: http://doi.org/10.1093/brain/awp226
Journal: Brain
E-pub date: 1 Nov 2010
Authors: M Bacigaluppi, S Pluchino, L Peruzzotti-Jametti, E Kilic, U Kilic, G Salani, E Brambilla, MJ West, G Comi, G Martino, DM Hermann

Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms.

DOI: http://doi.org/10.1093/brain/awp174
Journal: Brain
E-pub date: 31 Aug 2009
Authors: M Bacigaluppi, S Pluchino, L Peruzzotti-Jametti, E Kilic, U Kilic, G Salani, E Brambilla, MJ West, G Comi, G Martino, DM Hermann