In an established environment of Clinical Neuroscience Dept large quantities of data can be captured from bed-side monitors. Using that data, continuous assessment of changing cerebrovascular haemodynamics and oxygenation is possible but requires sophisticated signal analysis. My primary research involves development of ICM+ software which encapsulates 20 years of our experience in brain monitoring gained in multiple neurosurgical and intensive care centres. It collects data from bedside monitors and produces on-line trends of parameters defined using highly configurable signal processing formulae. Using a variety of statistical charts complex information coming off the bedside monitors can be summarized in a concise fashion and presented to medical staff in a simple way that alerts them to the development of various pathological processes. The software is now installed in a number of academic centres around the world providing basis for multi-centre collaborations in brain monitoring.