EMAIL es336@cam.ac.uk

College Corpus Christi College

Department

School

Biological Sciences

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Research Theme Beyond the Neuron Neurons, Circuits and Networks Lifelong Brain Development and Brain Ageing

Research Focus

Keywords

Chronic Pain

Inflammatory & Neuropathic Chronic Pain

Pain

Visceral Pain

Nociception

Nociceptor

Inflammation

Neurodegeneration

Ageing

Clinical Conditions

Pain

Equipment & Techniques

Electrophysiological recording techniques

Behavioural analysis

Immunohistochemistry

Calcium imaging

Cell culture

Whole cell patch clamp

Science Culture

Public Engagement

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Professor Ewan St. John Smith

(he/him/his)

University Position

Professor

Professor Ewan St. John Smith is pleased to consider applications from prospective PhD students.

Interests

The main interest of the Smith lab is to understand the molecular mechanisms by which sensory neurons detect noxious stimuli, so-called nociceptors. We are particularly interested in how nociceptors are activated in both physiological and pathophysiological states and how this changes during different disease states, something that we address using a combination of in vitro and in vivo techniques. We also try to understand how genetic variations identified in humans with differing pain sensation produce the effects that they do. A further area of interest in the Smith lab is the unusual physiology of the naked mole-rat, an animal that is cold-blooded, lives for 30+ years, is resistant to cancer and is also eusocial! Weconduct comparative physiology and genetics with the naked mole-rat to identify molecules and circuits that underlie aspects of their 'odd' physiology, results from such work will lead to a greater understanding of how 'normal' physiology works in other mammals including humans.

A subset of colonic sensory neurons express Mrgprd

Dorsal root ganglion section from a Mrgprd-GFP mouse with colonic sensory neurons stained with fast blue and anti-CGRP staining in red

Collaborators

Cambridge

External

Associated News Items

Key Publications

Mapping the neuroethological signatures of pain, analgesia, and recovery in mice.

DOI: http://doi.org/10.1016/j.neuron.2023.06.008
Journal: Neuron
E-pub date: 20 Sep 2023
Authors: M Bohic, LA Pattison, ZA Jhumka, H Rossi, JK Thackray, M Ricci, N Mossazghi, W Foster, S Ogundare, CR Twomey, H Hilton, J Arnold, MA Tischfield, EA Yttri, E St John Smith, I Abdus-Saboor, VE Abraira

Role of Human Mesenchymal Stem Cells and Derived Extracellular Vesicles in Reducing Sensory Neuron Hyperexcitability and Pain Behaviors in Murine Osteoarthritis.

DOI: http://doi.org/10.1002/art.42353
Journal: Arthritis Rheumatol
E-pub date: 1 Mar 2023
Authors: M Ai, WE Hotham, LA Pattison, Q Ma, FMD Henson, ESJ Smith

Persistent nociceptor hyperactivity as a painful evolutionary adaptation.

DOI: http://doi.org/10.1016/j.tins.2022.12.007
Journal: Trends Neurosci
E-pub date: 1 Mar 2023
Authors: ET Walters, RJ Crook, GG Neely, TJ Price, ESJ Smith

Cell-cell interactions in joint pain: rheumatoid arthritis and osteoarthritis.

DOI: http://doi.org/10.1097/j.pain.0000000000002174
Journal: Pain
E-pub date: 1 Mar 2021
Authors: LA Pattison, E Krock, CI Svensson, ESJ Smith

Intraarticular Adeno-Associated Virus Serotype AAV-PHP.S-Mediated Chemogenetic Targeting of Knee-Innervating Dorsal Root Ganglion Neurons Alleviates Inflammatory Pain in Mice.

DOI: http://doi.org/10.1002/art.41314
Journal: Arthritis Rheumatol
E-pub date: 1 Oct 2020
Authors: S Chakrabarti, LA Pattison, B Doleschall, RH Rickman, H Blake, G Callejo, PA Heppenstall, ESJ Smith

Sensitization of knee-innervating sensory neurons by tumor necrosis factor-α-activated fibroblast-like synoviocytes: an in vitro, coculture model of inflammatory pain.

DOI: http://doi.org/10.1097/j.pain.0000000000001890
Journal: Pain
E-pub date: 1 Sep 2020
Authors: S Chakrabarti, Z Hore, LA Pattison, S Lalnunhlimi, CN Bhebhe, G Callejo, DC Bulmer, LS Taams, F Denk, ESJ Smith

Human Labor Pain Is Influenced by the Voltage-Gated Potassium Channel KV6.4 Subunit.

DOI: http://doi.org/10.1016/j.celrep.2020.107941
Journal: Cell Rep
E-pub date: 21 Jul 2020
Authors: MC Lee, MS Nahorski, JRF Hockley, VB Lu, G Ison, LA Pattison, G Callejo, K Stouffer, E Fletcher, C Brown, I Drissi, D Wheeler, P Ernfors, D Menon, F Reimann, ESJ Smith, CG Woods

Transformation of naked mole-rat cells.

DOI: http://doi.org/10.1038/s41586-020-2410-x
Journal: Nature
E-pub date: 1 Jul 2020
Authors: F Hadi, Y Kulaberoglu, KA Lazarus, K Bach, R Ugur, P Beattie, ESJ Smith, WT Khaled

Evolution of acid nociception: ion channels and receptors for detecting acid.

DOI: http://doi.org/10.1098/rstb.2019.0291
Journal: Philos Trans R Soc Lond B Biol Sci
E-pub date: 11 Nov 2019
Authors: LA Pattison, G Callejo, E St John Smith

Sensitization of knee-innervating sensory neurons by tumor necrosis factor-α activated fibroblast-like synoviocytes: an in vitro, co-culture model of inflammatory pain

DOI: http://doi.org/10.1101/791251
Journal:
E-pub date: 1 Aug 2019
Authors: S Chakrabarti, Z Hore, L Pattison, S Lalnunhlimi, C Bhebhe, G Callejo, D Bulmer, L Taams, F Denk, ESJ Smith

Single-cell RNAseq reveals seven classes of colonic sensory neuron.

DOI: http://doi.org/10.1136/gutjnl-2017-315631
Journal: Gut
E-pub date: 1 Apr 2019
Authors: JRF Hockley, TS Taylor, G Callejo, AL Wilbrey, A Gutteridge, K Bach, WJ Winchester, DC Bulmer, G McMurray, ESJ Smith

Advances in understanding nociception and neuropathic pain.

DOI: http://doi.org/10.1007/s00415-017-8641-6
Journal: J Neurol
E-pub date: 1 Feb 2018
Authors: E St John Smith

The molecular basis of acid insensitivity in the African naked mole-rat.

DOI: http://doi.org/10.1126/science.1213760
Journal: Science
E-pub date: 16 Dec 2011
Authors: ESJ Smith, D Omerbašić, SG Lechner, G Anirudhan, L Lapatsina, GR Lewin

Nociceptors: a phylogenetic view.

DOI: http://doi.org/10.1007/s00359-009-0482-z
Journal: J Comp Physiol A Neuroethol Sens Neural Behav Physiol
E-pub date: 1 Dec 2009
Authors: ESJ Smith, GR Lewin

Publications

A note on estimating absolute cytosolic Ca2+ concentration in sensory neurons using a single wavelength Ca2+ indicator

DOI: http://doi.org/10.1177/17448069241230420
Journal: Mol Pain
E-pub date: 1 Aug 2024
Authors: J Higham, ESJ Smith, D Bulmer

TRPV4 stimulates colonic afferents through mucosal release of ATP and glutamate

DOI: http://doi.org/10.1101/2024.04.12.589184
Journal:
E-pub date: 1 Aug 2024
Authors: MY Meng, LW Paine, D Sagnat, I Bello, S Oldroyd, F Javid, MT Harper, JRF Hockley, ESJ Smith, RM Owens, L Alric, E Buscail, F Welsh, N Vergnolle, DC Bulmer

Activation of the proton-sensing GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory joint pain

DOI: http://doi.org/10.1101/2024.04.29.590277
Journal:
E-pub date: 1 Aug 2024
Authors: LA Pattison, RH Rickman, H Hilton, SN Wijesinghe, G Ladds, L Yang, SW Jones, ESJ Smith

Digging deeper into pain: an ethological behavior assay correlating well-being in mice with human pain experience.

DOI: http://doi.org/10.1097/j.pain.0000000000003190
Journal: Pain
E-pub date: 1 Aug 2024
Authors: LA Pattison, A Cloake, S Chakrabarti, H Hilton, RH Rickman, JP Higham, MY Meng, LW Paine, M Dannawi, L Qiu, A Ritoux, DC Bulmer, G Callejo, ESJ Smith

Intestinal barrier function in the naked mole-rat: an emergent model for gastrointestinal insights.

DOI: http://doi.org/10.1152/ajpgi.00080.2024
Journal: Am J Physiol Gastrointest Liver Physiol
E-pub date: 1 Aug 2024
Authors: J Aguilera-Lizarraga, A Ritoux, DC Bulmer, ESJ Smith

An interactive cellular ecosystem blocks epithelial transformation in naked mole-rat

DOI: http://doi.org/10.1101/2023.10.10.561212
Journal:
E-pub date: 12 Oct 2023
Authors: M Behm, P Baeza Centurión, L Penso-Dolfin, FJ Botey Bataller, N Hirschmüller, S Delaunay, M-L Koch, S Del Prete, D Sohn, C Reifenberg, M Schopp, F Lammers, L Solé-Boldo, J Dutton, S Begall, WT Khaled, ESJ Smith, DT Odom, M Frye, A Goncalves

A humanized chemogenetic system inhibits murine pain-related behavior and hyperactivity in human sensory neurons.

DOI: http://doi.org/10.1126/scitranslmed.adh3839
Journal: Sci Transl Med
E-pub date: 4 Oct 2023
Authors: J Perez-Sanchez, SJ Middleton, LA Pattison, H Hilton, M Ali Awadelkareem, SR Zuberi, MB Renke, H Hu, X Yang, AJ Clark, E St John Smith, DL Bennett

A new art to treating osteoarthritis pain?

DOI: http://doi.org/10.1016/j.joca.2023.07.001
Journal: Osteoarthritis Cartilage
E-pub date: 1 Oct 2023
Authors: ESJ Smith

Phylogenetic modeling of enhancer shifts in African mole-rats reveals regulatory changes associated with tissue-specific traits.

DOI: http://doi.org/10.1101/gr.277715.123
Journal: Genome Res
E-pub date: 1 Sep 2023
Authors: E Parey, DM Fernandez-Aroca, S Frost, A Uribarren, TJ Park, M Zoettl, ESJ Smith, C Berthelot, D Villar

Digging deeper into pain – an ethological behavior assay correlating well-being in mice with human pain experience

DOI: http://doi.org/10.1101/2023.08.18.553862
Journal:
E-pub date: 1 Aug 2023
Authors: LA Pattison, A Cloake, S Chakrabarti, H Hilton, RH Rickman, JP Higham, MY Meng, LW Paine, M Dannawi, L Qiu, A Ritoux, DC Bulmer, G Callejo, ESJ Smith

Dysregulation of ADAM10 shedding activity in naked mole-rat fibroblasts is due to deficient phosphatidylserine externalization.

DOI: http://doi.org/10.1002/jcp.30972
Journal: Journal of Cellular Physiology
E-pub date: 1 Apr 2023
Authors: P Urriola-Muñoz, LA Pattison, ESJ Smith

Sensitization of colonic nociceptors by IL-13 is dependent on JAK and p38 MAPK activity.

DOI: http://doi.org/10.1152/ajpgi.00280.2022
Journal: Am J Physiol Gastrointest Liver Physiol
E-pub date: 1 Apr 2023
Authors: KH Barker, JP Higham, LA Pattison, IP Chessell, F Welsh, ESJ Smith, DC Bulmer

Parallel evolution of semicircular canal form and sensitivity in subterranean mammals.

DOI: http://doi.org/10.1007/s00359-022-01578-7
Journal: J Comp Physiol A Neuroethol Sens Neural Behav Physiol
E-pub date: 1 Nov 2022
Authors: J Goyens, S Baeckens, ESJ Smith, J Pozzi, MJ Mason

Skin Aging in Long-Lived Naked Mole-Rats Is Accompanied by Increased Expression of Longevity-Associated and Tumor Suppressor Genes.

DOI: http://doi.org/10.1016/j.jid.2022.04.028
Journal: J Invest Dermatol
E-pub date: 1 Nov 2022
Authors: I Fatima, G Chen, NV Botchkareva, AA Sharov, D Thornton, HN Wilkinson, MJ Hardman, A Grutzkau, J Pedro de Magalhaes, A Seluanov, ESJ Smith, V Gorbunova, AN Mardaryev, CG Faulkes, VA Botchkarev

Sensitization of colonic nociceptors by TNFα is dependent on TNFR1 expression and p38 MAPK activity.

DOI: http://doi.org/10.1113/JP283170
Journal: J Physiol
E-pub date: 31 Aug 2022
Authors: KH Barker, JP Higham, LA Pattison, TS Taylor, IP Chessell, F Welsh, ESJ Smith, DC Bulmer

In vitro models for investigating itch.

DOI: http://doi.org/10.3389/fnmol.2022.984126
Journal: Front Mol Neurosci
E-pub date: 1 Aug 2022
Authors: H Mießner, J Seidel, ESJ Smith

Dysregulation of ADAM10 shedding activity in naked mole-rat fibroblasts is due to deficient phosphatidylserine externalisation

DOI: http://doi.org/10.1101/2022.06.09.495538
Journal:
E-pub date: 1 Aug 2022
Authors: P Urriola-Muñoz, L Pattison, ESJ Smith

Prdm12 modulates pain-related behavior by remodeling gene expression in mature nociceptors.

DOI: http://doi.org/10.1097/j.pain.0000000000002536
Journal: Pain
E-pub date: 1 Aug 2022
Authors: A Latragna, A Sabaté San José, P Tsimpos, S Vermeiren, R Gualdani, S Chakrabarti, G Callejo, S Desiderio, O Shomroni, M Sitte, S Kricha, M Luypaert, B Vanhollebeke, G Laumet, G Salinas, ESJ Smith, L Ris, EJ Bellefroid

Somatic mutation rates scale with lifespan across mammals.

DOI: http://doi.org/10.1038/s41586-022-04618-z
Journal: Nature
E-pub date: 1 Apr 2022
Authors: A Cagan, A Baez-Ortega, N Brzozowska, F Abascal, THH Coorens, MA Sanders, ARJ Lawson, LMR Harvey, S Bhosle, D Jones, RE Alcantara, TM Butler, Y Hooks, K Roberts, E Anderson, S Lunn, E Flach, S Spiro, I Januszczak, E Wrigglesworth, H Jenkins, T Dallas, N Masters, MW Perkins, R Deaville, M Druce, R Bogeska, MD Milsom, B Neumann, F Gorman, F Constantino-Casas, L Peachey, D Bochynska, ESJ Smith, M Gerstung, PJ Campbell, EP Murchison, MR Stratton, I Martincorena

Gut Reaction: The Impact of a Film on Public Understanding of Gastrointestinal Conditions

DOI: http://doi.org/10.3389/fcomm.2022.769052
Journal: Frontiers in Communication
E-pub date: 17 Feb 2022
Authors: D Gomes, A Loth, JRF Hockley, ESJ Smith

The naked truth: a comprehensive clarification and classification of current ‘myths’ in naked mole-rat biology.

DOI: http://doi.org/10.1111/brv.12791
Journal: Biol Rev Camb Philos Soc
E-pub date: 1 Feb 2022
Authors: R Buffenstein, V Amoroso, B Andziak, S Avdieiev, J Azpurua, AJ Barker, NC Bennett, MA Brieño-Enríquez, GN Bronner, C Coen, MA Delaney, CM Dengler-Crish, YH Edrey, CG Faulkes, D Frankel, G Friedlander, PA Gibney, V Gorbunova, C Hine, MM Holmes, JUM Jarvis, Y Kawamura, N Kutsukake, C Kenyon, WT Khaled, T Kikusui, J Kissil, S Lagestee, J Larson, A Lauer, LA Lavrenchenko, A Lee, JB Levitt, GR Lewin, KN Lewis Hardell, TD Lin, MJ Mason, D McCloskey, M McMahon, K Miura, K Mogi, V Narayan, TP O'Connor, K Okanoya, MJ O'Riain, TJ Park, NJ Place, K Podshivalova, ME Pamenter, SJ Pyott, J Reznick, JG Ruby, AB Salmon, J Santos-Sacchi, DK Sarko, A Seluanov, A Shepard, M Smith, KB Storey, X Tian, EN Vice, M Viltard, A Watarai, E Wywial, M Yamakawa, ED Zemlemerova, M Zions, ESJ Smith

Acid-sensing ion channel 3: An analgesic target.

DOI: http://doi.org/10.1080/19336950.2020.1852831
Journal: Channels (Austin)
E-pub date: 1 Dec 2021
Authors: JS Dulai, ESJ Smith, T Rahman

P2X4 Receptors Mediate Ca2+ Release from Lysosomes in Response to Stimulation of P2X7 and H1 Histamine Receptors.

DOI: http://doi.org/10.3390/ijms221910492
Journal: Int J Mol Sci
E-pub date: 28 Sep 2021
Authors: S-L Tan, M Barri, P Atakpa-Adaji, CW Taylor, E St John Smith, RD Murrell-Lagnado

The Somatosensory World of the African Naked Mole-Rat.

DOI: http://doi.org/10.1007/978-3-030-65943-1_7
Journal: Adv Exp Med Biol
E-pub date: 1 Aug 2021
Authors: GR Lewin, ESJ Smith, J Reznick, K Debus, AJ Barker, TJ Park

Naked Mole-Rats: Resistant to Developing Cancer or Good at Avoiding It?

DOI: http://doi.org/10.1007/978-3-030-65943-1_14
Journal: Adv Exp Med Biol
E-pub date: 1 Aug 2021
Authors: F Hadi, ESJ Smith, WT Khaled

African Naked Mole-Rats Demonstrate Extreme Tolerance to Hypoxia and Hypercapnia.

DOI: http://doi.org/10.1007/978-3-030-65943-1_9
Journal: Adv Exp Med Biol
E-pub date: 1 Aug 2021
Authors: TJ Park, ESJ Smith, J Reznick, NC Bennett, DT Applegate, J Larson, GR Lewin

Functional Characterization of Ovine Dorsal Root Ganglion Neurons Reveal Peripheral Sensitization after Osteochondral Defect.

DOI: http://doi.org/10.1523/ENEURO.0237-21.2021
Journal: eNeuro
E-pub date: 1 Aug 2021
Authors: S Chakrabarti, M Ai, K Wong, K Newell, FMD Henson, ESJ Smith

Some Exciting Future Directions for Work on Naked Mole-Rats.

DOI: http://doi.org/10.1007/978-3-030-65943-1_17
Journal: Adv Exp Med Biol
E-pub date: 1 Aug 2021
Authors: ESJ Smith, TJ Park, MM Holmes, R Buffenstein

Sensory Systems of the African Naked Mole-Rat.

DOI: http://doi.org/10.1007/978-3-030-65943-1_5
Journal: Adv Exp Med Biol
E-pub date: 1 Aug 2021
Authors: EN Vice, S Lagestee, BM Browe, D Deb, ESJ Smith, TJ Park

Cholesterol-rich naked mole-rat brain lipid membranes are susceptible to amyloid beta-induced damage in vitro.

DOI: http://doi.org/10.18632/aging.202138
Journal: Aging (Albany NY)
E-pub date: 4 Nov 2020
Authors: D Frankel, M Davies, B Bhushan, Y Kulaberoglu, P Urriola-Munoz, J Bertrand-Michel, MR Pergande, AA Smith, S Preet, TJ Park, M Vendruscolo, KS Rankin, SM Cologna, JR Kumita, N Cenac, E St John Smith

Probing the unfolded protein response in long-lived naked mole-rats.

DOI: http://doi.org/10.1016/j.bbrc.2020.06.118
Journal: Biochem Biophys Res Commun
E-pub date: 3 Sep 2020
Authors: Z Du, S Chakrabarti, Y Kulaberoglu, ESJ Smith, CM Dobson, LS Itzhaki, JR Kumita

Photoacoustics resolves species-specific differences in hemoglobin concentration and oxygenation.

DOI: http://doi.org/10.1117/1.JBO.25.9.095002
Journal: J Biomed Opt
E-pub date: 1 Sep 2020
Authors: L Hacker, J Brunker, ESJ Smith, I Quiros-Gonzalez, SE Bohndiek

Acid and inflammatory sensitisation of naked mole-rat colonic afferent nerves.

DOI: http://doi.org/10.1177/1744806920903150
Journal: Mol Pain
E-pub date: 1 Aug 2020
Authors: JR Hockley, KH Barker, TS Taylor, G Callejo, ZM Husson, DC Bulmer, ESJ Smith

The naked mole-rat has a functional purinergic pain pathway despite having a non-functional peptidergic pain pathway.

DOI: http://doi.org/10.1016/j.ynpai.2020.100047
Journal: Neurobiol Pain
E-pub date: 1 Aug 2020
Authors: BM Browe, AR Olsen, C Ramirez, RH Rickman, ESJ Smith, TJ Park

Peripheral mechanisms of arthritic pain: A proposal to leverage large animals for in vitro studies.

DOI: http://doi.org/10.1016/j.ynpai.2020.100051
Journal: Neurobiol Pain
E-pub date: 1 Aug 2020
Authors: S Chakrabarti, M Ai, FMD Henson, ESJ Smith

Neurobiology: Crowdsourcing CO2 to Conserve Brain Energy.

DOI: http://doi.org/10.1016/j.cub.2020.04.009
Journal: Curr Biol
E-pub date: 8 Jun 2020
Authors: E St John Smith, TJ Park

Independent evolution of pain insensitivity in African mole-rats: origins and mechanisms.

DOI: http://doi.org/10.1007/s00359-020-01414-w
Journal: J Comp Physiol A Neuroethol Sens Neural Behav Physiol
E-pub date: 1 May 2020
Authors: ESJ Smith, TJ Park, GR Lewin

In silico screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3.

DOI: http://doi.org/10.1016/j.bcp.2020.113834
Journal: Biochem Pharmacol
E-pub date: 1 Apr 2020
Authors: G Callejo, LA Pattison, JC Greenhalgh, S Chakrabarti, E Andreopoulou, JRF Hockley, ESJ Smith, T Rahman

Human osteoarthritic synovial fluid increases excitability of mouse dorsal root ganglion sensory neurons: an in-vitro translational model to study arthritic pain.

DOI: http://doi.org/10.1093/rheumatology/kez331
Journal: Rheumatology (Oxford)
E-pub date: 1 Mar 2020
Authors: S Chakrabarti, DR Jadon, DC Bulmer, ESJ Smith

Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuli.

DOI: http://doi.org/10.14814/phy2.14326
Journal: Physiol Rep
E-pub date: 1 Jan 2020
Authors: TS Taylor, P Konda, SS John, DC Bulmer, JRF Hockley, ESJ Smith

The material properties of naked mole-rat hyaluronan.

DOI: http://doi.org/10.1038/s41598-019-43194-7
Journal: Sci Rep
E-pub date: 29 Apr 2019
Authors: Y Kulaberoglu, B Bhushan, F Hadi, S Chakrabarti, WT Khaled, KS Rankin, ESJ Smith, D Frankel

5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein-coupled receptor D.

DOI: http://doi.org/10.1126/scisignal.aal2171
Journal: Sci Signal
E-pub date: 18 Dec 2018
Authors: T Bautzova, JRF Hockley, T Perez-Berezo, J Pujo, MM Tranter, C Desormeaux, MR Barbaro, L Basso, P Le Faouder, C Rolland, P Malapert, A Moqrich, H Eutamene, A Denadai-Souza, N Vergnolle, ESJ Smith, DI Hughes, G Barbara, G Dietrich, DC Bulmer, N Cenac

Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner.

DOI: http://doi.org/10.1016/j.neuropharm.2018.09.014
Journal: Neuropharmacology
E-pub date: 1 Dec 2018
Authors: S Chakrabarti, LA Pattison, K Singhal, JRF Hockley, G Callejo, ESJ Smith

Human visceral nociception: findings from translational studies in human tissue.

DOI: http://doi.org/10.1152/ajpgi.00398.2017
Journal: Am J Physiol Gastrointest Liver Physiol
E-pub date: 1 Oct 2018
Authors: JRF Hockley, ESJ Smith, DC Bulmer

Naked mole-rat cortical neurons are resistant to acid-induced cell death.

DOI: http://doi.org/10.1186/s13041-018-0369-4
Journal: Mol Brain
E-pub date: 9 May 2018
Authors: Z Husson, ESJ Smith

Increased hyperpolarized [1-13 C] lactate production in a model of joint inflammation is not accompanied by tissue acidosis as assessed using hyperpolarized 13 C-labelled bicarbonate.

DOI: http://doi.org/10.1002/nbm.3892
Journal: NMR Biomed
E-pub date: 1 Apr 2018
Authors: AJ Wright, ZMA Husson, D-E Hu, G Callejo, KM Brindle, ESJ Smith

Naked mole-rat acid-sensing ion channel 3 forms non-functional homomers, but functional heteromers

DOI: http://doi.org/10.1101/166272
Journal: Journal of Biological Chemistry
E-pub date: 2 Feb 2018
Authors: L-N Schuhmacher, G Callejo, S Srivats, ESJ Smith

Functional and Molecular Characterization of Mechanoinsensitive “Silent” Nociceptors.

DOI: http://doi.org/10.1016/j.celrep.2017.11.066
Journal: Cell Rep
E-pub date: 12 Dec 2017
Authors: V Prato, FJ Taberner, JRF Hockley, G Callejo, A Arcourt, B Tazir, L Hammer, P Schad, PA Heppenstall, ES Smith, SG Lechner

Stable MOB1 interaction with Hippo/MST is not essential for development and tissue growth control.

DOI: http://doi.org/10.1038/s41467-017-00795-y
Journal: Nat Commun
E-pub date: 25 Sep 2017
Authors: Y Kulaberoglu, K Lin, M Holder, Z Gai, M Gomez, B Assefa Shifa, M Mavis, L Hoa, AAD Sharif, C Lujan, ESJ Smith, I Bjedov, N Tapon, G Wu, A Hergovich

Peripheral KV7 channels regulate visceral sensory function in mouse and human colon.

DOI: http://doi.org/10.1177/1744806917709371
Journal: Mol Pain
E-pub date: 1 Aug 2017
Authors: M Peiris, JR Hockley, DE Reed, ESJ Smith, DC Bulmer, LA Blackshaw

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.

DOI: http://doi.org/10.1126/science.aab3896
Journal: Science
E-pub date: 21 Apr 2017
Authors: TJ Park, J Reznick, BL Peterson, G Blass, D Omerbašić, NC Bennett, PHJL Kuich, C Zasada, BM Browe, W Hamann, DT Applegate, MH Radke, T Kosten, H Lutermann, V Gavaghan, O Eigenbrod, V Bégay, VG Amoroso, V Govind, RD Minshall, ESJ Smith, J Larson, M Gotthardt, S Kempa, GR Lewin

Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.

DOI: http://doi.org/10.1038/nn.4454
Journal: Nat Neurosci
E-pub date: 1 Feb 2017
Authors: C Wetzel, S Pifferi, C Picci, C Gök, D Hoffmann, KK Bali, A Lampe, L Lapatsina, R Fleischer, ESJ Smith, V Bégay, M Moroni, L Estebanez, J Kühnemund, J Walcher, E Specker, M Neuenschwander, JP von Kries, V Haucke, R Kuner, JFA Poulet, J Schmoranzer, K Poole, GR Lewin

Expression of acid-sensing ion channels and selection of reference genes in mouse and naked mole rat.

DOI: http://doi.org/10.1186/s13041-016-0279-2
Journal: Mol Brain
E-pub date: 13 Dec 2016
Authors: L-N Schuhmacher, ESJ Smith

Hypofunctional TrkA Accounts for the Absence of Pain Sensitization in the African Naked Mole-Rat.

DOI: http://doi.org/10.1016/j.celrep.2016.09.035
Journal: Cell Rep
E-pub date: 11 Oct 2016
Authors: D Omerbašić, ESJ Smith, M Moroni, J Homfeld, O Eigenbrod, NC Bennett, J Reznick, CG Faulkes, M Selbach, GR Lewin

Ear Structures of the Naked Mole-Rat, Heterocephalus glaber, and Its Relatives (Rodentia: Bathyergidae).

DOI: http://doi.org/10.1371/journal.pone.0167079
Journal: PLoS One
E-pub date: 1 Aug 2016
Authors: MJ Mason, HL Cornwall, ESJ Smith

Characterization of cutaneous and articular sensory neurons.

DOI: http://doi.org/10.1177/1744806916636387
Journal: Mol Pain
E-pub date: 1 Aug 2016
Authors: I da Silva Serra, Z Husson, JD Bartlett, ESJ Smith

The naked mole-rat as an animal model in biomedical research: current perspectives

DOI: http://doi.org/10.2147/OAAP.S50376
Journal: Open Access Animal Physiology
E-pub date: 11 Aug 2015
Authors: ESJ Smith, L-N Schuhmacher, Z Husson

Atomic force microscopy imaging reveals the formation of ASIC/ENaC cross-clade ion channels.

DOI: http://doi.org/10.1016/j.bbrc.2015.05.091
Journal: Biochemical and Biophysical Research Communications
E-pub date: 20 Jul 2015
Authors: P Jeggle, ESJ Smith, AP Stewart, S Haerteis, C Korbmacher, JM Edwardson

ASICs and mammalian mechanoreceptor function.

DOI: http://doi.org/10.1016/j.neuropharm.2014.12.007
Journal: Neuropharmacology
E-pub date: 1 Jul 2015
Authors: D Omerbašić, L-N Schuhmacher, Y-A Bernal Sierra, ESJ Smith, GR Lewin

Structural domains underlying the activation of acid-sensing ion channel 2a.

DOI: http://doi.org/10.1124/mol.114.096909
Journal: Mol Pharmacol
E-pub date: 1 Apr 2015
Authors: L-N Schuhmacher, S Srivats, ESJ Smith

In silico assessment of interaction of sea anemone toxin APETx2 and acid sensing ion channel 3.

DOI: http://doi.org/10.1016/j.bbrc.2014.05.130
Journal: Biochem Biophys Res Commun
E-pub date: 18 Jul 2014
Authors: T Rahman, ESJ Smith

Subunit-specific inhibition of acid sensing ion channels by stomatin-like protein 1.

DOI: http://doi.org/10.1113/jphysiol.2013.258657
Journal: J Physiol
E-pub date: 15 Feb 2014
Authors: A Kozlenkov, L Lapatsina, GR Lewin, ESJ Smith

Nerve growth factor and nociception: from experimental embryology to new analgesic therapy.

DOI: http://doi.org/10.1007/978-3-642-45106-5_10
Journal:
E-pub date: 29 Jan 2014
Authors: GR Lewin, SG Lechner, ESJ Smith

A chemoreceptor that detects molecular carbon dioxide.

DOI: http://doi.org/10.1074/jbc.M113.517367
Journal: J Biol Chem
E-pub date: 27 Dec 2013
Authors: ESJ Smith, L Martinez-Velazquez, N Ringstad

Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1.

DOI: http://doi.org/10.1038/nm.2827
Journal: Nat Med
E-pub date: 31 Aug 2012
Authors: K Stock, J Kumar, M Synowitz, S Petrosino, R Imperatore, ESJ Smith, P Wend, B Purfürst, UA Nuber, U Gurok, V Matyash, J-H Wälzlein, SR Chirasani, G Dittmar, BF Cravatt, S Momma, GR Lewin, A Ligresti, L De Petrocellis, L Cristino, V Di Marzo, H Kettenmann, R Glass

A stomatin dimer modulates the activity of acid-sensing ion channels.

DOI: http://doi.org/10.1038/emboj.2012.203
Journal: EMBO J
E-pub date: 29 Aug 2012
Authors: J Brand, ESJ Smith, D Schwefel, L Lapatsina, K Poole, D Omerbašić, A Kozlenkov, J Behlke, GR Lewin, O Daumke

Specific paucity of unmyelinated C-fibers in cutaneous peripheral nerves of the African naked-mole rat: comparative analysis using six species of Bathyergidae.

DOI: http://doi.org/10.1002/cne.23133
Journal: J Comp Neurol
E-pub date: 15 Aug 2012
Authors: E St John Smith, B Purfürst, T Grigoryan, TJ Park, NC Bennett, GR Lewin

Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons.

DOI: http://doi.org/10.1098/rsob.120096
Journal: Open Biol
E-pub date: 1 Jun 2012
Authors: L Lapatsina, JA Jira, ESJ Smith, K Poole, A Kozlenkov, D Bilbao, GR Lewin, PA Heppenstall

The molecular and cellular identity of peripheral osmoreceptors.

DOI: http://doi.org/10.1016/j.neuron.2010.12.028
Journal: Neuron
E-pub date: 27 Jan 2011
Authors: SG Lechner, S Markworth, K Poole, ESJ Smith, L Lapatsina, S Frahm, M May, S Pischke, M Suzuki, I Ibañez-Tallon, FC Luft, J Jordan, GR Lewin

Functional neurokinin and NMDA receptor activity in an animal naturally lacking substance P: the naked mole-rat.

DOI: http://doi.org/10.1371/journal.pone.0015162
Journal: PLoS One
E-pub date: 21 Dec 2010
Authors: A Brand, ESJ Smith, GR Lewin, TJ Park

Absence of histamine-induced itch in the African naked mole-rat and “rescue” by Substance P.

DOI: http://doi.org/10.1186/1744-8069-6-29
Journal: Mol Pain
E-pub date: 24 May 2010
Authors: ESJ Smith, GRC Blass, GR Lewin, TJ Park

An in vivo tethered toxin approach for the cell-autonomous inactivation of voltage-gated sodium channel currents in nociceptors.

DOI: http://doi.org/10.1113/jphysiol.2010.187112
Journal: J Physiol
E-pub date: 15 May 2010
Authors: AS Stürzebecher, J Hu, ESJ Smith, S Frahm, J Santos-Torres, B Kampfrath, S Auer, GR Lewin, I Ibañez-Tallon