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EMAIL rnc1001@cam.ac.uk
Department
  • Psychiatry
    • School
  • Clinical Medicine
    • Institute
  • Behavioural and Clinical Neuroscience Institute
    • ORCID iDClick to view ORCID profile
    Research Theme Brains and Machines Adaptive Brain Computations Neurons, Circuits and Networks
    Research Focus

    Keywords

  • Psychiatry
  • Computational Psychiatry
  • Behavioural Neuroscience
  • Cognitive Neuroscience
  • Psychopharmacology

    • Clinical Conditions

  • Addiction
  • Depressive disorders
  • Psychotic disorders
  • Anxiety disorders
  • Other 

    • Equipment & Techniques

  • Computational modelling
  • Neuropsychological testing
  • Statistical analysis

    • Back

    Professor Rudolf Cardinal

    University Position
    Professor
    Professor Rudolf Cardinal is pleased to consider applications from prospective PhD students.

    Interests

    Clinical informatics (including data capture and the proper use and analysis of routinely collected NHS data); computational psychiatry (including computational models of mind and behaviour); behavioural/cognitive neuroscience; liaison psychiatry.

    Key Publications

    Atomoxetine reduces decisional impulsivity in human cocaine addiction.

    DOI: http://doi.org/10.1016/j.biopsych.2024.10.018
    Journal: Biol Psychiatry
    E-pub date: 29 Oct 2024
    Authors: TV Lim, RN Cardinal, H Ziauddeen, R Regenthal, BJ Sahakian, TW Robbins, KD Ersche

    Chronic escitalopram in healthy volunteers has specific effects on reinforcement sensitivity: a double-blind, placebo-controlled semi-randomised study.

    DOI: http://doi.org/10.1038/s41386-022-01523-x
    Journal: Neuropsychopharmacology
    E-pub date: 1 Mar 2023
    Authors: C Langley, S Armand, Q Luo, G Savulich, T Segerberg, A Søndergaard, EB Pedersen, N Svart, O Overgaard-Hansen, A Johansen, C Borgsted, RN Cardinal, TW Robbins, DS Stenbæk, GM Knudsen, BJ Sahakian

    Predicting treatment resistance from first-episode psychosis using routinely collected clinical information.

    DOI: http://doi.org/10.1038/s44220-022-00001-z
    Journal: Nat Ment Health
    E-pub date: 19 Jan 2023
    Authors: EF Osimo, BI Perry, P Mallikarjun, M Pritchard, J Lewis, A Katunda, GK Murray, J Perez, PB Jones, RN Cardinal, OD Howes, R Upthegrove, GM Khandaker

    Association between antidementia medication use and mortality in people diagnosed with dementia with Lewy bodies in the UK: A retrospective cohort study.

    DOI: http://doi.org/10.1371/journal.pmed.1004124
    Journal: PLoS Med
    E-pub date: 1 Dec 2022
    Authors: S Chen, AC Price, RN Cardinal, S Moylett, AD Kershenbaum, J Fitzgerald, C Mueller, R Stewart, JT O'Brien

    Public opinion on sharing data from health services for clinical and research purposes without explicit consent: an anonymous online survey in the UK.

    DOI: http://doi.org/10.1136/bmjopen-2021-057579
    Journal: BMJ Open
    E-pub date: 25 Apr 2022
    Authors: LA Jones, JR Nelder, JM Fryer, PH Alsop, MR Geary, M Prince, RN Cardinal

    Association between lithium use and the incidence of dementia and its subtypes: A retrospective cohort study.

    DOI: http://doi.org/10.1371/journal.pmed.1003941
    Journal: PLoS Med
    E-pub date: 1 Mar 2022
    Authors: S Chen, BR Underwood, PB Jones, JR Lewis, RN Cardinal

    Impaired Learning From Negative Feedback in Stimulant Use Disorder: Dopaminergic Modulation.

    DOI: http://doi.org/10.1093/ijnp/pyab041
    Journal: Int J Neuropsychopharmacol
    E-pub date: 12 Nov 2021
    Authors: TV Lim, RN Cardinal, ET Bullmore, TW Robbins, KD Ersche

    Controlling one’s world: Identification of sub-regions of primate PFC underlying goal-directed behavior.

    DOI: http://doi.org/10.1016/j.neuron.2021.06.003
    Journal: Neuron
    E-pub date: 4 Aug 2021
    Authors: LY Duan, NK Horst, SAW Cranmore, N Horiguchi, RN Cardinal, AC Roberts, TW Robbins

    The Cambridge Cognitive and Psychiatric Assessment Kit (CamCOPS): A Secure Open-Source Client-Server System for Mobile Research and Clinical Data Capture.

    DOI: http://doi.org/10.3389/fpsyt.2021.578298
    Journal: Front Psychiatry
    E-pub date: 1 Aug 2021
    Authors: RN Cardinal, M Burchell

    Effect of lysergic acid diethylamide (LSD) on reinforcement learning in humans

    DOI: http://doi.org/10.1101/2020.12.04.412189
    Journal:
    E-pub date: 13 Jan 2021
    Authors: J Kanen, Q Luo, M Kandroodi, R Cardinal, T Robbins, R Carhart-Harris, HEM den Ouden

    Computational modelling reveals contrasting effects on reinforcement learning and cognitive flexibility in stimulant use disorder and obsessive-compulsive disorder: remediating effects of dopaminergic D2/3 receptor agents.

    DOI: http://doi.org/10.1007/s00213-019-05325-w
    Journal: Psychopharmacology (Berl)
    E-pub date: 31 Aug 2019
    Authors: JW Kanen, KD Ersche, NA Fineberg, TW Robbins, RN Cardinal

    Glutamate Within the Marmoset Anterior Hippocampus Interacts with Area 25 to Regulate the Behavioral and Cardiovascular Correlates of High-Trait Anxiety.

    DOI: http://doi.org/10.1523/JNEUROSCI.2451-18.2018
    Journal: J Neurosci
    E-pub date: 17 Apr 2019
    Authors: JL Zeredo, SKL Quah, CU Wallis, L Alexander, GJ Cockcroft, AM Santangelo, J Xia, Y Shiba, JW Dalley, RN Cardinal, AC Roberts, HF Clarke

    Mortality in dementia with Lewy bodies compared with Alzheimer’s dementia: a retrospective naturalistic cohort study.

    DOI: http://doi.org/10.1136/bmjopen-2017-017504
    Journal: BMJ Open
    E-pub date: 3 Nov 2017
    Authors: A Price, R Farooq, J-M Yuan, VB Menon, RN Cardinal, JT O'Brien

    Opposing roles of primate areas 25 and 32 and their putative rodent homologs in the regulation of negative emotion.

    DOI: http://doi.org/10.1073/pnas.1620115114
    Journal: Proc Natl Acad Sci U S A
    E-pub date: 16 May 2017
    Authors: CU Wallis, RN Cardinal, L Alexander, AC Roberts, HF Clarke

    Clinical records anonymisation and text extraction (CRATE): an open-source software system.

    DOI: http://doi.org/10.1186/s12911-017-0437-1
    Journal: BMC Med Inform Decis Mak
    E-pub date: 26 Apr 2017
    Authors: RN Cardinal

    ANOVA for the behavioural sciences researcher

    DOI: http://doi.org/10.4324/9780203763933
    Journal:
    E-pub date: 1 Jan 2013
    Authors: RN Cardinal, MRF Aitken

    Neural systems implicated in delayed and probabilistic reinforcement.

    DOI: http://doi.org/10.1016/j.neunet.2006.03.004
    Journal: Neural Netw
    E-pub date: 1 Oct 2006
    Authors: RN Cardinal

    Effects of lesions of the nucleus accumbens core on choice between small certain rewards and large uncertain rewards in rats.

    DOI: http://doi.org/10.1186/1471-2202-6-37
    Journal: BMC Neurosci
    E-pub date: 28 May 2005
    Authors: RN Cardinal, NJ Howes

    Hippocampal lesions facilitate instrumental learning with delayed reinforcement but induce impulsive choice in rats.

    DOI: http://doi.org/10.1186/1471-2202-6-36
    Journal: BMC Neurosci
    E-pub date: 13 May 2005
    Authors: THC Cheung, RN Cardinal

    Nucleus accumbens core lesions retard instrumental learning and performance with delayed reinforcement in the rat

    DOI: http://doi.org/10.1183/1471-2202-6-9
    Journal: BMC NEUROSCI
    E-pub date: 3 Feb 2005
    Authors: RN Cardinal, TH Cheung

    Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates.

    DOI: http://doi.org/10.1016/j.neubiorev.2004.09.006
    Journal: Neurosci Biobehav Rev
    E-pub date: 1 Nov 2004
    Authors: JW Dalley, RN Cardinal, TW Robbins

    Contrasting roles of basolateral amygdala and orbitofrontal cortex in impulsive choice.

    DOI: http://doi.org/10.1523/JNEUROSCI.5606-03.2004
    Journal: J Neurosci
    E-pub date: 19 May 2004
    Authors: CA Winstanley, DEH Theobald, RN Cardinal, TW Robbins

    Role of the anterior cingulate cortex in the control over behavior by Pavlovian conditioned stimuli in rats.

    DOI: http://doi.org/10.1037/0735-7044.117.3.566
    Journal: Behav Neurosci
    E-pub date: 1 Jun 2003
    Authors: RN Cardinal, JA Parkinson, HD Marbini, AJ Toner, TJ Bussey, TW Robbins, BJ Everitt

    Effects of selective excitotoxic lesions of the nucleus accumbens core, anterior cingulate cortex, and central nucleus of the amygdala on autoshaping performance in rats.

    DOI: http://doi.org/10.1037//0735-7044.116.4.553
    Journal: Behavioral Neuroscience
    E-pub date: 1 Aug 2002
    Authors: RN Cardinal, JA Parkinson, G Lachenal, KM Halkerston, N Rudarakanchana, J Hall, CH Morrison, SR Howes, TW Robbins, BJ Everitt

    Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex.

    DOI: http://doi.org/10.1016/s0149-7634(02)00007-6
    Journal: Neurosci Biobehav Rev
    E-pub date: 1 May 2002
    Authors: RN Cardinal, JA Parkinson, J Hall, BJ Everitt

    Impulsive choice induced in rats by lesions of the nucleus accumbens core.

    DOI: http://doi.org/10.1126/science.1060818
    Journal: Science
    E-pub date: 29 Jun 2001
    Authors: RN Cardinal, DR Pennicott, CL Sugathapala, TW Robbins, BJ Everitt

    The Diagnosis of Psychosis

    DOI: https://doi.org/10.1017/CBO9780511686917
    Journal: [Book, Cambridge University Press]
    Year: 2011
    Authors: RN Cardinal, ET Bullmore

    Whisker: a client-server high-performance multimedia research control system

    DOI: https://doi.org/10.3758/BRM.42.4.1059
    Journal: Behavior Research Methods
    Year: 2010
    Authors: RN Cardinal, MRF Aitken

    Publications

    Temporal trends in population attributable fractions of modifiable risk factors for dementia: a time-series study of the English Longitudinal Study of Ageing (2004–2019)

    DOI: http://doi.org/10.1186/s12916-024-03464-2
    Journal: BMC Med
    E-pub date: 26 Jun 2024
    Authors: S Chen, BR Underwood, RN Cardinal, X Chen, S Chen, J Amin, H Jin, J Huang, C Mueller, LL Yan, C Brayne, H Kuper

    Predicting patients with dementia most at risk of needing psychiatric in-patient or enhanced community care using routinely collected clinical data: retrospective multi-site cohort study.

    DOI: http://doi.org/10.1192/bjp.2024.14
    Journal: Br J Psychiatry
    E-pub date: 1 Jun 2024
    Authors: SR London, S Chen, E Sidhom, JR Lewis, E Wolverson, RN Cardinal, D Roalf, C Mueller, BR Underwood

    The role of psychosis and clozapine load in excessive checking in treatment-resistant schizophrenia: longitudinal observational study.

    DOI: http://doi.org/10.1192/bjp.2024.30
    Journal: Br J Psychiatry
    E-pub date: 1 May 2024
    Authors: E Fernandez-Egea, S Chen, E Sangüesa, P Gassó, M Biria, J Plaistow, I Jarratt-Barnham, N Segarra, S Mas, M-P Ribate, CB García, NA Fineberg, Y Worbe, RN Cardinal, TW Robbins

    Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making.

    DOI: http://doi.org/10.1038/s41386-023-01762-6
    Journal: Neuropsychopharmacology
    E-pub date: 1 Feb 2024
    Authors: Q Luo, JW Kanen, A Bari, N Skandali, C Langley, GM Knudsen, J Alsiö, BU Phillips, BJ Sahakian, RN Cardinal, TW Robbins

    Perseveration and shifting in obsessive–compulsive disorder as a function of uncertainty, punishment, and serotonergic medication

    DOI: http://doi.org/10.1016/j.bpsgos.2023.06.004
    Journal: Biol Psychiatry Glob Open Sci
    E-pub date: 1 Jan 2024
    Authors: T Robbins

    Computational modelling of reinforcement learning and functional neuroimaging of probabilistic reversal for dissociating compulsive behaviours in gambling and cocaine use disorders.

    DOI: http://doi.org/10.1192/bjo.2023.611
    Journal: BJPsych Open
    E-pub date: 11 Dec 2023
    Authors: K Zühlsdorff, J Verdejo-Román, L Clark, N Albein-Urios, C Soriano-Mas, RN Cardinal, TW Robbins, JW Dalley, A Verdejo-García, JW Kanen

    Perturbing Brain Function

    DOI: http://doi.org/10.1017/9781911623137.014
    Journal:
    E-pub date: 16 Nov 2023
    Authors: RN Cardinal

    Functional Neuroimaging and Connectivity

    DOI: http://doi.org/10.1017/9781911623137.017
    Journal:
    E-pub date: 16 Nov 2023
    Authors: RN Cardinal

    Recording from the Brain

    DOI: http://doi.org/10.1017/9781911623137.013
    Journal:
    E-pub date: 16 Nov 2023
    Authors: RN Cardinal

    Data Analysis and Computational Modelling

    DOI: http://doi.org/10.1017/9781911623137.016
    Journal:
    E-pub date: 16 Nov 2023
    Authors: RN Cardinal

    Natural Language Processing: Unlocking the Potential of Electronic Health Record Data to Support Transdiagnostic Psychiatric Research.

    DOI: http://doi.org/10.1016/j.bpsc.2022.09.002
    Journal: Biol Psychiatry Cogn Neurosci Neuroimaging
    E-pub date: 1 Oct 2023
    Authors: R Patel, M Wickersham, RN Cardinal, P Fusar-Poli, CU Correll

    Effect of lysergic acid diethylamide (LSD) on reinforcement learning in humans.

    DOI: http://doi.org/10.1017/S0033291722002963
    Journal: Psychol Med
    E-pub date: 1 Oct 2023
    Authors: JW Kanen, Q Luo, M Rostami Kandroodi, RN Cardinal, TW Robbins, DJ Nutt, RL Carhart-Harris, HEM den Ouden

    Risk Factors for Longer-Term Mortality in Discharged Patients with Dementia and SARS-CoV-2 Infection: A Matched Case-Control Study.

    DOI: http://doi.org/10.3233/JAD-221093
    Journal: J Alzheimers Dis
    E-pub date: 1 Aug 2023
    Authors: S Chen, RN Cardinal, K Auckland, EpiCov Database, S Gräf, JT O'Brien, BR Underwood

    Trends in Gender and Racial/Ethnic Disparities in Physical Disability and Social Support Among U.S. Older Adults With Cognitive Impairment Living Alone, 2000-2018.

    DOI: http://doi.org/10.1093/geroni/igad028
    Journal: Innov Aging
    E-pub date: 1 Aug 2023
    Authors: S Chen, H Zhang, BR Underwood, D Wang, X Chen, RN Cardinal

    Economic evaluation of interventions for treatment-resistant depression: A systematic review.

    DOI: http://doi.org/10.3389/fpsyt.2023.1056210
    Journal: Front Psychiatry
    E-pub date: 1 Aug 2023
    Authors: LA Hannah, CM Walsh, L Jopling, J Perez, RN Cardinal, RA Cameron

    Longitudinal effect of clozapine-associated sedation on motivation in schizophrenia: naturalistic longitudinal study.

    DOI: http://doi.org/10.1192/bjp.2022.191
    Journal: Br J Psychiatry
    E-pub date: 1 Jul 2023
    Authors: N Wolpe, S Chen, B Kirkpatrick, PB Jones, C Jenkins, RN Cardinal, E Fernandez-Egea

    Author’s Reply. RE: Longitudinal effect of clozapine-associated sedation on motivation in schizophrenia: naturalistic longitudinal study.

    DOI: http://doi.org/10.1192/bjp.2023.84
    Journal: Br J Psychiatry
    E-pub date: 1 Jul 2023
    Authors: N Wolpe, S Chen, B Kirkpatrick, PB Jones, C Jenkins, RN Cardinal, E Fernandez-Egea

    De-identified Bayesian personal identity matching for privacy-preserving record linkage despite errors: development and validation.

    DOI: http://doi.org/10.1186/s12911-023-02176-6
    Journal: BMC Med Inform Decis Mak
    E-pub date: 5 May 2023
    Authors: RN Cardinal, A Moore, M Burchell, JR Lewis

    Clozapine-related obsessive-compulsive symptoms and their impact on wellbeing: a naturalistic longitudinal study.

    DOI: http://doi.org/10.1017/S003329172100492X
    Journal: Psychol Med
    E-pub date: 1 May 2023
    Authors: K Parkin, S Chen, M Biria, J Plaistow, H Beckwith, I Jarratt-Barnham, N Segarra, Y Worbe, NA Fineberg, RN Cardinal, TW Robbins, E Fernandez-Egea

    195. Predicting Patients With Dementia Most at Risk of Needing Psychiatric Inpatient or Enhanced Community Care Using Routinely Collected Clinical Data

    DOI: http://doi.org/10.1016/j.biopsych.2023.02.435
    Journal: Biological Psychiatry
    E-pub date: 1 May 2023
    Authors: S London, S Chen, E Sidhom, J Lewis, R Cardinal, D Roalf, B Underwood

    Mortality rates and proximal causes of death in patients with Lewy body dementia versus Alzheimer’s disease: A longitudinal study using secondary care mental health records.

    DOI: http://doi.org/10.1002/gps.5937
    Journal: International Journal of Geriatric Psychiatry
    E-pub date: 1 May 2023
    Authors: AD Kershenbaum, AC Price, RN Cardinal, S Chen, JM Fitzgerald, J Lewis, S Moylett, JT O'Brien

    Clozapine treatment and risk of COVID-19.

    DOI: http://doi.org/10.1192/bjo.2022.537
    Journal: BJPsych Open
    E-pub date: 11 Jul 2022
    Authors: EF Osimo, J Lewis, RN Cardinal, GM Khandaker

    Patient and public involvement to build trust in artificial intelligence: A framework, tools, and case studies.

    DOI: http://doi.org/10.1016/j.patter.2022.100506
    Journal: Patterns (N Y)
    E-pub date: 10 Jun 2022
    Authors: S Banerjee, P Alsop, L Jones, RN Cardinal

    Prevalence, progress, and subgroup disparities in pharmacological antidepressant treatment of those who screen positive for depressive symptoms: A repetitive cross-sectional study in 19 European countries.

    DOI: http://doi.org/10.1016/j.lanepe.2022.100368
    Journal: Lancet Reg Health Eur
    E-pub date: 1 Jun 2022
    Authors: S Chen, TJ Ford, PB Jones, RN Cardinal

    Difficulty and help with activities of daily living among older adults living alone during the COVID-19 pandemic: a multi-country population-based study.

    DOI: http://doi.org/10.1186/s12877-022-02799-w
    Journal: BMC Geriatrics
    E-pub date: 4 Mar 2022
    Authors: S Chen, LA Jones, S Jiang, H Jin, D Dong, X Chen, D Wang, Y Zhang, L Xiang, A Zhu, RN Cardinal

    Mental health outcomes after SARS-CoV-2 vaccination in the United States: A national cross-sectional study.

    DOI: http://doi.org/10.1016/j.jad.2021.10.134
    Journal: J Affect Disord
    E-pub date: 1 Feb 2022
    Authors: S Chen, AR Aruldass, RN Cardinal

    A class-contrastive human-interpretable machine learning approach to predict mortality in severe mental illness.

    DOI: http://doi.org/10.1038/s41537-021-00191-y
    Journal: NPJ Schizophr
    E-pub date: 8 Dec 2021
    Authors: S Banerjee, P Lio, PB Jones, RN Cardinal

    Risk factors for excess deaths during lockdown among older users of secondary care mental health services without confirmed COVID-19: A retrospective cohort study.

    DOI: http://doi.org/10.1002/gps.5610
    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Dec 2021
    Authors: S Chen, PB Jones, BR Underwood, E Fernandez-Egea, P Qin, JR Lewis, RN Cardinal

    Individual differences in the engagement of habitual control over alcohol seeking predict the development of compulsive alcohol seeking and drinking.

    DOI: http://doi.org/10.1111/adb.13041
    Journal: Addict Biol
    E-pub date: 1 Nov 2021
    Authors: C Giuliano, M Puaud, RN Cardinal, D Belin, BJ Everitt

    Longer-term mortality following SARS-CoV-2 infection in people with severe mental illness: retrospective case-matched study.

    DOI: http://doi.org/10.1192/bjo.2021.1046
    Journal: BJPsych Open
    E-pub date: 1 Nov 2021
    Authors: S Chen, E Fernandez-Egea, PB Jones, JR Lewis, RN Cardinal

    The Effect of Clozapine on Self-reported Duration of Sleep and Its Interaction With 23 Other Medications: A 5-Year Naturalistic Study.

    DOI: http://doi.org/10.1097/JCP.0000000000001432
    Journal: J Clin Psychopharmacol
    E-pub date: 1 Sep 2021
    Authors: E Fernandez-Egea, S Chen, C Jenkins, C Turrion, SP Mitchell, DJF Dodwell, LM Mann, JB Deakin, ZH Syed, S Hafizi, J Zimbron, AS Praseedom, RN Cardinal

    Accessibility and efficiency of mental health services, United Kingdom of Great Britain and Northern Ireland.

    DOI: http://doi.org/10.2471/BLT.20.273383
    Journal: Bull World Health Organ
    E-pub date: 1 Sep 2021
    Authors: S Chen, RN Cardinal

    Simulating a Community Mental Health Service During the COVID-19 Pandemic: Effects of Clinician-Clinician Encounters, Clinician-Patient-Family Encounters, Symptom-Triggered Protective Behaviour, and Household Clustering.

    DOI: http://doi.org/10.3389/fpsyt.2021.620842
    Journal: Front Psychiatry
    E-pub date: 1 Aug 2021
    Authors: RN Cardinal, CE Meiser-Stedman, DM Christmas, AC Price, C Denman, BR Underwood, S Chen, S Banerjee, SR White, L Su, TJ Ford, SR Chamberlain, CM Walsh

    Atomoxetine partially restores loss sensitivity in cocaine use disorder

    DOI: http://doi.org/10.1016/j.euroneuro.2021.10.016
    Journal:
    E-pub date: 1 Aug 2021
    Authors: L Cincikas, RN Cardinal, H Ziauddeen, E Fernandez-Egea, R Regenthal, BJ Sahakian, TW Robbins, KD Ersche

    Iatrogenic Complications of Compulsory Treatment in a Patient Presenting with an Emotionally Unstable Personality Disorder and Self-Harm.

    DOI: http://doi.org/10.1155/2021/6615723
    Journal: Case Rep Psychiatry
    E-pub date: 1 Aug 2021
    Authors: C Burrin, NF Daniels, RN Cardinal, C Hayhurst, D Christmas, J Zimbron

    Changes in daily mental health service use and mortality at the commencement and lifting of COVID-19 ‘lockdown’ policy in 10 UK sites: a regression discontinuity in time design.

    DOI: http://doi.org/10.1136/bmjopen-2021-049721
    Journal: BMJ Open
    E-pub date: 26 May 2021
    Authors: I Bakolis, R Stewart, D Baldwin, J Beenstock, P Bibby, M Broadbent, R Cardinal, S Chen, K Chinnasamy, A Cipriani, S Douglas, P Horner, CA Jackson, A John, DW Joyce, SC Lee, J Lewis, A McIntosh, N Nixon, D Osborn, P Phiri, S Rathod, T Smith, R Sokal, R Waller, S Landau

    Investigation of risk of dementia diagnosis and death in patients in older people’s secondary care mental health services.

    DOI: http://doi.org/10.1002/gps.5455
    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Apr 2021
    Authors: A Kershenbaum, RN Cardinal, S Chen, BR Underwood, A Seyedsalehi, J Lewis, JS Rubinsztein

    Early versus late risk factors for deficit and nondeficit schizophrenia.

    DOI: http://doi.org/10.1016/j.rpsm.2021.03.002
    Journal: Rev Psiquiatr Salud Ment (Engl Ed)
    E-pub date: 1 Apr 2021
    Authors: S Alabaf, B Kirkpatrick, S Chen, RN Cardinal, E Fernandez-Egea

    Survey of CAMHS clinicians about their experience of remote consultation: brief report.

    DOI: http://doi.org/10.1192/bjo.2020.160
    Journal: BJPsych Open
    E-pub date: 13 Jan 2021
    Authors: A Bhardwaj, A Moore, RN Cardinal, C Bradley, L Cross, TJ Ford

    Inflammatory and cardiometabolic markers at presentation with first episode psychosis and long-term clinical outcomes: A longitudinal study using electronic health records.

    DOI: http://doi.org/10.1016/j.bbi.2020.09.011
    Journal: Brain Behav Immun
    E-pub date: 1 Jan 2021
    Authors: EF Osimo, BI Perry, RN Cardinal, M-E Lynall, J Lewis, A Kudchadkar, GK Murray, J Perez, PB Jones, GM Khandaker

    The early impact of COVID-19 on mental health and community physical health services and their patients’ mortality in Cambridgeshire and Peterborough, UK.

    DOI: http://doi.org/10.1016/j.jpsychires.2020.09.020
    Journal: J Psychiatr Res
    E-pub date: 1 Dec 2020
    Authors: S Chen, PB Jones, BR Underwood, A Moore, ET Bullmore, S Banerjee, EF Osimo, JB Deakin, CF Hatfield, FJ Thompson, JD Artingstall, MP Slann, JR Lewis, RN Cardinal

    Distinguishing between Dementia with Lewy Bodies (DLB) and Alzheimer’s Disease (AD) using Mental Health Records: a Classification Approach

    DOI: http://doi.org/10.18653/v1/2020.clinicalnlp-1.19
    Journal: Clinical NLP 2020
    E-pub date: 1 Nov 2020
    Authors: Z Wang, J Ive, S Moylett, C Mueller, RN Cardinal, S Velupillai, J O'Brien, R Stewart

    Simulating a community mental health service during the COVID-19 pandemic: effects of clinician–clinician encounters, clinician–patient–family encounters, symptom-triggered protective behaviour, and household clustering

    DOI: http://doi.org/10.1101/2020.04.27.20081505
    Journal:
    E-pub date: 1 Aug 2020
    Authors: R Cardinal, C Meiser-Stedman, D Christmas, A Price, C Denman, B Underwood, S Chen, S Banerjee, S White, L Su, T Ford, S Chamberlain, C Walsh

    The Medium-Term Impact of COVID-19 Lockdown on Referrals to Secondary Care Mental Health Services: A Controlled Interrupted Time Series Study.

    DOI: http://doi.org/10.3389/fpsyt.2020.585915
    Journal: Front Psychiatry
    E-pub date: 1 Aug 2020
    Authors: S Chen, R She, P Qin, A Kershenbaum, E Fernandez-Egea, JR Nelder, C Ma, J Lewis, C Wang, RN Cardinal

    Risk Factors for Excess Deaths Among Older Adults Without Confirmed COVID-19 During Lockdown: A Retrospective Cohort Study

    DOI: http://doi.org/10.2139/ssrn.3672334
    Journal:
    E-pub date: 1 Aug 2020
    Authors: S Chen, P Jones, B Underwood, E Fernandez-Egea, P Qin, J Lewis, R Cardinal

    Generation and evaluation of artificial mental health records for Natural Language Processing.

    DOI: http://doi.org/10.1038/s41746-020-0267-x
    Journal: NPJ Digit Med
    E-pub date: 1 Aug 2020
    Authors: J Ive, N Viani, J Kam, L Yin, S Verma, S Puntis, RN Cardinal, A Roberts, R Stewart, S Velupillai

    Causes of death in clozapine-treated patients in a catchment area: a 10-year retrospective case-control study.

    DOI: http://doi.org/10.1016/j.euroneuro.2020.05.011
    Journal: Eur Neuropsychopharmacol
    E-pub date: 1 Jul 2020
    Authors: E Rose, S Chen, C Turrion, C Jenkins, RN Cardinal, E Fernandez-Egea

    Probabilistic reversal learning under acute tryptophan depletion in healthy humans: a conventional analysis.

    DOI: http://doi.org/10.1177/0269881120907991
    Journal: J Psychopharmacol
    E-pub date: 1 May 2020
    Authors: JW Kanen, FE Arntz, R Yellowlees, RN Cardinal, A Price, DM Christmas, BJ Sahakian, AM Apergis-Schoute, TW Robbins

    Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans

    DOI: http://doi.org/10.1101/2020.04.26.062463
    Journal:
    E-pub date: 27 Apr 2020
    Authors: J Kanen, A Apergis-Schoute, R Yellowlees, F Arntz, F van der Flier, A Price, R Cardinal, D Christmas, L Clark, B Sahakian, M Crockett, T Robbins

    Effect of tryptophan depletion on conditioned threat memory expression: role of intolerance of uncertainty

    DOI: http://doi.org/10.1101/2020.04.26.062505
    Journal:
    E-pub date: 27 Apr 2020
    Authors: J Kanen, F Arntz, R Yellowlees, D Christmas, A Price, A Apergis-Schoute, B Sahakian, R Cardinal, T Robbins

    Birth weight, family history of diabetes and diabetes onset in schizophrenia.

    DOI: http://doi.org/10.1136/bmjdrc-2019-001036
    Journal: BMJ Open Diabetes Res Care
    E-pub date: 1 Jan 2020
    Authors: E Fernandez-Egea, R Walker, H Ziauddeen, RN Cardinal, ET Bullmore

    Hippocampal Interaction With Area 25, but not Area 32, Regulates Marmoset Approach-Avoidance Behavior.

    DOI: http://doi.org/10.1093/cercor/bhz015
    Journal: Cereb Cortex
    E-pub date: 17 Dec 2019
    Authors: CU Wallis, GJ Cockcroft, RN Cardinal, AC Roberts, HF Clarke

    Prevalence of mental health disorders and medication use in Cambridge and Peterborough National Health Service foundation trust service users

    DOI: http://doi.org/10.1016/j.euroneuro.2019.09.684
    Journal:
    E-pub date: 1 Dec 2019
    Authors: K Klaus, T Dalgleish, R Cardinal

    Dopamine D2-like receptor stimulation blocks negative feedback in visual and spatial reversal learning in the rat: behavioural and computational evidence.

    DOI: http://doi.org/10.1007/s00213-019-05296-y
    Journal: Psychopharmacology (Berl)
    E-pub date: 31 Aug 2019
    Authors: J Alsiö, BU Phillips, J Sala-Bayo, SRO Nilsson, TC Calafat-Pla, A Rizwand, JM Plumbridge, L López-Cruz, JW Dalley, RN Cardinal, AC Mar, TW Robbins

    Impairments in reinforcement learning do not explain enhanced habit formation in cocaine use disorder.

    DOI: http://doi.org/10.1007/s00213-019-05330-z
    Journal: Psychopharmacology (Berl)
    E-pub date: 31 Aug 2019
    Authors: TV Lim, RN Cardinal, G Savulich, PS Jones, AA Moustafa, TW Robbins, KD Ersche

    Computational psychopharmacology: a translational and pragmatic approach.

    DOI: http://doi.org/10.1007/s00213-019-05302-3
    Journal: Psychopharmacology (Berl)
    E-pub date: 31 Aug 2019
    Authors: TW Robbins, RN Cardinal

    Serotonin depletion amplifies distinct human social emotions as a function of individual differences in personality

    DOI: http://doi.org/10.1101/789669
    Journal:
    E-pub date: 1 Aug 2019
    Authors: J Kanen, F Arntz, R Yellowlees, R Cardinal, A Price, D Christmas, A Apergis-Schoute, B Sahakian, T Robbins

    Clinical Presentation, Diagnostic Features, and Mortality in Dementia with Lewy Bodies.

    DOI: http://doi.org/10.3233/JAD-180877
    Journal: J Alzheimers Dis
    E-pub date: 1 Aug 2019
    Authors: S Moylett, A Price, RN Cardinal, D Aarsland, C Mueller, R Stewart, JT O'Brien

    Deconstructing appetitive learning in cocaine addiction using hierarchical Bayesian modelling

    DOI: http://doi.org/10.1016/j.euroneuro.2018.11.323
    Journal:
    E-pub date: 1 Aug 2019
    Authors: TV Lim, RN Cardinal, PS Jones, TW Robbins, KD Ersche

    Impaired awareness of action-outcome contingency and causality during healthy ageing and following ventromedial prefrontal cortex lesions.

    DOI: http://doi.org/10.1016/j.neuropsychologia.2018.01.021
    Journal: Neuropsychologia
    E-pub date: 1 May 2019
    Authors: C O'Callaghan, MM Vaghi, B Brummerloh, RN Cardinal, TW Robbins

    Action-Outcome Knowledge Dissociates From Behavior in Obsessive-Compulsive Disorder Following Contingency Degradation.

    DOI: http://doi.org/10.1016/j.bpsc.2018.09.014
    Journal: Biol Psychiatry Cogn Neurosci Neuroimaging
    E-pub date: 1 Feb 2019
    Authors: MM Vaghi, RN Cardinal, AM Apergis-Schoute, NA Fineberg, A Sule, TW Robbins

    Novel Smartphone Interventions Improve Cognitive Flexibility and Obsessive-Compulsive Disorder Symptoms in Individuals with Contamination Fears.

    DOI: http://doi.org/10.1038/s41598-018-33142-2
    Journal: Sci Rep
    E-pub date: 23 Oct 2018
    Authors: B Jalal, A Brühl, C O'Callaghan, T Piercy, RN Cardinal, VS Ramachandran, BJ Sahakian

    Evidence for a Long-Lasting Compulsive Alcohol Seeking Phenotype in Rats.

    DOI: http://doi.org/10.1038/npp.2017.105
    Journal: Neuropsychopharmacology
    E-pub date: 1 Mar 2018
    Authors: C Giuliano, Y Peña-Oliver, CR Goodlett, RN Cardinal, TW Robbins, ET Bullmore, D Belin, BJ Everitt

    Prevalence and correlates of low-grade systemic inflammation in adult psychiatric inpatients: An electronic health record-based study.

    DOI: http://doi.org/10.1016/j.psyneuen.2018.02.031
    Journal: Psychoneuroendocrinology
    E-pub date: 1 Mar 2018
    Authors: EF Osimo, RN Cardinal, PB Jones, GM Khandaker

    Negative Allosteric Modulators Selective for The NR2B Subtype of The NMDA Receptor Impair Cognition in Multiple Domains.

    DOI: http://doi.org/10.1038/npp.2015.184
    Journal: Neuropsychopharmacology
    E-pub date: 1 Jan 2016
    Authors: MR Weed, M Bookbinder, J Polino, D Keavy, RN Cardinal, J Simmermacher-Mayer, F-NL Cometa, D King, S Thangathirupathy, JE Macor, LJ Bristow

    Role of Central Serotonin in Anticipation of Rewarding and Punishing Outcomes: Effects of Selective Amygdala or Orbitofrontal 5-HT Depletion.

    DOI: http://doi.org/10.1093/cercor/bhu102
    Journal: Cereb Cortex
    E-pub date: 1 Sep 2015
    Authors: R Rygula, HF Clarke, RN Cardinal, GJ Cockcroft, J Xia, JW Dalley, TW Robbins, AC Roberts

    Association between antipsychotic/antidepressant drug treatments and hospital admissions in schizophrenia assessed using a mental health case register.

    DOI: http://doi.org/10.1038/npjschz.2015.35
    Journal: NPJ Schizophr
    E-pub date: 1 Aug 2015
    Authors: RN Cardinal, G Savulich, LM Mann, E Fernández-Egea

    Impulsivity in borderline personality disorder.

    DOI: http://doi.org/10.1017/S0033291714003079
    Journal: Psychol Med
    E-pub date: 1 Jul 2015
    Authors: V Barker, L Romaniuk, RN Cardinal, M Pope, K Nicol, J Hall

    Early life stress produces compulsive-like, but not impulsive, behavior in females.

    DOI: http://doi.org/10.1037/bne0000059
    Journal: Behav Neurosci
    E-pub date: 1 Jun 2015
    Authors: NM Brydges, MC Holmes, AP Harris, RN Cardinal, J Hall

    Orbitofrontal dopamine depletion upregulates caudate dopamine and alters behavior via changes in reinforcement sensitivity.

    DOI: http://doi.org/10.1523/JNEUROSCI.0718-14.2014
    Journal: J Neurosci
    E-pub date: 28 May 2014
    Authors: HF Clarke, RN Cardinal, R Rygula, YT Hong, TD Fryer, SJ Sawiak, V Ferrari, G Cockcroft, FI Aigbirhio, TW Robbins, AC Roberts

    Counterfactual processing of economic action-outcome alternatives in obsessive-compulsive disorder: further evidence of impaired goal-directed behavior.

    DOI: http://doi.org/10.1016/j.biopsych.2013.01.018
    Journal: Biol Psychiatry
    E-pub date: 15 Apr 2014
    Authors: CM Gillan, S Morein-Zamir, M Kaser, NA Fineberg, A Sule, BJ Sahakian, RN Cardinal, TW Robbins

    Case Studies: Stahl’s Essential Psychopharmacology

    DOI: http://doi.org/10.1111/j.1600-0447.2012.01856.x
    Journal: ACTA PSYCHIATRICA SCANDINAVICA
    E-pub date: 1 Aug 2012
    Authors: R Cardinal

    Analysis of Variance

    DOI: http://doi.org/10.1002/9780470479216.corpsy0054
    Journal:
    E-pub date: 30 Jan 2010
    Authors: RN Cardinal

    Neural Systems of Motivation

    DOI: http://doi.org/10.1016/B978-0-08-045396-5.00167-6
    Journal:
    E-pub date: 1 Jan 2010
    Authors: RN Cardinal, BJ Everitt

    Psychosis and catatonia as a first presentation of antiphospholipid syndrome.

    DOI: http://doi.org/10.1192/bjp.195.3.272
    Journal: Br J Psychiatry
    E-pub date: 1 Sep 2009
    Authors: RN Cardinal, DN Shah, CJ Edwards, GRV Hughes, E Fernández-Egea

    Osteomalacia and vitamin D deficiency in a psychiatric rehabilitation unit: case report and survey.

    DOI: http://doi.org/10.1186/1756-0500-2-82
    Journal: BMC Res Notes
    E-pub date: 9 May 2009
    Authors: RN Cardinal, CA Gregory

    Explaining the escalation of drug use in substance dependence: models and appropriate animal laboratory tests.

    DOI: http://doi.org/10.1159/000103923
    Journal: Pharmacology
    E-pub date: 1 Aug 2007
    Authors: G Zernig, SH Ahmed, RN Cardinal, D Morgan, E Acquas, RW Foltin, P Vezina, SS Negus, JA Crespo, P Stöckl, P Grubinger, E Madlung, C Haring, M Kurz, A Saria

    Lack of deleterious effects of buspirone on cognition in healthy male volunteers.

    DOI: http://doi.org/10.1177/0269881107068066
    Journal: J Psychopharmacol
    E-pub date: 1 Mar 2007
    Authors: SR Chamberlain, U Müller, JB Deakin, PR Corlett, J Dowson, RN Cardinal, MRF Aitken, TW Robbins, BJ Sahakian

    Neural systems involved in delay and risk assessment in the rat

    DOI: http://doi.org/10.17863/CAM.16465
    Journal:
    E-pub date: 23 Jan 2007
    Authors: RN Cardinal

    Lack of deleterious effects of buspirone on cognition in healthy male volunteers

    DOI: http://doi.org/10.1177/0269881106068066
    Journal: Journal of Psychopharmacology
    E-pub date: 18 Oct 2006
    Authors: SR Chamberlain, U Muller, JB Deakin, PR Corlett, J Dowson, R Cardinal, MR Aitken, TW Robbins, BJ Sahakian

    Chapter 3 Neuroscience of Drugs and Addiction

    DOI: http://doi.org/10.1016/B978-012370624-9/50006-2
    Journal:
    E-pub date: 29 Sep 2006
    Authors: T Robbins, RN Cardinal, P DiCiano, PW Halligan, K Hellemans, J Lee, BJ Everitt

    Double dissociation between serotonergic and dopaminergic modulation of medial prefrontal and orbitofrontal cortex during a test of impulsive choice.

    DOI: http://doi.org/10.1093/cercor/bhi088
    Journal: Cereb Cortex
    E-pub date: 1 Jan 2006
    Authors: CA Winstanley, DEH Theobald, JW Dalley, RN Cardinal, TW Robbins

    Cortical cholinergic function and deficits in visual attentional performance in rats following 192 IgG-saporin-induced lesions of the medial prefrontal cortex.

    DOI: http://doi.org/10.1093/cercor/bhh052
    Journal: Cereb Cortex
    E-pub date: 31 Aug 2004
    Authors: JW Dalley, DE Theobald, P Bouger, Y Chudasama, RN Cardinal, TW Robbins

    Limbic corticostriatal systems and delayed reinforcement.

    DOI: http://doi.org/10.1196/annals.1308.004
    Journal: Ann N Y Acad Sci
    E-pub date: 1 Jun 2004
    Authors: RN Cardinal, CA Winstanley, TW Robbins, BJ Everitt

    Neural and psychological mechanisms underlying appetitive learning: links to drug addiction.

    DOI: http://doi.org/10.1016/j.conb.2004.03.004
    Journal: Curr Opin Neurobiol
    E-pub date: 1 Apr 2004
    Authors: RN Cardinal, BJ Everitt

    The contribution of the amygdala, nucleus accumbens, and prefrontal cortex to emotion and motivated behaviour

    DOI: http://doi.org/10.1016/S0531-5131(03)01013-6
    Journal: COGNITION AND EMOTION IN THE BRAIN
    E-pub date: 1 Aug 2003
    Authors: RN Cardinal, JA Parkinson, J Hall, BJ Everitt

    Chapter 7 Choosing Delayed Rewards Perspectives from Learning Theory, Neurochemistry, and Neuroanatomy

    DOI: http://doi.org/10.1016/b978-008044056-9/50048-8
    Journal:
    E-pub date: 1 Aug 2003
    Authors: RN Cardinal, TW Robbins, BJ Everitt

    Appetitive Behavior

    DOI: http://doi.org/10.1111/j.1749-6632.2003.tb07085.x
    Journal: Annals of the New York Academy of Sciences
    E-pub date: 1 Apr 2003
    Authors: BJ EVERITT, RN CARDINAL, JA PARKINSON, TW ROBBINS

    Nucleus accumbens dopamine depletion impairs both acquisition and performance of appetitive Pavlovian approach behaviour: implications for mesoaccumbens dopamine function.

    DOI: http://doi.org/10.1016/s0166-4328(02)00291-7
    Journal: Behav Brain Res
    E-pub date: 2 Dec 2002
    Authors: JA Parkinson, JW Dalley, RN Cardinal, A Bamford, B Fehnert, G Lachenal, N Rudarakanchana, KM Halkerston, TW Robbins, BJ Everitt

    Local analysis of behaviour in the adjusting-delay task for assessing choice of delayed reinforcement.

    DOI: http://doi.org/10.1016/s0893-6080(02)00053-9
    Journal: Neural Netw
    E-pub date: 1 Aug 2002
    Authors: RN Cardinal, N Daw, TW Robbins, BJ Everitt

    Differential involvement of NMDA, AMPA/kainate, and dopamine receptors in the nucleus accumbens core in the acquisition and performance of pavlovian approach behavior.

    DOI: http://doi.org/10.1523/JNEUROSCI.21-23-09471.2001
    Journal: J Neurosci
    E-pub date: 1 Dec 2001
    Authors: P Di Ciano, RN Cardinal, RA Cowell, SJ Little, BJ Everitt

    Neuropsychology of reinforcement processes in the rat

    DOI: http://doi.org/10.17863/CAM.16462
    Journal:
    E-pub date: 17 Jul 2001
    Authors: RN Cardinal

    Distinct changes in cortical acetylcholine and noradrenaline efflux during contingent and noncontingent performance of a visual attentional task.

    DOI: http://doi.org/10.1523/JNEUROSCI.21-13-04908.2001
    Journal: J Neurosci
    E-pub date: 1 Jul 2001
    Authors: JW Dalley, J McGaughy, MT O'Connell, RN Cardinal, L Levita, TW Robbins

    Decision making and neuropsychiatry.

    DOI: http://doi.org/10.1016/s1364-6613(00)01650-8
    Journal: Trends Cogn Sci
    E-pub date: 1 Jun 2001
    Authors: S Rahman, B J Sahakia, R N Cardinal, R Rogers, T Robbins

    The effects of d-amphetamine, chlordiazepoxide, alpha-flupenthixol and behavioural manipulations on choice of signalled and unsignalled delayed reinforcement in rats.

    DOI: http://doi.org/10.1007/s002130000536
    Journal: Psychopharmacology (Berl)
    E-pub date: 1 Nov 2000
    Authors: RN Cardinal, TW Robbins, BJ Everitt

    Limbic cortical-ventral striatal systems underlying appetitive conditioning.

    DOI: http://doi.org/10.1016/S0079-6123(00)26019-6
    Journal: Prog Brain Res
    E-pub date: 1 Aug 2000
    Authors: JA Parkinson, RN Cardinal, BJ Everitt