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College Clare College
Department
  • Physiology, Development and Neuroscience
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    Research Theme Neurons, Circuits and Networks Lifelong Brain Development and Brain Ageing The Social Brain
    Research Focus

    Keywords

  • NMDA Receptors
  • Excitatory Synaptic Transmission
  • GABAergic Inhibition
  • Electrophysiology
  • Functional Networks
  • Brain Networks
  • Autism
  • Rett Syndrome
  • Neurology

    • Clinical Conditions

  • Autism
  • Rett syndrome

    • Equipment & Techniques

  • Electrophysiological recording techniques
  • Whole cell patch clamp

    • Science Culture

  • Mentorship
  • Public Outreach
  • Teaching

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    Dr Susanna Mierau MD, DPhil

    University Position
    Affiliated Member

    Interests

    My research focuses on the fundamental rules that govern the development of synaptic and network activity in the cortex and how this process is disrupted in autism and related disorders, with the ultimate goal of developing novel therapies. I combine electrophysiological recordings at the synaptic and network level with optogenetic techniques to investigate the cell-type specific mechanisms underlying NMDA and AMPA receptor development, impact on circuit function and synaptic plasticity, and role in neurodevelopmental disorders in acute cortical slices, primary cortical cultures, and human cerebral organoids. I collaborate with computational groups at Cambridge and MIT to develop novel methods for analyzing the development of network activity.

    Collaborators

    Cambridge
  • Ole Paulsen
  • Andras Lakatos
  • Madeline Lancaster
  • Petra Vertes
  • Duncan Astle
  • Kate Baker
  • Stephen Eglen
  • Alexander Dunn
  • Yin Yuan

    • Associated News Items

    Key Publications

    Cerebral organoids at the air-liquid interface generate diverse nerve tracts with functional output.

    DOI: http://doi.org/10.1038/s41593-019-0350-2
    Journal: Nat Neurosci
    E-pub date: 1 Apr 2019
    Authors: SL Giandomenico, SB Mierau, GM Gibbons, LMD Wenger, L Masullo, T Sit, M Sutcliffe, J Boulanger, M Tripodi, E Derivery, O Paulsen, A Lakatos, MA Lancaster

    Cell-Specific Regulation of N-Methyl-D-Aspartate Receptor Maturation by Mecp2 in Cortical Circuits.

    DOI: http://doi.org/10.1016/j.biopsych.2015.05.018
    Journal: Biol Psychiatry
    E-pub date: 1 May 2016
    Authors: SB Mierau, A Patrizi, TK Hensch, M Fagiolini

    Dissociation of experience-dependent and -independent changes in excitatory synaptic transmission during development of barrel cortex

    DOI: http://doi.org/10.1073/pnas.0402915101
    Journal: P NATL ACAD SCI USA
    E-pub date: 26 Oct 2004
    Authors: SB Mierau, RM Meredith, AL Upton, O Paulsen

    Publications

    Neuromodulation of Spike-Timing-Dependent Plasticity: Past, Present, and Future.

    DOI: http://doi.org/10.1016/j.neuron.2019.05.041
    Journal: Neuron
    E-pub date: 21 Aug 2019
    Authors: Z Brzosko, SB Mierau, O Paulsen

    MPX-004 and MPX-007: New Pharmacological Tools to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit.

    DOI: http://doi.org/10.1371/journal.pone.0148129
    Journal: PLoS One
    E-pub date: 1 Aug 2016
    Authors: RA Volkmann, CM Fanger, DR Anderson, VR Sirivolu, K Paschetto, E Gordon, C Virginio, M Gleyzes, B Buisson, E Steidl, SB Mierau, M Fagiolini, FS Menniti

    Double dissociation of spike timing-dependent potentiation and depression by subunit-preferring NMDA receptor antagonists in mouse barrel cortex.

    DOI: http://doi.org/10.1093/cercor/bhp067
    Journal: Cereb Cortex
    E-pub date: 1 Dec 2009
    Authors: A Banerjee, RM Meredith, A Rodríguez-Moreno, SB Mierau, YP Auberson, O Paulsen