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Department
  • Psychiatry
    • Research Theme Beyond the Neuron Lifelong Brain Development and Brain Ageing Neurons, Circuits and Networks
    Research Focus

    Keywords

  • PET Imaging
  • MRI
  • PET/MRI

    • Clinical Conditions

  • Alzheimer's disease
  • Lewy body dementia

    • Equipment & Techniques

  • Positron Emission Tomography (PET)
  • Magnetic resonance imaging (MRI)
  • Neuropsychological testing

    • Back

    Dr Stephen F. Carter PhD

    University Position
    Senior Research Associate
    Dr Stephen F. Carter is pleased to consider applications from prospective PhD students.

    Interests

    As a cognitive neuroscientist my principal research interest is understanding the pathological cascade of Alzheimer's disease in humans. This is primarily achieved with PET biomarkers of amyloid and tau, but also incorporates MRI and fluid biomarkers. My research uses techniques that include high-resolution neuroimaging and neuropsychological testing with the objective of providing convergent information within the same individuals along the continuum of disease (presymptomatic to manifest dementia). Along with the main PET biomarkers used in dementia research (amyloid-β; tau), I'm also interested in understanding the role astrocytes play in the pathological cascade by using novel PET radiotracers that can measure astrocyte function in vivo.

    Collaborators

    Cambridge
  • John O'Brien
  • Li Su
    • External
  • Konstantinos Chiotis; Karolinska Institutet
  • Elena Rodriguez-Vieitez ; Karolinska Institutet
  • Agneta Nordberg ; Karolinska Institutet
  • Eduardo Zimmer, Universidade Federal do Rio Grande do Sul
  • Rainer Hinz; University of Manchester
  • Karl Herholz; University of Manchester

    • Key Publications

    Evaluation of in vivo staging of amyloid deposition in cognitively unimpaired elderly aged 78-94.

    DOI: http://doi.org/10.1038/s41380-022-01685-6
    Journal: Mol Psychiatry
    E-pub date: 1 Oct 2022
    Authors: MM Michalowska, K Herholz, R Hinz, C Amadi, L McInnes, JM Anton-Rodriguez, TK Karikari, K Blennow, H Zetterberg, NJ Ashton, N Pendleton, SF Carter

    Astrocyte Biomarkers in Alzheimer’s Disease.

    DOI: http://doi.org/10.1016/j.molmed.2018.11.006
    Journal: Trends Mol Med
    E-pub date: 1 Feb 2019
    Authors: SF Carter, K Herholz, P Rosa-Neto, L Pellerin, A Nordberg, ER Zimmer

    Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer’s disease.

    DOI: http://doi.org/10.1093/brain/awv404
    Journal: Brain
    E-pub date: 1 Mar 2016
    Authors: E Rodriguez-Vieitez, L Saint-Aubert, SF Carter, O Almkvist, K Farid, M Schöll, K Chiotis, S Thordardottir, C Graff, A Wall, B Långström, A Nordberg

    Regional neuronal network failure and cognition in late-onset sporadic Alzheimer disease.

    DOI: http://doi.org/10.3174/ajnr.A3895
    Journal: AJNR Am J Neuroradiol
    E-pub date: 1 Jun 2014
    Authors: SF Carter, KV Embleton, JM Anton-Rodriguez, A Burns, MAL Ralph, K Herholz

    A European multicentre PET study of fibrillar amyloid in Alzheimer’s disease.

    DOI: http://doi.org/10.1007/s00259-012-2237-2
    Journal: Eur J Nucl Med Mol Imaging
    E-pub date: 1 Jan 2013
    Authors: A Nordberg, SF Carter, J Rinne, A Drzezga, DJ Brooks, R Vandenberghe, D Perani, A Forsberg, B Långström, N Scheinin, M Karrasch, K Någren, T Grimmer, I Miederer, P Edison, A Okello, K Van Laere, N Nelissen, M Vandenbulcke, V Garibotto, O Almkvist, E Kalbe, R Hinz, K Herholz

    Staging of the cognitive decline in Alzheimer’s disease: insights from a detailed neuropsychological investigation of mild cognitive impairment and mild Alzheimer’s disease.

    DOI: http://doi.org/10.1002/gps.2738
    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Apr 2012
    Authors: SF Carter, D Caine, A Burns, K Herholz, MA Lambon Ralph

    Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B and 18F-FDG.

    DOI: http://doi.org/10.2967/jnumed.110.087031
    Journal: J Nucl Med
    E-pub date: 1 Jan 2012
    Authors: SF Carter, M Schöll, O Almkvist, A Wall, H Engler, B Långström, A Nordberg

    Publications

    Modifiable and non-modifiable risk factors of dementia on midlife cerebral small vessel disease in cognitively healthy middle-aged adults: the PREVENT-Dementia study.

    DOI: http://doi.org/10.1186/s13195-022-01095-4
    Journal: Alzheimers Res Ther
    E-pub date: 12 Oct 2022
    Authors: A Low, MA Prats-Sedano, E McKiernan, SF Carter, JD Stefaniak, S Nannoni, L Su, M-E Dounavi, G Muniz-Terrera, K Ritchie, B Lawlor, L Naci, P Malhotra, C Mackay, I Koychev, CW Ritchie, HS Markus, JT O'Brien

    CAIDE dementia risk score relates to severity and progression of cerebral small vessel disease in healthy midlife adults: the PREVENT-Dementia study.

    DOI: http://doi.org/10.1136/jnnp-2021-327462
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 May 2022
    Authors: A Low, MA Prats-Sedano, JD Stefaniak, EF McKiernan, SF Carter, M-E Douvani, E Mak, L Su, O Stupart, G Muniz, K Ritchie, CW Ritchie, HS Markus, JT O'Brien

    Astrocyte Biomarkers in Alzheimer Disease: A Systematic Review and Meta-analysis.

    DOI: http://doi.org/10.1212/WNL.0000000000012109
    Journal: Neurology
    E-pub date: 14 Jun 2021
    Authors: B Bellaver, JP Ferrari-Souza, L Uglione da Ros, SF Carter, E Rodriguez-Vieitez, A Nordberg, L Pellerin, P Rosa-Neto, DT Leffa, ER Zimmer

    Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2020.11.006
    Journal: Neurobiol Aging
    E-pub date: 1 May 2021
    Authors: E Mak, N Nicastro, M Malpetti, G Savulich, A Surendranathan, N Holland, L Passamonti, PS Jones, SF Carter, L Su, YT Hong, TD Fryer, GB Williams, F Aigbirhio, JB Rowe, JT O'Brien

    Proximity to dementia onset and multi-modal neuroimaging changes: The prevent-dementia study.

    DOI: http://doi.org/10.1016/j.neuroimage.2021.117749
    Journal: Neuroimage
    E-pub date: 1 Apr 2021
    Authors: E Mak, M-E Dounavi, A Low, SF Carter, E McKiernan, GB Williams, PS Jones, I Carriere, GT Muniz, K Ritchie, C Ritchie, L Su, JT O'Brien

    Gray matter changes related to microglial activation in Alzheimer’s disease.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2020.06.010
    Journal: Neurobiol Aging
    E-pub date: 1 Oct 2020
    Authors: N Nicastro, M Malpetti, E Mak, GB Williams, WR Bevan-Jones, SF Carter, L Passamonti, TD Fryer, YT Hong, FI Aigbirhio, JB Rowe, JT O'Brien

    11C-UCB-J synaptic PET and multimodal imaging in dementia with Lewy bodies.

    DOI: http://doi.org/10.1186/s41824-020-00093-9
    Journal: Eur J Hybrid Imaging
    E-pub date: 1 Aug 2020
    Authors: N Nicastro, N Holland, G Savulich, SF Carter, E Mak, YT Hong, S Milicevic Sephton, TD Fryer, FI Aigbirhio, JB Rowe, JT O'Brien

    Relevance of biomarkers across different neurodegenerative diseases.

    DOI: http://doi.org/10.1186/s13195-020-00601-w
    Journal: Alzheimers Res Ther
    E-pub date: 13 May 2020
    Authors: AJ Ehrenberg, A Khatun, E Coomans, MJ Betts, F Capraro, EH Thijssen, K Senkevich, T Bharucha, M Jafarpour, PNE Young, W Jagust, SF Carter, T Lashley, LT Grinberg, JB Pereira, N Mattsson-Carlgren, NJ Ashton, J Hanrieder, H Zetterberg, M Schöll, RW Paterson

    Imaging biomarkers in neurodegeneration: current and future practices.

    DOI: http://doi.org/10.1186/s13195-020-00612-7
    Journal: Alzheimers Res Ther
    E-pub date: 27 Apr 2020
    Authors: PNE Young, M Estarellas, E Coomans, M Srikrishna, H Beaumont, A Maass, AV Venkataraman, R Lissaman, D Jiménez, MJ Betts, E McGlinchey, D Berron, A O'Connor, NC Fox, JB Pereira, W Jagust, SF Carter, RW Paterson, M Schöll

    Prognostic value of Alzheimer’s biomarkers in mild cognitive impairment: the effect of age at onset.

    DOI: http://doi.org/10.1007/s00415-019-09441-7
    Journal: J Neurol
    E-pub date: 1 Oct 2019
    Authors: D Altomare, C Ferrari, A Caroli, S Galluzzi, A Prestia, WM van der Flier, R Ossenkoppele, B Van Berckel, F Barkhof, CE Teunissen, A Wall, SF Carter, M Schöll, ILH Choo, T Grimmer, A Redolfi, A Nordberg, P Scheltens, A Drzezga, GB Frisoni, Alzheimer’s Disease Neuroimaging Initiative

    Longitudinal association between astrocyte function and glucose metabolism in autosomal dominant Alzheimer’s disease.

    DOI: http://doi.org/10.1007/s00259-018-4217-7
    Journal: Eur J Nucl Med Mol Imaging
    E-pub date: 1 Feb 2019
    Authors: SF Carter, K Chiotis, A Nordberg, E Rodriguez-Vieitez

    Dual-phase [18F]florbetapir in frontotemporal dementia.

    DOI: http://doi.org/10.1007/s00259-018-4238-2
    Journal: Eur J Nucl Med Mol Imaging
    E-pub date: 1 Feb 2019
    Authors: M Asghar, R Hinz, K Herholz, SF Carter

    Resilience to cognitive impairment in the oldest-old: design of the EMIF-AD 90+ study.

    DOI: http://doi.org/10.1186/s12877-018-0984-z
    Journal: BMC Geriatr
    E-pub date: 26 Nov 2018
    Authors: N Legdeur, M Badissi, SF Carter, S de Crom, A van de Kreeke, R Vreeswijk, MC Trappenburg, ML Oudega, HL Koek, JP van Campen, CJPW Keijsers, C Amadi, R Hinz, MF Gordon, G Novak, J Podhorna, E Serné, F Verbraak, M Yaqub, A Hillebrand, A Griffa, N Pendleton, SE Kramer, CE Teunissen, A Lammertsma, F Barkhof, BNM van Berckel, P Scheltens, M Muller, AB Maier, K Herholz, PJ Visser

    The EMIF-AD PreclinAD study: study design and baseline cohort overview.

    DOI: http://doi.org/10.1186/s13195-018-0406-7
    Journal: Alzheimers Res Ther
    E-pub date: 4 Aug 2018
    Authors: E Konijnenberg, SF Carter, M Ten Kate, A den Braber, J Tomassen, C Amadi, L Wesselman, H-T Nguyen, JA van de Kreeke, M Yaqub, M Demuru, SD Mulder, A Hillebrand, FH Bouwman, CE Teunissen, EH Serné, AC Moll, FD Verbraak, R Hinz, N Pendleton, AA Lammertsma, BNM van Berckel, F Barkhof, DI Boomsma, P Scheltens, K Herholz, PJ Visser

    Comparison of Early-Phase 11C-Deuterium-l-Deprenyl and 11C-Pittsburgh Compound B PET for Assessing Brain Perfusion in Alzheimer Disease.

    DOI: http://doi.org/10.2967/jnumed.115.168732
    Journal: J Nucl Med
    E-pub date: 1 Jul 2016
    Authors: E Rodriguez-Vieitez, SF Carter, K Chiotis, L Saint-Aubert, A Leuzy, M Schöll, O Almkvist, A Wall, B Långström, A Nordberg

    Use of amyloid-PET to determine cutpoints for CSF markers: A multicenter study.

    DOI: http://doi.org/10.1212/WNL.0000000000002081
    Journal: Neurology
    E-pub date: 5 Jan 2016
    Authors: MD Zwan, JO Rinne, SG Hasselbalch, A Nordberg, A Lleó, S-K Herukka, H Soininen, I Law, JMC Bahl, SF Carter, J Fortea, R Blesa, CE Teunissen, FH Bouwman, BNM van Berckel, PJ Visser

    Early astrocytosis in autosomal dominant Alzheimer’s disease measured in vivo by multi-tracer positron emission tomography.

    DOI: http://doi.org/10.1038/srep16404
    Journal: Sci Rep
    E-pub date: 10 Nov 2015
    Authors: M Schöll, SF Carter, E Westman, E Rodriguez-Vieitez, O Almkvist, S Thordardottir, A Wall, C Graff, B Långström, A Nordberg

    Prediction of AD dementia by biomarkers following the NIA-AA and IWG diagnostic criteria in MCI patients from three European memory clinics.

    DOI: http://doi.org/10.1016/j.jalz.2014.12.001
    Journal: Alzheimers Dement
    E-pub date: 1 Oct 2015
    Authors: A Prestia, A Caroli, SK Wade, WM van der Flier, R Ossenkoppele, B Van Berckel, F Barkhof, CE Teunissen, A Wall, SF Carter, M Schöll, IH Choo, A Nordberg, P Scheltens, GB Frisoni

    Amyloid PET in European and North American cohorts; and exploring age as a limit to clinical use of amyloid imaging.

    DOI: http://doi.org/10.1007/s00259-015-3115-5
    Journal: Eur J Nucl Med Mol Imaging
    E-pub date: 1 Sep 2015
    Authors: K Chiotis, SF Carter, K Farid, I Savitcheva, A Nordberg, Diagnostic Molecular Imaging (DiMI) network and the Alzheimer’s Disease Neuroimaging Initiative

    Case Report of Complex Amyotrophic Lateral Sclerosis with Cognitive Impairment and Cortical Amyloid Deposition.

    DOI: http://doi.org/10.3233/JAD-141965
    Journal: J Alzheimers Dis
    E-pub date: 1 Aug 2015
    Authors: K Farid, SF Carter, E Rodriguez-Vieitez, O Almkvist, P Andersen, A Wall, K Blennow, E Portelius, H Zetterberg, A Nordberg

    Concordance and Diagnostic Accuracy of [11C]PIB PET and Cerebrospinal Fluid Biomarkers in a Sample of Patients with Mild Cognitive Impairment and Alzheimer’s Disease.

    DOI: http://doi.org/10.3233/JAD-142952
    Journal: J Alzheimers Dis
    E-pub date: 1 Aug 2015
    Authors: A Leuzy, SF Carter, K Chiotis, O Almkvist, A Wall, A Nordberg

    Mild cognitive impairment with suspected nonamyloid pathology (SNAP): Prediction of progression.

    DOI: http://doi.org/10.1212/WNL.0000000000001209
    Journal: Neurology
    E-pub date: 3 Feb 2015
    Authors: A Caroli, A Prestia, S Galluzzi, C Ferrari, WM van der Flier, R Ossenkoppele, B Van Berckel, F Barkhof, C Teunissen, AE Wall, SF Carter, M Schöll, IH Choo, T Grimmer, A Redolfi, A Nordberg, P Scheltens, A Drzezga, GB Frisoni, Alzheimer's Disease Neuroimaging Initiative

    Astrocytosis measured by ¹¹C-deprenyl PET correlates with decrease in gray matter density in the parahippocampus of prodromal Alzheimer’s patients.

    DOI: http://doi.org/10.1007/s00259-014-2859-7
    Journal: Eur J Nucl Med Mol Imaging
    E-pub date: 1 Nov 2014
    Authors: ILH Choo, SF Carter, ML Schöll, A Nordberg

    Comparison of MRI based and PET template based approaches in the quantitative analysis of amyloid imaging with PIB-PET.

    DOI: http://doi.org/10.1016/j.neuroimage.2012.12.014
    Journal: Neuroimage
    E-pub date: 15 Apr 2013
    Authors: P Edison, SF Carter, JO Rinne, G Gelosa, K Herholz, A Nordberg, DJ Brooks, R Hinz

    Prediction of dementia in MCI patients based on core diagnostic markers for Alzheimer disease.

    DOI: http://doi.org/10.1212/WNL.0b013e3182872830
    Journal: Neurology
    E-pub date: 12 Mar 2013
    Authors: A Prestia, A Caroli, WM van der Flier, R Ossenkoppele, B Van Berckel, F Barkhof, CE Teunissen, AE Wall, SF Carter, M Schöll, IH Choo, A Nordberg, P Scheltens, GB Frisoni

    Positron emission tomography imaging in dementia.

    DOI: http://doi.org/10.1259/bjr/97295129
    Journal: Br J Radiol
    E-pub date: 1 Dec 2007
    Authors: K Herholz, SF Carter, M Jones