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Department
  • Psychiatry
  • Research Focus

    Keywords

  • Dementia
  • Lewy Body Dementia
  • Magnetic Resonance Imaging
  • Positron Emission Tomography
  • Clinical Conditions

  • Lewy body dementia
  • Dementia
  • Equipment & Techniques

  • Magnetic resonance imaging (MRI)
  • Positron Emission Tomography (PET)
  • Back

    Professor John O'Brien

    University Position
    Professor
    Professor John O'Brien is pleased to consider applications from prospective PhD students.

    Interests

    Professor John O’Brien leads the Old Age Psychiatry Research Group which is part of the Department of Psychiatry at the University of Cambridge. His own research focusses on the study of dementia, especially Lewy body dementia, and uses a number of methodologies to try to improve the diagnosis and management of these disorders. In particular, utilising multi-modal imaging with MRI, MEG and novel PET and fluid markers to study pathophysiological processes and develop biomarkers for diagnosis and disease progression, and conduct clinical trials to improve patient management. We study the common cases of dementia in later life, so as well as Lewy body dementia we study Alzheimer’s disease and vascular dementia, and their prodromes and preclinical stages, as well as closely related conditions like late life depression. We have close links with other departments in Cambridge, especially Clinical Neurosciences, and the Cambridge Biomedical Research Centre as well as Cambridgeshire and Peterborough NHS Foundation Trust. We collaborate widely with other groups, including within the UK and internationally, through many routes including the Dementias Platform UK, the NIHR Dementia Translational Research Collaboration, the European DLB Group and the International DLB Consortium.

    Key Publications

    A robust harmonization approach for cognitive data from multiple aging and dementia cohorts.

    DOI: http://doi.org/10.1002/dad2.12453
    Journal: Alzheimers Dement (Amst)
    E-pub date: 1 Aug 2023
    Authors: J Giorgio, A Tanna, M Malpetti, SR White, J Wang, S Baker, S Landau, T Tanaka, C Chen, JB Rowe, J O'Brien, J Fripp, M Breakspear, W Jagust, Z Kourtzi, Alzheimer's Disease Neuroimaging Initiative, Australian Imaging Biomarkers and Lifestyle flagship study

    Illuminating neurodegeneration: a future perspective on near-infrared spectroscopy in dementia research.

    DOI: http://doi.org/10.1117/1.NPh.10.2.023514
    Journal: Neurophotonics
    E-pub date: 1 Apr 2023
    Authors: S Srinivasan, E Butters, L Collins-Jones, L Su, J O'Brien, G Bale

    Association between antidementia medication use and mortality in people diagnosed with dementia with Lewy bodies in the UK: A retrospective cohort study.

    DOI: http://doi.org/10.1371/journal.pmed.1004124
    Journal: PLoS Med
    E-pub date: 1 Dec 2022
    Authors: S Chen, AC Price, RN Cardinal, S Moylett, AD Kershenbaum, J Fitzgerald, C Mueller, R Stewart, JT O'Brien

    Macrostructural brain alterations at midlife are connected to cardiovascular and not inherited risk of future dementia: the PREVENT-Dementia study.

    DOI: http://doi.org/10.1007/s00415-022-11061-7
    Journal: J Neurol
    E-pub date: 31 Aug 2022
    Authors: M-E Dounavi, C Newton, N Jenkins, E Mak, A Low, G Muniz-Terrera, GB Williams, B Lawlor, L Naci, P Malhotra, CE Mackay, I Koychev, K Ritchie, CW Ritchie, L Su, JT O'Brien

    Fluid-attenuated inversion recovery magnetic resonance imaging textural features as sensitive markers of white matter damage in midlife adults.

    DOI: http://doi.org/10.1093/braincomms/fcac116
    Journal: Brain Commun
    E-pub date: 1 Aug 2022
    Authors: M-E Dounavi, A Low, G Muniz-Terrera, K Ritchie, CW Ritchie, L Su, HS Markus, JT O'Brien

    Differential levels of plasma biomarkers of neurodegeneration in Lewy body dementia, Alzheimer’s disease, frontotemporal dementia and progressive supranuclear palsy.

    DOI: http://doi.org/10.1136/jnnp-2021-327788
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jun 2022
    Authors: L Chouliaras, A Thomas, M Malpetti, P Donaghy, J Kane, E Mak, G Savulich, MA Prats-Sedano, AJ Heslegrave, H Zetterberg, L Su, JB Rowe, JT O'Brien

    Study of mirtazapine for agitated behaviours in dementia (SYMBAD): a randomised, double-blind, placebo-controlled trial.

    DOI: http://doi.org/10.1016/S0140-6736(21)01210-1
    Journal: Lancet
    E-pub date: 23 Oct 2021
    Authors: S Banerjee, J High, S Stirling, L Shepstone, AM Swart, T Telling, C Henderson, C Ballard, P Bentham, A Burns, N Farina, C Fox, P Francis, R Howard, M Knapp, I Leroi, G Livingston, R Nilforooshan, S Nurock, J O'Brien, A Price, AJ Thomas, N Tabet

    Progression of Clinical Features in Lewy Body Dementia Can Be Detected Over 6 Months.

    DOI: http://doi.org/10.1212/WNL.0000000000012450
    Journal: Neurology
    E-pub date: 7 Sep 2021
    Authors: E Matar, SR White, J-P Taylor, A Thomas, IG McKeith, JPM Kane, A Surendranathan, GM Halliday, SJG Lewis, JT O'Brien

    Visual hallucinations in neurological and ophthalmological disease: pathophysiology and management.

    DOI: http://doi.org/10.1136/jnnp-2019-322702
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 May 2020
    Authors: J O'Brien, JP Taylor, C Ballard, RA Barker, C Bradley, A Burns, D Collerton, S Dave, R Dudley, P Francis, A Gibbons, K Harris, V Lawrence, I Leroi, I McKeith, M Michaelides, C Naik, C O'Callaghan, K Olsen, M Onofrj, R Pinto, G Russell, P Swann, A Thomas, P Urwyler, RS Weil, D Ffytche

    Inflammation and cerebral small vessel disease: A systematic review.

    DOI: http://doi.org/10.1016/j.arr.2019.100916
    Journal: Ageing Res Rev
    E-pub date: 31 Aug 2019
    Authors: A Low, E Mak, JB Rowe, HS Markus, JT O'Brien

    Mortality in dementia with Lewy bodies compared with Alzheimer’s dementia: a retrospective naturalistic cohort study.

    DOI: http://doi.org/10.1136/bmjopen-2017-017504
    Journal: BMJ Open
    E-pub date: 3 Nov 2017
    Authors: A Price, R Farooq, J-M Yuan, VB Menon, RN Cardinal, JT O'Brien

    Synaptic Loss in Frontotemporal Dementia Revealed by [11 C]UCB-J Positron Emission Tomography

    DOI: https://doi.org/10.1002/ana.26543
    Journal: Annals of Neurology
    Year: 2023
    Authors: Malpetti M, Jones PS, Cope TE, Holland N, Naessens M, Rouse MA, Rittman T, Savulich G, Whiteside DJ, Street D, Fryer TD, Hong YT, Milicevic Sephton S, Aigbirhio FI, O Brien JT, Rowe JB

    Dementia: assessment, management and support: summary of updated NICE guidance

    DOI: https://doi.org/10.1136/bmj.k2438
    Journal: British Medical Journal
    Year: 2018
    Authors: Pink J, O’Brien J, Robinson L, Longson D

    Minocycline in Alzheimer Disease Efficacy (MADE) Trialist Group. Minocycline at 2 Different Dosages vs Placebo for Patients With Mild Alzheimer Disease: A Randomized Clinical Trial

    DOI: https://doi.org/10.1001%2Fjamaneurol.2019.3762
    Journal: JAMA Neurology
    Year: 2019
    Authors: Howard R, Zubko O, Bradley R, Harper E, Pank L, O'Brien J, Fox C, Tabet N, Livingston G, Bentham P, McShane R, Burns A, Ritchie C, Reeves S, Lovestone S, Ballard C, Noble W, Nilforooshan R, Wilcock G, Gray R

    Publications

    Differential Synaptic Loss in β‐Amyloid Positive Versus β‐Amyloid Negative Corticobasal Syndrome

    DOI: http://doi.org/10.1002/mds.29814
    Journal: Movement Disorders
    E-pub date: 26 Apr 2024
    Authors: N Holland, G Savulich, PS Jones, DJ Whiteside, D Street, P Swann, M Naessens, M Malpetti, YT Hong, TD Fryer, T Rittman, E Mulroy, FI Aigbirhio, KP Bhatia, JT O'Brien, JB Rowe

    MINocyclinE to Reduce inflammation and blood-brain barrier leakage in small Vessel diseAse (MINERVA): A phase II, randomized, double-blind, placebo-controlled experimental medicine trial

    DOI: http://doi.org/10.1002/alz.13830
    Journal: Alzheimers Dement
    E-pub date: 17 Apr 2024
    Authors: RB Brown, DJ Tozer, L Loubière, EL Harshfield, YT Hong, TD Fryer, GB Williams, MJ Graves, F Aigbirhio, JT O'Brien, HS Markus

    Are Central and Systemic Inflammation associated with Fatigue in Cerebral Small Vessel Disease?

    DOI: http://doi.org/10.1177/17474930241245613
    Journal: Int J Stroke
    E-pub date: 12 Apr 2024
    Authors: AA Jolly, RB Brown, DJ Tozer, YT Hong, TD Fryer, F Aigbirhio, J O'brien, HS Markus

    Neuroinflammation is linked to dementia risk in Parkinson’s disease.

    DOI: http://doi.org/10.1093/brain/awad322
    Journal: Brain
    E-pub date: 1 Mar 2024
    Authors: A Kouli, LRB Spindler, TD Fryer, YT Hong, M Malpetti, FI Aigbirhio, SR White, M Camacho, JT O'Brien, CH Williams-Gray

    Synaptic density affects clinical severity via network dysfunction in syndromes associated with frontotemporal lobar degeneration.

    DOI: http://doi.org/10.1038/s41467-023-44307-7
    Journal: Nat Commun
    E-pub date: 20 Dec 2023
    Authors: DJ Whiteside, N Holland, KA Tsvetanov, E Mak, M Malpetti, G Savulich, PS Jones, M Naessens, MA Rouse, TD Fryer, YT Hong, FI Aigbirhio, E Mulroy, KP Bhatia, T Rittman, JT O'Brien, JB Rowe

    Plasma biomarkers of neurodegeneration in mild cognitive impairment with Lewy bodies.

    DOI: http://doi.org/10.1017/S0033291723001952
    Journal: Psychol Med
    E-pub date: 1 Dec 2023
    Authors: CA Hamilton, J O'Brien, A Heslegrave, R Laban, P Donaghy, R Durcan, S Lawley, N Barnett, G Roberts, M Firbank, J-P Taylor, H Zetterberg, A Thomas

    The use of neuroimaging techniques in the early and differential diagnosis of dementia.

    DOI: http://doi.org/10.1038/s41380-023-02215-8
    Journal: Mol Psychiatry
    E-pub date: 1 Oct 2023
    Authors: L Chouliaras, JT O'Brien

    Genetic risk factors of Alzheimer’s Disease disrupt resting-state functional connectivity in cognitively intact young individuals.

    DOI: http://doi.org/10.1007/s00415-023-11809-9
    Journal: J Neurol
    E-pub date: 1 Oct 2023
    Authors: L Kucikova, J Zeng, C Muñoz-Neira, G Muniz-Terrera, W Huang, S Gregory, C Ritchie, J O'Brien, L Su

    Predicting cognitive decline using neuropsychiatric symptoms in prodromal Lewy body dementia: A longitudinal study.

    DOI: http://doi.org/10.1016/j.parkreldis.2023.105762
    Journal: Parkinsonism Relat Disord
    E-pub date: 31 Aug 2023
    Authors: LM Wright, PC Donaghy, DJ Burn, J-P Taylor, JT O'Brien, AJ Yarnall, FE Matthews, MJ Firbank, AJ Thomas, RA Lawson

    Genetic risks of Alzheimer’s by APOE and MAPT on cortical morphology in young healthy adults.

    DOI: http://doi.org/10.1093/braincomms/fcad234
    Journal: Brain Commun
    E-pub date: 1 Aug 2023
    Authors: W Huang, J Zeng, L Jia, D Zhu, J O'Brien, C Ritchie, N Shu, L Su

    Risk Factors for Longer-Term Mortality in Discharged Patients with Dementia and SARS-CoV-2 Infection: A Matched Case-Control Study.

    DOI: http://doi.org/10.3233/JAD-221093
    Journal: J Alzheimers Dis
    E-pub date: 1 Aug 2023
    Authors: S Chen, RN Cardinal, K Auckland, EpiCov Database, S Gräf, JT O'Brien, BR Underwood

    Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia.

    DOI: http://doi.org/10.1093/brain/awad078
    Journal: Brain
    E-pub date: 1 Aug 2023
    Authors: M Malpetti, TE Cope, D Street, PS Jones, FH Hezemans, E Mak, KA Tsvetanov, T Rittman, WR Bevan-Jones, K Patterson, L Passamonti, TD Fryer, YT Hong, FI Aigbirhio, JT O'Brien, JB Rowe

    Longitudinal Synaptic Loss in Primary Tauopathies: An In Vivo [11 C]UCB-J Positron Emission Tomography Study.

    DOI: http://doi.org/10.1002/mds.29421
    Journal: Mov Disord
    E-pub date: 1 Jul 2023
    Authors: N Holland, PS Jones, G Savulich, M Naessens, M Malpetti, DJ Whiteside, D Street, P Swann, YT Hong, TD Fryer, T Rittman, E Mulroy, FI Aigbirhio, KP Bhatia, JT O'Brien, JB Rowe

    Predicting cognitive decline using neuropsychiatric symptoms in prodromal Lewy body disease

    DOI: http://doi.org/10.1002/alz.061849
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Jun 2023
    Authors: LM Wright, P Donaghy, D Burn, J Taylor, JT O'Brien, AJ Yarnall, FE Matthews, MJ Firbank, AJ Thomas, RA Lawson

    Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson’s Disease Dementia.

    DOI: http://doi.org/10.1002/mdc3.13752
    Journal: Mov Disord Clin Pract
    E-pub date: 1 Jun 2023
    Authors: MC Gonzalez, DA Tovar-Rios, G Alves, I Dalen, CH Williams-Gray, M Camacho, L Forsgren, D Bäckström, RA Lawson, AD Macleod, CE Counsell, C Paquet, C DeLena, F D'Antonio, A Pilotto, A Padovani, F Blanc, C Falup-Pecurariu, SJG Lewis, K Rejdak, E Papuc, J Hort, Z Nedelska, J O'Brien, L Bonanni, M Marquié, M Boada, V Pytel, C Abdelnour, D Alcolea, K Beyer, O-B Tysnes, D Aarsland, J Maple-Grødem

    The role of plasma inflammatory markers in late-life depression and conversion to dementia: a 3-year follow-up study

    DOI: http://doi.org/10.21203/rs.3.rs-2924784/v1
    Journal:
    E-pub date: 16 May 2023
    Authors: D Aarsland, A Young, K Engedal, J O'Brien, G Selbaek, A-V Idland, L-O Watne, T Borza, M Bocharova

    Mortality rates and proximal causes of death in patients with Lewy body dementia versus Alzheimer’s disease: A longitudinal study using secondary care mental health records.

    DOI: http://doi.org/10.1002/gps.5937
    Journal: International Journal of Geriatric Psychiatry
    E-pub date: 1 May 2023
    Authors: AD Kershenbaum, AC Price, RN Cardinal, S Chen, JM Fitzgerald, J Lewis, S Moylett, JT O'Brien

    APOEε4 associates with microglial activation independently of Aβ plaques and tau tangles.

    DOI: http://doi.org/10.1126/sciadv.ade1474
    Journal: Sci Adv
    E-pub date: 5 Apr 2023
    Authors: JP Ferrari-Souza, FZ Lussier, DT Leffa, J Therriault, C Tissot, B Bellaver, PCL Ferreira, M Malpetti, Y-T Wang, G Povala, AL Benedet, NJ Ashton, M Chamoun, S Servaes, G Bezgin, MS Kang, J Stevenson, N Rahmouni, V Pallen, NM Poltronetti, JT O'Brien, JB Rowe, AD Cohen, OL Lopez, DL Tudorascu, TK Karikari, WE Klunk, VL Villemagne, J-P Soucy, S Gauthier, DO Souza, H Zetterberg, K Blennow, ER Zimmer, P Rosa-Neto, TA Pascoal

    Free-water imaging of the cholinergic basal forebrain and pedunculopontine nucleus in Parkinson’s disease.

    DOI: http://doi.org/10.1093/brain/awac127
    Journal: Brain
    E-pub date: 1 Mar 2023
    Authors: NJ Ray, RA Lawson, SL Martin, HP Sigurdsson, J Wilson, B Galna, S Lord, L Alcock, GW Duncan, TK Khoo, JT O'Brien, DJ Burn, J-P Taylor, RC Rea, M Bergamino, L Rochester, AJ Yarnall

    Path integration selectively predicts midlife risk of Alzheimer’s disease.

    DOI: http://doi.org/10.1101/2023.01.31.526473
    Journal:
    E-pub date: 3 Feb 2023
    Authors: C Newton, M Pope, C Rua, R Henson, Z Ji, N Burgess, CT Rodgers, M Stangl, M-E Dounavi, A Castegnaro, I Koychev, P Malhotra, T Wolbers, K Ritchie, CW Ritchie, J O'Brien, L Su, D Chan, PREVENT Dementia Research Programme

    Do Regions of Increased Inflammation Progress to New White Matter Hyperintensities?: A Longitudinal Positron Emission Tomography-Magnetic Resonance Imaging Study.

    DOI: http://doi.org/10.1161/STROKEAHA.122.039517
    Journal: Stroke
    E-pub date: 1 Feb 2023
    Authors: DJ Tozer, RB Brown, J Walsh, YT Hong, GB Williams, JT O'Brien, FI Aigbirhio, TD Fryer, HS Markus

    From protein biomarkers to proteomics in dementia with Lewy Bodies.

    DOI: http://doi.org/10.1016/j.arr.2022.101771
    Journal: Ageing Res Rev
    E-pub date: 1 Jan 2023
    Authors: A Tsamourgelis, P Swann, L Chouliaras, JT O'Brien

    Synaptic Loss in Frontotemporal Dementia Revealed by [11 C]UCB-J Positron Emission Tomography.

    DOI: http://doi.org/10.1002/ana.26543
    Journal: Ann Neurol
    E-pub date: 1 Jan 2023
    Authors: M Malpetti, PS Jones, TE Cope, N Holland, M Naessens, MA Rouse, T Rittman, G Savulich, DJ Whiteside, D Street, TD Fryer, YT Hong, S Milicevic Sephton, FI Aigbirhio, JT O Brien, JB Rowe

    RENEWAL: REpurposing study to find NEW compounds with Activity for Lewy body dementia-an international Delphi consensus.

    DOI: http://doi.org/10.1186/s13195-022-01103-7
    Journal: Alzheimers Res Ther
    E-pub date: 11 Nov 2022
    Authors: JT O'Brien, L Chouliaras, J Sultana, J-P Taylor, C Ballard, RENEWAL Study Group

    Modifiable and non-modifiable risk factors of dementia on midlife cerebral small vessel disease in cognitively healthy middle-aged adults: the PREVENT-Dementia study.

    DOI: http://doi.org/10.1186/s13195-022-01095-4
    Journal: Alzheimers Res Ther
    E-pub date: 12 Oct 2022
    Authors: A Low, MA Prats-Sedano, E McKiernan, SF Carter, JD Stefaniak, S Nannoni, L Su, M-E Dounavi, G Muniz-Terrera, K Ritchie, B Lawlor, L Naci, P Malhotra, C Mackay, I Koychev, CW Ritchie, HS Markus, JT O'Brien

    Neuropsychological Impairments and Their Cognitive Architecture in Mild Cognitive Impairment (MCI) with Lewy Bodies and MCI-Alzheimer’s Disease.

    DOI: http://doi.org/10.1017/S1355617721001181
    Journal: J Int Neuropsychol Soc
    E-pub date: 1 Oct 2022
    Authors: J Ciafone, A Thomas, R Durcan, PC Donaghy, CA Hamilton, S Lawley, G Roberts, S Colloby, MJ Firbank, L Allan, G Petrides, J-P Taylor, JT O'Brien, P Gallagher

    High coffee consumption, brain volume and risk of dementia and stroke.

    DOI: http://doi.org/10.1080/1028415X.2021.1945858
    Journal: Nutr Neurosci
    E-pub date: 1 Oct 2022
    Authors: K Pham, A Mulugeta, A Zhou, JT O'Brien, DJ Llewellyn, E Hyppönen

    Blood mRNA Expression in Alzheimer’s Disease and Dementia With Lewy Bodies.

    DOI: http://doi.org/10.1016/j.jagp.2022.02.003
    Journal: Am J Geriatr Psychiatry
    E-pub date: 1 Sep 2022
    Authors: PC Donaghy, SJ Cockell, C Martin-Ruiz, J Coxhead, J Kane, D Erskine, D Koss, J-P Taylor, CM Morris, JT O'Brien, AJ Thomas

    MINocyclinE to Reduce inflammation and blood brain barrier leakage in small Vessel diseAse (MINERVA) trial study protocol.

    DOI: http://doi.org/10.1177/23969873221100338
    Journal: Eur Stroke J
    E-pub date: 1 Sep 2022
    Authors: RB Brown, DJ Tozer, L Loubière, YT Hong, TD Fryer, GB Williams, MJ Graves, FI Aigbirhio, JT O'Brien, HS Markus

    The relationship between plasma biomarkers and amyloid PET in dementia with Lewy bodies.

    DOI: http://doi.org/10.1016/j.parkreldis.2022.07.008
    Journal: Parkinsonism Relat Disord
    E-pub date: 31 Aug 2022
    Authors: PC Donaghy, M Firbank, G Petrides, J Lloyd, N Barnett, K Olsen, A Heslegrave, H Zetterberg, AJ Thomas, JT O'Brien

    The promise of amplification assays for accurate early detection of α-synucleinopathies: A review.

    DOI: http://doi.org/10.1016/j.exger.2022.111842
    Journal: Exp Gerontol
    E-pub date: 31 Aug 2022
    Authors: R Kurapova, L Chouliaras, JT O'Brien

    Trazodone and patient outcomes in dementia-Limitations of naturalistic cohort data.

    DOI: http://doi.org/10.1002/gps.5777
    Journal: Int J Geriatr Psychiatry
    E-pub date: 31 Aug 2022
    Authors: E Sidhom, MS Padilla, J Lewis, S White, JT O'Brien, GR Mallucci, BR Underwood

    Gray matter network properties show distinct associations with CSF p-tau 181 levels and amyloid status in individuals without dementia.

    DOI: http://doi.org/10.1016/j.nbas.2022.100054
    Journal: Aging Brain
    E-pub date: 1 Aug 2022
    Authors: L Luigi, I Silvia, W Viktor, AM Wink, HJ Mutsaerts, H Sven, B Kaj, JT O'Brien, FB Giovanni, C Gael, P Pierre, M-L Pablo, W Adam, W Joanna, R Craig, JD Gispert, PJ Visser, S Philip, B Frederik, BM Tijms

    Synaptic loss in behavioural variant frontotemporal dementia revealed by [11C]UCB-J PET

    DOI: http://doi.org/10.1101/2022.01.30.22270123
    Journal:
    E-pub date: 1 Aug 2022
    Authors: M Malpetti, S Jones, T Cope, N Holland, M Naessens, M Rouse, G Savulich, T Fryer, Y Hong, SM Sephton, F Aigbirhio, J O’Brien, J Rowe

    A Longitudinal Study of Plasma pTau181 in Mild Cognitive Impairment with Lewy Bodies and Alzheimer’s Disease.

    DOI: http://doi.org/10.1002/mds.28994
    Journal: Mov Disord
    E-pub date: 1 Jul 2022
    Authors: AJ Thomas, CA Hamilton, A Heslegrave, S Barker, R Durcan, S Lawley, N Barnett, D Lett, M Firbank, G Roberts, J-P Taylor, PC Donaghy, H Zetterberg, J O'Brien

    In Vivo 18F-Flortaucipir PET Does Not Accurately Support the Staging of Progressive Supranuclear Palsy.

    DOI: http://doi.org/10.2967/jnumed.121.262985
    Journal: J Nucl Med
    E-pub date: 1 Jul 2022
    Authors: M Malpetti, SS Kaalund, KA Tsvetanov, T Rittman, M Briggs, KSJ Allinson, L Passamonti, N Holland, PS Jones, TD Fryer, YT Hong, A Kouli, WR Bevan-Jones, E Mak, G Savulich, MG Spillantini, FI Aigbirhio, CH Williams-Gray, JT O'Brien, JB Rowe

    Can early phase cardiac [123I]mIBG images be used to diagnose Lewy body disease?

    DOI: http://doi.org/10.1097/MNM.0000000000001581
    Journal: Nucl Med Commun
    E-pub date: 1 Jul 2022
    Authors: G Roberts, JPM Kane, J Lloyd, M Firbank, PC Donaghy, GS Petrides, J-P Taylor, J O'Brien, AJ Thomas

    Functional and structural brain network correlates of visual hallucinations in Lewy body dementia.

    DOI: http://doi.org/10.1093/brain/awac094
    Journal: Brain
    E-pub date: 30 Jun 2022
    Authors: R Mehraram, LR Peraza, NRE Murphy, RA Cromarty, S Graziadio, JT O'Brien, A Killen, SJ Colloby, M Firbank, L Su, D Collerton, JP Taylor, M Kaiser

    Inflammation in dementia with Lewy bodies.

    DOI: http://doi.org/10.1016/j.nbd.2022.105698
    Journal: Neurobiol Dis
    E-pub date: 15 Jun 2022
    Authors: J Amin, D Erskine, PC Donaghy, A Surendranathan, P Swann, AP Kunicki, D Boche, C Holmes, IG McKeith, JT O'Brien, JL Teeling, AJ Thomas

    Cholinergic white matter pathways in dementia with Lewy bodies and Alzheimer’s disease.

    DOI: http://doi.org/10.1093/brain/awab372
    Journal: Brain
    E-pub date: 3 Jun 2022
    Authors: J Schumacher, NJ Ray, CA Hamilton, PC Donaghy, M Firbank, G Roberts, L Allan, R Durcan, N Barnett, JT O'Brien, J-P Taylor, AJ Thomas

    Gait-Related Metabolic Covariance Networks at Rest in Parkinson’s Disease.

    DOI: http://doi.org/10.1002/mds.28977
    Journal: Mov Disord
    E-pub date: 1 Jun 2022
    Authors: HP Sigurdsson, AJ Yarnall, B Galna, S Lord, L Alcock, RA Lawson, SJ Colloby, MJ Firbank, J-P Taylor, N Pavese, DJ Brooks, JT O'Brien, DJ Burn, L Rochester

    Olfactory impairment in mild cognitive impairment with Lewy bodies and Alzheimer’s disease.

    DOI: http://doi.org/10.1017/S1041610221001265
    Journal: Int Psychogeriatr
    E-pub date: 1 Jun 2022
    Authors: AJ Thomas, CA Hamilton, S Barker, R Durcan, S Lawley, N Barnett, M Firbank, G Roberts, LM Allan, J O'Brien, J-P Taylor, PC Donaghy

    Spatial covariance analysis of FDG-PET and HMPAO-SPECT for the differential diagnosis of dementia with Lewy bodies and Alzheimer’s disease.

    DOI: http://doi.org/10.1016/j.pscychresns.2022.111460
    Journal: Psychiatry Res Neuroimaging
    E-pub date: 1 Jun 2022
    Authors: M Ingram, SJ Colloby, MJ Firbank, JJ Lloyd, JT O'Brien, J-P Taylor

    A synergistic core for human brain evolution and cognition.

    DOI: http://doi.org/10.1038/s41593-022-01070-0
    Journal: Nat Neurosci
    E-pub date: 1 Jun 2022
    Authors: AI Luppi, PAM Mediano, FE Rosas, N Holland, TD Fryer, JT O'Brien, JB Rowe, DK Menon, D Bor, EA Stamatakis

    CAIDE dementia risk score relates to severity and progression of cerebral small vessel disease in healthy midlife adults: the PREVENT-Dementia study.

    DOI: http://doi.org/10.1136/jnnp-2021-327462
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 May 2022
    Authors: A Low, MA Prats-Sedano, JD Stefaniak, EF McKiernan, SF Carter, M-E Douvani, E Mak, L Su, O Stupart, G Muniz, K Ritchie, CW Ritchie, HS Markus, JT O'Brien

    Blood pressure and heart rate responses to orthostatic challenge and Valsalva manoeuvre in mild cognitive impairment with Lewy bodies.

    DOI: http://doi.org/10.1002/gps.5709
    Journal: Int J Geriatr Psychiatry
    E-pub date: 2 Apr 2022
    Authors: CA Hamilton, J Frith, PC Donaghy, SAH Barker, R Durcan, S Lawley, N Barnett, M Firbank, G Roberts, J-P Taylor, LM Allan, J O'Brien, AJ Yarnall, AJ Thomas

    The influence of cerebrovascular disease in dementia with Lewy bodies and Parkinson’s disease dementia.

    DOI: http://doi.org/10.1111/ene.15211
    Journal: Eur J Neurol
    E-pub date: 1 Apr 2022
    Authors: Z Hijazi, N Yassi, JT O'Brien, R Watson

    Assessment of autonomic symptoms may assist with early identification of mild cognitive impairment with Lewy bodies.

    DOI: http://doi.org/10.1002/gps.5703
    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Apr 2022
    Authors: CA Hamilton, J Frith, PC Donaghy, SAH Barker, R Durcan, S Lawley, N Barnett, M Firbank, G Roberts, J-P Taylor, LM Allan, J O'Brien, AJ Yarnall, AJ Thomas

    Mild cognitive impairment with Lewy bodies: neuropsychiatric supportive symptoms and cognitive profile.

    DOI: http://doi.org/10.1017/S0033291720002901
    Journal: Psychol Med
    E-pub date: 1 Apr 2022
    Authors: PC Donaghy, J Ciafone, R Durcan, CA Hamilton, S Barker, J Lloyd, M Firbank, LM Allan, JT O'Brien, J-P Taylor, AJ Thomas

    Molecular pathology and synaptic loss in primary tauopathies: A [18F]AV-1451 and [11C]UCB-J PET study

    DOI: http://doi.org/10.1093/brain/awab282
    Journal: Brain
    E-pub date: 29 Mar 2022
    Authors: N Holland, M Malpetti, T Rittman, E Mak, L Passamonti, S Kaalund, F Hezemans, P Jones, G Savulich, Y Hong, T Fryer, F Aigbirhio, J O'Brien, J Rowe

    Targeting the Unfolded Protein Response as a Disease-Modifying Pathway in Dementia

    DOI: http://doi.org/10.3390/ijms23042021
    Journal: International Journal of Molecular Sciences
    E-pub date: 11 Feb 2022
    Authors: E Sidhom, JT O’Brien, AJ Butcher, HL Smith, GR Mallucci, BR Underwood

    A report from the NIHR UK working group on remote trial delivery for the COVID-19 pandemic and beyond.

    DOI: http://doi.org/10.1186/s13063-021-05880-8
    Journal: Trials
    E-pub date: 11 Dec 2021
    Authors: JAH Masoli, K Down, G Nestor, S Hudson, JT O'Brien, JD Williamson, CA Young, C Carroll, NIHR Remote Trial Delivery Working Group

    Slowing on quantitative EEG is associated with transition to dementia in mild cognitive impairment.

    DOI: http://doi.org/10.1017/S1041610221001083
    Journal: Int Psychogeriatr
    E-pub date: 1 Dec 2021
    Authors: CA Hamilton, J Schumacher, F Matthews, J-P Taylor, L Allan, N Barnett, RA Cromarty, PC Donaghy, R Durcan, M Firbank, S Lawley, JT O'Brien, G Roberts, AJ Thomas

    Functional connectivity in mild cognitive impairment with Lewy bodies.

    DOI: http://doi.org/10.1007/s00415-021-10580-z
    Journal: J Neurol
    E-pub date: 1 Dec 2021
    Authors: J Schumacher, J-P Taylor, CA Hamilton, M Firbank, PC Donaghy, G Roberts, L Allan, R Durcan, N Barnett, JT O'Brien, AJ Thomas

    Microglial activation and atrophy in frontal cortex predict executive dysfunction in frontotemporal dementia

    DOI: http://doi.org/10.1002/alz.055456
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2021
    Authors: M Malpetti, PS Jones, FH Hezemans, E Mak, D Street, L Passamonti, T Rittman, TE Cope, WR Bevan‐Jones, K Patterson, TD Fryer, YT Hong, FI Aigbirho, JT O'Brien, JB Rowe

    A role for epigenetic mechanisms in Lewy body dementias

    DOI: http://doi.org/10.1002/alz.051637
    Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association
    E-pub date: 1 Dec 2021
    Authors: JL Imm, J Harvey, E Pishva, B Creese, L Chouliaras, E Dempster, C Ballard, JT O'Brien, D Aarsland, J Mill, K Lunnon

    Evidence of cerebral hemodynamic dysregulation in middle-aged APOE ε4 carriers: The PREVENT-Dementia study.

    DOI: http://doi.org/10.1177/0271678X211020863
    Journal: J Cereb Blood Flow Metab
    E-pub date: 1 Nov 2021
    Authors: M-E Dounavi, A Low, EF McKiernan, E Mak, G Muniz-Terrera, K Ritchie, CW Ritchie, L Su, JT O'Brien

    Prospective predictors of decline v. stability in mild cognitive impairment with Lewy bodies or Alzheimer’s disease.

    DOI: http://doi.org/10.1017/S0033291720001130
    Journal: Psychol Med
    E-pub date: 1 Nov 2021
    Authors: CA Hamilton, FE Matthews, PC Donaghy, J-P Taylor, JT O'Brien, N Barnett, K Olsen, IG McKeith, AJ Thomas

    The use of PET/MRI in Dementia: A Literature Review

    DOI: http://doi.org/10.1002/gps.5586
    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Oct 2021
    Authors: N Lorking, AD Murray, J O'Brien

    Altered structural connectivity networks in dementia with lewy bodies.

    DOI: http://doi.org/10.1007/s11682-020-00444-x
    Journal: Brain Imaging Behav
    E-pub date: 1 Oct 2021
    Authors: N Nicastro, E Mak, A Surendranathan, T Rittman, JB Rowe, JT O'Brien

    Authors’ response.

    DOI: http://doi.org/10.1192/bjp.2021.72
    Journal: Br J Psychiatry
    E-pub date: 1 Sep 2021
    Authors: G Roberts, J-P Taylor, J O'Brien, AJ Thomas

    Utility of the pareidolia test in mild cognitive impairment with Lewy bodies and Alzheimer’s disease.

    DOI: http://doi.org/10.1002/gps.5546
    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Sep 2021
    Authors: CA Hamilton, FE Matthews, LM Allan, S Barker, J Ciafone, PC Donaghy, R Durcan, MJ Firbank, S Lawley, JT O'Brien, G Roberts, J-P Taylor, AJ Thomas

    Spatial Covariance of Cholinergic Muscarinic M1 /M4 Receptors in Parkinson’s Disease.

    DOI: http://doi.org/10.1002/mds.28564
    Journal: Mov Disord
    E-pub date: 31 Aug 2021
    Authors: SJ Colloby, PJ Nathan, G Bakker, RA Lawson, AJ Yarnall, DJ Burn, JT O'Brien, J-P Taylor

    The functional brain favours segregated modular connectivity at old age unless affected by neurodegeneration.

    DOI: http://doi.org/10.1038/s42003-021-02497-0
    Journal: Commun Biol
    E-pub date: 16 Aug 2021
    Authors: X Chen, J Necus, LR Peraza, R Mehraram, Y Wang, JT O'Brien, A Blamire, M Kaiser, J-P Taylor

    WHOLE HIPPOCAMPAL VOLUMES AND HIPPOCAMPAL SUBFIELD VOLUMES IN MCI-LB AND MCI-AD

    DOI: http://doi.org/10.1093/ageing/afab219.157
    Journal: AGE AND AGEING
    E-pub date: 1 Aug 2021
    Authors: R Durcan, SJ Colloby, PC Donaghy, S Lawley, J-P Taylor, JT O'Brien, AJ Thomas

    In vivo nucleus basalis of Meynert degeneration in mild cognitive impairment with Lewy bodies.

    DOI: http://doi.org/10.1016/j.nicl.2021.102604
    Journal: Neuroimage Clin
    E-pub date: 1 Aug 2021
    Authors: J Schumacher, J-P Taylor, CA Hamilton, M Firbank, RA Cromarty, PC Donaghy, G Roberts, L Allan, J Lloyd, R Durcan, N Barnett, JT O'Brien, AJ Thomas

    Impaired sensory evidence accumulation and network function in Lewy body dementia.

    DOI: http://doi.org/10.1093/braincomms/fcab089
    Journal: Brain Commun
    E-pub date: 1 Aug 2021
    Authors: C O'Callaghan, M Firbank, A Tomassini, J Schumacher, JT O'Brien, J-P Taylor

    [18F]-AV-1451 binding in the substantia nigra as a marker of neuromelanin in Lewy body diseases.

    DOI: http://doi.org/10.1093/braincomms/fcab177
    Journal: Brain Commun
    E-pub date: 1 Aug 2021
    Authors: E Mak, A Kouli, N Holland, N Nicastro, G Savulich, A Surendranathan, M Malpetti, R Manavaki, YT Hong, TD Fryer, F Aigbirhio, JB Rowe, JT O'Brien, CH Williams-Gray

    Deep learning-based automated speech detection as a marker of social functioning in late-life depression.

    DOI: http://doi.org/10.1017/S0033291719003994
    Journal: Psychol Med
    E-pub date: 1 Jul 2021
    Authors: B Little, O Alshabrawy, D Stow, IN Ferrier, R McNaney, DG Jackson, K Ladha, C Ladha, T Ploetz, J Bacardit, P Olivier, P Gallagher, JT O'Brien

    Synaptic density in carriers of C9orf72 mutations: a [11 C]UCB-J PET study.

    DOI: http://doi.org/10.1002/acn3.51407
    Journal: Ann Clin Transl Neurol
    E-pub date: 1 Jul 2021
    Authors: M Malpetti, N Holland, PS Jones, R Ye, TE Cope, TD Fryer, YT Hong, G Savulich, T Rittman, L Passamonti, E Mak, FI Aigbirhio, JT O'Brien, JB Rowe

    Neuroinflammation predicts disease progression in progressive supranuclear palsy.

    DOI: http://doi.org/10.1136/jnnp-2020-325549
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jul 2021
    Authors: M Malpetti, L Passamonti, PS Jones, D Street, T Rittman, TD Fryer, YT Hong, P Vàsquez Rodriguez, WR Bevan-Jones, FI Aigbirhio, JT O'Brien, JB Rowe

    Microglial activation and blood-brain barrier permeability in cerebral small vessel disease.

    DOI: http://doi.org/10.1093/brain/awab003
    Journal: Brain
    E-pub date: 22 Jun 2021
    Authors: J Walsh, DJ Tozer, H Sari, YT Hong, A Drazyk, G Williams, NJ Shah, JT O'Brien, FI Aigbirhio, G Rosenberg, TD Fryer, HS Markus

    Accuracy of Cardiac Innervation Scintigraphy for Mild Cognitive Impairment With Lewy Bodies.

    DOI: http://doi.org/10.1212/WNL.0000000000012060
    Journal: Neurology
    E-pub date: 8 Jun 2021
    Authors: G Roberts, R Durcan, PC Donaghy, S Lawley, J Ciafone, CA Hamilton, SJ Colloby, MJ Firbank, L Allan, N Barnett, S Barker, K Howe, T Ali, GS Petrides, J Lloyd, J-P Taylor, J O'Brien, AJ Thomas

    Progression to Dementia in Mild Cognitive Impairment With Lewy Bodies or Alzheimer Disease.

    DOI: http://doi.org/10.1212/WNL.0000000000012024
    Journal: Neurology
    E-pub date: 31 May 2021
    Authors: CA Hamilton, FE Matthews, PC Donaghy, J-P Taylor, JT O'Brien, N Barnett, K Olsen, R Durcan, G Roberts, J Ciafone, SAH Barker, M Firbank, IG McKeith, AJ Thomas

    The effectiveness and cost-effectiveness of assistive technology and telecare for independent living in dementia: a randomised controlled trial.

    DOI: http://doi.org/10.1093/ageing/afaa284
    Journal: Age Ageing
    E-pub date: 5 May 2021
    Authors: R Howard, R Gathercole, R Bradley, E Harper, L Davis, L Pank, N Lam, E Talbot, E Hooper, R Winson, B Scutt, V Ordonez Montano, S Nunn, G Lavelle, A Bateman, P Bentham, A Burns, B Dunk, K Forsyth, C Fox, F Poland, I Leroi, S Newman, J O'Brien, C Henderson, M Knapp, J Woolham, R Gray

    In vivo coupling of dendritic complexity with presynaptic density in primary tauopathies.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2021.01.016
    Journal: Neurobiol Aging
    E-pub date: 1 May 2021
    Authors: E Mak, N Holland, PS Jones, G Savulich, A Low, M Malpetti, SS Kaalund, L Passamonti, T Rittman, R Romero-Garcia, R Manavaki, GB Williams, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Hippocampal and insula volume in mild cognitive impairment with Lewy bodies.

    DOI: http://doi.org/10.1016/j.parkreldis.2021.03.011
    Journal: Parkinsonism Relat Disord
    E-pub date: 1 May 2021
    Authors: MJ Firbank, R Durcan, JT O'Brien, LM Allan, S Barker, J Ciafone, PC Donaghy, CA Hamilton, S Lawley, G Roberts, J-P Taylor, AJ Thomas

    Higher midlife CAIDE score is associated with increased brain atrophy in a cohort of cognitively healthy middle-aged individuals.

    DOI: http://doi.org/10.1007/s00415-020-10383-8
    Journal: J Neurol
    E-pub date: 1 May 2021
    Authors: X Liu, M-E Dounavi, K Ritchie, K Wells, CW Ritchie, L Su, G Muniz-Terrera, JT O'Brien

    Accuracy of dopaminergic imaging as a biomarker for mild cognitive impairment with Lewy bodies.

    DOI: http://doi.org/10.1192/bjp.2020.234
    Journal: Br J Psychiatry
    E-pub date: 1 May 2021
    Authors: G Roberts, PC Donaghy, J Lloyd, R Durcan, G Petrides, SJ Colloby, S Lawley, J Ciafone, CA Hamilton, M Firbank, L Allan, N Barnett, S Barker, K Olsen, K Howe, T Ali, J-P Taylor, J O'Brien, AJ Thomas

    Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2020.11.006
    Journal: Neurobiol Aging
    E-pub date: 1 May 2021
    Authors: E Mak, N Nicastro, M Malpetti, G Savulich, A Surendranathan, N Holland, L Passamonti, PS Jones, SF Carter, L Su, YT Hong, TD Fryer, GB Williams, F Aigbirhio, JB Rowe, JT O'Brien

    Mild cognitive impairment with Lewy bodies: blood perfusion with arterial spin labelling.

    DOI: http://doi.org/10.1007/s00415-020-10271-1
    Journal: J Neurol
    E-pub date: 1 Apr 2021
    Authors: MJ Firbank, JT O'Brien, R Durcan, LM Allan, S Barker, J Ciafone, PC Donaghy, CA Hamilton, S Lawley, J Lloyd, G Roberts, J-P Taylor, AJ Thomas

    Proximity to dementia onset and multi-modal neuroimaging changes: The prevent-dementia study.

    DOI: http://doi.org/10.1016/j.neuroimage.2021.117749
    Journal: Neuroimage
    E-pub date: 1 Apr 2021
    Authors: E Mak, M-E Dounavi, A Low, SF Carter, E McKiernan, GB Williams, PS Jones, I Carriere, GT Muniz, K Ritchie, C Ritchie, L Su, JT O'Brien

    Cholinergic Basal Forebrain Volumes Predict Gait Decline in Parkinson’s Disease.

    DOI: http://doi.org/10.1002/mds.28453
    Journal: Mov Disord
    E-pub date: 1 Mar 2021
    Authors: J Wilson, AJ Yarnall, CE Craig, B Galna, S Lord, R Morris, RA Lawson, L Alcock, GW Duncan, TK Khoo, JT O'Brien, DJ Burn, J-P Taylor, NJ Ray, L Rochester

    Cognitive Decline in Mild Cognitive Impairment With Lewy Bodies or Alzheimer Disease: A Prospective Cohort Study.

    DOI: http://doi.org/10.1016/j.jagp.2020.07.018
    Journal: Am J Geriatr Psychiatry
    E-pub date: 1 Mar 2021
    Authors: CA Hamilton, FE Matthews, PC Donaghy, J-P Taylor, JT O'Brien, N Barnett, K Olsen, J Lloyd, G Petrides, IG McKeith, AJ Thomas

    In vivo PET imaging of neuroinflammation in familial frontotemporal dementia.

    DOI: http://doi.org/10.1136/jnnp-2020-323698
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Mar 2021
    Authors: M Malpetti, T Rittman, PS Jones, TE Cope, L Passamonti, WR Bevan-Jones, K Patterson, TD Fryer, YT Hong, FI Aigbirhio, JT O'Brien, JB Rowe

    Relationship between tau, neuroinflammation and atrophy in Alzheimer’s disease: The NIMROD study

    DOI: http://doi.org/10.1016/j.inffus.2020.10.006
    Journal: Information Fusion
    E-pub date: 1 Mar 2021
    Authors: L Su, A Surendranathan, Y Huang, WR Bevan-Jones, L Passamonti, YT Hong, R Arnold, PV Rodríguez, Y Wang, E Mak, TD Fryer, F Aigbirhio, JB Rowe, JT O'Brien

    Introduction of an assessment toolkit associated with increased rate of DLB diagnosis.

    DOI: http://doi.org/10.1186/s13195-021-00786-8
    Journal: Alzheimers Res Ther
    E-pub date: 19 Feb 2021
    Authors: A Surendranathan, J Kane, A Bentley, S Barker, R McNally, C Bamford, J-P Taylor, A Thomas, I McKeith, D Burn, JT O'Brien

    Inherited risk of dementia and the progression of cerebral small vessel disease and inflammatory markers in cognitively healthy midlife adults: the PREVENT-Dementia study.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2020.10.029
    Journal: Neurobiol Aging
    E-pub date: 1 Feb 2021
    Authors: A Low, L Su, JD Stefaniak, E Mak, M-E Dounavi, G Muniz-Terrera, K Ritchie, CW Ritchie, HS Markus, JT O'Brien

    Mild cognitive impairment: the Manchester consensus.

    DOI: http://doi.org/10.1093/ageing/afaa228
    Journal: Age Ageing
    E-pub date: 8 Jan 2021
    Authors: RA Dunne, D Aarsland, JT O'Brien, C Ballard, S Banerjee, NC Fox, JD Isaacs, BR Underwood, RJ Perry, D Chan, T Dening, AJ Thomas, J Schryer, A-M Jones, AR Evans, C Alessi, EJ Coulthard, J Pickett, P Elton, RW Jones, S Mitchell, N Hooper, C Kalafatis, JGC Rasmussen, H Martin, JM Schott, A Burns

    Functional connectivity of the nucleus basalis of Meynert in Lewy body dementia and Alzheimer’s disease.

    DOI: http://doi.org/10.1017/S1041610220003944
    Journal: Int Psychogeriatr
    E-pub date: 1 Jan 2021
    Authors: J Schumacher, AJ Thomas, LR Peraza, M Firbank, JT O'Brien, J-P Taylor

    Introduction of a Management Toolkit for Lewy Body Dementia: A Pilot Cluster-Randomized Trial.

    DOI: http://doi.org/10.1002/mds.28282
    Journal: Mov Disord
    E-pub date: 1 Jan 2021
    Authors: JT O'Brien, IG McKeith, AJ Thomas, C Bamford, L Vale, S Hill, L Allan, T Finch, R McNally, L Hayes, A Surendranathan, JPM Kane, S Dunn, A Bentley, S Barker, J Mason, D Burn, J-P Taylor

    The challenges of COVID-19 for people with dementia with Lewy bodies and family caregivers.

    DOI: http://doi.org/10.1002/gps.5393
    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Dec 2020
    Authors: A Killen, K Olsen, IG McKeith, AJ Thomas, JT O'Brien, P Donaghy, J-P Taylor

    Drug repositioning and repurposing for Alzheimer disease.

    DOI: http://doi.org/10.1038/s41582-020-0397-4
    Journal: Nat Rev Neurol
    E-pub date: 1 Dec 2020
    Authors: C Ballard, D Aarsland, J Cummings, J O'Brien, R Mills, JL Molinuevo, T Fladby, G Williams, P Doherty, A Corbett, J Sultana

    A cross‐cohort cognitive composite for tracking changes in pre‐clinical and prodromal Alzheimer’s disease

    DOI: http://doi.org/10.1002/alz.037928
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2020
    Authors: J Giorgio, A Tanna, WJ Jagust, SL Baker, SM Landau, T Tanaka, CP Chen, A Reilhac, M Malpetti, JB Rowe, JT O'Brien, Z Kourtzi

    Multimodal imaging markers of tau, neuroinflammation and atrophy to predict clinical progression in progressive supranuclear palsy

    DOI: http://doi.org/10.1002/alz.044724
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2020
    Authors: M Malpetti, L Passamonti, PS Jones, T Rittman, TD Fryer, YT Hong, D Street, PV Rodríguez, WR Bevan‐Jones, FI Aigbirhio, JT O'Brien, JB Rowe

    The prognostic role of microglia and tau PET in Alzheimer’s disease

    DOI: http://doi.org/10.1002/alz.039817
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2020
    Authors: M Malpetti, RA Kievit, L Passamonti, PS Jones, KA Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan‐Jones, L Su, YT Hong, TD Fryer, FI Aigbirho, JT O'Brien, JB Rowe

    Neuroinflammation and Tau Colocalize in vivo in Progressive Supranuclear Palsy.

    DOI: http://doi.org/10.1002/ana.25911
    Journal: Ann Neurol
    E-pub date: 1 Dec 2020
    Authors: M Malpetti, L Passamonti, T Rittman, PS Jones, P Vázquez Rodríguez, WR Bevan-Jones, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Hallucinations in Older Adults: A Practical Review.

    DOI: http://doi.org/10.1093/schbul/sbaa073
    Journal: Schizophr Bull
    E-pub date: 1 Dec 2020
    Authors: JC Badcock, F Larøi, K Kamp, I Kelsall-Foreman, RS Bucks, M Weinborn, M Begemann, J-P Taylor, D Collerton, JT O'Brien, M El Haj, D Ffytche, IE Sommer

    Ensuring that COVID-19 research is inclusive: guidance from the NIHR INCLUDE project.

    DOI: http://doi.org/10.1136/bmjopen-2020-043634
    Journal: BMJ Open
    E-pub date: 5 Nov 2020
    Authors: MD Witham, E Anderson, CB Carroll, PM Dark, K Down, AS Hall, J Knee, ER Maher, RH Maier, GA Mountain, G Nestor, JT O'Brien, L Oliva, J Wason, L Rochester, NIHR CRN INCLUDE Steering Group

    Distinguishing between Dementia with Lewy Bodies (DLB) and Alzheimer’s Disease (AD) using Mental Health Records: a Classification Approach

    DOI: http://doi.org/10.18653/v1/2020.clinicalnlp-1.19
    Journal: Clinical NLP 2020
    E-pub date: 1 Nov 2020
    Authors: Z Wang, J Ive, S Moylett, C Mueller, RN Cardinal, S Velupillai, J O'Brien, R Stewart

    Research with older people in a world with COVID-19: identification of current and future priorities, challenges and opportunities.

    DOI: http://doi.org/10.1093/ageing/afaa149
    Journal: Age Ageing
    E-pub date: 23 Oct 2020
    Authors: SJ Richardson, CB Carroll, J Close, AL Gordon, J O'Brien, TJ Quinn, L Rochester, AA Sayer, SD Shenkin, N van der Velde, J Woo, MD Witham

    Trauma and depressive symptomatology in middle-aged persons at high risk of dementia: the PREVENT Dementia Study.

    DOI: http://doi.org/10.1136/jnnp-2020-323823
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 21 Oct 2020
    Authors: K Ritchie, I Carrière, S Gregory, T Watermeyer, S Danso, L Su, CW Ritchie, JT O'Brien

    Prospective longitudinal evaluation of cytokines in mild cognitive impairment due to AD and Lewy body disease.

    DOI: http://doi.org/10.1002/gps.5365
    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Oct 2020
    Authors: AJ Thomas, CA Hamilton, PC Donaghy, C Martin-Ruiz, CM Morris, N Barnett, K Olsen, J-P Taylor, JT O'Brien

    Synaptic Loss in Primary Tauopathies Revealed by [11 C]UCB-J Positron Emission Tomography.

    DOI: http://doi.org/10.1002/mds.28188
    Journal: Mov Disord
    E-pub date: 1 Oct 2020
    Authors: N Holland, PS Jones, G Savulich, JK Wiggins, YT Hong, TD Fryer, R Manavaki, SM Sephton, I Boros, M Malpetti, FH Hezemans, FI Aigbirhio, JP Coles, J O'Brien, JB Rowe

    Gray matter changes related to microglial activation in Alzheimer’s disease.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2020.06.010
    Journal: Neurobiol Aging
    E-pub date: 1 Oct 2020
    Authors: N Nicastro, M Malpetti, E Mak, GB Williams, WR Bevan-Jones, SF Carter, L Passamonti, TD Fryer, YT Hong, FI Aigbirhio, JB Rowe, JT O'Brien

    In vivo neuroinflammation and cerebral small vessel disease in mild cognitive impairment and Alzheimer’s disease.

    DOI: http://doi.org/10.1136/jnnp-2020-323894
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 11 Sep 2020
    Authors: A Low, E Mak, M Malpetti, L Passamonti, N Nicastro, JD Stefaniak, G Savulich, L Chouliaras, L Su, JB Rowe, HS Markus, JT O'Brien

    Diffusion imaging in dementia with Lewy bodies: Associations with amyloid burden, atrophy, vascular factors and clinical features.

    DOI: http://doi.org/10.1016/j.parkreldis.2020.07.025
    Journal: Parkinsonism Relat Disord
    E-pub date: 1 Sep 2020
    Authors: PC Donaghy, M Firbank, G Petrides, J Lloyd, N Barnett, K Olsen, AJ Thomas, JT O'Brien

    Epigenetic regulation in the pathophysiology of Lewy body dementia.

    DOI: http://doi.org/10.1016/j.pneurobio.2020.101822
    Journal: Prog Neurobiol
    E-pub date: 1 Sep 2020
    Authors: L Chouliaras, GS Kumar, AJ Thomas, K Lunnon, PF Chinnery, JT O'Brien

    Peak Width of Skeletonized Mean Diffusivity as a Marker of Diffuse Cerebrovascular Damage.

    DOI: http://doi.org/10.3389/fnins.2020.00238
    Journal: Front Neurosci
    E-pub date: 1 Aug 2020
    Authors: A Low, E Mak, JD Stefaniak, M Malpetti, N Nicastro, G Savulich, L Chouliaras, HS Markus, JB Rowe, JT O'Brien

    Cholinergic muscarinic M1/M4 receptor networks in dementia with Lewy bodies.

    DOI: http://doi.org/10.1093/braincomms/fcaa098
    Journal: Brain Commun
    E-pub date: 1 Aug 2020
    Authors: SJ Colloby, PJ Nathan, IG McKeith, G Bakker, JT O'Brien, J-P Taylor

    The impact of assistive technology on burden and psychological well-being in informal caregivers of people with dementia (ATTILA Study).

    DOI: http://doi.org/10.1002/trc2.12064
    Journal: Alzheimers Dement (N Y)
    E-pub date: 1 Aug 2020
    Authors: A Davies, S Brini, S Hirani, R Gathercole, K Forsyth, C Henderson, R Bradley, L Davies, B Dunk, E Harper, N Lam, L Pank, I Leroi, J Woolham, C Fox, J O'Brien, A Bateman, F Poland, P Bentham, A Burns, R Gray, M Knapp, E Talbot, E Hooper, R Winson, B Scutt, V Ordonez, S Nunn, G Lavelle, R Howard, S Newman

    Hippocampal Subfield Volumes in Middle-Aged Adults at Risk of Dementia.

    DOI: http://doi.org/10.3233/JAD-200238
    Journal: J Alzheimers Dis
    E-pub date: 1 Aug 2020
    Authors: A McKeever, AF Paris, J Cullen, L Hayes, CW Ritchie, K Ritchie, AD Waldman, K Wells, A Busza, I Carriere, JT O'Brien, L Su

    Competencies and training of radiographers and technologists for PET/MR imaging – a study from the UK MR-PET network.

    DOI: http://doi.org/10.1186/s41824-019-0070-6
    Journal: Eur J Hybrid Imaging
    E-pub date: 1 Aug 2020
    Authors: MO Mada, P Hindmarch, J Stirling, J Davies, D Brian, A Barnes, A Hammers, N Gulliver, K Herholz, J O'Brien, J-P Taylor

    Cortical Complexity Analyses and Their Cognitive Correlate in Alzheimer’s Disease and Frontotemporal Dementia.

    DOI: http://doi.org/10.3233/JAD-200246
    Journal: J Alzheimers Dis
    E-pub date: 1 Aug 2020
    Authors: N Nicastro, M Malpetti, TE Cope, WR Bevan-Jones, E Mak, L Passamonti, JB Rowe, JT O'Brien

    Neuroinflammation predicts disease progression in progressive supranuclear palsy

    DOI: http://doi.org/10.1101/2020.05.19.20106393
    Journal:
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    Authors: M Malpetti, L Passamonti, S Jones, D Street, T Rittman, T Fryer, Y Hong, P Vasquez-Rodriguez, WR Bevan-Jones, F Aigbirhio, J O'Brien, J Rowe

    In vivo PET imaging of neuroinflammation in familial frontotemporal dementia

    DOI: http://doi.org/10.1101/2020.05.11.20098046
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    Authors: M Malpetti, T Rittman, S Jones, T Cope, L Passamonti, R Bevan-Jones, K Patterson, T Fryer, Y Hong, F Aigbirhio, J O’Brien, J Rowe

    Synaptic loss in primary tauopathies revealed by [11C]UCB-J positron emission tomography

    DOI: http://doi.org/10.1101/2020.01.24.20018697
    Journal:
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    Authors: N Holland, S Jones, G Savulich, J Wiggins, Y Hong, T Fryer, R Manavaki, SM Sephton, I Boros, M Malpetti, F Hezemans, F Aigbirhio, J Coles, J O’Brien, J Rowe

    In vivo coupling of dendritic complexity with presynaptic density in primary tauopathies

    DOI: http://doi.org/10.1101/2020.12.24.20248838
    Journal:
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    Authors: E Mak, N Holland, S Jones, G Savulich, A Low, M Malpetti, S Kaalund, L Passamonti, T Rittman, R Romero-Garcia, R Manavaki, G Williams, Y Hong, T Fryer, F Aigbirhio, J O’Brien, J Rowe

    A synergistic core for human brain evolution and cognition

    DOI: http://doi.org/10.1101/2020.09.22.308981
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    Authors: A Luppi, PAM Mediano, F Rosas, N Holland, T Fryer, J O’Brien, J Rowe, D Menon, D Bor, E Stamatakis

    11C-UCB-J synaptic PET and multimodal imaging in dementia with Lewy bodies.

    DOI: http://doi.org/10.1186/s41824-020-00093-9
    Journal: Eur J Hybrid Imaging
    E-pub date: 1 Aug 2020
    Authors: N Nicastro, N Holland, G Savulich, SF Carter, E Mak, YT Hong, S Milicevic Sephton, TD Fryer, FI Aigbirhio, JB Rowe, JT O'Brien

    Correlation of microglial activation with white matter changes in dementia with Lewy bodies.

    DOI: http://doi.org/10.1016/j.nicl.2020.102200
    Journal: Neuroimage Clin
    E-pub date: 1 Aug 2020
    Authors: N Nicastro, E Mak, GB Williams, A Surendranathan, WR Bevan-Jones, L Passamonti, P Vàzquez Rodrìguez, L Su, R Arnold, TD Fryer, YT Hong, FI Aigbirhio, JB Rowe, JT O'Brien

    Quantitative EEG as a biomarker in mild cognitive impairment with Lewy bodies.

    DOI: http://doi.org/10.1186/s13195-020-00650-1
    Journal: Alzheimers Res Ther
    E-pub date: 8 Jul 2020
    Authors: J Schumacher, J-P Taylor, CA Hamilton, M Firbank, RA Cromarty, PC Donaghy, G Roberts, L Allan, J Lloyd, R Durcan, N Barnett, JT O'Brien, AJ Thomas

    The application of stratified medicine to dementia care

    DOI: http://doi.org/10.1192/bja.2020.28
    Journal: BJPsych Advances
    E-pub date: 1 Jul 2020
    Authors: E Sidhom, J O'Brien, BR Underwood

    Clinical diagnosis of Lewy body dementia.

    DOI: http://doi.org/10.1192/bjo.2020.44
    Journal: BJPsych Open
    E-pub date: 16 Jun 2020
    Authors: A Surendranathan, JPM Kane, A Bentley, SAH Barker, J-P Taylor, AJ Thomas, LM Allan, RJ McNally, PW James, IG McKeith, DJ Burn, JT O'Brien

    Cortical thinning in dementia with Lewy bodies and Parkinson disease dementia.

    DOI: http://doi.org/10.1177/0004867419885165
    Journal: Aust N Z J Psychiatry
    E-pub date: 1 Jun 2020
    Authors: SJ Colloby, R Watson, AM Blamire, JT O'Brien, J-P Taylor

    Microbleeds in dementia with Lewy bodies.

    DOI: http://doi.org/10.1007/s00415-020-09736-0
    Journal: J Neurol
    E-pub date: 1 May 2020
    Authors: PC Donaghy, M Firbank, D Mitra, G Petrides, J Lloyd, N Barnett, K Olsen, AJ Thomas, JT O'Brien

    Amyloid Imaging and Longitudinal Clinical Progression in Dementia With Lewy Bodies.

    DOI: http://doi.org/10.1016/j.jagp.2019.12.009
    Journal: Am J Geriatr Psychiatry
    E-pub date: 1 May 2020
    Authors: PC Donaghy, MJ Firbank, AJ Thomas, J Lloyd, G Petrides, N Barnett, K Olsen, JT O'Brien

    Microglial activation and tau burden predict cognitive decline in Alzheimer’s disease.

    DOI: http://doi.org/10.1093/brain/awaa088
    Journal: Brain
    E-pub date: 1 May 2020
    Authors: M Malpetti, RA Kievit, L Passamonti, PS Jones, KA Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Research criteria for the diagnosis of prodromal dementia with Lewy bodies.

    DOI: http://doi.org/10.1212/WNL.0000000000009323
    Journal: Neurology
    E-pub date: 28 Apr 2020
    Authors: IG McKeith, TJ Ferman, AJ Thomas, F Blanc, BF Boeve, H Fujishiro, K Kantarci, C Muscio, JT O'Brien, RB Postuma, D Aarsland, C Ballard, L Bonanni, P Donaghy, M Emre, JE Galvin, D Galasko, JG Goldman, SN Gomperts, LS Honig, M Ikeda, JB Leverenz, SJG Lewis, KS Marder, M Masellis, DP Salmon, JP Taylor, DW Tsuang, Z Walker, P Tiraboschi, prodromal DLB Diagnostic Study Group

    EEG alpha reactivity and cholinergic system integrity in Lewy body dementia and Alzheimer’s disease.

    DOI: http://doi.org/10.1186/s13195-020-00613-6
    Journal: Alzheimers Res Ther
    E-pub date: 22 Apr 2020
    Authors: J Schumacher, AJ Thomas, LR Peraza, M Firbank, R Cromarty, CA Hamilton, PC Donaghy, JT O'Brien, J-P Taylor

    18F-AV1451 PET imaging and multimodal MRI changes in progressive supranuclear palsy.

    DOI: http://doi.org/10.1007/s00415-019-09566-9
    Journal: J Neurol
    E-pub date: 1 Feb 2020
    Authors: N Nicastro, PV Rodriguez, M Malpetti, WR Bevan-Jones, P Simon Jones, L Passamonti, FI Aigbirhio, JT O'Brien, JB Rowe

    Minocycline at 2 Different Dosages vs Placebo for Patients With Mild Alzheimer Disease: A Randomized Clinical Trial.

    DOI: http://doi.org/10.1001/jamaneurol.2019.3762
    Journal: JAMA Neurol
    E-pub date: 1 Feb 2020
    Authors: R Howard, O Zubko, R Bradley, E Harper, L Pank, J O'Brien, C Fox, N Tabet, G Livingston, P Bentham, R McShane, A Burns, C Ritchie, S Reeves, S Lovestone, C Ballard, W Noble, R Nilforooshan, G Wilcock, R Gray, Minocycline in Alzheimer Disease Efficacy (MADE) Trialist Group

    Global Burden of Small Vessel Disease-Related Brain Changes on MRI Predicts Cognitive and Functional Decline.

    DOI: http://doi.org/10.1161/STROKEAHA.119.026170
    Journal: Stroke
    E-pub date: 1 Jan 2020
    Authors: H Jokinen, J Koikkalainen, HM Laakso, S Melkas, T Nieminen, A Brander, A Korvenoja, D Rueckert, F Barkhof, P Scheltens, R Schmidt, F Fazekas, S Madureira, A Verdelho, A Wallin, L-O Wahlund, G Waldemar, H Chabriat, M Hennerici, J O'Brien, D Inzitari, J Lötjönen, L Pantoni, T Erkinjuntti

    Cardiac 123I-MIBG planar heart to mediastinum ratios depend on patient size; phantom studies suggest SPECT-CT could improve quantification.

    DOI: http://doi.org/10.1088/2057-1976/ab5c09
    Journal: Biomed Phys Eng Express
    E-pub date: 19 Dec 2019
    Authors: G Roberts, JJ Lloyd, GS Petrides, JT O'Brien, AJ Thomas

    Asymmetrical atrophy of thalamic subnuclei in Alzheimer’s disease and amyloid-positive mild cognitive impairment is associated with key clinical features.

    DOI: http://doi.org/10.1016/j.dadm.2019.08.001
    Journal: Alzheimers Dement (Amst)
    E-pub date: 1 Dec 2019
    Authors: A Low, E Mak, M Malpetti, L Chouliaras, N Nicastro, L Su, N Holland, T Rittman, PV Rodríguez, L Passamonti, WR Bevan-Jones, PS Jones, JB Rowe, JT O'Brien

    Microglial activation and tau burden predict cognitive decline in Alzheimer’s Disease

    DOI: http://doi.org/10.1101/19011189
    Journal:
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    Authors: M Malpetti, R Kievit, L Passamonti, S Jones, K Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, Y Hong, T Fryer, F Aigbirhio, J O'Brien, J Rowe

    PET markers of tau and neuroinflammation are co-localized in progressive supranuclear palsy

    DOI: http://doi.org/10.1101/19010702
    Journal:
    E-pub date: 2 Nov 2019
    Authors: M Malpetti, L Passamonti, T Rittman, S Jones, P Vázquez Rodríguez, R Bevan-Jones, Y Hong, T Fryer, F Aigbirhio, J O’Brien, J Rowe

    Management of Lewy body dementia

    DOI: http://doi.org/10.1016/S1474-4422(19)30153-X
    Journal: The Lancet Neurology
    E-pub date: 10 Sep 2019
    Authors: J-P Taylor, I McKieth, D Burn, B Boeve, D Weintraub, C Bamford, L Allan, AJ Thomas, J O'Brien

    Inflammation in mild cognitive impairment due to Parkinson’s disease, Lewy body disease, and Alzheimer’s disease.

    DOI: http://doi.org/10.1002/gps.5124
    Journal: Int J Geriatr Psychiatry
    E-pub date: 31 Aug 2019
    Authors: E King, J O'Brien, P Donaghy, CH Williams-Gray, RA Lawson, CM Morris, N Barnett, K Olsen, C Martin-Ruiz, D Burn, AJ Yarnall, J-P Taylor, G Duncan, TK Khoo, A Thomas

    Assessment of need and practice for assistive technology and telecare for people with dementia-The ATTILA (Assistive Technology and Telecare to maintain Independent Living At home for people with dementia) trial.

    DOI: http://doi.org/10.1016/j.trci.2019.07.010
    Journal: Alzheimers Dement (N Y)
    E-pub date: 1 Aug 2019
    Authors: K Forsyth, C Henderson, L Davis, A Singh Roy, B Dunk, E Curnow, R Gathercole, N Lam, E Harper, I Leroi, J Woolham, C Fox, J O'Brien, A Bateman, F Poland, P Bentham, A Burns, A Davies, R Gray, R Bradley, M Knapp, S Newman, R McShane, C Ritchie, E Talbot, E Hooper, R Winson, B Scutt, V Ordonez, S Nunn, G Lavelle, R Howard

    Dynamic functional connectivity changes in dementia with Lewy bodies and Alzheimer’s disease.

    DOI: http://doi.org/10.1016/j.nicl.2019.101812
    Journal: Neuroimage Clin
    E-pub date: 1 Aug 2019
    Authors: J Schumacher, LR Peraza, M Firbank, AJ Thomas, M Kaiser, P Gallagher, JT O'Brien, AM Blamire, J-P Taylor

    Correlation of Lobar Cerebral Microbleeds with Amyloid, Perfusion, and Metabolism in Alzheimer’s Disease.

    DOI: http://doi.org/10.3233/JAD-180443
    Journal: J Alzheimers Dis
    E-pub date: 1 Aug 2019
    Authors: N Sheikh-Bahaei, R Manavaki, SA Sajjadi, AN Priest, JT O'Brien, JH Gillard

    Clinical Presentation, Diagnostic Features, and Mortality in Dementia with Lewy Bodies.

    DOI: http://doi.org/10.3233/JAD-180877
    Journal: J Alzheimers Dis
    E-pub date: 1 Aug 2019
    Authors: S Moylett, A Price, RN Cardinal, D Aarsland, C Mueller, R Stewart, JT O'Brien

    IC‐P‐095: THE ASSOCIATION BETWEEN MICROVASCULAR CHANGES AND PET MEASURES OF AMYLOID, PERFUSION AND METABOLISM IN ALZHEIMER’S DISEASE

    DOI: http://doi.org/10.1016/j.jalz.2019.06.4938
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Jul 2019
    Authors: N Sheikh-Bahaei, SA Sajjadi, R Manavaki, A Priest, JT O'Brien, JH Gillard

    A comparison of visual and semiquantitative analysis methods for planar cardiac 123I-MIBG scintigraphy in dementia with Lewy bodies.

    DOI: http://doi.org/10.1097/MNM.0000000000001024
    Journal: Nucl Med Commun
    E-pub date: 1 Jul 2019
    Authors: G Roberts, JPM Kane, JJ Lloyd, GS Petrides, K Howe, JT O'Brien, AJ Thomas

    Structural correlates of attention dysfunction in Lewy body dementia and Alzheimer’s disease: an ex-Gaussian analysis.

    DOI: http://doi.org/10.1007/s00415-019-09323-y
    Journal: J Neurol
    E-pub date: 1 Jul 2019
    Authors: J Schumacher, R Cromarty, P Gallagher, MJ Firbank, AJ Thomas, M Kaiser, AM Blamire, JT O'Brien, LR Peraza, J-P Taylor

    Prevalence and severity of symptoms suggestive of gastroparesis in prodromal dementia with Lewy bodies.

    DOI: http://doi.org/10.1002/gps.5100
    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Jul 2019
    Authors: R Durcan, PC Donaghy, NA Barnett, K Olsen, AJ Yarnall, J-P Taylor, I McKeith, JT O'Brien, AJ Thomas

    123I-FP-CIT striatal binding ratios do not decrease significantly with age in older adults.

    DOI: http://doi.org/10.1007/s12149-019-01352-x
    Journal: Ann Nucl Med
    E-pub date: 1 Jun 2019
    Authors: G Roberts, JJ Lloyd, GS Petrides, PC Donaghy, JPM Kane, R Durcan, S Lawley, K Howe, AJ Sims, J-P Taylor, JT O'Brien, AJ Thomas

    Identifying dementia outcomes in UK Biobank: a validation study of primary care, hospital admissions and mortality data.

    DOI: http://doi.org/10.1007/s10654-019-00499-1
    Journal: Eur J Epidemiol
    E-pub date: 1 Jun 2019
    Authors: T Wilkinson, C Schnier, K Bush, K Rannikmäe, DE Henshall, C Lerpiniere, NE Allen, R Flaig, TC Russ, D Bathgate, S Pal, JT O'Brien, CLM Sudlow, Dementias Platform UK and UK Biobank

    Management of visual hallucinations in dementia and Parkinson’s disease.

    DOI: http://doi.org/10.1017/S1041610218001400
    Journal: Int Psychogeriatr
    E-pub date: 1 Jun 2019
    Authors: P Swann, JT O'Brien

    Dysfunctional brain dynamics and their origin in Lewy body dementia.

    DOI: http://doi.org/10.1093/brain/awz069
    Journal: Brain
    E-pub date: 1 Jun 2019
    Authors: J Schumacher, LR Peraza, M Firbank, AJ Thomas, M Kaiser, P Gallagher, JT O'Brien, AM Blamire, J-P Taylor

    123I-MIBG scintigraphy utility and cut-off value in a clinically representative dementia cohort.

    DOI: http://doi.org/10.1016/j.parkreldis.2019.01.024
    Journal: Parkinsonism Relat Disord
    E-pub date: 1 May 2019
    Authors: JPM Kane, G Roberts, GS Petrides, JJ Lloyd, JT O'Brien, AJ Thomas

    The Incidence of Recorded Delirium Episodes Before and After Dementia Diagnosis: Differences Between Dementia With Lewy Bodies and Alzheimer’s Disease.

    DOI: http://doi.org/10.1016/j.jamda.2018.09.021
    Journal: J Am Med Dir Assoc
    E-pub date: 1 May 2019
    Authors: JM FitzGerald, G Perera, A Chang-Tave, A Price, AP Rajkumar, M Bhattarai, JT O'Brien, C Ballard, D Aarsland, R Stewart, C Mueller

    Peripheral inflammation in mild cognitive impairment with possible and probable Lewy body disease and Alzheimer’s disease.

    DOI: http://doi.org/10.1017/S1041610218001126
    Journal: Int Psychogeriatr
    E-pub date: 1 Apr 2019
    Authors: E King, JT O'Brien, P Donaghy, C Morris, N Barnett, K Olsen, C Martin-Ruiz, JP Taylor, AJ Thomas

    Ammon’s Horn 2 (CA2) of the Hippocampus: A Long-Known Region with a New Potential Role in Neurodegeneration.

    DOI: http://doi.org/10.1177/1073858418778747
    Journal: Neuroscientist
    E-pub date: 1 Apr 2019
    Authors: CC-C Pang, C Kiecker, JT O'Brien, W Noble, RC-C Chang

    Survival time and differences between dementia with Lewy bodies and Alzheimer’s disease following diagnosis: A meta-analysis of longitudinal studies.

    DOI: http://doi.org/10.1016/j.arr.2019.01.005
    Journal: Ageing Res Rev
    E-pub date: 1 Mar 2019
    Authors: C Mueller, P Soysal, A Rongve, AT Isik, T Thompson, S Maggi, L Smith, C Basso, R Stewart, C Ballard, JT O'Brien, D Aarsland, B Stubbs, N Veronese

    Diagnostic accuracy of dopaminergic imaging in prodromal dementia with Lewy bodies.

    DOI: http://doi.org/10.1017/S0033291718000995
    Journal: Psychol Med
    E-pub date: 1 Feb 2019
    Authors: AJ Thomas, P Donaghy, G Roberts, SJ Colloby, NA Barnett, G Petrides, J Lloyd, K Olsen, J-P Taylor, I McKeith, JT O'Brien

    Dementia with Lewy bodies – from scientific knowledge to clinical insights.

    DOI: http://doi.org/10.1038/s41582-018-0107-7
    Journal: Nat Rev Neurol
    E-pub date: 1 Feb 2019
    Authors: NA Arnaoutoglou, JT O'Brien, BR Underwood

    In vivo evidence for pre-symptomatic neuroinflammation in a MAPT mutation carrier.

    DOI: http://doi.org/10.1002/acn3.683
    Journal: Ann Clin Transl Neurol
    E-pub date: 1 Feb 2019
    Authors: WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, YT Hong, T Fryer, R Arnold, JP Coles, FI Aigbirhio, JT O'Brien, JB Rowe

    Early microglial activation and peripheral inflammation in dementia with Lewy bodies.

    DOI: http://doi.org/10.1093/brain/awy265
    Journal: Brain
    E-pub date: 1 Dec 2018
    Authors: A Surendranathan, L Su, E Mak, L Passamonti, YT Hong, R Arnold, P Vázquez Rodríguez, WR Bevan-Jones, SAE Brain, TD Fryer, FI Aigbirhio, JB Rowe, JT O'Brien

    Revision of assessment toolkits for improving the diagnosis of Lewy body dementia: The DIAMOND Lewy study.

    DOI: http://doi.org/10.1002/gps.4948
    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Oct 2018
    Authors: AJ Thomas, JP Taylor, I McKeith, C Bamford, D Burn, L Allan, J O'Brien

    Neuropsychiatric symptoms and cognitive profile in mild cognitive impairment with Lewy bodies.

    DOI: http://doi.org/10.1017/S0033291717003956
    Journal: Psychol Med
    E-pub date: 1 Oct 2018
    Authors: PC Donaghy, J-P Taylor, JT O'Brien, N Barnett, K Olsen, SJ Colloby, J Lloyd, G Petrides, IG McKeith, AJ Thomas

    [18F]AV-1451 binding is increased in frontotemporal dementia due to C9orf72 expansion.

    DOI: http://doi.org/10.1002/acn3.631
    Journal: Ann Clin Transl Neurol
    E-pub date: 1 Oct 2018
    Authors: RW Bevan-Jones, TE Cope, SP Jones, L Passamonti, YT Hong, T Fryer, R Arnold, JP Coles, FA Aigbirhio, K Patterson, JT O'Brien, JB Rowe

    [18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia.

    DOI: http://doi.org/10.1136/jnnp-2017-316402
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Oct 2018
    Authors: WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, YT Hong, TD Fryer, R Arnold, KSJ Allinson, JP Coles, FI Aigbirhio, K Patterson, JT O'Brien, JB Rowe

    Non-pharmacological interventions for Lewy body dementia: a systematic review.

    DOI: http://doi.org/10.1017/S0033291717003257
    Journal: Psychol Med
    E-pub date: 31 Aug 2018
    Authors: MH Connors, L Quinto, I McKeith, H Brodaty, L Allan, C Bamford, A Thomas, J-P Taylor, JT O'Brien

    A new visual rating scale for Ioflupane imaging in Lewy body disease.

    DOI: http://doi.org/10.1016/j.nicl.2018.09.012
    Journal: Neuroimage Clin
    E-pub date: 1 Aug 2018
    Authors: JJ Lloyd, G Petrides, PC Donaghy, SJ Colloby, J Attems, JT O'Brien, G Roberts, AJ Thomas

    Structural Brain Correlates of Attention Dysfunction in Lewy Body Dementias and Alzheimer’s Disease.

    DOI: http://doi.org/10.3389/fnagi.2018.00347
    Journal: Front Aging Neurosci
    E-pub date: 1 Aug 2018
    Authors: RA Cromarty, J Schumacher, S Graziadio, P Gallagher, A Killen, MJ Firbank, A Blamire, M Kaiser, AJ Thomas, JT O'Brien, LR Peraza, J-P Taylor

    Platelet Tau Protein as a Potential Peripheral Biomarker in Alzheimer’s Disease: An Explorative Study.

    DOI: http://doi.org/10.2174/1567205015666180404165915
    Journal: Curr Alzheimer Res
    E-pub date: 1 Aug 2018
    Authors: EB Mukaetova-Ladinska, Z Abdell-All, J Andrade, JA da Silva, I Boksha, G Burbaeva, RN Kalaria, J T O Brien

    In vivo coupling of tau pathology and cortical thinning in Alzheimer’s disease.

    DOI: http://doi.org/10.1016/j.dadm.2018.08.005
    Journal: Alzheimers Dement (Amst)
    E-pub date: 1 Aug 2018
    Authors: E Mak, RAI Bethlehem, R Romero-Garcia, S Cervenka, T Rittman, S Gabel, A Surendranathan, RW Bevan-Jones, L Passamonti, P Vázquez Rodríguez, L Su, R Arnold, GB Williams, YT Hong, TD Fryer, FI Aigbirhio, JB Rowe, JT O'Brien

    Correction to: The Edinburgh Consensus: preparing for the advent of disease-modifying therapies for Alzheimer’s disease.

    DOI: http://doi.org/10.1186/s13195-018-0372-0
    Journal: Alzheimers Res Ther
    E-pub date: 30 Jul 2018
    Authors: CW Ritchie, TC Russ, S Banerjee, B Barber, A Boaden, NC Fox, C Holmes, JD Isaacs, I Leroi, S Lovestone, M Norton, J O'Brien, J Pearson, R Perry, J Pickett, AD Waldman, WL Wong, MN Rossor, A Burns

    Clinical and imaging correlates of amyloid deposition in dementia with Lewy bodies.

    DOI: http://doi.org/10.1002/mds.27403
    Journal: Mov Disord
    E-pub date: 1 Jul 2018
    Authors: PC Donaghy, MJ Firbank, AJ Thomas, J Lloyd, G Petrides, N Barnett, K Olsen, JT O'Brien

    Quantitative electroencephalography as a marker of cognitive fluctuations in dementia with Lewy bodies and an aid to differential diagnosis.

    DOI: http://doi.org/10.1016/j.clinph.2018.03.013
    Journal: Clin Neurophysiol
    E-pub date: 1 Jun 2018
    Authors: M Stylianou, N Murphy, LR Peraza, S Graziadio, R Cromarty, A Killen, JT O' Brien, AJ Thomas, FEN LeBeau, J-P Taylor

    [11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1212/WNL.0000000000005610
    Journal: Neurology
    E-pub date: 29 May 2018
    Authors: L Passamonti, PV Rodríguez, YT Hong, KSJ Allinson, WR Bevan-Jones, D Williamson, PS Jones, R Arnold, RJ Borchert, A Surendranathan, E Mak, L Su, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Positron emission tomography-guided magnetic resonance spectroscopy in Alzheimer disease.

    DOI: http://doi.org/10.1002/ana.25202
    Journal: Ann Neurol
    E-pub date: 1 Apr 2018
    Authors: N Sheikh-Bahaei, SA Sajjadi, R Manavaki, M McLean, JT O'Brien, JH Gillard

    Peripheral inflammation in prodromal Alzheimer’s and Lewy body dementias.

    DOI: http://doi.org/10.1136/jnnp-2017-317134
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Apr 2018
    Authors: E King, JT O'Brien, P Donaghy, C Morris, N Barnett, K Olsen, C Martin-Ruiz, J-P Taylor, AJ Thomas

    Electroencephalographic derived network differences in Lewy body dementia compared to Alzheimer’s disease patients.

    DOI: http://doi.org/10.1038/s41598-018-22984-5
    Journal: Sci Rep
    E-pub date: 15 Mar 2018
    Authors: LR Peraza, R Cromarty, X Kobeleva, MJ Firbank, A Killen, S Graziadio, AJ Thomas, JT O'Brien, J-P Taylor

    Functional connectivity in dementia with Lewy bodies: A within- and between-network analysis.

    DOI: http://doi.org/10.1002/hbm.23901
    Journal: Hum Brain Mapp
    E-pub date: 1 Mar 2018
    Authors: J Schumacher, LR Peraza, M Firbank, AJ Thomas, M Kaiser, P Gallagher, JT O'Brien, AM Blamire, J-P Taylor

    Long reaction times are associated with delayed brain activity in lewy body dementia.

    DOI: http://doi.org/10.1002/hbm.23866
    Journal: Hum Brain Mapp
    E-pub date: 1 Feb 2018
    Authors: MJ Firbank, JT O'Brien, JP Taylor

    Tau burden and the functional connectome in Alzheimer’s disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1093/brain/awx347
    Journal: Brain
    E-pub date: 1 Feb 2018
    Authors: TE Cope, T Rittman, RJ Borchert, PS Jones, D Vatansever, K Allinson, L Passamonti, P Vazquez Rodriguez, WR Bevan-Jones, JT O'Brien, JB Rowe

    Hospitalization in people with dementia with Lewy bodies: Frequency, duration, and cost implications.

    DOI: http://doi.org/10.1016/j.dadm.2017.12.001
    Journal: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
    E-pub date: 1 Jan 2018
    Authors: C Mueller, G Perera, AP Rajkumar, M Bhattarai, A Price, JT O'Brien, C Ballard, R Stewart, D Aarsland

    Does attentional dysfunction and thalamic atrophy predict decline in dementia with Lewy bodies?

    DOI: http://doi.org/10.1016/j.parkreldis.2017.10.006
    Journal: Parkinsonism Relat Disord
    E-pub date: 1 Dec 2017
    Authors: R Watson, SJ Colloby, AM Blamire, KA Wesnes, J Wood, JT O'Brien

    Development of assessment toolkits for improving the diagnosis of the Lewy body dementias: feasibility study within the DIAMOND Lewy study.

    DOI: http://doi.org/10.1002/gps.4609
    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Dec 2017
    Authors: AJ Thomas, JP Taylor, I McKeith, C Bamford, D Burn, L Allan, J O'Brien

    Cost-effectiveness of donepezil and memantine in moderate to severe Alzheimer’s disease (the DOMINO-AD trial).

    DOI: http://doi.org/10.1002/gps.4583
    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Dec 2017
    Authors: M Knapp, D King, R Romeo, J Adams, A Baldwin, C Ballard, S Banerjee, R Barber, P Bentham, RG Brown, A Burns, T Dening, D Findlay, C Holmes, T Johnson, R Jones, C Katona, J Lindesay, A Macharouthu, I McKeith, R McShane, JT O'Brien, PPJ Phillips, B Sheehan, R Howard

    Symptoms associated with Lewy body disease in mild cognitive impairment.

    DOI: http://doi.org/10.1002/gps.4742
    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Nov 2017
    Authors: PC Donaghy, N Barnett, K Olsen, J-P Taylor, IG McKeith, JT O'Brien, AJ Thomas

    The influence of hippocampal atrophy on the cognitive phenotype of dementia with Lewy bodies.

    DOI: http://doi.org/10.1002/gps.4719
    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Nov 2017
    Authors: GJ Elder, K Mactier, SJ Colloby, R Watson, AM Blamire, JT O'Brien, J-P Taylor

    Patterns of atrophy in pathologically confirmed dementias: a voxelwise analysis.

    DOI: http://doi.org/10.1136/jnnp-2016-314978
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Nov 2017
    Authors: L Harper, F Bouwman, EJ Burton, F Barkhof, P Scheltens, JT O'Brien, NC Fox, GR Ridgway, JM Schott

    The Edinburgh Consensus: preparing for the advent of disease-modifying therapies for Alzheimer’s disease.

    DOI: http://doi.org/10.1186/s13195-017-0312-4
    Journal: Alzheimers Res Ther
    E-pub date: 26 Oct 2017
    Authors: CW Ritchie, TC Russ, S Banerjee, B Barber, A Boaden, NC Fox, C Holmes, JD Isaacs, I Leroi, S Lovestone, M Norton, J O'Brien, J Pearson, R Perry, J Pickett, AD Waldman, WL Wong, MN Rossor, A Burns

    Teaching provision for old age psychiatry in medical schools in the UK and Ireland: a survey.

    DOI: http://doi.org/10.1192/pb.bp.116.055210
    Journal: BJPsych Bull
    E-pub date: 1 Oct 2017
    Authors: S Bennett, P Ilderton, JT O'Brien, J-P Taylor, A Teodorczuk

    The midlife cognitive profiles of adults at high risk of late-onset Alzheimer’s disease: The PREVENT study.

    DOI: http://doi.org/10.1016/j.jalz.2017.02.008
    Journal: Alzheimers Dement
    E-pub date: 1 Oct 2017
    Authors: K Ritchie, I Carrière, L Su, JT O'Brien, S Lovestone, K Wells, CW Ritchie

    Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis.

    DOI: http://doi.org/10.1038/mp.2016.72
    Journal: Mol Psychiatry
    E-pub date: 1 Oct 2017
    Authors: T Wise, J Radua, E Via, N Cardoner, O Abe, TM Adams, F Amico, Y Cheng, JH Cole, C de Azevedo Marques Périco, DP Dickstein, TFD Farrow, T Frodl, G Wagner, IH Gotlib, O Gruber, BJ Ham, DE Job, MJ Kempton, MJ Kim, PCMP Koolschijn, GS Malhi, D Mataix-Cols, AM McIntosh, AC Nugent, JT O'Brien, S Pezzoli, ML Phillips, PS Sachdev, G Salvadore, S Selvaraj, AC Stanfield, AJ Thomas, MJ van Tol, NJA van der Wee, DJ Veltman, AH Young, CH Fu, AJ Cleare, D Arnone

    Stability of mild cognitive impairment in newly diagnosed Parkinson’s disease.

    DOI: http://doi.org/10.1136/jnnp-2016-315099
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 31 Aug 2017
    Authors: RA Lawson, AJ Yarnall, GW Duncan, DP Breen, TK Khoo, CH Williams-Gray, RA Barker, DJ Burn, ICICLE-PD study group

    Author response: Autopsy validation of 123I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLB.

    DOI: http://doi.org/10.1212/WNL.0000000000004254
    Journal: Neurology
    E-pub date: 15 Aug 2017
    Authors: AJ Thomas, J Attems, SJ Colloby, JT O'Brien, I McKeith, R Walker, L Lee, D Burn, DJ Lett, Z Walker

    Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia.

    DOI: http://doi.org/10.3233/JAD-160946
    Journal: J Alzheimers Dis
    E-pub date: 1 Aug 2017
    Authors: A Alghamdi, J Vallortigara, DR Howlett, M Broadstock, T Hortobágyi, C Ballard, AJ Thomas, JT O'Brien, D Aarsland, J Attems, PT Francis, DR Whitfield

    Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium.

    DOI: http://doi.org/10.1212/WNL.0000000000004058
    Journal: Neurology
    E-pub date: 4 Jul 2017
    Authors: IG McKeith, BF Boeve, DW Dickson, G Halliday, J-P Taylor, D Weintraub, D Aarsland, J Galvin, J Attems, CG Ballard, A Bayston, TG Beach, F Blanc, N Bohnen, L Bonanni, J Bras, P Brundin, D Burn, A Chen-Plotkin, JE Duda, O El-Agnaf, H Feldman, TJ Ferman, D Ffytche, H Fujishiro, D Galasko, JG Goldman, SN Gomperts, NR Graff-Radford, LS Honig, A Iranzo, K Kantarci, D Kaufer, W Kukull, VMY Lee, JB Leverenz, S Lewis, C Lippa, A Lunde, M Masellis, E Masliah, P McLean, B Mollenhauer, TJ Montine, E Moreno, E Mori, M Murray, JT O'Brien, S Orimo, RB Postuma, S Ramaswamy, OA Ross, DP Salmon, A Singleton, A Taylor, A Thomas, P Tiraboschi, JB Toledo, JQ Trojanowski, D Tsuang, Z Walker, M Yamada, K Kosaka

    [P2–371]: CEREBRAL MICROBLEEDS ARE ASSOCIATED WITH TEMPORAL LOBE HYPOMETABOLISM IN ALZHEIMER’s DISEASE

    DOI: http://doi.org/10.1016/j.jalz.2017.06.1026
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Jul 2017
    Authors: N Sheikh‐Bahaei, SA Sajjadi, R Manavaki, JT O'Brien, JH Gillard

    [P1–419]: PET‐GUIDED MR SPECTROSCOPY REVEALS DISTINCT RELATIONS BETWEEN BRAIN METABOLITES, AMYLOID AND HYPOMETABOLISM IN ALZHEIMER’S DISEASE

    DOI: http://doi.org/10.1016/j.jalz.2017.06.435
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Jul 2017
    Authors: N Sheikh‐Bahaei, SA Sajjadi, R Manavaki, M McLean, JH Gillard, JT O'Brien

    Divergent functional connectivity during attentional processing in Lewy body dementia and Alzheimer’s disease.

    DOI: http://doi.org/10.1016/j.cortex.2017.02.016
    Journal: Cortex
    E-pub date: 1 Jul 2017
    Authors: X Kobeleva, M Firbank, L Peraza, P Gallagher, A Thomas, DJ Burn, J O'Brien, J-P Taylor

    Structural grey matter changes in the substantia innominata in Alzheimer’s disease and dementia with Lewy bodies: a DARTEL-VBM study.

    DOI: http://doi.org/10.1002/gps.4500
    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Jun 2017
    Authors: SJ Colloby, GJ Elder, R Rabee, JT O'Brien, J-P Taylor

    The impact and measurement of social dysfunction in late-life depression: an evaluation of current methods with a focus on wearable technology.

    DOI: http://doi.org/10.1002/gps.4632
    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Mar 2017
    Authors: S Hodgetts, P Gallagher, D Stow, IN Ferrier, JT O'Brien

    18F-AV-1451 positron emission tomography in Alzheimer’s disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1093/brain/aww340
    Journal: Brain
    E-pub date: 1 Mar 2017
    Authors: L Passamonti, P Vázquez Rodríguez, YT Hong, KSJ Allinson, D Williamson, RJ Borchert, S Sami, TE Cope, WR Bevan-Jones, PS Jones, R Arnold, A Surendranathan, E Mak, L Su, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Clinical practice with anti-dementia drugs: A revised (third) consensus statement from the British Association for Psychopharmacology.

    DOI: http://doi.org/10.1177/0269881116680924
    Journal: J Psychopharmacol
    E-pub date: 1 Feb 2017
    Authors: JT O'Brien, C Holmes, M Jones, R Jones, G Livingston, I McKeith, P Mittler, P Passmore, C Ritchie, L Robinson, EL Sampson, J-P Taylor, A Thomas, A Burns

    Autopsy validation of 123I-FP-CIT dopaminergic neuroimaging for the diagnosis of DLB.

    DOI: http://doi.org/10.1212/WNL.0000000000003512
    Journal: Neurology
    E-pub date: 17 Jan 2017
    Authors: AJ Thomas, J Attems, SJ Colloby, JT O'Brien, I McKeith, R Walker, L Lee, D Burn, DJ Lett, Z Walker

    Neuroimaging of Inflammation in Memory and Related Other Disorders (NIMROD) study protocol: a deep phenotyping cohort study of the role of brain inflammation in dementia, depression and other neurological illnesses.

    DOI: http://doi.org/10.1136/bmjopen-2016-013187
    Journal: BMJ Open
    E-pub date: 7 Jan 2017
    Authors: WR Bevan-Jones, A Surendranathan, L Passamonti, P Vázquez Rodríguez, R Arnold, E Mak, L Su, JP Coles, TD Fryer, YT Hong, G Williams, F Aigbirhio, JB Rowe, JT O'Brien

    A study of wrist-worn activity measurement as a potential real-world biomarker for late-life depression.

    DOI: http://doi.org/10.1017/S0033291716002166
    Journal: Psychol Med
    E-pub date: 1 Jan 2017
    Authors: JT O'Brien, P Gallagher, D Stow, N Hammerla, T Ploetz, M Firbank, C Ladha, K Ladha, D Jackson, R McNaney, IN Ferrier, P Olivier

    Peripheral Inflammatory Parameters in Late-Life Depression: A Systematic Review.

    DOI: http://doi.org/10.3390/ijms17122022
    Journal: Int J Mol Sci
    E-pub date: 2 Dec 2016
    Authors: M Martínez-Cengotitabengoa, L Carrascón, JT O'Brien, M-J Díaz-Gutiérrez, C Bermúdez-Ampudia, K Sanada, M Arrasate, A González-Pinto

    [18F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation.

    DOI: http://doi.org/10.1002/acn3.366
    Journal: Ann Clin Transl Neurol
    E-pub date: 1 Dec 2016
    Authors: WR Bevan Jones, TE Cope, L Passamonti, TD Fryer, YT Hong, F Aigbirhio, JJ Kril, SL Forrest, K Allinson, JP Coles, P Simon Jones, MG Spillantini, JR Hodges, JT O'Brien, JB Rowe

    Neuroinflammatory and morphological changes in late-life depression: the NIMROD study.

    DOI: http://doi.org/10.1192/bjp.bp.116.190165
    Journal: BRITISH JOURNAL OF PSYCHIATRY
    E-pub date: 1 Dec 2016
    Authors: L Su, YO Faluyi, YT Hong, TD Fryer, E Mak, S Gabel, L Hayes, S Soteriades, GB Williams, R Arnold, L Passamonti, PV Rodríguez, A Surendranathan, RW Bevan-Jones, J Coles, F Aigbirhio, JB Rowe, JT O'Brien

    A spatial covariance 123I-5IA-85380 SPECT study of α4β2 nicotinic receptors in Alzheimer’s disease.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2016.07.017
    Journal: Neurobiol Aging
    E-pub date: 1 Nov 2016
    Authors: SJ Colloby, RH Field, DJ Wyper, JT O'Brien, J-P Taylor

    The relationship between hallucinations and FDG-PET in dementia with Lewy bodies.

    DOI: http://doi.org/10.1007/s11682-015-9434-0
    Journal: Brain Imaging Behav
    E-pub date: 1 Sep 2016
    Authors: MJ Firbank, J Lloyd, JT O'Brien

    Whole-brain patterns of (1)H-magnetic resonance spectroscopy imaging in Alzheimer’s disease and dementia with Lewy bodies.

    DOI: http://doi.org/10.1038/tp.2016.140
    Journal: Transl Psychiatry
    E-pub date: 30 Aug 2016
    Authors: L Su, AM Blamire, R Watson, J He, L Hayes, JT O'Brien

    Decreased Levels of VAMP2 and Monomeric Alpha-Synuclein Correlate with Duration of Dementia.

    DOI: http://doi.org/10.3233/JAD-150707
    Journal: J Alzheimers Dis
    E-pub date: 1 Aug 2016
    Authors: J Vallortigara, D Whitfield, W Quelch, A Alghamdi, D Howlett, T Hortobágyi, M Johnson, J Attems, JT O'Brien, A Thomas, CG Ballard, D Aarsland, PT Francis

    Cortical and Subcortical Changes in Alzheimer’s Disease: A Longitudinal and Quantitative MRI Study.

    DOI: http://doi.org/10.2174/1567205013666151116141416
    Journal: Curr Alzheimer Res
    E-pub date: 1 Aug 2016
    Authors: L Su, AM Blamire, R Watson, J He, B Aribisala, JT O'Brien

    Alzheimer’s Disease is Associated with Increased Risk of Osteoporosis: The Chongqing Aging Study.

    DOI: http://doi.org/10.2174/15672050113109990149
    Journal: Curr Alzheimer Res
    E-pub date: 1 Aug 2016
    Authors: D Liu, H Zhou, Y Tao, J Tan, L Chen, H Huang, Y Chen, Y Li, R Zhou

    Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer’s disease.

    DOI: http://doi.org/10.1186/s13195-016-0198-6
    Journal: Alzheimers Res Ther
    E-pub date: 20 Jul 2016
    Authors: F Blanc, SJ Colloby, B Cretin, PL de Sousa, C Demuynck, JT O'Brien, C Martin-Hunyadi, I McKeith, N Philippi, J-P Taylor

    Cholinergic and perfusion brain networks in Parkinson disease dementia.

    DOI: http://doi.org/10.1212/WNL.0000000000002839
    Journal: Neurology
    E-pub date: 12 Jul 2016
    Authors: SJ Colloby, IG McKeith, DJ Burn, DJ Wyper, JT O'Brien, J-P Taylor

    P3‐249: Magnetic Resonance Spectroscopy Based Metabolite Measurement Differentiates Alzheimer’s From Healthy Brain

    DOI: http://doi.org/10.1016/j.jalz.2016.06.1912
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Jul 2016
    Authors: N Sheikh-Bahaei, SA Sajjadi, R Manavaki, M McLean, JT O'Brien, JH Gillard

    Multimodal EEG-MRI in the differential diagnosis of Alzheimer’s disease and dementia with Lewy bodies.

    DOI: http://doi.org/10.1016/j.jpsychires.2016.03.010
    Journal: J Psychiatr Res
    E-pub date: 1 Jul 2016
    Authors: SJ Colloby, RA Cromarty, LR Peraza, K Johnsen, G Jóhannesson, L Bonanni, M Onofrj, R Barber, JT O'Brien, J-P Taylor

    Regional functional synchronizations in dementia with Lewy bodies and Alzheimer’s disease.

    DOI: http://doi.org/10.1017/S1041610216000429
    Journal: Int Psychogeriatr
    E-pub date: 1 Jul 2016
    Authors: LR Peraza, SJ Colloby, L Deboys, JT O'Brien, M Kaiser, J-P Taylor

    Depressive symptoms are associated with daytime sleepiness and subjective sleep quality in dementia with Lewy bodies.

    DOI: http://doi.org/10.1002/gps.4389
    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Jul 2016
    Authors: GJ Elder, SJ Colloby, DJ Lett, JT O'Brien, KN Anderson, DJ Burn, IG McKeith, J-P Taylor

    Analysis of primary visual cortex in dementia with Lewy bodies indicates GABAergic involvement associated with recurrent complex visual hallucinations.

    DOI: http://doi.org/10.1186/s40478-016-0334-3
    Journal: Acta Neuropathol Commun
    E-pub date: 30 Jun 2016
    Authors: AA Khundakar, PS Hanson, D Erskine, NZ Lax, J Roscamp, E Karyka, E Tsefou, P Singh, SJ Cockell, A Gribben, L Ramsay, PG Blain, UP Mosimann, DJ Lett, M Elstner, DM Turnbull, CC Xiang, MJ Brownstein, JT O'Brien, J-P Taylor, J Attems, AJ Thomas, IG McKeith, CM Morris

    Changes to the lateral geniculate nucleus in Alzheimer’s disease but not dementia with Lewy bodies.

    DOI: http://doi.org/10.1111/nan.12249
    Journal: Neuropathol Appl Neurobiol
    E-pub date: 1 Jun 2016
    Authors: D Erskine, JP Taylor, MJ Firbank, L Patterson, M Onofrj, JT O'Brien, IG McKeith, J Attems, AJ Thomas, CM Morris, AA Khundakar

    Visual cortical excitability in dementia with Lewy bodies.

    DOI: http://doi.org/10.1192/bjp.bp.114.152736
    Journal: Br J Psychiatry
    E-pub date: 1 May 2016
    Authors: J-P Taylor, M Firbank, JT O'Brien

    An evidence-based algorithm for the utility of FDG-PET for diagnosing Alzheimer’s disease according to presence of medial temporal lobe atrophy.

    DOI: http://doi.org/10.1192/bjp.bp.114.160804
    Journal: Br J Psychiatry
    E-pub date: 1 May 2016
    Authors: MJ Firbank, J Lloyd, D Williams, R Barber, SJ Colloby, N Barnett, K Olsen, C Davison, C Donaldson, K Herholz, JT O'Brien

    MRI visual rating scales in the diagnosis of dementia: evaluation in 184 post-mortem confirmed cases.

    DOI: http://doi.org/10.1093/brain/aww005
    Journal: Brain
    E-pub date: 1 Apr 2016
    Authors: L Harper, GG Fumagalli, F Barkhof, P Scheltens, JT O'Brien, F Bouwman, EJ Burton, JD Rohrer, NC Fox, GR Ridgway, JM Schott

    Computational meta-analysis of statistical parametric maps in major depression.

    DOI: http://doi.org/10.1002/hbm.23108
    Journal: Hum Brain Mapp
    E-pub date: 1 Apr 2016
    Authors: D Arnone, D Job, S Selvaraj, O Abe, F Amico, Y Cheng, SJ Colloby, JT O'Brien, T Frodl, IH Gotlib, B-J Ham, MJ Kim, PCMP Koolschijn, CA-M Périco, G Salvadore, AJ Thomas, M-J Van Tol, NJA van der Wee, DJ Veltman, G Wagner, AM McIntosh

    Subcortical volume changes in dementia with Lewy bodies and Alzheimer’s disease. A comparison with healthy aging.

    DOI: http://doi.org/10.1017/S1041610215001805
    Journal: Int Psychogeriatr
    E-pub date: 1 Apr 2016
    Authors: R Watson, SJ Colloby, AM Blamire, JT O'Brien

    Continuation of the ESH-CHL-SHOT trial after publication of the SPRINT: rationale for further study on blood pressure targets of antihypertensive treatment after stroke.

    DOI: http://doi.org/10.1097/HJH.0000000000000853
    Journal: J Hypertens
    E-pub date: 1 Mar 2016
    Authors: A Zanchetti, L Liu, G Mancia, G Parati, G Grassi, M Stramba-Badiale, V Silani, G Bilo, G Corrao, A Zambon, L Scotti, X Zhang, TR Guan, Y Zhang, X Zhang, E Berge, J Redon, K Narkiewicz, A Dominiczak, P Nilsson, M Viigimaa, S Laurent, E Agabiti-Rosei, Z Wu, D Zhu, JL Rodicio, LM Ruilope, N Martell-Claros, F Pinto, RE Schmieder, M Burnier, M Banach, R Cifkova, C Farsang, A Konradi, I Lazareva, Y Sirenko, M Dorobantu, A Postadzhiyan, R Accetto, B Jelakovic, D Lovic, AJ Manolis, P Stylianou, D Dicker, G Wei, C Xu, H Xie, A Coca, J O'Brien, G Ford, ESH-CHL-SHOT trial investigators

    Neural correlates of attention-executive dysfunction in lewy body dementia and Alzheimer’s disease.

    DOI: http://doi.org/10.1002/hbm.23100
    Journal: Hum Brain Mapp
    E-pub date: 1 Mar 2016
    Authors: M Firbank, X Kobeleva, G Cherry, A Killen, P Gallagher, DJ Burn, AJ Thomas, JT O'Brien, J-P Taylor

    Support and information needs following a diagnosis of dementia with Lewy bodies.

    DOI: http://doi.org/10.1017/S1041610215001362
    Journal: Int Psychogeriatr
    E-pub date: 1 Mar 2016
    Authors: A Killen, D Flynn, A De Brún, N O'Brien, J O'Brien, AJ Thomas, I McKeith, J-P Taylor

    Exome sequencing in dementia with Lewy bodies.

    DOI: http://doi.org/10.1038/tp.2015.220
    Journal: Transl Psychiatry
    E-pub date: 2 Feb 2016
    Authors: MJ Keogh, M Kurzawa-Akanbi, H Griffin, K Douroudis, KL Ayers, RI Hussein, G Hudson, A Pyle, HJ Cordell, J Attems, IG McKeith, JT O'Brien, DJ Burn, CM Morris, AJ Thomas, PF Chinnery

    Multiplex analyte assays to characterize different dementias: brain inflammatory cytokines in poststroke and other dementias.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2015.10.021
    Journal: Neurobiol Aging
    E-pub date: 1 Feb 2016
    Authors: A Chen, AE Oakley, M Monteiro, K Tuomela, LM Allan, EB Mukaetova-Ladinska, JT O'Brien, RN Kalaria

    Frontal white matter hyperintensities, clasmatodendrosis and gliovascular abnormalities in ageing and post-stroke dementia.

    DOI: http://doi.org/10.1093/brain/awv328
    Journal: Brain
    E-pub date: 1 Jan 2016
    Authors: A Chen, RO Akinyemi, Y Hase, MJ Firbank, MN Ndung'u, V Foster, LJL Craggs, K Washida, Y Okamoto, AJ Thomas, TM Polvikoski, LM Allan, AE Oakley, JT O'Brien, K Horsburgh, M Ihara, RN Kalaria

    Imaging of neuroinflammation in dementia: a review.

    DOI: http://doi.org/10.1136/jnnp-2015-311336
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jan 2016
    Authors: J Stefaniak, J O'Brien

    Is there a preference for PET or SPECT brain imaging in diagnosing dementia? The views of people with dementia, carers, and healthy controls.

    DOI: http://doi.org/10.1017/S1041610215001039
    Journal: Int Psychogeriatr
    E-pub date: 1 Jan 2016
    Authors: C Bamford, K Olsen, C Davison, N Barnett, J Lloyd, D Williams, M Firbank, H Mason, C Donaldson, J O'Brien

    Neurophysiological biomarkers for Lewy body dementias.

    DOI: http://doi.org/10.1016/j.clinph.2015.06.020
    Journal: Clin Neurophysiol
    E-pub date: 1 Jan 2016
    Authors: RA Cromarty, GJ Elder, S Graziadio, M Baker, L Bonanni, M Onofrj, JT O'Brien, J-P Taylor

    Management of late-life depression: a major leap forward.

    DOI: http://doi.org/10.1016/S0140-6736(15)00304-9
    Journal: Lancet
    E-pub date: 12 Dec 2015
    Authors: A Thomas, JT O'Brien

    Nursing home placement in the Donepezil and Memantine in Moderate to Severe Alzheimer’s Disease (DOMINO-AD) trial: secondary and post-hoc analyses.

    DOI: http://doi.org/10.1016/S1474-4422(15)00258-6
    Journal: Lancet Neurol
    E-pub date: 1 Dec 2015
    Authors: R Howard, R McShane, J Lindesay, C Ritchie, A Baldwin, R Barber, A Burns, T Dening, D Findlay, C Holmes, R Jones, R Jones, I McKeith, A Macharouthu, J O'Brien, B Sheehan, E Juszczak, C Katona, R Hills, M Knapp, C Ballard, RG Brown, S Banerjee, J Adams, T Johnson, P Bentham, PPJ Phillips

    Resting state in Parkinson’s disease dementia and dementia with Lewy bodies: commonalities and differences.

    DOI: http://doi.org/10.1002/gps.4342
    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Nov 2015
    Authors: LR Peraza, SJ Colloby, MJ Firbank, GS Greasy, IG McKeith, M Kaiser, J O'Brien, J-P Taylor

    Vascular dementia.

    DOI: http://doi.org/10.1016/S0140-6736(15)00463-8
    Journal: Lancet
    E-pub date: 24 Oct 2015
    Authors: JT O'Brien, A Thomas

    Cortical tau load is associated with white matter hyperintensities.

    DOI: http://doi.org/10.1186/s40478-015-0240-0
    Journal: Acta Neuropathol Commun
    E-pub date: 30 Sep 2015
    Authors: KE McAleese, M Firbank, M Dey, SJ Colloby, L Walker, M Johnson, JR Beverley, JP Taylor, AJ Thomas, JT O'Brien, J Attems

    Regional covariance of muscarinic acetylcholine receptors in Alzheimer’s disease using (R, R) [(123)I]-QNB SPECT.

    DOI: http://doi.org/10.1007/s00415-015-7827-z
    Journal: J Neurol
    E-pub date: 1 Sep 2015
    Authors: SJ Colloby, IG McKeith, DJ Wyper, JT O'Brien, J-P Taylor

    Lessons from a pilot and feasibility randomised trial in depression (Blood pressure Rapid Intensive Lowering And Normal Treatment for Mood and cognition in persistent depression (BRILiANT mood study)).

    DOI: http://doi.org/10.1186/s40814-015-0042-y
    Journal: Pilot Feasibility Stud
    E-pub date: 1 Aug 2015
    Authors: K Olsen, D Howel, R Barber, GA Ford, P Gallagher, RH McAllister-Williams, J Nilsson, J O'Brien, J Parker, A Thomas

    Cortical Thickness in Dementia with Lewy Bodies and Alzheimer’s Disease: A Comparison of Prodromal and Dementia Stages.

    DOI: http://doi.org/10.1371/journal.pone.0127396
    Journal: PLoS One
    E-pub date: 1 Aug 2015
    Authors: F Blanc, SJ Colloby, N Philippi, X de Pétigny, B Jung, C Demuynck, C Phillipps, P Anthony, A Thomas, F Bing, J Lamy, C Martin-Hunyadi, JT O'Brien, B Cretin, I McKeith, J-P Armspach, J-P Taylor

    Amyloid imaging for dementia in clinical practice.

    DOI: http://doi.org/10.1186/s12916-015-0404-6
    Journal: BMC Med
    E-pub date: 13 Jul 2015
    Authors: JT O'Brien, K Herholz

    Physical activity in the elderly is associated with improved executive function and processing speed: the LADIS Study.

    DOI: http://doi.org/10.1002/gps.4220
    Journal: Int J Geriatr Psychiatry
    E-pub date: 1 Jul 2015
    Authors: KS Frederiksen, A Verdelho, S Madureira, H Bäzner, JT O'Brien, F Fazekas, P Scheltens, R Schmidt, A Wallin, L-O Wahlund, T Erkinjunttii, A Poggesi, L Pantoni, D Inzitari, G Waldemar, LADIS Study

    Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias.

    DOI: http://doi.org/10.1111/bpa.12182
    Journal: Brain Pathology
    E-pub date: 1 Jul 2015
    Authors: DR Howlett, D Whitfield, M Johnson, J Attems, JT O'Brien, D Aarsland, MKP Lai, JH Lee, C Chen, C Ballard, T Hortobágyi, PT Francis

    EFNS-ENS/EAN Guideline on concomitant use of cholinesterase inhibitors and memantine in moderate to severe Alzheimer’s disease.

    DOI: http://doi.org/10.1111/ene.12707
    Journal: Eur J Neurol
    E-pub date: 1 Jun 2015
    Authors: R Schmidt, E Hofer, FH Bouwman, K Buerger, C Cordonnier, T Fladby, D Galimberti, J Georges, MT Heneka, J Hort, J Laczó, JL Molinuevo, JT O'Brien, D Religa, P Scheltens, JM Schott, S Sorbi

    Plasma and platelet clusterin ratio is altered in Alzheimer’s disease patients with distinct neuropsychiatric symptoms: findings from a pilot study.

    DOI: http://doi.org/10.1002/gps.4145
    Journal: International Journal of Geriatric Psychiatry
    E-pub date: 1 Apr 2015
    Authors: EB Mukaetova-Ladinska, Z Abdel-All, J Andrade, J Alves da Silva, JT O'Brien, RN Kalaria

    Depression and synaptic zinc regulation in Alzheimer disease, dementia with lewy bodies, and Parkinson disease dementia.

    DOI: http://doi.org/10.1016/j.jagp.2014.05.001
    Journal: American Journal of Geriatric Psychiatry
    E-pub date: 1 Feb 2015
    Authors: DR Whitfield, J Vallortigara, A Alghamdi, T Hortobágyi, C Ballard, AJ Thomas, JT O'Brien, D Aarsland, PT Francis

    Driving and dementia: a clinical decision pathway.

    DOI: http://doi.org/10.1002/gps.4132
    Journal: International Journal of Geriatric Psychiatry
    E-pub date: 1 Feb 2015
    Authors: K Carter, S Monaghan, J O'Brien, A Teodorczuk, U Mosimann, J-P Taylor

    Prodromal dementia with Lewy bodies.

    DOI: http://doi.org/10.1017/S0033291714000816
    Journal: Psychological Medicine
    E-pub date: 12 Jan 2015
    Authors: PC Donaghy, JT O'Brien, AJ Thomas

    Shape abnormalities of the caudate nucleus correlate with poorer gait and balance: results from a subset of the LADIS study.

    DOI: http://doi.org/10.1016/j.jagp.2013.04.011
    Journal: Am J Geriatr Psychiatry
    E-pub date: 1 Jan 2015
    Authors: MD Macfarlane, JCL Looi, M Walterfang, G Spulber, D Velakoulis, M Styner, M Crisby, E Orndahl, T Erkinjuntti, G Waldemar, E Garde, MG Hennerici, H Bäzner, C Blahak, A Wallin, L-O Wahlund, LADIS Study Group

    Tissue microstructural changes in dementia with Lewy bodies revealed by quantitative MRI.

    DOI: http://doi.org/10.1007/s00415-014-7541-2
    Journal: J Neurol
    E-pub date: 1 Jan 2015
    Authors: L Su, AM Blamire, R Watson, J He, B Aribisala, JT O'Brien

    Assessment of regional gray matter loss in dementia with Lewy bodies: a surface-based MRI analysis.

    DOI: http://doi.org/10.1016/j.jagp.2014.07.005
    Journal: Am J Geriatr Psychiatry
    E-pub date: 1 Jan 2015
    Authors: R Watson, SJ Colloby, AM Blamire, JT O'Brien

    The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: evidence of validity.

    DOI: http://doi.org/10.1016/j.jalz.2014.05.1756
    Journal: Alzheimer's and Dementia
    E-pub date: 1 Jan 2015
    Authors: GB Frisoni, CR Jack, M Bocchetta, C Bauer, KS Frederiksen, Y Liu, G Preboske, T Swihart, M Blair, E Cavedo, MJ Grothe, M Lanfredi, O Martinez, M Nishikawa, M Portegies, T Stoub, C Ward, LG Apostolova, R Ganzola, D Wolf, F Barkhof, G Bartzokis, C DeCarli, JG Csernansky, L deToledo-Morrell, MI Geerlings, J Kaye, RJ Killiany, S Lehéricy, H Matsuda, J O'Brien, LC Silbert, P Scheltens, H Soininen, S Teipel, G Waldemar, A Fellgiebel, J Barnes, M Firbank, L Gerritsen, W Henneman, N Malykhin, JC Pruessner, L Wang, C Watson, H Wolf, M deLeon, J Pantel, C Ferrari, P Bosco, P Pasqualetti, S Duchesne, H Duvernoy, M Boccardi, EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging Initiative

    Delirium and dementia with Lewy bodies: distinct diagnoses or part of the same spectrum?

    DOI: http://doi.org/10.1136/jnnp-2013-306389
    Journal: Journal of Neurology, Neurosurgery and Psychiatry
    E-pub date: 1 Jan 2015
    Authors: RL Gore, ERLC Vardy, JT O'Brien

    Amyloid PET Imaging in Lewy body disorders.

    DOI: http://doi.org/10.1016/j.jagp.2013.03.001
    Journal: American Journal of Geriatric Psychiatry
    E-pub date: 1 Jan 2015
    Authors: P Donaghy, AJ Thomas, JT O'Brien

    Neuropsychiatric outcomes after stroke–authors’ reply.

    DOI: http://doi.org/10.1016/S1474-4422(14)70226-1
    Journal: Lancet Neurol
    E-pub date: 1 Dec 2014
    Authors: S Köhler, ML Hackett, JT O'Brien, GE Mead

    18F-FDG PET and perfusion SPECT in the diagnosis of Alzheimer and Lewy body dementias.

    DOI: http://doi.org/10.2967/jnumed.114.143347
    Journal: J Nucl Med
    E-pub date: 1 Dec 2014
    Authors: JT O'Brien, MJ Firbank, C Davison, N Barnett, C Bamford, C Donaldson, K Olsen, K Herholz, D Williams, J Lloyd

    Biomarkers in dementia: clinical utility and new directions.

    DOI: http://doi.org/10.1136/jnnp-2014-307662
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Dec 2014
    Authors: RM Ahmed, RW Paterson, JD Warren, H Zetterberg, JT O'Brien, NC Fox, GM Halliday, JM Schott

    Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer’s disease: association with cognitive impairment.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2014.06.015
    Journal: Neurobiology of Aging
    E-pub date: 1 Dec 2014
    Authors: DR Whitfield, J Vallortigara, A Alghamdi, D Howlett, T Hortobágyi, M Johnson, J Attems, S Newhouse, C Ballard, AJ Thomas, JT O'Brien, D Aarsland, PT Francis

    Patterns of cerebellar volume loss in dementia with Lewy bodies and Alzheimer׳s disease: A VBM-DARTEL study.

    DOI: http://doi.org/10.1016/j.pscychresns.2014.06.006
    Journal: Psychiatry Research - Neuroimaging
    E-pub date: 30 Sep 2014
    Authors: SJ Colloby, JT O'Brien, J-P Taylor

    Lewy body compared with Alzheimer dementia is associated with decreased functional connectivity in resting state networks.

    DOI: http://doi.org/10.1016/j.pscychresns.2014.06.004
    Journal: Psychiatry Research - Neuroimaging
    E-pub date: 30 Sep 2014
    Authors: ER Lowther, JT O'Brien, MJ Firbank, AM Blamire

    Blood pressure and low-density lipoprotein-cholesterol lowering for prevention of strokes and cognitive decline: a review of available trial evidence.

    DOI: http://doi.org/10.1097/HJH.0000000000000253
    Journal: J Hypertens
    E-pub date: 1 Sep 2014
    Authors: A Zanchetti, L Liu, G Mancia, G Parati, G Grassi, M Stramba-Badiale, V Silani, G Bilo, G Corrao, A Zambon, L Scotti, X Zhang, H Wang, Y Zhang, X Zhang, TR Guan, E Berge, J Redon, K Narkiewicz, A Dominiczak, P Nilsson, M Viigimaa, S Laurent, E Agabiti-Rosei, Z Wu, D Zhu, JL Rodicio, LM Ruilope, N Martell-Claros, F Pinto, RE Schmieder, M Burnier, M Banach, R Cifkova, C Farsang, A Konradi, I Lazareva, Y Sirenko, M Dorobantu, A Postadzhiyan, R Accetto, B Jelakovic, D Lovic, AJ Manolis, P Stylianou, S Erdine, D Dicker, G Wei, C Xu, H Xie, A Coca, J O'Brien, G Ford

    Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient: design of the European Society of Hypertension-Chinese Hypertension League Stroke in Hypertension Optimal Treatment randomized trial.

    DOI: http://doi.org/10.1097/HJH.0000000000000254
    Journal: J Hypertens
    E-pub date: 1 Sep 2014
    Authors: A Zanchetti, L Liu, G Mancia, G Parati, G Grassi, M Stramba-Badiale, V Silani, G Bilo, G Corrao, A Zambon, L Scotti, X Zhang, H Wang, Y Zhang, X Zhang, TR Guan, E Berge, J Redon, K Narkiewicz, A Dominiczak, P Nilsson, M Viigimaa, S Laurent, E Agabiti-Rosei, Z Wu, D Zhu, JL Rodicio, LM Ruilope, N Martell-Claros, F Pinto, RE Schmieder, M Burnier, M Banach, R Cifkova, C Farsang, A Konradi, I Lazareva, Y Sirenko, M Dorobantu, A Postadzhiyan, R Accetto, B Jelakovic, D Lovic, AJ Manolis, P Stylianou, S Erdine, D Dicker, G Wei, C Xu, H Xie, A Coca, J O'Brien, G Ford

    Safety analysis of 10 clinical trials and for 13 years after first approval of ioflupane 123I injection (DaTscan).

    DOI: http://doi.org/10.2967/jnumed.114.138032
    Journal: J Nucl Med
    E-pub date: 31 Aug 2014
    Authors: DG Grosset, K Tatsch, WH Oertel, E Tolosa, N Bajaj, A Kupsch, JT O'Brien, J Seibyl, Z Walker, P Sherwin, C Chen, ID Grachev

    Individual-reader diagnostic performance and between-reader agreement in assessment of subjects with Parkinsonian syndrome or dementia using 123I-ioflupane injection (DaTscan) imaging.

    DOI: http://doi.org/10.2967/jnumed.114.140228
    Journal: J Nucl Med
    E-pub date: 31 Aug 2014
    Authors: JP Seibyl, A Kupsch, J Booij, DG Grosset, DC Costa, RA Hauser, J Darcourt, N Bajaj, Z Walker, K Marek, I McKeith, JT O'Brien, K Tatsch, E Tolosa, RA Dierckx, ID Grachev

    Dynamin1 concentration in the prefrontal cortex is associated with cognitive impairment in Lewy body dementia.

    DOI: http://doi.org/10.12688/f1000research.3786.1
    Journal: F1000Res
    E-pub date: 1 Aug 2014
    Authors: J Vallortigara, S Rangarajan, D Whitfield, A Alghamdi, D Howlett, T Hortobágyi, M Johnson, J Attems, C Ballard, A Thomas, J O'Brien, D Aarsland, P Francis

    fMRI resting state networks and their association with cognitive fluctuations in dementia with Lewy bodies.

    DOI: http://doi.org/10.1016/j.nicl.2014.03.013
    Journal: Neuroimage Clin
    E-pub date: 1 Aug 2014
    Authors: LR Peraza, M Kaiser, M Firbank, S Graziadio, L Bonanni, M Onofrj, SJ Colloby, A Blamire, J O'Brien, J-P Taylor

    Diagnostic criteria for vascular cognitive disorders: a VASCOG statement.

    DOI: http://doi.org/10.1097/WAD.0000000000000034
    Journal: Alzheimer Dis Assoc Disord
    E-pub date: 1 Aug 2014
    Authors: P Sachdev, R Kalaria, J O'Brien, I Skoog, S Alladi, SE Black, D Blacker, DG Blazer, C Chen, H Chui, M Ganguli, K Jellinger, DV Jeste, F Pasquier, J Paulsen, N Prins, K Rockwood, G Roman, P Scheltens, Internationlal Society for Vascular Behavioral and Cognitive Disorders

    Is ioflupane I123 injection diagnostically effective in patients with movement disorders and dementia? Pooled analysis of four clinical trials.

    DOI: http://doi.org/10.1136/bmjopen-2014-005122
    Journal: BMJ Open
    E-pub date: 3 Jul 2014
    Authors: JT O'Brien, WH Oertel, IG McKeith, DG Grosset, Z Walker, K Tatsch, E Tolosa, PF Sherwin, ID Grachev

    Neuropsychiatric outcomes of stroke.

    DOI: http://doi.org/10.1016/S1474-4422(14)70016-X
    Journal: Lancet Neurol
    E-pub date: 1 May 2014
    Authors: ML Hackett, S Köhler, JT O'Brien, GE Mead

    White matter and cognitive decline in aging: a focus on processing speed and variability.

    DOI: http://doi.org/10.1017/S1355617713001458
    Journal: Journal of the International Neuropsychological Society
    E-pub date: 24 Feb 2014
    Authors: J Nilsson, AJ Thomas, JT O'Brien, P Gallagher

    Neurological abnormalities predict disability: the LADIS (Leukoaraiosis And DISability) study.

    DOI: http://doi.org/10.1007/s00415-014-7332-9
    Journal: Journal of Neurology
    E-pub date: 1 Jan 2014
    Authors: A Poggesi, A Gouw, W van der Flier, G Pracucci, H Chabriat, T Erkinjuntti, F Fazekas, JM Ferro, C Blahak, P Langhorne, J O'Brien, R Schmidt, MC Visser, L-O Wahlund, G Waldemar, A Wallin, P Scheltens, D Inzitari, L Pantoni

    Assessment of regional MR diffusion changes in dementia with Lewy bodies and Alzheimer’s disease.

    DOI: http://doi.org/10.1017/S1041610213002317
    Journal: International Psychogeriatrics
    E-pub date: 1 Jan 2014
    Authors: J O'Donovan, R Watson, SJ Colloby, AM Blamire, JT O'Brien

    A comparison of FDG-PET and blood flow SPECT in the diagnosis of neurodegenerative dementias: a systematic review.

    DOI: http://doi.org/10.1002/gps.4036
    Journal: International Journal of Geriatric Psychiatry
    E-pub date: 1 Jan 2014
    Authors: CM Davison, JT O'Brien

    Clinical significance of white matter changes.

    DOI: http://doi.org/10.1016/j.jagp.2013.07.006
    Journal: American Journal of Geriatric Psychiatry
    E-pub date: 1 Jan 2014
    Authors: JT O'Brien

    Long-term incidence of depression and predictors of depressive symptoms in older stroke survivors.

    DOI: http://doi.org/10.1192/bjp.bp.113.128355
    Journal: Br J Psychiatry
    E-pub date: 1 Dec 2013
    Authors: LM Allan, EN Rowan, AJ Thomas, TM Polvikoski, JT O'Brien, RN Kalaria

    Distinct cognitive phenotypes in Alzheimer’s disease in older people.

    DOI: http://doi.org/10.1017/S1041610213000914
    Journal: International Psychogeriatrics
    E-pub date: 1 Oct 2013
    Authors: ERLC Vardy, AH Ford, P Gallagher, R Watson, IG McKeith, A Blamire, JT O'Brien

    Subcortical connectivity in dementia with Lewy bodies and Alzheimer’s disease.

    DOI: http://doi.org/10.1192/bjp.bp.112.108464
    Journal: Br J Psychiatry
    E-pub date: 1 Sep 2013
    Authors: ER Kenny, JT O'Brien, MJ Firbank, AM Blamire

    Deterioration of gait and balance over time: the effects of age-related white matter change–the LADIS study.

    DOI: http://doi.org/10.1159/000350725
    Journal: Cerebrovasc Dis
    E-pub date: 1 Aug 2013
    Authors: SH Kreisel, C Blahak, H Bäzner, D Inzitari, L Pantoni, A Poggesi, H Chabriat, T Erkinjuntti, F Fazekas, JM Ferro, P Langhorne, J O'Brien, P Scheltens, MC Visser, L-O Wahlund, G Waldemar, A Wallin, MG Hennerici

    Testing visual perception in dementia with Lewy bodies and Alzheimer disease.

    DOI: http://doi.org/10.1016/j.jagp.2012.11.015
    Journal: Am J Geriatr Psychiatry
    E-pub date: 1 Jun 2013
    Authors: JS Wood, MJ Firbank, UP Mosimann, R Watson, R Barber, AM Blamire, JT O'Brien

    Cerebral white matter changes are associated with abnormalities on neurological examination in non-disabled elderly: the LADIS study.

    DOI: http://doi.org/10.1007/s00415-012-6748-3
    Journal: J Neurol
    E-pub date: 1 Apr 2013
    Authors: A Poggesi, A Gouw, W van der Flier, G Pracucci, H Chabriat, T Erkinjuntti, F Fazekas, JM Ferro, M Hennerici, P Langhorne, JT O'Brien, MC Visser, L-O Wahlund, G Waldemar, A Wallin, P Scheltens, D Inzitari, L Pantoni

    Study of the use of antidepressants for depression in dementia: the HTA-SADD trial–a multicentre, randomised, double-blind, placebo-controlled trial of the clinical effectiveness and cost-effectiveness of sertraline and mirtazapine.

    DOI: http://doi.org/10.3310/hta17070
    Journal: Health Technol Assess
    E-pub date: 1 Feb 2013
    Authors: S Banerjee, J Hellier, R Romeo, M Dewey, M Knapp, C Ballard, R Baldwin, P Bentham, C Fox, C Holmes, C Katona, C Lawton, J Lindesay, G Livingston, N McCrae, E Moniz-Cook, J Murray, S Nurock, M Orrell, J O'Brien, M Poppe, A Thomas, R Walwyn, K Wilson, A Burns

    Depressive symptoms predict cognitive decline and dementia in older people independently of cerebral white matter changes: the LADIS study.

    DOI: http://doi.org/10.1136/jnnp-2012-304191
    Journal: Journal of Neurology, Neurosurgery and Psychiatry
    E-pub date: 1 Jan 2013
    Authors: A Verdelho, S Madureira, C Moleiro, JM Ferro, JT O'Brien, A Poggesi, L Pantoni, F Fazekas, P Scheltens, G Waldemar, A Wallin, T Erkinjuntti, D Inzitari, LADIS Study

    Preface

    DOI: http://doi.org/10.1159/000332437
    Journal:
    E-pub date: 4 Dec 2012
    Authors: KP Ebmeier, JT O'Brien, JP Taylor

    Psychiatry of Parkinson’s disease

    DOI: http://doi.org/10.1159/isbn.978-3-8055-9801-9
    Journal:
    E-pub date: 9 Jan 2012
    Authors: KP Ebmeier, JT O'Brien, JP Taylor

    White matter hyperintensities in mild lewy body dementia.

    DOI: http://doi.org/10.1159/000343480
    Journal: Dement Geriatr Cogn Dis Extra
    E-pub date: 1 Jan 2012
    Authors: K Oppedal, D Aarsland, MJ Firbank, H Sonnesyn, OB Tysnes, JT O'Brien, MK Beyer

    Alzheimer’s Disease

    DOI: http://doi.org/10.1002/9781444328394.ch16
    Journal:
    E-pub date: 6 Sep 2010
    Authors: J Hort, JT O'Brien, G Gainotti, T Pirttila, BO Popescu, I Rektorova, S Sorbi, P Scheltens

    International Psychogeriatrics to increase publication frequency to six issues per annum in 2007

    DOI: http://doi.org/10.1017/S1041610206004285
    Journal: International Psychogeriatrics
    E-pub date: 1 Dec 2006
    Authors: D Ames, J O'Brien

    Design and development of selective muscarinic agonists for the treatment of Alzheimer’s disease: characterization of tetrahydropyrimidine derivatives and development of new approaches for improved affinity and selectivity for M1 receptors.

    DOI: http://doi.org/10.1016/s0031-6865(99)00026-6
    Journal: Pharm Acta Helv
    E-pub date: 1 Mar 2000
    Authors: WS Messer, WG Rajeswaran, Y Cao, HJ Zhang, AA el-Assadi, C Dockery, J Liske, J O'Brien, FE Williams, XP Huang, ME Wroblewski, PI Nagy, SM Peseckis

    Psychotic symptoms in dementia and the rate of cognitive decline.

    DOI: http://doi.org/10.1111/j.1532-5415.1997.tb02980.x
    Journal: J Am Geriatr Soc
    E-pub date: 31 Aug 1997
    Authors: CG Ballard, JT O'Brien, B Coope, G Wilcock

    White matter lesions in depression and Alzheimer’s disease.

    DOI: http://doi.org/10.1192/bjp.169.5.671a
    Journal: Br J Psychiatry
    E-pub date: 1 Nov 1996
    Authors: JT O'Brien, D Ames

    Plasma catechols and monoamine oxidase metabolites in untreated Parkinson’s and Alzheimer’s diseases.

    DOI: http://doi.org/10.1016/0022-510x(95)00318-v
    Journal: J Neurol Sci
    E-pub date: 1 Mar 1996
    Authors: JE Ahlskog, RJ Uitti, GM Tyce, JF O'Brien, RC Petersen, E Kokmen

    Is hippocampal atrophy on magnetic resonance imaging a marker for Alzheimer’s disease?

    DOI: http://doi.org/10.1002/gps.930100602
    Journal: International Journal of Geriatric Psychiatry
    E-pub date: 1 Jan 1995
    Authors: JT O'Brien

    Cost-effectiveness of antidepressants.

    DOI: http://doi.org/10.1192/bjp.165.3.411a
    Journal: British Journal of Psychiatry
    E-pub date: 1 Jan 1994
    Authors: JT O'Brien

    Age-Associated Memory Impairment: A Real Disease Entity?

    DOI: http://doi.org/10.2165/00023210-199401020-00001
    Journal: CNS Drugs
    E-pub date: 1 Jan 1994
    Authors: JT O’Brien

    The rabbit syndrome: Occurrence in a neuroleptic naive patient

    DOI: http://doi.org/10.1002/gps.930080910
    Journal: International Journal of Geriatric Psychiatry
    E-pub date: 1 Jan 1993
    Authors: R Kelvin, J O'Brien, T Dening

    Demographic and clinical features of patients attending a memory clinic

    DOI: http://doi.org/10.1002/gps.930080607
    Journal: International Journal of Geriatric Psychiatry
    E-pub date: 1 Jan 1993
    Authors: OP Almeida, K Hill, R Howard, J O'brien, R Levy

    Letters to the editor

    DOI: http://doi.org/10.1002/gps.930080911
    Journal: International Journal of Geriatric Psychiatry
    E-pub date: 1 Jan 1993
    Authors: JT O'Brien, R Levy, A Barker, R Jones, GKW Ilcock, M Scott, T Pearsall, K Neubauer, M Boyle, G Razay, C Katona, G Livingston, C Ball

    Suicide and vehicle exhaust emissions.

    DOI: http://doi.org/10.1136/bmj.304.6838.1376-a
    Journal: BMJ
    E-pub date: 23 May 1992
    Authors: JT O'Brien, AF Tarbuck

    The effects of tacrine on regional cerebral blood flow in Alzheimer’s disease

    DOI: http://doi.org/10.1002/gps.930071110
    Journal: International Journal of Geriatric Psychiatry
    E-pub date: 1 Jan 1992
    Authors: JT O'Brien, GMS Syed, R Levy

    Permeable walls, floors, ceilings and doors. Partition delusions in late paraphrenia

    DOI: http://doi.org/10.1002/gps.930071006
    Journal: International Journal of Geriatric Psychiatry
    E-pub date: 1 Jan 1992
    Authors: R Howard, D Castle, J O'Brien, O Almeida, R Levy