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EMAIL spj24@cam.ac.uk
Department
  • Clinical Neurosciences
    • School
  • Clinical Medicine
    • Institute
  • Behavioural and Clinical Neuroscience Institute
    • Research Theme Lifelong Brain Development and Brain Ageing Neurons, Circuits and Networks
    Research Focus

    Keywords

  • Neuroimaging
  • Multimodality Imaging
  • Ageing

    • Clinical Conditions

  • Progressive supranuclear palsy
  • Frontotemporal dementia
  • Parkinson's disease

    • Equipment & Techniques

  • Magnetic resonance imaging (MRI)
  • Positron Emission Tomography (PET)
  • Statistical analysis

    • Back

    Mr Simon Jones

    University Position
    Research Associate

    Interests

    Imaging analysis and study design in Professor James Rowe's Group. Mainly looking at impulsivity in Parkinson's disease, PSP, FTD, CBD, dementia using structutral MR, PET and fMRI.

    Control group compared with PSP-RS and MSA-C

    Key Publications

    Evidence for causal top-down frontal contributions to predictive processes in speech perception.

    DOI: http://doi.org/10.1038/s41467-017-01958-7
    Journal: Nat Commun
    E-pub date: 18 Dec 2017
    Authors: TE Cope, E Sohoglu, W Sedley, K Patterson, PS Jones, J Wiggins, C Dawson, M Grube, RP Carlyon, TD Griffiths, MH Davis, JB Rowe

    B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebo-controlled trial.

    DOI: http://doi.org/10.1016/S1474-4422(10)70187-3
    Journal: Lancet Neurol
    E-pub date: 1 Sep 2010
    Authors: VITATOPS Trial Study Group

    Publications

    Synaptic density affects clinical severity via network dysfunction in syndromes associated with frontotemporal lobar degeneration.

    DOI: http://doi.org/10.1038/s41467-023-44307-7
    Journal: Nat Commun
    E-pub date: 20 Dec 2023
    Authors: DJ Whiteside, N Holland, KA Tsvetanov, E Mak, M Malpetti, G Savulich, PS Jones, M Naessens, MA Rouse, TD Fryer, YT Hong, FI Aigbirhio, E Mulroy, KP Bhatia, T Rittman, JT O'Brien, JB Rowe

    Structural correlates of survival in progressive supranuclear palsy.

    DOI: http://doi.org/10.1016/j.parkreldis.2023.105866
    Journal: Parkinsonism Relat Disord
    E-pub date: 1 Nov 2023
    Authors: D Street, WR Bevan-Jones, M Malpetti, PS Jones, L Passamonti, BC Ghosh, T Rittman, IT Coyle-Gilchrist, K Allinson, CE Dawson, JB Rowe

    Locus coeruleus integrity is linked to response inhibition deficits in Parkinson’s disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1523/JNEUROSCI.0289-22.2023
    Journal: J Neurosci
    E-pub date: 18 Oct 2023
    Authors: R Ye, FH Hezemans, C O'Callaghan, KA Tsvetanov, C Rua, PS Jones, N Holland, M Malpetti, AG Murley, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

    The neurophysiological effect of NMDA-R antagonism of frontotemporal lobar degeneration is conditional on individual GABA concentration.

    DOI: http://doi.org/10.1038/s41398-022-02114-6
    Journal: Transl Psychiatry
    E-pub date: 27 Aug 2022
    Authors: A Perry, LE Hughes, N Adams, M Naessens, AG Murley, MA Rouse, D Street, PS Jones, TE Cope, E Kocagoncu, JB Rowe

    Synaptic loss in behavioural variant frontotemporal dementia revealed by [11C]UCB-J PET

    DOI: http://doi.org/10.1101/2022.01.30.22270123
    Journal:
    E-pub date: 1 Aug 2022
    Authors: M Malpetti, S Jones, T Cope, N Holland, M Naessens, M Rouse, G Savulich, T Fryer, Y Hong, SM Sephton, F Aigbirhio, J O’Brien, J Rowe

    Noradrenergic deficits contribute to apathy in Parkinson’s disease through the precision of expected outcomes.

    DOI: http://doi.org/10.1371/journal.pcbi.1010079
    Journal: PLoS Comput Biol
    E-pub date: 1 May 2022
    Authors: FH Hezemans, N Wolpe, C O'Callaghan, R Ye, C Rua, PS Jones, AG Murley, N Holland, R Regenthal, KA Tsvetanov, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

    Molecular pathology and synaptic loss in primary tauopathies: A [18F]AV-1451 and [11C]UCB-J PET study

    DOI: http://doi.org/10.1093/brain/awab282
    Journal: Brain
    E-pub date: 29 Mar 2022
    Authors: N Holland, M Malpetti, T Rittman, E Mak, L Passamonti, S Kaalund, F Hezemans, P Jones, G Savulich, Y Hong, T Fryer, F Aigbirhio, J O'Brien, J Rowe

    Proton magnetic resonance spectroscopy in frontotemporal lobar degeneration-related syndromes.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2021.10.012
    Journal: Neurobiol Aging
    E-pub date: 1 Mar 2022
    Authors: AG Murley, KA Tsvetanov, MA Rouse, PS Jones, K Sværke, W Li, A Carpenter, JB Rowe

    Altered network stability in progressive supranuclear palsy.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2021.07.007
    Journal: Neurobiol Aging
    E-pub date: 1 Nov 2021
    Authors: DJ Whiteside, PS Jones, BCP Ghosh, I Coyle-Gilchrist, A Gerhard, MT Hu, JC Klein, PN Leigh, A Church, DJ Burn, HR Morris, JB Rowe, T Rittman

    Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease.

    DOI: http://doi.org/10.1093/brain/awab142
    Journal: Brain
    E-pub date: 4 Sep 2021
    Authors: C O'Callaghan, FH Hezemans, R Ye, C Rua, PS Jones, AG Murley, N Holland, R Regenthal, KA Tsvetanov, N Wolpe, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

    Noradrenergic deficits contribute to apathy in Parkinson’s disease through the precision of expected outcomes

    DOI: http://doi.org/10.1101/2021.07.04.21259922
    Journal:
    E-pub date: 1 Aug 2021
    Authors: F Hezemans, N Wolpe, C O’Callaghan, R Ye, C Rua, S Jones, A Murley, N Holland, R Regenthal, K Tsvetanov, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

    Substantia nigra ferric overload and neuromelanin loss in Parkinson’s disease measured with 7T MRI

    DOI: http://doi.org/10.1101/2021.04.13.21255416
    Journal:
    E-pub date: 1 Aug 2021
    Authors: C Rua, C O’Callaghan, R Ye, F Hezemans, L Passamonti, S Jones, G Williams, C Rodgers, J Rowe

    Predicting loss of independence and mortality in frontotemporal lobar degeneration syndromes.

    DOI: http://doi.org/10.1136/jnnp-2020-324903
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jul 2021
    Authors: AG Murley, MA Rouse, ITS Coyle-Gilchrist, PS Jones, W Li, J Wiggins, C Lansdall, P Vázquez Rodríguez, A Wilcox, K Patterson, JB Rowe

    Neuroinflammation predicts disease progression in progressive supranuclear palsy.

    DOI: http://doi.org/10.1136/jnnp-2020-325549
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jul 2021
    Authors: M Malpetti, L Passamonti, PS Jones, D Street, T Rittman, TD Fryer, YT Hong, P Vàsquez Rodriguez, WR Bevan-Jones, FI Aigbirhio, JT O'Brien, JB Rowe

    Synaptic density in carriers of C9orf72 mutations: a [11 C]UCB-J PET study.

    DOI: http://doi.org/10.1002/acn3.51407
    Journal: Ann Clin Transl Neurol
    E-pub date: 1 Jul 2021
    Authors: M Malpetti, N Holland, PS Jones, R Ye, TE Cope, TD Fryer, YT Hong, G Savulich, T Rittman, L Passamonti, E Mak, FI Aigbirhio, JT O'Brien, JB Rowe

    Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes.

    DOI: http://doi.org/10.1002/alz.12252
    Journal: Alzheimers Dement
    E-pub date: 1 Jun 2021
    Authors: M Malpetti, PS Jones, KA Tsvetanov, T Rittman, JC van Swieten, B Borroni, R Sanchez-Valle, F Moreno, R Laforce, C Graff, M Synofzik, D Galimberti, M Masellis, MC Tartaglia, E Finger, R Vandenberghe, A de Mendonça, F Tagliavini, I Santana, S Ducharme, CR Butler, A Gerhard, J Levin, A Danek, M Otto, GB Frisoni, R Ghidoni, S Sorbi, C Heller, EG Todd, M Bocchetta, DM Cash, RS Convery, G Peakman, KM Moore, JD Rohrer, RA Kievit, JB Rowe, Genetic FTD Initiative (GENFI)

    In vivo coupling of dendritic complexity with presynaptic density in primary tauopathies.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2021.01.016
    Journal: Neurobiol Aging
    E-pub date: 1 May 2021
    Authors: E Mak, N Holland, PS Jones, G Savulich, A Low, M Malpetti, SS Kaalund, L Passamonti, T Rittman, R Romero-Garcia, R Manavaki, GB Williams, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2020.11.006
    Journal: Neurobiol Aging
    E-pub date: 1 May 2021
    Authors: E Mak, N Nicastro, M Malpetti, G Savulich, A Surendranathan, N Holland, L Passamonti, PS Jones, SF Carter, L Su, YT Hong, TD Fryer, GB Williams, F Aigbirhio, JB Rowe, JT O'Brien

    Proximity to dementia onset and multi-modal neuroimaging changes: The prevent-dementia study.

    DOI: http://doi.org/10.1016/j.neuroimage.2021.117749
    Journal: Neuroimage
    E-pub date: 1 Apr 2021
    Authors: E Mak, M-E Dounavi, A Low, SF Carter, E McKiernan, GB Williams, PS Jones, I Carriere, GT Muniz, K Ritchie, C Ritchie, L Su, JT O'Brien

    In vivo PET imaging of neuroinflammation in familial frontotemporal dementia.

    DOI: http://doi.org/10.1136/jnnp-2020-323698
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Mar 2021
    Authors: M Malpetti, T Rittman, PS Jones, TE Cope, L Passamonti, WR Bevan-Jones, K Patterson, TD Fryer, YT Hong, FI Aigbirhio, JT O'Brien, JB Rowe

    Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia.

    DOI: http://doi.org/10.1002/alz.12209
    Journal: Alzheimers Dement
    E-pub date: 1 Mar 2021
    Authors: KA Tsvetanov, S Gazzina, PS Jones, J van Swieten, B Borroni, R Sanchez-Valle, F Moreno, R Laforce, C Graff, M Synofzik, D Galimberti, M Masellis, MC Tartaglia, E Finger, R Vandenberghe, A de Mendonça, F Tagliavini, I Santana, S Ducharme, C Butler, A Gerhard, A Danek, J Levin, M Otto, G Frisoni, R Ghidoni, S Sorbi, JD Rohrer, JB Rowe, Genetic FTD Initiative, GENFI

    An in vivo probabilistic atlas of the human locus coeruleus at ultra-high field.

    DOI: http://doi.org/10.1016/j.neuroimage.2020.117487
    Journal: Neuroimage
    E-pub date: 15 Jan 2021
    Authors: R Ye, C Rua, C O'Callaghan, PS Jones, FH Hezemans, SS Kaalund, KA Tsvetanov, CT Rodgers, G Williams, L Passamonti, JB Rowe

    GABA and glutamate deficits from frontotemporal lobar degeneration are associated with disinhibition.

    DOI: http://doi.org/10.1093/brain/awaa305
    Journal: Brain
    E-pub date: 5 Dec 2020
    Authors: AG Murley, MA Rouse, PS Jones, R Ye, FH Hezemans, C O'Callaghan, P Frangou, Z Kourtzi, C Rua, TA Carpenter, CT Rodgers, JB Rowe

    Neuroinflammation and Tau Colocalize in vivo in Progressive Supranuclear Palsy.

    DOI: http://doi.org/10.1002/ana.25911
    Journal: Ann Neurol
    E-pub date: 1 Dec 2020
    Authors: M Malpetti, L Passamonti, T Rittman, PS Jones, P Vázquez Rodríguez, WR Bevan-Jones, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Multimodal imaging markers of tau, neuroinflammation and atrophy to predict clinical progression in progressive supranuclear palsy

    DOI: http://doi.org/10.1002/alz.044724
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2020
    Authors: M Malpetti, L Passamonti, PS Jones, T Rittman, TD Fryer, YT Hong, D Street, PV Rodríguez, WR Bevan‐Jones, FI Aigbirhio, JT O'Brien, JB Rowe

    The prognostic role of microglia and tau PET in Alzheimer’s disease

    DOI: http://doi.org/10.1002/alz.039817
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2020
    Authors: M Malpetti, RA Kievit, L Passamonti, PS Jones, KA Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan‐Jones, L Su, YT Hong, TD Fryer, FI Aigbirho, JT O'Brien, JB Rowe

    Early-stage 11C-Flumazenil PET predicts day-14 selective neuronal loss in a rodent model of transient focal cerebral ischemia.

    DOI: http://doi.org/10.1177/0271678X19883040
    Journal: J Cereb Blood Flow Metab
    E-pub date: 1 Oct 2020
    Authors: JL Hughes, JS Beech, PS Jones, D Wang, DK Menon, FI Aigbirhio, TD Fryer, J-C Baron

    Synaptic Loss in Primary Tauopathies Revealed by [11 C]UCB-J Positron Emission Tomography.

    DOI: http://doi.org/10.1002/mds.28188
    Journal: Mov Disord
    E-pub date: 1 Oct 2020
    Authors: N Holland, PS Jones, G Savulich, JK Wiggins, YT Hong, TD Fryer, R Manavaki, SM Sephton, I Boros, M Malpetti, FH Hezemans, FI Aigbirhio, JP Coles, J O'Brien, JB Rowe

    Metabolomic changes associated with frontotemporal lobar degeneration syndromes.

    DOI: http://doi.org/10.1007/s00415-020-09824-1
    Journal: J Neurol
    E-pub date: 31 Aug 2020
    Authors: AG Murley, PS Jones, I Coyle Gilchrist, L Bowns, J Wiggins, KA Tsvetanov, JB Rowe

    Synaptic loss in primary tauopathies revealed by [11C]UCB-J positron emission tomography

    DOI: http://doi.org/10.1101/2020.01.24.20018697
    Journal:
    E-pub date: 1 Aug 2020
    Authors: N Holland, S Jones, G Savulich, J Wiggins, Y Hong, T Fryer, R Manavaki, SM Sephton, I Boros, M Malpetti, F Hezemans, F Aigbirhio, J Coles, J O’Brien, J Rowe

    In vivo PET imaging of neuroinflammation in familial frontotemporal dementia

    DOI: http://doi.org/10.1101/2020.05.11.20098046
    Journal:
    E-pub date: 1 Aug 2020
    Authors: M Malpetti, T Rittman, S Jones, T Cope, L Passamonti, R Bevan-Jones, K Patterson, T Fryer, Y Hong, F Aigbirhio, J O’Brien, J Rowe

    Redefining the multidimensional clinical phenotypes of frontotemporal lobar degeneration syndromes.

    DOI: http://doi.org/10.1093/brain/awaa097
    Journal: Brain
    E-pub date: 1 May 2020
    Authors: AG Murley, I Coyle-Gilchrist, MA Rouse, PS Jones, W Li, J Wiggins, C Lansdall, PV Rodríguez, A Wilcox, KA Tsvetanov, K Patterson, MA Lambon Ralph, JB Rowe

    Microglial activation and tau burden predict cognitive decline in Alzheimer’s disease.

    DOI: http://doi.org/10.1093/brain/awaa088
    Journal: Brain
    E-pub date: 1 May 2020
    Authors: M Malpetti, RA Kievit, L Passamonti, PS Jones, KA Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.

    DOI: http://doi.org/10.1093/brain/awaa033
    Journal: Brain
    E-pub date: 1 Mar 2020
    Authors: WR Bevan-Jones, TE Cope, PS Jones, SS Kaalund, L Passamonti, K Allinson, O Green, YT Hong, TD Fryer, R Arnold, JP Coles, FI Aigbirhio, AJ Larner, K Patterson, JT O'Brien, JB Rowe

    Asymmetrical atrophy of thalamic subnuclei in Alzheimer’s disease and amyloid-positive mild cognitive impairment is associated with key clinical features.

    DOI: http://doi.org/10.1016/j.dadm.2019.08.001
    Journal: Alzheimers Dement (Amst)
    E-pub date: 1 Dec 2019
    Authors: A Low, E Mak, M Malpetti, L Chouliaras, N Nicastro, L Su, N Holland, T Rittman, PV Rodríguez, L Passamonti, WR Bevan-Jones, PS Jones, JB Rowe, JT O'Brien

    Impairments in reinforcement learning do not explain enhanced habit formation in cocaine use disorder.

    DOI: http://doi.org/10.1007/s00213-019-05330-z
    Journal: Psychopharmacology (Berl)
    E-pub date: 31 Aug 2019
    Authors: TV Lim, RN Cardinal, G Savulich, PS Jones, AA Moustafa, TW Robbins, KD Ersche

    Microglial activation and tau burden predict cognitive decline in Alzheimer’s Disease

    DOI: http://doi.org/10.1101/19011189
    Journal:
    E-pub date: 1 Aug 2019
    Authors: M Malpetti, R Kievit, L Passamonti, S Jones, K Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, Y Hong, T Fryer, F Aigbirhio, J O'Brien, J Rowe

    PET markers of tau and neuroinflammation are co-localized in progressive supranuclear palsy

    DOI: http://doi.org/10.1101/19010702
    Journal:
    E-pub date: 1 Aug 2019
    Authors: M Malpetti, L Passamonti, T Rittman, S Jones, P Vázquez Rodríguez, R Bevan-Jones, Y Hong, T Fryer, F Aigbirhio, J O’Brien, J Rowe

    Deconstructing appetitive learning in cocaine addiction using hierarchical Bayesian modelling

    DOI: http://doi.org/10.1016/j.euroneuro.2018.11.323
    Journal:
    E-pub date: 1 Aug 2019
    Authors: TV Lim, RN Cardinal, PS Jones, TW Robbins, KD Ersche

    Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2018.12.009
    Journal: Neurobiol Aging
    E-pub date: 1 May 2019
    Authors: T Rittman, R Borchert, S Jones, J van Swieten, B Borroni, D Galimberti, M Masellis, MC Tartaglia, C Graff, F Tagliavini, GB Frisoni, R Laforce, E Finger, A Mendonça, S Sorbi, JD Rohrer, JB Rowe, Genetic Frontotemporal Dementia Initiative (GENFI)

    In vivo evidence for pre-symptomatic neuroinflammation in a MAPT mutation carrier.

    DOI: http://doi.org/10.1002/acn3.683
    Journal: Ann Clin Transl Neurol
    E-pub date: 1 Feb 2019
    Authors: WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, YT Hong, T Fryer, R Arnold, JP Coles, FI Aigbirhio, JT O'Brien, JB Rowe

    [18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia.

    DOI: http://doi.org/10.1136/jnnp-2017-316402
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Oct 2018
    Authors: WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, YT Hong, TD Fryer, R Arnold, KSJ Allinson, JP Coles, FI Aigbirhio, K Patterson, JT O'Brien, JB Rowe

    [18F]AV-1451 binding is increased in frontotemporal dementia due to C9orf72 expansion.

    DOI: http://doi.org/10.1002/acn3.631
    Journal: Ann Clin Transl Neurol
    E-pub date: 1 Oct 2018
    Authors: RW Bevan-Jones, TE Cope, SP Jones, L Passamonti, YT Hong, T Fryer, R Arnold, JP Coles, FA Aigbirhio, K Patterson, JT O'Brien, JB Rowe

    Relationships between selective neuronal loss and microglial activation after ischaemic stroke in man.

    DOI: http://doi.org/10.1093/brain/awy121
    Journal: Brain
    E-pub date: 1 Jul 2018
    Authors: RS Morris, P Simon Jones, JA Alawneh, YT Hong, TD Fryer, FI Aigbirhio, EA Warburton, J-C Baron

    [11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1212/WNL.0000000000005610
    Journal: Neurology
    E-pub date: 29 May 2018
    Authors: L Passamonti, PV Rodríguez, YT Hong, KSJ Allinson, WR Bevan-Jones, D Williamson, PS Jones, R Arnold, RJ Borchert, A Surendranathan, E Mak, L Su, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    White matter change with apathy and impulsivity in frontotemporal lobar degeneration syndromes.

    DOI: http://doi.org/10.1212/WNL.0000000000005175
    Journal: Neurology
    E-pub date: 20 Mar 2018
    Authors: CJ Lansdall, ITS Coyle-Gilchrist, PS Jones, P Vázquez Rodríguez, A Wilcox, E Wehmann, KM Dick, TW Robbins, JB Rowe

    Tau burden and the functional connectome in Alzheimer’s disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1093/brain/awx347
    Journal: Brain
    E-pub date: 1 Feb 2018
    Authors: TE Cope, T Rittman, RJ Borchert, PS Jones, D Vatansever, K Allinson, L Passamonti, P Vazquez Rodriguez, WR Bevan-Jones, JT O'Brien, JB Rowe

    An open-label study to assess the feasibility and tolerability of rilmenidine for the treatment of Huntington’s disease.

    DOI: http://doi.org/10.1007/s00415-017-8647-0
    Journal: J Neurol
    E-pub date: 1 Dec 2017
    Authors: BR Underwood, ZW Green-Thompson, PJ Pugh, SE Lazic, SL Mason, J Griffin, PS Jones, JB Rowe, DC Rubinsztein, RA Barker

    Artificial grammar learning in vascular and progressive non-fluent aphasias.

    DOI: http://doi.org/10.1016/j.neuropsychologia.2017.08.022
    Journal: Neuropsychologia
    E-pub date: 1 Sep 2017
    Authors: TE Cope, B Wilson, H Robson, R Drinkall, L Dean, M Grube, PS Jones, K Patterson, TD Griffiths, JB Rowe, CI Petkov

    18F-AV-1451 positron emission tomography in Alzheimer’s disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1093/brain/aww340
    Journal: Brain
    E-pub date: 1 Mar 2017
    Authors: L Passamonti, P Vázquez Rodríguez, YT Hong, KSJ Allinson, D Williamson, RJ Borchert, S Sami, TE Cope, WR Bevan-Jones, PS Jones, R Arnold, A Surendranathan, E Mak, L Su, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Disrupted iron regulation in the brain and periphery in cocaine addiction.

    DOI: http://doi.org/10.1038/tp.2016.271
    Journal: Transl Psychiatry
    E-pub date: 21 Feb 2017
    Authors: KD Ersche, J Acosta-Cabronero, PS Jones, H Ziauddeen, RPL van Swelm, CMM Laarakkers, R Raha-Chowdhury, GB Williams

    [18F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation.

    DOI: http://doi.org/10.1002/acn3.366
    Journal: Ann Clin Transl Neurol
    E-pub date: 1 Dec 2016
    Authors: WR Bevan Jones, TE Cope, L Passamonti, TD Fryer, YT Hong, F Aigbirhio, JJ Kril, SL Forrest, K Allinson, JP Coles, P Simon Jones, MG Spillantini, JR Hodges, JT O'Brien, JB Rowe

    Atomoxetine restores the response inhibition network in Parkinson’s disease.

    DOI: http://doi.org/10.1093/brain/aww138
    Journal: Brain
    E-pub date: 31 Aug 2016
    Authors: CL Rae, C Nombela, PV Rodríguez, Z Ye, LE Hughes, PS Jones, T Ham, T Rittman, I Coyle-Gilchrist, R Regenthal, BJ Sahakian, RA Barker, TW Robbins, JB Rowe

    Hypothalamic volume loss is associated with reduced melatonin output in Parkinson’s disease.

    DOI: http://doi.org/10.1002/mds.26592
    Journal: Mov Disord
    E-pub date: 1 Jul 2016
    Authors: DP Breen, C Nombela, R Vuono, PS Jones, K Fisher, DJ Burn, DJ Brooks, AB Reddy, JB Rowe, RA Barker

    Atomoxetine Enhances Connectivity of Prefrontal Networks in Parkinson’s Disease.

    DOI: http://doi.org/10.1038/npp.2016.18
    Journal: Neuropsychopharmacology
    E-pub date: 1 Jul 2016
    Authors: RJ Borchert, T Rittman, L Passamonti, Z Ye, S Sami, SP Jones, C Nombela, P Vázquez Rodríguez, D Vatansever, CL Rae, LE Hughes, TW Robbins, JB Rowe

    Atomoxetine Enhances Connectivity of Prefrontal Networks in Parkinson’s Disease.

    DOI: http://doi.org/10.1038/npp.2016.46
    Journal: Neuropsychopharmacology
    E-pub date: 1 Jul 2016
    Authors: RJ Borchert, T Rittman, L Passamonti, Z Ye, S Sami, SP Jones, C Nombela, PV Rodríguez, D Vatansever, CL Rae, LE Hughes, TW Robbins, JB Rowe

    Carrots and sticks fail to change behavior in cocaine addiction.

    DOI: http://doi.org/10.1126/science.aaf3700
    Journal: Science
    E-pub date: 17 Jun 2016
    Authors: KD Ersche, CM Gillan, PS Jones, GB Williams, LHE Ward, M Luijten, S de Wit, BJ Sahakian, ET Bullmore, TW Robbins

    Predicting beneficial effects of atomoxetine and citalopram on response inhibition in Parkinson’s disease with clinical and neuroimaging measures.

    DOI: http://doi.org/10.1002/hbm.23087
    Journal: Hum Brain Mapp
    E-pub date: 1 Mar 2016
    Authors: Z Ye, CL Rae, C Nombela, T Ham, T Rittman, PS Jones, PV Rodríguez, I Coyle-Gilchrist, R Regenthal, E Altena, CR Housden, H Maxwell, BJ Sahakian, RA Barker, TW Robbins, JB Rowe

    Does stroke location predict walk speed response to gait rehabilitation?

    DOI: http://doi.org/10.1002/hbm.23059
    Journal: Hum Brain Mapp
    E-pub date: 1 Feb 2016
    Authors: PS Jones, VM Pomeroy, J Wang, G Schlaug, S Tulasi Marrapu, S Geva, PJ Rowe, E Chandler, A Kerr, J-C Baron, SWIFT-Cast investigators

    Is CT-Based Perfusion and Collateral Imaging Sensitive to Time Since Stroke Onset?

    DOI: http://doi.org/10.3389/fneur.2015.00070
    Journal: Front Neurol
    E-pub date: 1 Aug 2015
    Authors: S Agarwal, T Matys, ST Marrapu, DJ Scoffings, J Mitchell, PS Jones, J-C Baron, EA Warburton

    Diffusion and perfusion correlates of the 18F-MISO PET lesion in acute stroke: pilot study.

    DOI: http://doi.org/10.1007/s00259-013-2581-x
    Journal: Eur J Nucl Med Mol Imaging
    E-pub date: 1 Apr 2014
    Authors: JA Alawneh, RR Moustafa, ST Marrapu, U Jensen-Kondering, RS Morris, PS Jones, FI Aigbirhio, TD Fryer, TA Carpenter, EA Warburton, J-C Baron

    Prefrontal hypoactivity associated with impaired inhibition in stimulant-dependent individuals but evidence for hyperactivation in their unaffected siblings.

    DOI: http://doi.org/10.1038/npp.2013.90
    Journal: Neuropsychopharmacology
    E-pub date: 1 Sep 2013
    Authors: S Morein-Zamir, P Simon Jones, ET Bullmore, TW Robbins, KD Ersche

    Is neural activation within the rescued penumbra impeded by selective neuronal loss?

    DOI: http://doi.org/10.1093/brain/awt112
    Journal: Brain
    E-pub date: 1 Jun 2013
    Authors: E Carrera, PS Jones, RS Morris, J Alawneh, YT Hong, FI Aigbirhio, TD Fryer, TA Carpenter, EA Warburton, J-C Baron

    A comparison of VLSM and VBM in a cohort of patients with post-stroke aphasia.

    DOI: http://doi.org/10.1016/j.nicl.2012.08.003
    Journal: Neuroimage Clin
    E-pub date: 1 Aug 2012
    Authors: S Geva, J-C Baron, PS Jones, CJ Price, EA Warburton

    Abnormal brain structure implicated in stimulant drug addiction.

    DOI: http://doi.org/10.1126/science.1214463
    Journal: Science
    E-pub date: 3 Feb 2012
    Authors: KD Ersche, PS Jones, GB Williams, AJ Turton, TW Robbins, ET Bullmore

    A microPET study of the regional distribution of [11C]-PK11195 binding following temporary focal cerebral ischemia in the rat. Correlation with post mortem mapping of microglia activation.

    DOI: http://doi.org/10.1016/j.neuroimage.2011.10.060
    Journal: NeuroImage
    E-pub date: 1 Feb 2012
    Authors: JL Hughes, PS Jones, JS Beech, D Wang, DK Menon, FI Aigbirhio, TD Fryer, JC Baron

    Microembolism versus hemodynamic impairment in rosary-like deep watershed infarcts: a combined positron emission tomography and transcranial Doppler study.

    DOI: http://doi.org/10.1161/STROKEAHA.111.616334
    Journal: Stroke
    E-pub date: 1 Nov 2011
    Authors: RR Moustafa, I Momjian-Mayor, PS Jones, S Morbelli, DJ Day, FI Aigbirhio, TD Fryer, EA Warburton, J-C Baron

    The neural correlates of inner speech defined by voxel-based lesion-symptom mapping.

    DOI: http://doi.org/10.1093/brain/awr232
    Journal: Brain
    E-pub date: 1 Oct 2011
    Authors: S Geva, PS Jones, JT Crinion, CJ Price, J-C Baron, EA Warburton

    Abnormal structure of frontostriatal brain systems is associated with aspects of impulsivity and compulsivity in cocaine dependence.

    DOI: http://doi.org/10.1093/brain/awr138
    Journal: Brain
    E-pub date: 1 Jul 2011
    Authors: KD Ersche, A Barnes, PS Jones, S Morein-Zamir, TW Robbins, ET Bullmore

    Predicting infarction within the diffusion-weighted imaging lesion: does the mean transit time have added value?

    DOI: http://doi.org/10.1161/STROKEAHA.110.606970
    Journal: Stroke
    E-pub date: 1 Jun 2011
    Authors: E Carrera, PS Jones, JA Alawneh, I Klærke Mikkelsen, T-H Cho, S Siemonsen, JV Guadagno, K Mouridsen, L Ribe, N Hjort, TD Fryer, TA Carpenter, FI Aigbirhio, J Fiehler, N Nighoghossian, EA Warburton, L Ostergaard, J-C Baron

    Single-subject statistical mapping of acute brain hypoxia in the rat following middle cerebral artery occlusion: a microPET study.

    DOI: http://doi.org/10.1016/j.expneurol.2011.02.005
    Journal: Experimental Neurology
    E-pub date: 1 Jun 2011
    Authors: M Takasawa, JS Beech, TD Fryer, PS Jones, T Ahmed, R Smith, FI Aigbirhio, J-C Baron

    The vascular mean transit time: a surrogate for the penumbra flow threshold?

    DOI: http://doi.org/10.1038/jcbfm.2010.197
    Journal: Journal of Cerebral Blood Flow and Metabolism
    E-pub date: 1 Apr 2011
    Authors: E Carrera, PS Jones, S Iglesias, JV Guadagno, EA Warburton, TD Fryer, FI Aigbirhio, J-C Baron

    Watershed infarcts in transient ischemic attack/minor stroke with > or = 50% carotid stenosis: hemodynamic or embolic?

    DOI: http://doi.org/10.1161/STROKEAHA.110.580415
    Journal: Stroke
    E-pub date: 1 Jul 2010
    Authors: RR Moustafa, D Izquierdo-Garcia, PS Jones, MJ Graves, TD Fryer, JH Gillard, EA Warburton, J-C Baron

    T2*-weighted MRI versus oxygen extraction fraction PET in acute stroke.

    DOI: http://doi.org/10.1159/000229017
    Journal: Cerebrovasc Dis
    E-pub date: 1 Aug 2009
    Authors: ML Donswijk, PS Jones, JV Guadagno, TA Carpenter, RR Moustafa, TD Fryer, FI Aigbirhio, EA Warburton, JC Baron

    Selective neuronal loss in rescued penumbra relates to initial hypoperfusion.

    DOI: http://doi.org/10.1093/brain/awn175
    Journal: Brain
    E-pub date: 1 Oct 2008
    Authors: JV Guadagno, PS Jones, FI Aigbirhio, D Wang, TD Fryer, DJ Day, N Antoun, I Nimmo-Smith, EA Warburton, JC Baron

    How reliable is perfusion MR in acute stroke? Validation and determination of the penumbra threshold against quantitative PET.

    DOI: http://doi.org/10.1161/STROKEAHA.107.500090
    Journal: Stroke
    E-pub date: 1 Mar 2008
    Authors: M Takasawa, PS Jones, JV Guadagno, S Christensen, TD Fryer, S Harding, JH Gillard, GB Williams, FI Aigbirhio, EA Warburton, L Østergaard, J-C Baron

    Imaging of brain hypoxia in permanent and temporary middle cerebral artery occlusion in the rat using 18F-fluoromisonidazole and positron emission tomography: a pilot study.

    DOI: http://doi.org/10.1038/sj.jcbfm.9600405
    Journal: J Cereb Blood Flow Metab
    E-pub date: 1 Apr 2007
    Authors: M Takasawa, JS Beech, TD Fryer, YT Hong, JL Hughes, K Igase, PS Jones, R Smith, FI Aigbirhio, DK Menon, JC Clark, J-C Baron

    How affected is oxygen metabolism in DWI lesions?: A combined acute stroke PET-MR study.

    DOI: http://doi.org/10.1212/01.wnl.0000233984.66907.db
    Journal: Neurology
    E-pub date: 12 Sep 2006
    Authors: JV Guadagno, EA Warburton, PS Jones, DJ Day, FI Aigbirhio, TD Fryer, S Harding, CJ Price, HA Green, O Barret, JH Gillard, J-C Baron

    Assessment of brain tissue hypoxia during and after MCA occlusion in the rat using 18F-fluoromisonidazole (F-MISO) and microPET

    DOI: http://doi.org/10.1016/j.neuroimage.2006.04.132
    Journal: NEUROIMAGE
    E-pub date: 1 Aug 2006
    Authors: M Takasawa, J Beech, T Fryer, J Hughes, K Igase, PS Jones, R Smith, F Aigbirhio, J Clark, JC Baron

    Local relationships between restricted water diffusion and oxygen consumption in the ischemic human brain.

    DOI: http://doi.org/10.1161/01.STR.0000232437.00621.86
    Journal: Stroke
    E-pub date: 1 Jul 2006
    Authors: JV Guadagno, PS Jones, TD Fryer, O Barret, FI Aigbirhio, TA Carpenter, CJ Price, JH Gillard, EA Warburton, J-C Baron

    The diffusion-weighted lesion in acute stroke: heterogeneous patterns of flow/metabolism uncoupling as assessed by quantitative positron emission tomography.

    DOI: http://doi.org/10.1159/000084087
    Journal: Cerebrovasc Dis
    E-pub date: 1 Aug 2005
    Authors: JV Guadagno, EA Warburton, PS Jones, TD Fryer, DJ Day, JH Gillard, TA Carpenter, FI Aigbirhio, CJ Price, J-C Baron