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    Dr Yuan Huang

    University Position
    Research Associate


    I am interested in using mathematical and mechanical tools to describe the biological systems. Better understanding of diseases can be achieved by further analysing the structural and functional imaging data. We hope our work will improve the diagnostic and prognostic values of current imaging modalities, and ultimately aid the risk stratification and clinical management.

    Key Publications


    Association of Collagen, Elastin, Glycosaminoglycans, and Macrophages With Tissue Ultimate Material Strength and Stretch in Human Thoracic Aortic Aneurysms: A Uniaxial Tension Study.

    Journal: J Biomech Eng
    E-pub date: 1 Oct 2022
    Authors: A Tokgoz, S Wang, P Sastry, C Sun, NL Figg, Y Huang, MR Bennett, S Sinha, JH Gillard, MPF Sutcliffe, Z Teng

    Pericoronary and periaortic adipose tissue density are associated with inflammatory disease activity in Takayasu arteritis and atherosclerosis.

    Journal: Eur Heart J Open
    E-pub date: 1 Sep 2021
    Authors: C Wall, Y Huang, EPV Le, A Ćorović, CP Uy, D Gopalan, C Ma, R Manavaki, TD Fryer, L Aloj, MJ Graves, E Tombetti, B Ariff, P Bambrough, SP Hoole, RA Rusk, DR Jayne, MR Dweck, D Newby, ZA Fayad, MR Bennett, JE Peters, P Slomka, D Dey, JC Mason, JHF Rudd, JM Tarkin

    Study on the association of wall shear stress and vessel structural stress with atherosclerosis: An experimental animal study.

    Journal: Atherosclerosis
    E-pub date: 1 Mar 2021
    Authors: Z Teng, S Wang, A Tokgoz, V Taviani, J Bird, U Sadat, Y Huang, AJ Patterson, N Figg, MJ Graves, JH Gillard

    Assessing robustness of carotid artery CT angiography radiomics in the identification of culprit lesions in cerebrovascular events.

    Journal: Sci Rep
    E-pub date: 10 Feb 2021
    Authors: EPV Le, L Rundo, JM Tarkin, NR Evans, MM Chowdhury, PA Coughlin, H Pavey, C Wall, F Zaccagna, FA Gallagher, Y Huang, R Sriranjan, A Le, JR Weir-McCall, M Roberts, FJ Gilbert, EA Warburton, C-B Schönlieb, E Sala, JHF Rudd

    A Bayesian Updating Scheme for Pandemics: Estimating the Infection Dynamics of COVID-19

    Journal: IEEE Computational Intelligence Magazine
    E-pub date: 1 Nov 2020
    Authors: S Wang, X Yang, L Li, P Nadler, R Arcucci, Y Huang, Z Teng, Y Guo

    Greater aortic inflammation and calcification in abdominal aortic aneurysmal disease than atherosclerosis: a prospective matched cohort study.

    Journal: Open Heart
    E-pub date: 1 Aug 2020
    Authors: NV Joshi, M Elkhawad, RO Forsythe, OMB McBride, NK Rajani, JM Tarkin, MM Chowdhury, E Donoghue, JMJ Robson, JR Boyle, TD Fryer, Y Huang, Z Teng, MR Dweck, AA Tawakol, JH Gillard, PA Coughlin, IB Wilkinson, DE Newby, JHF Rudd

    Heterogeneity of Plaque Structural Stress Is Increased in Plaques Leading to MACE: Insights From the PROSPECT Study.

    Journal: JACC Cardiovasc Imaging
    E-pub date: 1 May 2020
    Authors: C Costopoulos, A Maehara, Y Huang, AJ Brown, JH Gillard, Z Teng, GW Stone, MR Bennett

    The role of porosity and 3D cross-stent configuration of multiple overlapping uncovered stents in the management of complex aortic aneurysms – insights from haemodynamics

    Journal: Medicine in Novel Technology and Devices
    E-pub date: 1 Dec 2019
    Authors: S Wang, Y Zhang, J Feng, Y Huang, P Hui, JH Gillard, Q Lu, Z Teng

    Bayesian Inference-Based Estimation of Normal Aortic, Aneurysmal and Atherosclerotic Tissue Mechanical Properties: From Material Testing, Modeling and Histology.

    Journal: IEEE Trans Biomed Eng
    E-pub date: 31 Aug 2019
    Authors: S Wang, A Tokgoz, Y Huang, Y Zhang, J Feng, P Sastry, C Sun, N Figg, Q Lu, MPF Sutcliffe, Z Teng, JH Gillard

    Impact of combined plaque structural stress and wall shear stress on coronary plaque progression, regression, and changes in composition.

    Journal: Eur Heart J
    E-pub date: 7 May 2019
    Authors: C Costopoulos, LH Timmins, Y Huang, OY Hung, DS Molony, AJ Brown, EL Davis, Z Teng, JH Gillard, H Samady, MR Bennett

    Neural network fusion: a novel CT-MR Aortic Aneurysm image segmentation method.

    Journal: Proc SPIE Int Soc Opt Eng
    E-pub date: 2 Mar 2018
    Authors: D Wang, R Zhang, J Zhu, Z Teng, Y Huang, F Spiga, M Hong-Fei Du, JH Gillard, Q Lu, P Liò

    Plaque Rupture in Coronary Atherosclerosis Is Associated With Increased Plaque Structural Stress.

    Journal: JACC Cardiovasc Imaging
    E-pub date: 1 Dec 2017
    Authors: C Costopoulos, Y Huang, AJ Brown, PA Calvert, SP Hoole, NEJ West, JH Gillard, Z Teng, MR Bennett

    Influence of overlapping pattern of multiple overlapping uncovered stents on the local mechanical environment: A patient-specific parameter study.

    Journal: J Biomech
    E-pub date: 26 Jul 2017
    Authors: S Wang, Y Zhang, J Feng, Y Huang, A Tokgoz, U Sadat, JH Gillard, Q Lu, Z Teng

    High Structural Stress and Presence of Intraluminal Thrombus Predict Abdominal Aortic Aneurysm 18F-FDG Uptake: Insights From Biomechanics.

    Journal: Circ Cardiovasc Imaging
    E-pub date: 1 Nov 2016
    Authors: Y Huang, Z Teng, M Elkhawad, JM Tarkin, N Joshi, JR Boyle, JR Buscombe, TD Fryer, Y Zhang, AY Park, IB Wilkinson, DE Newby, JH Gillard, JHF Rudd

    TCT-598 Plaque rupture in coronary atherosclerosis is associated with increased plaque structural stress.

    Journal: J Am Coll Cardiol
    E-pub date: 1 Nov 2016
    Authors: C Costopoulos, Y Huang, A Brown, P Calvert, S Hoole, N West, J Gillard, Z Teng, M Bennett

    Plaque Structural Stress Estimations Improve Prediction of Future Major Adverse Cardiovascular Events After Intracoronary Imaging.

    Journal: Circ Cardiovasc Imaging
    E-pub date: 1 Jun 2016
    Authors: AJ Brown, Z Teng, PA Calvert, NK Rajani, O Hennessy, N Nerlekar, DR Obaid, C Costopoulos, Y Huang, SP Hoole, M Goddard, NEJ West, JH Gillard, MR Bennett

    A uni-extension study on the ultimate material strength and extreme extensibility of atherosclerotic tissue in human carotid plaques.

    Journal: J Biomech
    E-pub date: 5 Nov 2015
    Authors: Z Teng, J Feng, Y Zhang, MPF Sutcliffe, Y Huang, AJ Brown, Z Jing, Q Lu, JH Gillard

    Layer- and Direction-Specific Material Properties, Extreme Extensibility and Ultimate Material Strength of Human Abdominal Aorta and Aneurysm: A Uniaxial Extension Study.

    Journal: Ann Biomed Eng
    E-pub date: 1 Nov 2015
    Authors: Z Teng, J Feng, Y Zhang, Y Huang, MPF Sutcliffe, AJ Brown, Z Jing, JH Gillard, Q Lu

    Management of complicated aortic aneurysms using multiple overlapping uncovered stents: mid-term outcome from a cohort study.

    Journal: Medicine (Baltimore)
    E-pub date: 1 Dec 2014
    Authors: Y Zhang, Z Teng, Q Lu, Z Zhao, J Bao, X Feng, R Feng, Z Chen, Y Huang, U Sadat, JH Gillard, Z Jing

    Material properties of components in human carotid atherosclerotic plaques: a uniaxial extension study.

    Journal: Acta Biomater
    E-pub date: 1 Dec 2014
    Authors: Z Teng, Y Zhang, Y Huang, J Feng, J Yuan, Q Lu, MPF Sutcliffe, AJ Brown, Z Jing, JH Gillard


    E-pub date: 1 Aug 2014
    Authors: AJ Brown, Z Teng, P Calvert, Y Huang, DR Obaid, S Hoole, N West, JH Gillard, M Bennett

    Coronary plaque structural stress is associated with plaque composition and subtype and higher in acute coronary syndrome: the BEACON I (Biomechanical Evaluation of Atheromatous Coronary Arteries) study.

    Journal: Circ Cardiovasc Imaging
    E-pub date: 1 May 2014
    Authors: Z Teng, AJ Brown, PA Calvert, RA Parker, DR Obaid, Y Huang, SP Hoole, NEJ West, JH Gillard, MR Bennett

    In vivo MRI-based simulation of fatigue process: a possible trigger for human carotid atherosclerotic plaque rupture.

    Journal: Biomed Eng Online
    E-pub date: 23 Apr 2013
    Authors: Y Huang, Z Teng, U Sadat, J He, MJ Graves, JH Gillard

    Microcalcification acts as a stress and stretch amplifier in the coronary atherosclerotic plaque affecting its vulnerability – An ivus-based finite element study

    Journal: ASME 2012 Summer Bioengineering Conference, SBC 2012
    E-pub date: 1 Dec 2012
    Authors: Y Huang, W Wang, Z Teng, DR Obaid, J He, PA Calvert, MR Bennett, JH Gillard

    Non-uniform shrinkage for obtaining computational start shape for in-vivo MRI-based plaque vulnerability assessment.

    Journal: J Biomech
    E-pub date: 11 Aug 2011
    Authors: Y Huang, Z Teng, U Sadat, S Hilborne, VE Young, MJ Graves, JH Gillard