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Dr Young T. Hong

University Position
Senior Research Associate

Interests

My main research area is developing mathematical models and numerical techniques in analysis of positron emission tomography (PET) data. Most of the PET images are obtained for acute head injury, psychiatry and neurology clinical research.

Key Publications

Metabolic derangements are associated with impaired glucose delivery following traumatic brain injury.

DOI: http://doi.org/10.1093/brain/awab255
Journal: Brain
E-pub date: 16 Dec 2021
Authors: J Hermanides, YT Hong, M Trivedi, J Outtrim, F Aigbirhio, PJ Nestor, M Guilfoyle, S Winzeck, VFJ Newcombe, T Das, MM Correia, KLH Carpenter, PJA Hutchinson, AK Gupta, TD Fryer, JD Pickard, DK Menon, JP Coles

Spatial and Temporal Pattern of Ischemia and Abnormal Vascular Function Following Traumatic Brain Injury.

DOI: http://doi.org/10.1001/jamaneurol.2019.3854
Journal: JAMA Neurol
E-pub date: 1 Mar 2020
Authors: Y Launey, TD Fryer, YT Hong, LA Steiner, J Nortje, TV Veenith, PJ Hutchinson, A Ercole, AK Gupta, FI Aigbirhio, JD Pickard, JP Coles, DK Menon

Pathophysiologic Mechanisms of Cerebral Ischemia and Diffusion Hypoxia in Traumatic Brain Injury.

DOI: http://doi.org/10.1001/jamaneurol.2016.0091
Journal: JAMA Neurol
E-pub date: 1 May 2016
Authors: TV Veenith, EL Carter, T Geeraerts, J Grossac, VFJ Newcombe, J Outtrim, GS Gee, V Lupson, R Smith, FI Aigbirhio, TD Fryer, YT Hong, DK Menon, JP Coles

Quantification of receptor-ligand binding potential in sub-striatal domains using probabilistic and template regions of interest.

DOI: http://doi.org/10.1016/j.neuroimage.2010.11.071
Journal: NeuroImage
E-pub date: 1 Mar 2011
Authors: N del Campo, RJ Tait, J Acosta-Cabronero, YT Hong, D Izquierdo-Garcia, R Smith, FI Aigbirhio, BJ Sahakian, U Müller, TW Robbins, TD Fryer

Parametric mapping of [18F]fluoromisonidazole positron emission tomography using basis functions.

DOI: http://doi.org/10.1038/jcbfm.2010.141
Journal: J Cereb Blood Flow Metab
E-pub date: 1 Feb 2011
Authors: YT Hong, JS Beech, R Smith, J-C Baron, TD Fryer

Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement.

DOI: http://doi.org/10.1126/science.1137073
Journal: Science
E-pub date: 2 Mar 2007
Authors: JW Dalley, TD Fryer, L Brichard, ESJ Robinson, DEH Theobald, K Lääne, Y Peña, ER Murphy, Y Shah, K Probst, I Abakumova, FI Aigbirhio, HK Richards, Y Hong, J-C Baron, BJ Everitt, TW Robbins

Publications

Synaptic Loss in Frontotemporal Dementia Revealed by [11 C]UCB-J Positron Emission Tomography.

DOI: http://doi.org/10.1002/ana.26543
Journal: Ann Neurol
E-pub date: 1 Jan 2023
Authors: M Malpetti, PS Jones, TE Cope, N Holland, M Naessens, MA Rouse, T Rittman, G Savulich, DJ Whiteside, D Street, TD Fryer, YT Hong, S Milicevic Sephton, FI Aigbirhio, JT O Brien, JB Rowe

Amyloid- β and tau deposition influences cognitive and functional decline in Down syndrome.

DOI: http://doi.org/10.1016/j.neurobiolaging.2022.07.003
Journal: Neurobiol Aging
E-pub date: 1 Nov 2022
Authors: M Grigorova, E Mak, SSG Brown, J Beresford-Webb, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, D Tudorascu, A Cohen, BT Christian, B Ances, BL Handen, CM Laymon, WE Klunk, ICH Clare, AJ Holland, SH Zaman

MINocyclinE to Reduce inflammation and blood brain barrier leakage in small Vessel diseAse (MINERVA) trial study protocol.

DOI: http://doi.org/10.1177/23969873221100338
Journal: Eur Stroke J
E-pub date: 1 Sep 2022
Authors: RB Brown, DJ Tozer, L Loubière, YT Hong, TD Fryer, GB Williams, MJ Graves, FI Aigbirhio, JT O'Brien, HS Markus

Synaptic loss in behavioural variant frontotemporal dementia revealed by [11C]UCB-J PET

DOI: http://doi.org/10.1101/2022.01.30.22270123
Journal:
E-pub date: 1 Aug 2022
Authors: M Malpetti, S Jones, T Cope, N Holland, M Naessens, M Rouse, G Savulich, T Fryer, Y Hong, SM Sephton, F Aigbirhio, J O’Brien, J Rowe

In Vivo 18F-Flortaucipir PET Does Not Accurately Support the Staging of Progressive Supranuclear Palsy.

DOI: http://doi.org/10.2967/jnumed.121.262985
Journal: J Nucl Med
E-pub date: 1 Jul 2022
Authors: M Malpetti, SS Kaalund, KA Tsvetanov, T Rittman, M Briggs, KSJ Allinson, L Passamonti, N Holland, PS Jones, TD Fryer, YT Hong, A Kouli, WR Bevan-Jones, E Mak, G Savulich, MG Spillantini, FI Aigbirhio, CH Williams-Gray, JT O'Brien, JB Rowe

Support vector machine learning and diffusion-derived structural networks predict amyloid quantity and cognition in adults with Down’s syndrome.

DOI: http://doi.org/10.1016/j.neurobiolaging.2022.02.013
Journal: Neurobiol Aging
E-pub date: 1 Jul 2022
Authors: SSG Brown, E Mak, I Clare, M Grigorova, J Beresford-Webb, M Walpert, E Jones, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, D Tudorascu, A Cohen, BT Christian, BL Handen, WE Klunk, DK Menon, PJ Nestor, AJ Holland, SH Zaman

Molecular pathology and synaptic loss in primary tauopathies: A [18F]AV-1451 and [11C]UCB-J PET study

DOI: http://doi.org/10.1093/brain/awab282
Journal: Brain
E-pub date: 29 Mar 2022
Authors: N Holland, M Malpetti, T Rittman, E Mak, L Passamonti, S Kaalund, F Hezemans, P Jones, G Savulich, Y Hong, T Fryer, F Aigbirhio, J O'Brien, J Rowe

Cortical atrophy and amyloid and tau deposition in Down syndrome: A longitudinal study.

DOI: http://doi.org/10.1002/dad2.12288
Journal: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
E-pub date: 1 Jan 2022
Authors: C Padilla, V Montal, MJ Walpert, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, SL Hartley, AD Cohen, DL Tudorascu, BT Christian, BL Handen, WE Klunk, AJ Holland, SH Zaman

Amyloid and tau deposition influences cognitive decline in Down syndrome

DOI: http://doi.org/10.1002/alz.056384
Journal: Alzheimer's & Dementia
E-pub date: 1 Dec 2021
Authors: M Grigorova, E Mak, J Beresford‐Webb, SSG Brown, E Jones, I Clare, T Holland, YT Hong, TD Fryer, JP Coles, GB Williams, FI Aigbirhio, BM Ances, BT Christian, BL Handen, WE Klunk, CM Laymon, DL Tudorascu, S Zaman

Microglial activation and atrophy in frontal cortex predict executive dysfunction in frontotemporal dementia

DOI: http://doi.org/10.1002/alz.055456
Journal: Alzheimer's & Dementia
E-pub date: 1 Dec 2021
Authors: M Malpetti, PS Jones, FH Hezemans, E Mak, D Street, L Passamonti, T Rittman, TE Cope, WR Bevan‐Jones, K Patterson, TD Fryer, YT Hong, FI Aigbirho, JT O'Brien, JB Rowe

Validation of a combined image derived input function and venous sampling approach for the quantification of [18F]GE-179 PET binding in the brain.

DOI: http://doi.org/10.1016/j.neuroimage.2021.118194
Journal: Neuroimage
E-pub date: 15 Aug 2021
Authors: M Galovic, K Erlandsson, TD Fryer, YT Hong, R Manavaki, H Sari, S Chetcuti, BA Thomas, M Fisher, S Sephton, R Canales, JJ Russell, K Sander, E Årstad, FI Aigbirhio, AM Groves, JS Duncan, K Thielemans, BF Hutton, JP Coles, MJ Koepp, NEST investigators

[18F]-AV-1451 binding in the substantia nigra as a marker of neuromelanin in Lewy body diseases.

DOI: http://doi.org/10.1093/braincomms/fcab177
Journal: Brain Commun
E-pub date: 1 Aug 2021
Authors: E Mak, A Kouli, N Holland, N Nicastro, G Savulich, A Surendranathan, M Malpetti, R Manavaki, YT Hong, TD Fryer, F Aigbirhio, JB Rowe, JT O'Brien, CH Williams-Gray

Measuring cerebral perfusion with [11C]-PiB R1 in Down syndrome: associations with amyloid burden and longitudinal cognitive decline.

DOI: http://doi.org/10.1093/braincomms/fcaa198
Journal: Brain Commun
E-pub date: 1 Aug 2021
Authors: E Mak, M Grigorova, J Beresford-Webb, M Malpetti, M Walpert, S Brown, E Jones, I Clare, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DK Menon, PJ Nestor, AJ Holland, SH Zaman

Neuroinflammation predicts disease progression in progressive supranuclear palsy.

DOI: http://doi.org/10.1136/jnnp-2020-325549
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Jul 2021
Authors: M Malpetti, L Passamonti, PS Jones, D Street, T Rittman, TD Fryer, YT Hong, P Vàsquez Rodriguez, WR Bevan-Jones, FI Aigbirhio, JT O'Brien, JB Rowe

Synaptic density in carriers of C9orf72 mutations: a [11 C]UCB-J PET study.

DOI: http://doi.org/10.1002/acn3.51407
Journal: Ann Clin Transl Neurol
E-pub date: 1 Jul 2021
Authors: M Malpetti, N Holland, PS Jones, R Ye, TE Cope, TD Fryer, YT Hong, G Savulich, T Rittman, L Passamonti, E Mak, FI Aigbirhio, JT O'Brien, JB Rowe

Microglial activation and blood-brain barrier permeability in cerebral small vessel disease.

DOI: http://doi.org/10.1093/brain/awab003
Journal: Brain
E-pub date: 22 Jun 2021
Authors: J Walsh, DJ Tozer, H Sari, YT Hong, A Drazyk, G Williams, NJ Shah, JT O'Brien, FI Aigbirhio, G Rosenberg, TD Fryer, HS Markus

[11C]PK11195-PET Brain Imaging of the Mitochondrial Translocator Protein in Mitochondrial Disease.

DOI: http://doi.org/10.1212/WNL.0000000000012033
Journal: Neurology
E-pub date: 31 May 2021
Authors: J van den Ameele, Y Hong, R Manavaki, A Kouli, H Biggs, Z MacIntyre, R Horvath, P Yu-Wai-Man, E Reid, CH Williams-Gray, E Bullmore, F Aigbirhio, T Fryer, P Chinnery

In vivo coupling of dendritic complexity with presynaptic density in primary tauopathies.

DOI: http://doi.org/10.1016/j.neurobiolaging.2021.01.016
Journal: Neurobiol Aging
E-pub date: 1 May 2021
Authors: E Mak, N Holland, PS Jones, G Savulich, A Low, M Malpetti, SS Kaalund, L Passamonti, T Rittman, R Romero-Garcia, R Manavaki, GB Williams, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography.

DOI: http://doi.org/10.1016/j.neurobiolaging.2020.11.006
Journal: Neurobiol Aging
E-pub date: 1 May 2021
Authors: E Mak, N Nicastro, M Malpetti, G Savulich, A Surendranathan, N Holland, L Passamonti, PS Jones, SF Carter, L Su, YT Hong, TD Fryer, GB Williams, F Aigbirhio, JB Rowe, JT O'Brien

In vivo PET imaging of neuroinflammation in familial frontotemporal dementia.

DOI: http://doi.org/10.1136/jnnp-2020-323698
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Mar 2021
Authors: M Malpetti, T Rittman, PS Jones, TE Cope, L Passamonti, WR Bevan-Jones, K Patterson, TD Fryer, YT Hong, FI Aigbirhio, JT O'Brien, JB Rowe

Relationship between tau, neuroinflammation and atrophy in Alzheimer’s disease: The NIMROD study

DOI: http://doi.org/10.1016/j.inffus.2020.10.006
Journal: Information Fusion
E-pub date: 1 Mar 2021
Authors: L Su, A Surendranathan, Y Huang, WR Bevan-Jones, L Passamonti, YT Hong, R Arnold, PV Rodríguez, Y Wang, E Mak, TD Fryer, F Aigbirhio, JB Rowe, JT O'Brien

Diffusion structural network metrics as a predictor for Alzheimer’s disease diagnosis in Down syndrome using support vector machine classification

DOI: http://doi.org/10.1002/alz.040261
Journal: Alzheimer's & Dementia
E-pub date: 1 Dec 2020
Authors: SSG Brown, E Mak, M Grigorova, J Beresford‐Webb, MJ Walpert, E Jones, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, BL Handen, BT Christian, WE Klunk, DK Menon, PJ Nestor, AJ Holland, S Zaman

Neuroinflammation and Tau Colocalize in vivo in Progressive Supranuclear Palsy.

DOI: http://doi.org/10.1002/ana.25911
Journal: Ann Neurol
E-pub date: 1 Dec 2020
Authors: M Malpetti, L Passamonti, T Rittman, PS Jones, P Vázquez Rodríguez, WR Bevan-Jones, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

Multimodal imaging markers of tau, neuroinflammation and atrophy to predict clinical progression in progressive supranuclear palsy

DOI: http://doi.org/10.1002/alz.044724
Journal: Alzheimer's & Dementia
E-pub date: 1 Dec 2020
Authors: M Malpetti, L Passamonti, PS Jones, T Rittman, TD Fryer, YT Hong, D Street, PV Rodríguez, WR Bevan‐Jones, FI Aigbirhio, JT O'Brien, JB Rowe

The prognostic role of microglia and tau PET in Alzheimer’s disease

DOI: http://doi.org/10.1002/alz.039817
Journal: Alzheimer's & Dementia
E-pub date: 1 Dec 2020
Authors: M Malpetti, RA Kievit, L Passamonti, PS Jones, KA Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan‐Jones, L Su, YT Hong, TD Fryer, FI Aigbirho, JT O'Brien, JB Rowe

Over-activation of primate subgenual cingulate cortex enhances the cardiovascular, behavioral and neural responses to threat.

DOI: http://doi.org/10.1038/s41467-020-19167-0
Journal: Nat Commun
E-pub date: 26 Oct 2020
Authors: L Alexander, CM Wood, PLR Gaskin, SJ Sawiak, TD Fryer, YT Hong, L McIver, HF Clarke, AC Roberts

Synaptic Loss in Primary Tauopathies Revealed by [11 C]UCB-J Positron Emission Tomography.

DOI: http://doi.org/10.1002/mds.28188
Journal: Mov Disord
E-pub date: 1 Oct 2020
Authors: N Holland, PS Jones, G Savulich, JK Wiggins, YT Hong, TD Fryer, R Manavaki, SM Sephton, I Boros, M Malpetti, FH Hezemans, FI Aigbirhio, JP Coles, J O'Brien, JB Rowe

Gray matter changes related to microglial activation in Alzheimer’s disease.

DOI: http://doi.org/10.1016/j.neurobiolaging.2020.06.010
Journal: Neurobiol Aging
E-pub date: 1 Oct 2020
Authors: N Nicastro, M Malpetti, E Mak, GB Williams, WR Bevan-Jones, SF Carter, L Passamonti, TD Fryer, YT Hong, FI Aigbirhio, JB Rowe, JT O'Brien

Correlation of microglial activation with white matter changes in dementia with Lewy bodies.

DOI: http://doi.org/10.1016/j.nicl.2020.102200
Journal: Neuroimage Clin
E-pub date: 1 Aug 2020
Authors: N Nicastro, E Mak, GB Williams, A Surendranathan, WR Bevan-Jones, L Passamonti, P Vàzquez Rodrìguez, L Su, R Arnold, TD Fryer, YT Hong, FI Aigbirhio, JB Rowe, JT O'Brien

Synaptic loss in primary tauopathies revealed by [11C]UCB-J positron emission tomography

DOI: http://doi.org/10.1101/2020.01.24.20018697
Journal:
E-pub date: 1 Aug 2020
Authors: N Holland, S Jones, G Savulich, J Wiggins, Y Hong, T Fryer, R Manavaki, SM Sephton, I Boros, M Malpetti, F Hezemans, F Aigbirhio, J Coles, J O’Brien, J Rowe

In vivo PET imaging of neuroinflammation in familial frontotemporal dementia

DOI: http://doi.org/10.1101/2020.05.11.20098046
Journal:
E-pub date: 1 Aug 2020
Authors: M Malpetti, T Rittman, S Jones, T Cope, L Passamonti, R Bevan-Jones, K Patterson, T Fryer, Y Hong, F Aigbirhio, J O’Brien, J Rowe

Neuroinflammation predicts disease progression in progressive supranuclear palsy

DOI: http://doi.org/10.1101/2020.05.19.20106393
Journal:
E-pub date: 1 Aug 2020
Authors: M Malpetti, L Passamonti, S Jones, D Street, T Rittman, T Fryer, Y Hong, P Vasquez-Rodriguez, WR Bevan-Jones, F Aigbirhio, J O'Brien, J Rowe

11C-UCB-J synaptic PET and multimodal imaging in dementia with Lewy bodies.

DOI: http://doi.org/10.1186/s41824-020-00093-9
Journal: Eur J Hybrid Imaging
E-pub date: 1 Aug 2020
Authors: N Nicastro, N Holland, G Savulich, SF Carter, E Mak, YT Hong, S Milicevic Sephton, TD Fryer, FI Aigbirhio, JB Rowe, JT O'Brien

Microglial activation and tau burden predict cognitive decline in Alzheimer’s disease.

DOI: http://doi.org/10.1093/brain/awaa088
Journal: Brain
E-pub date: 1 May 2020
Authors: M Malpetti, RA Kievit, L Passamonti, PS Jones, KA Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.

DOI: http://doi.org/10.1093/brain/awaa033
Journal: Brain
E-pub date: 1 Mar 2020
Authors: WR Bevan-Jones, TE Cope, PS Jones, SS Kaalund, L Passamonti, K Allinson, O Green, YT Hong, TD Fryer, R Arnold, JP Coles, FI Aigbirhio, AJ Larner, K Patterson, JT O'Brien, JB Rowe

Longitudinal trajectories of amyloid deposition, cortical thickness, and tau in Down syndrome: A deep-phenotyping case report.

DOI: http://doi.org/10.1016/j.dadm.2019.04.006
Journal: Alzheimers Dement (Amst)
E-pub date: 1 Dec 2019
Authors: E Mak, A Bickerton, C Padilla, MJ Walpert, T Annus, LR Wilson, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, BT Christian, BL Handen, WE Klunk, DK Menon, PJ Nestor, SH Zaman, AJ Holland

Assessing the Effects of Cytoprotectants on Selective Neuronal Loss, Sensorimotor Deficit and Microglial Activation after Temporary Middle Cerebral Occlusion.

DOI: http://doi.org/10.3390/brainsci9100287
Journal: Brain Sci
E-pub date: 22 Oct 2019
Authors: JV Emmrich, S Ejaz, DJ Williamson, YT Hong, S Sitnikov, TD Fryer, FI Aigbirhio, H Wulff, J-C Baron

Differential effects of Down’s syndrome and Alzheimer’s neuropathology on default mode connectivity.

DOI: http://doi.org/10.1002/hbm.24720
Journal: Hum Brain Mapp
E-pub date: 15 Oct 2019
Authors: LR Wilson, D Vatansever, T Annus, GB Williams, YT Hong, TD Fryer, PJ Nestor, AJ Holland, SH Zaman

Brain MRI Coil Attenuation Map Processing for the GE SIGNA PET/MR: Impact on PET Image Quantification and Uniformity

DOI: http://doi.org/10.1109/NSS/MIC42101.2019.9059867
Journal: 2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019
E-pub date: 1 Oct 2019
Authors: R Manavaki, YT Hong, TD Fryer

Delineating the topography of amyloid-associated cortical atrophy in Down syndrome.

DOI: http://doi.org/10.1016/j.neurobiolaging.2019.02.018
Journal: Neurobiol Aging
E-pub date: 31 Aug 2019
Authors: E Mak, C Padilla, T Annus, LR Wilson, YT Hong, TD Fryer, JP Coles, FI Aigbirhio, DK Menon, PJ Nestor, SH Zaman, AJ Holland

Microglial activation and tau burden predict cognitive decline in Alzheimer’s Disease

DOI: http://doi.org/10.1101/19011189
Journal:
E-pub date: 1 Aug 2019
Authors: M Malpetti, R Kievit, L Passamonti, S Jones, K Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, Y Hong, T Fryer, F Aigbirhio, J O'Brien, J Rowe

Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.: weak correlations were observed between our cohorts of controls for each ligand (supplementary figure 1)

DOI: http://doi.org/10.1101/525642
Journal:
E-pub date: 1 Aug 2019
Authors: WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, Y Hong, T Fryer, R Arnold, J Coles, F Aigbirhio, A Larner, K Patterson, J O'Brien, J Rowe

PET markers of tau and neuroinflammation are co-localized in progressive supranuclear palsy

DOI: http://doi.org/10.1101/19010702
Journal:
E-pub date: 1 Aug 2019
Authors: M Malpetti, L Passamonti, T Rittman, S Jones, P Vázquez Rodríguez, R Bevan-Jones, Y Hong, T Fryer, F Aigbirhio, J O’Brien, J Rowe

Insula serotonin 2A receptor binding and gene expression contribute to serotonin transporter polymorphism anxious phenotype in primates.

DOI: http://doi.org/10.1073/pnas.1902087116
Journal: Proc Natl Acad Sci U S A
E-pub date: 16 Jul 2019
Authors: AM Santangelo, SJ Sawiak, T Fryer, Y Hong, Y Shiba, HF Clarke, PJ Riss, V Ferrari, R Tait, J Suckling, FI Aigbirhio, AC Roberts

In vivo evidence for pre-symptomatic neuroinflammation in a MAPT mutation carrier.

DOI: http://doi.org/10.1002/acn3.683
Journal: Ann Clin Transl Neurol
E-pub date: 1 Feb 2019
Authors: WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, YT Hong, T Fryer, R Arnold, JP Coles, FI Aigbirhio, JT O'Brien, JB Rowe

Fractionating Blunted Reward Processing Characteristic of Anhedonia by Over-Activating Primate Subgenual Anterior Cingulate Cortex.

DOI: http://doi.org/10.1016/j.neuron.2018.11.021
Journal: Neuron
E-pub date: 16 Jan 2019
Authors: L Alexander, PLR Gaskin, SJ Sawiak, TD Fryer, YT Hong, GJ Cockcroft, HF Clarke, AC Roberts

Early microglial activation and peripheral inflammation in dementia with Lewy bodies.

DOI: http://doi.org/10.1093/brain/awy265
Journal: Brain
E-pub date: 1 Dec 2018
Authors: A Surendranathan, L Su, E Mak, L Passamonti, YT Hong, R Arnold, P Vázquez Rodríguez, WR Bevan-Jones, SAE Brain, TD Fryer, FI Aigbirhio, JB Rowe, JT O'Brien

[18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia.

DOI: http://doi.org/10.1136/jnnp-2017-316402
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Oct 2018
Authors: WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, YT Hong, TD Fryer, R Arnold, KSJ Allinson, JP Coles, FI Aigbirhio, K Patterson, JT O'Brien, JB Rowe

[18F]AV-1451 binding is increased in frontotemporal dementia due to C9orf72 expansion.

DOI: http://doi.org/10.1002/acn3.631
Journal: Ann Clin Transl Neurol
E-pub date: 1 Oct 2018
Authors: RW Bevan-Jones, TE Cope, SP Jones, L Passamonti, YT Hong, T Fryer, R Arnold, JP Coles, FA Aigbirhio, K Patterson, JT O'Brien, JB Rowe

In vivo coupling of tau pathology and cortical thinning in Alzheimer’s disease.

DOI: http://doi.org/10.1016/j.dadm.2018.08.005
Journal: Alzheimers Dement (Amst)
E-pub date: 1 Aug 2018
Authors: E Mak, RAI Bethlehem, R Romero-Garcia, S Cervenka, T Rittman, S Gabel, A Surendranathan, RW Bevan-Jones, L Passamonti, P Vázquez Rodríguez, L Su, R Arnold, GB Williams, YT Hong, TD Fryer, FI Aigbirhio, JB Rowe, JT O'Brien

Relationships between selective neuronal loss and microglial activation after ischaemic stroke in man.

DOI: http://doi.org/10.1093/brain/awy121
Journal: Brain
E-pub date: 1 Jul 2018
Authors: RS Morris, P Simon Jones, JA Alawneh, YT Hong, TD Fryer, FI Aigbirhio, EA Warburton, J-C Baron

[11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy.

DOI: http://doi.org/10.1212/WNL.0000000000005610
Journal: Neurology
E-pub date: 29 May 2018
Authors: L Passamonti, PV Rodríguez, YT Hong, KSJ Allinson, WR Bevan-Jones, D Williamson, PS Jones, R Arnold, RJ Borchert, A Surendranathan, E Mak, L Su, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

Converging Prefronto-Insula-Amygdala Pathways in Negative Emotion Regulation in Marmoset Monkeys.

DOI: http://doi.org/10.1016/j.biopsych.2017.06.016
Journal: Biol Psychiatry
E-pub date: 15 Dec 2017
Authors: Y Shiba, L Oikonomidis, S Sawiak, TD Fryer, YT Hong, G Cockcroft, AM Santangelo, AC Roberts

Behavior of Supramolecular Assemblies of Radiometal-Filled and Fluorescent Carbon Nanocapsules In Vitro and In Vivo

DOI: http://doi.org/10.1016/j.chempr.2017.06.013
Journal: Chem
E-pub date: 14 Sep 2017
Authors: H Ge, PJ Riss, V Mirabello, DG Calatayud, SE Flower, RL Arrowsmith, TD Fryer, Y Hong, S Sawiak, RMJ Jacobs, SW Botchway, RM Tyrrell, TD James, JS Fossey, JR Dilworth, FI Aigbirhio, SI Pascu

Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline.

DOI: http://doi.org/10.1016/j.neurobiolaging.2017.04.006
Journal: Neurobiol Aging
E-pub date: 31 Aug 2017
Authors: JH Cole, T Annus, LR Wilson, R Remtulla, YT Hong, TD Fryer, J Acosta-Cabronero, A Cardenas-Blanco, R Smith, DK Menon, SH Zaman, PJ Nestor, AJ Holland

Effects of hyperoxia on 18F-fluoro-misonidazole brain uptake and tissue oxygen tension following middle cerebral artery occlusion in rodents: Pilot studies.

DOI: http://doi.org/10.1371/journal.pone.0187087
Journal: PLoS One
E-pub date: 1 Aug 2017
Authors: TD Fryer, S Ejaz, U Jensen-Kondering, DJ Williamson, S Sitnikov, SJ Sawiak, FI Aigbirhio, YT Hong, J-C Baron

The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis.

DOI: http://doi.org/10.1016/j.neurobiolaging.2017.01.009
Journal: Neurobiol Aging
E-pub date: 1 May 2017
Authors: T Annus, LR Wilson, J Acosta-Cabronero, A Cardenas-Blanco, YT Hong, TD Fryer, JP Coles, DK Menon, SH Zaman, AJ Holland, PJ Nestor

18F-AV-1451 positron emission tomography in Alzheimer’s disease and progressive supranuclear palsy.

DOI: http://doi.org/10.1093/brain/aww340
Journal: Brain
E-pub date: 1 Mar 2017
Authors: L Passamonti, P Vázquez Rodríguez, YT Hong, KSJ Allinson, D Williamson, RJ Borchert, S Sami, TE Cope, WR Bevan-Jones, PS Jones, R Arnold, A Surendranathan, E Mak, L Su, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

Neuroimaging of Inflammation in Memory and Related Other Disorders (NIMROD) study protocol: a deep phenotyping cohort study of the role of brain inflammation in dementia, depression and other neurological illnesses.

DOI: http://doi.org/10.1136/bmjopen-2016-013187
Journal: BMJ Open
E-pub date: 7 Jan 2017
Authors: WR Bevan-Jones, A Surendranathan, L Passamonti, P Vázquez Rodríguez, R Arnold, E Mak, L Su, JP Coles, TD Fryer, YT Hong, G Williams, F Aigbirhio, JB Rowe, JT O'Brien

Neuroinflammatory and morphological changes in late-life depression: the NIMROD study.

DOI: http://doi.org/10.1192/bjp.bp.116.190165
Journal: BRITISH JOURNAL OF PSYCHIATRY
E-pub date: 1 Dec 2016
Authors: L Su, YO Faluyi, YT Hong, TD Fryer, E Mak, S Gabel, L Hayes, S Soteriades, GB Williams, R Arnold, L Passamonti, PV Rodríguez, A Surendranathan, RW Bevan-Jones, J Coles, F Aigbirhio, JB Rowe, JT O'Brien

Hypoxia and tissue destruction in pulmonary TB.

DOI: http://doi.org/10.1136/thoraxjnl-2015-207402
Journal: Thorax
E-pub date: 1 Dec 2016
Authors: M Belton, S Brilha, R Manavaki, F Mauri, K Nijran, YT Hong, NH Patel, M Dembek, L Tezera, J Green, R Moores, F Aigbirhio, A Al-Nahhas, TD Fryer, PT Elkington, JS Friedland

[18F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation.

DOI: http://doi.org/10.1002/acn3.366
Journal: Ann Clin Transl Neurol
E-pub date: 1 Dec 2016
Authors: WR Bevan Jones, TE Cope, L Passamonti, TD Fryer, YT Hong, F Aigbirhio, JJ Kril, SL Forrest, K Allinson, JP Coles, P Simon Jones, MG Spillantini, JR Hodges, JT O'Brien, JB Rowe

The pattern of amyloid accumulation in the brains of adults with Down syndrome.

DOI: http://doi.org/10.1016/j.jalz.2015.07.490
Journal: Alzheimers Dement
E-pub date: 1 May 2016
Authors: T Annus, LR Wilson, YT Hong, J Acosta-Cabronero, TD Fryer, A Cardenas-Blanco, R Smith, I Boros, JP Coles, FI Aigbirhio, DK Menon, SH Zaman, PJ Nestor, AJ Holland

Normobaric hyperoxia markedly reduces brain damage and sensorimotor deficits following brief focal ischaemia.

DOI: http://doi.org/10.1093/brain/awv391
Journal: Brain
E-pub date: 1 Mar 2016
Authors: S Ejaz, JV Emmrich, SL Sitnikov, YT Hong, SJ Sawiak, TD Fryer, FI Aigbirhio, DJ Williamson, J-C Baron

Early-Phase 11C-PiB PET in Amyloid Angiopathy-Related Symptomatic Cerebral Hemorrhage: Potential Diagnostic Value?

DOI: http://doi.org/10.1371/journal.pone.0139926
Journal: PLoS One
E-pub date: 1 Aug 2015
Authors: K Farid, YT Hong, FI Aigbirhio, TD Fryer, DK Menon, EA Warburton, J-C Baron

White matter perivascular spaces on magnetic resonance imaging: marker of cerebrovascular amyloid burden?

DOI: http://doi.org/10.1161/STROKEAHA.115.009090
Journal: Stroke
E-pub date: 1 Jun 2015
Authors: A Charidimou, YT Hong, HR Jäger, Z Fox, FI Aigbirhio, TD Fryer, DK Menon, EA Warburton, DJ Werring, J-C Baron

Synthesis and Initial in Vivo Studies with [(11)C]SB-216763: The First Radiolabeled Brain Penetrative Inhibitor of GSK-3.

DOI: http://doi.org/10.1021/acsmedchemlett.5b00044
Journal: ACS Med Chem Lett
E-pub date: 14 May 2015
Authors: L Li, X Shao, EL Cole, SA Ohnmacht, V Ferrari, YT Hong, DJ Williamson, TD Fryer, CA Quesada, P Sherman, PJ Riss, PJH Scott, FI Aigbirhio

Dissociable rate-dependent effects of oral methylphenidate on impulsivity and D2/3 receptor availability in the striatum.

DOI: http://doi.org/10.1523/JNEUROSCI.3890-14.2015
Journal: J Neurosci
E-pub date: 4 Mar 2015
Authors: D Caprioli, B Jupp, YT Hong, SJ Sawiak, V Ferrari, L Wharton, DJ Williamson, C McNabb, D Berry, FI Aigbirhio, TW Robbins, TD Fryer, JW Dalley

Orbitofrontal dopamine depletion upregulates caudate dopamine and alters behavior via changes in reinforcement sensitivity.

DOI: http://doi.org/10.1523/JNEUROSCI.0718-14.2014
Journal: J Neurosci
E-pub date: 28 May 2014
Authors: HF Clarke, RN Cardinal, R Rygula, YT Hong, TD Fryer, SJ Sawiak, V Ferrari, G Cockcroft, FI Aigbirhio, TW Robbins, AC Roberts

Amyloid imaging with carbon 11-labeled Pittsburgh compound B for traumatic brain injury.

DOI: http://doi.org/10.1001/jamaneurol.2013.4847
Journal: JAMA Neurol
E-pub date: 1 Jan 2014
Authors: YT Hong, T Veenith, D Dewar, JG Outtrim, V Mani, C Williams, S Pimlott, PJA Hutchinson, A Tavares, R Canales, CA Mathis, WE Klunk, FI Aigbirhio, JP Coles, J-C Baron, JD Pickard, TD Fryer, W Stewart, DK Menon

Diagnostic utility of amyloid PET in cerebral amyloid angiopathy-related symptomatic intracerebral hemorrhage.

DOI: http://doi.org/10.1038/jcbfm.2014.43
Journal: Journal of Cerebral Blood Flow and Metabolism
E-pub date: 1 Jan 2014
Authors: J-C Baron, K Farid, E Dolan, G Turc, ST Marrapu, E O'Brien, FI Aigbirhio, TD Fryer, DK Menon, EA Warburton, YT Hong

A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment.

DOI: http://doi.org/10.1093/brain/awt263
Journal: Brain
E-pub date: 10 Oct 2013
Authors: N del Campo, TD Fryer, YT Hong, R Smith, L Brichard, J Acosta-Cabronero, SR Chamberlain, R Tait, D Izquierdo, R Regenthal, J Dowson, J Suckling, J-C Baron, FI Aigbirhio, TW Robbins, BJ Sahakian, U Müller

Baseline-dependent effects of cocaine pre-exposure on impulsivity and D2/3 receptor availability in the rat striatum: possible relevance to the attention-deficit hyperactivity syndrome.

DOI: http://doi.org/10.1038/npp.2013.44
Journal: Neuropsychopharmacology
E-pub date: 1 Jul 2013
Authors: D Caprioli, YT Hong, SJ Sawiak, V Ferrari, DJ Williamson, B Jupp, T Adrian Carpenter, FI Aigbirhio, BJ Everitt, TW Robbins, TD Fryer, JW Dalley

Is neural activation within the rescued penumbra impeded by selective neuronal loss?

DOI: http://doi.org/10.1093/brain/awt112
Journal: Brain
E-pub date: 1 Jun 2013
Authors: E Carrera, PS Jones, RS Morris, J Alawneh, YT Hong, FI Aigbirhio, TD Fryer, TA Carpenter, EA Warburton, J-C Baron

Radiosynthesis and characterization of astemizole derivatives as lead compounds toward PET imaging of τ-pathology

DOI: http://doi.org/10.1039/c3md00017f
Journal: MedChemComm
E-pub date: 1 May 2013
Authors: PJ Riss, L Brichard, V Ferrari, DJ Williamson, TD Fryer, YT Hong, JC Baron, FI Aigbirhio

Characterizing infarction and selective neuronal loss following temporary focal cerebral ischemia in the rat: a multi-modality imaging study.

DOI: http://doi.org/10.1016/j.nbd.2012.11.002
Journal: Neurobiol Dis
E-pub date: 1 Mar 2013
Authors: S Ejaz, DJ Williamson, T Ahmed, S Sitnikov, YT Hong, SJ Sawiak, TD Fryer, FI Aigbirhio, J-C Baron

Synthesis and evaluation of 18F-FE-PEO in rodents: an 18F-labeled full agonist for opioid receptor imaging.

DOI: http://doi.org/10.2967/jnumed.112.108688
Journal: J Nucl Med
E-pub date: 1 Feb 2013
Authors: PJ Riss, YT Hong, J Marton, D Caprioli, DJ Williamson, V Ferrari, N Saigal, BL Roth, G Henriksen, TD Fryer, JW Dalley, FI Aigbirhio

The relationship of topographical memory performance to regional neurodegeneration in Alzheimer’s disease.

DOI: http://doi.org/10.3389/fnagi.2012.00017
Journal: Front Aging Neurosci
E-pub date: 1 Aug 2012
Authors: G Pengas, GB Williams, J Acosta-Cabronero, TWJ Ash, YT Hong, D Izquierdo-Garcia, TD Fryer, JR Hodges, PJ Nestor

Validation and quantification of [18F]altanserin binding in the rat brain using blood input and reference tissue modeling.

DOI: http://doi.org/10.1038/jcbfm.2011.94
Journal: J Cereb Blood Flow Metab
E-pub date: 1 Dec 2011
Authors: PJ Riss, YT Hong, D Williamson, D Caprioli, S Sitnikov, V Ferrari, SJ Sawiak, J-C Baron, JW Dalley, TD Fryer, FI Aigbirhio

Pharmacodynamic study of antiangiogenic therapy in patients with renal cell carcinoma.

DOI: http://doi.org/10.1200/jco.2011.29.15_suppl.tps155
Journal: JOURNAL OF CLINICAL ONCOLOGY
E-pub date: 1 Aug 2011
Authors: G Anandappa, E Sala, HK Cheow, NJ Bird, A Shaw, AN Priest, A Gill, T Fryer, YT Hong, R Smith, A Backen, B Whitcher, A Jonson, D Richards, L Cookson, WMF Lee, C Dive, KM Fife, DI Jodrell, T Eisen

Using positron emission tomography and Carbon 11-labeled Pittsburgh Compound B to image Brain Fibrillar β-amyloid in adults with down syndrome: safety, acceptability, and feasibility.

DOI: http://doi.org/10.1001/archneurol.2011.36
Journal: Arch Neurol
E-pub date: 1 Jul 2011
Authors: J Landt, JC D'Abrera, AJ Holland, FI Aigbirhio, TD Fryer, R Canales, YT Hong, DK Menon, J-C Baron, SH Zaman

Validation of reference tissue modelling for [11C]flumazenil positron emission tomography following head injury.

DOI: http://doi.org/10.1007/s12149-011-0480-4
Journal: Annals of Nuclear Medicine
E-pub date: 1 Jul 2011
Authors: T Geeraerts, JP Coles, FI Aigbirhio, JD Pickard, DK Menon, TD Fryer, YT Hong

What the left and right anterior fusiform gyri tell us about semantic memory.

DOI: http://doi.org/10.1093/brain/awq272
Journal: Brain
E-pub date: 1 Nov 2010
Authors: M Mion, K Patterson, J Acosta-Cabronero, G Pengas, D Izquierdo-Garcia, YT Hong, TD Fryer, GB Williams, JR Hodges, PJ Nestor

The role of dopamine in sustained attention: Imaging the effects of methylphenidate in ADHD patients and healthy controls

DOI: http://doi.org/10.1016/j.neuroimage.2010.04.082
Journal: NEUROIMAGE
E-pub date: 31 Aug 2010
Authors: N del Campo, T Fryer, Y Hong, D Izquierdo, R Smith, L Brichard, S Chamberlain, JC Baron, F Aigbirhio, T Robbins, B Sahakian, U Muller

Modelling human drug abuse and addiction with dedicated small animal positron emission tomography.

DOI: http://doi.org/10.1016/j.neuropharm.2008.05.029
Journal: Neuropharmacology
E-pub date: 1 Aug 2009
Authors: JW Dalley, TD Fryer, FI Aigbirhio, L Brichard, HK Richards, YT Hong, J-C Baron, BJ Everitt, TW Robbins

Dopamine release in dissociable striatal subregions predicts the different effects of oral methylphenidate on reversal learning and spatial working memory.

DOI: http://doi.org/10.1523/JNEUROSCI.3266-08.2009
Journal: J Neurosci
E-pub date: 15 Apr 2009
Authors: PL Clatworthy, SJG Lewis, L Brichard, YT Hong, D Izquierdo, L Clark, R Cools, FI Aigbirhio, J-C Baron, TD Fryer, TW Robbins

Imaging of brain hypoxia in permanent and temporary middle cerebral artery occlusion in the rat using 18F-fluoromisonidazole and positron emission tomography: a pilot study.

DOI: http://doi.org/10.1038/sj.jcbfm.9600405
Journal: J Cereb Blood Flow Metab
E-pub date: 1 Apr 2007
Authors: M Takasawa, JS Beech, TD Fryer, YT Hong, JL Hughes, K Igase, PS Jones, R Smith, FI Aigbirhio, DK Menon, JC Clark, J-C Baron