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    Professor Trevor Robbins

    University Position
    Professor

    Interests

    Research interests span the areas of cognitive neuroscience, behavioural neuroscience and psychopharmacology. Main work focuses on the functions of the frontal lobes of the brain and their connections with other regions. These brain systems are relevant to such psychiatric and neurological disorders as Parkinson?s and Huntington?s disease, dementia, schizophrenia, depression, drug addiction, obsessive-compulsive disorder and attention deficit/hyperactivity disorder, as well as frontal lobe injury. The lab uses a variety of methods for studying these systems, including sophisticated psychological paradigms for investigating cognitive functions and impulsivity in both normal subjects and patients; these include the computerised CANTAB battery. Also employed are MRI or PET to determine where in the human brain various cognitive operations are carried out. We are also interested in establishing how drugs work to produce changes in brain chemistry, and how these affect behaviour.

    Key Publications

    Impaired Learning From Negative Feedback in Stimulant Use Disorder: Dopaminergic Modulation.

    DOI: http://doi.org/10.1093/ijnp/pyab041
    Journal: Int J Neuropsychopharmacol
    E-pub date: 12 Nov 2021
    Authors: TV Lim, RN Cardinal, ET Bullmore, TW Robbins, KD Ersche

    Controlling one’s world: Identification of sub-regions of primate PFC underlying goal-directed behavior.

    DOI: http://doi.org/10.1016/j.neuron.2021.06.003
    Journal: Neuron
    E-pub date: 4 Aug 2021
    Authors: LY Duan, NK Horst, SAW Cranmore, N Horiguchi, RN Cardinal, AC Roberts, TW Robbins

    Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans

    DOI: http://doi.org/10.1101/2020.04.26.062463
    Journal:
    E-pub date: 1 Aug 2020
    Authors: J Kanen, A Apergis-Schoute, R Yellowlees, F Arntz, F van der Flier, A Price, R Cardinal, D Christmas, L Clark, B Sahakian, M Crockett, T Robbins

    Effect of lysergic acid diethylamide (LSD) on reinforcement learning in humans

    DOI: http://doi.org/10.1101/2020.12.04.412189
    Journal:
    E-pub date: 1 Aug 2020
    Authors: J Kanen, Q Luo, M Kandroodi, R Cardinal, T Robbins, R Carhart-Harris, HEM den Ouden

    Impairments in reinforcement learning do not explain enhanced habit formation in cocaine use disorder.

    DOI: http://doi.org/10.1007/s00213-019-05330-z
    Journal: Psychopharmacology (Berl)
    E-pub date: 31 Aug 2019
    Authors: TV Lim, RN Cardinal, G Savulich, PS Jones, AA Moustafa, TW Robbins, KD Ersche

    Creature of Habit: A self-report measure of habitual routines and automatic tendencies in everyday life.

    DOI: http://doi.org/10.1016/j.paid.2017.04.024
    Journal: Pers Individ Dif
    E-pub date: 1 Oct 2017
    Authors: KD Ersche, T-V Lim, LHE Ward, TW Robbins, J Stochl

    The profile of executive function in OCD hoarders and hoarding disorder.

    DOI: http://doi.org/10.1016/j.psychres.2013.12.026
    Journal: Psychiatry Research
    E-pub date: 30 Mar 2014
    Authors: S Morein-Zamir, M Papmeyer, A Pertusa, SR Chamberlain, NA Fineberg, BJ Sahakian, D Mataix-Cols, TW Robbins

    The CamPaIGN study of Parkinson’s disease: 10-year outlook in an incident population-based cohort.

    DOI: http://doi.org/10.1136/jnnp-2013-305277
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Nov 2013
    Authors: CH Williams-Gray, SL Mason, JR Evans, T Foltynie, C Brayne, TW Robbins, RA Barker

    Quantification of receptor-ligand binding potential in sub-striatal domains using probabilistic and template regions of interest.

    DOI: http://doi.org/10.1016/j.neuroimage.2010.11.071
    Journal: NeuroImage
    E-pub date: 1 Mar 2011
    Authors: N del Campo, RJ Tait, J Acosta-Cabronero, YT Hong, D Izquierdo-Garcia, R Smith, FI Aigbirhio, BJ Sahakian, U Müller, TW Robbins, TD Fryer

    The distinct cognitive syndromes of Parkinson’s disease: 5 year follow-up of the CamPaIGN cohort.

    DOI: http://doi.org/10.1093/brain/awp245
    Journal: Brain
    E-pub date: 1 Nov 2009
    Authors: CH Williams-Gray, JR Evans, A Goris, T Foltynie, M Ban, TW Robbins, C Brayne, BS Kolachana, DR Weinberger, SJ Sawcer, RA Barker

    Evolution of cognitive dysfunction in an incident Parkinson’s disease cohort.

    DOI: http://doi.org/10.1093/brain/awm111
    Journal: Brain
    E-pub date: 1 Jul 2007
    Authors: CH Williams-Gray, T Foltynie, CEG Brayne, TW Robbins, RA Barker

    Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement.

    DOI: http://doi.org/10.1126/science.1137073
    Journal: Science
    E-pub date: 2 Mar 2007
    Authors: JW Dalley, TD Fryer, L Brichard, ESJ Robinson, DEH Theobald, K Lääne, Y Peña, ER Murphy, Y Shah, K Probst, I Abakumova, FI Aigbirhio, HK Richards, Y Hong, J-C Baron, BJ Everitt, TW Robbins

    Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates.

    DOI: http://doi.org/10.1016/j.neubiorev.2004.09.006
    Journal: Neurosci Biobehav Rev
    E-pub date: 1 Nov 2004
    Authors: JW Dalley, RN Cardinal, TW Robbins

    Contrasting roles of basolateral amygdala and orbitofrontal cortex in impulsive choice.

    DOI: http://doi.org/10.1523/JNEUROSCI.5606-03.2004
    Journal: J Neurosci
    E-pub date: 19 May 2004
    Authors: CA Winstanley, DEH Theobald, RN Cardinal, TW Robbins

    Cognitive inflexibility after prefrontal serotonin depletion.

    DOI: http://doi.org/10.1126/science.1094987
    Journal: Science
    E-pub date: 7 May 2004
    Authors: HF Clarke, JW Dalley, HS Crofts, TW Robbins, AC Roberts

    Role of the anterior cingulate cortex in the control over behavior by Pavlovian conditioned stimuli in rats.

    DOI: http://doi.org/10.1037/0735-7044.117.3.566
    Journal: Behav Neurosci
    E-pub date: 1 Jun 2003
    Authors: RN Cardinal, JA Parkinson, HD Marbini, AJ Toner, TJ Bussey, TW Robbins, BJ Everitt

    Effects of selective excitotoxic lesions of the nucleus accumbens core, anterior cingulate cortex, and central nucleus of the amygdala on autoshaping performance in rats.

    DOI: http://doi.org/10.1037//0735-7044.116.4.553
    Journal: Behavioral Neuroscience
    E-pub date: 1 Aug 2002
    Authors: RN Cardinal, JA Parkinson, G Lachenal, KM Halkerston, N Rudarakanchana, J Hall, CH Morrison, SR Howes, TW Robbins, BJ Everitt

    Impulsive choice induced in rats by lesions of the nucleus accumbens core.

    DOI: http://doi.org/10.1126/science.1060818
    Journal: Science
    E-pub date: 29 Jun 2001
    Authors: RN Cardinal, DR Pennicott, CL Sugathapala, TW Robbins, BJ Everitt

    Publications

    Comparable roles for serotonin in rats and humans for computations underlying flexible decision-making.

    DOI: http://doi.org/10.1038/s41386-023-01762-6
    Journal: Neuropsychopharmacology
    E-pub date: 1 Feb 2024
    Authors: Q Luo, JW Kanen, A Bari, N Skandali, C Langley, GM Knudsen, J Alsiö, BU Phillips, BJ Sahakian, RN Cardinal, TW Robbins

    Cortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls.

    DOI: http://doi.org/10.1038/s41467-023-38695-z
    Journal: Nat Commun
    E-pub date: 27 Jun 2023
    Authors: M Biria, P Banca, MP Healy, E Keser, SJ Sawiak, CT Rodgers, C Rua, AMFLP de Souza, AA Marzuki, A Sule, KD Ersche, TW Robbins

    Clozapine-related obsessive-compulsive symptoms and their impact on wellbeing: a naturalistic longitudinal study.

    DOI: http://doi.org/10.1017/S003329172100492X
    Journal: Psychol Med
    E-pub date: 1 May 2023
    Authors: K Parkin, S Chen, M Biria, J Plaistow, H Beckwith, I Jarratt-Barnham, N Segarra, Y Worbe, NA Fineberg, RN Cardinal, TW Robbins, E Fernandez-Egea

    Early-life stress biases responding to negative feedback and increases amygdala volume and vulnerability to later-life stress.

    DOI: http://doi.org/10.1038/s41398-023-02385-7
    Journal: Transl Psychiatry
    E-pub date: 7 Mar 2023
    Authors: EG Dutcher, L Lopez-Cruz, EAC Pama, M-E Lynall, ICR Bevers, JA Jones, S Khan, SJ Sawiak, AL Milton, MR Clatworthy, TW Robbins, ET Bullmore, JW Dalley

    Chronic escitalopram in healthy volunteers has specific effects on reinforcement sensitivity: a double-blind, placebo-controlled semi-randomised study.

    DOI: http://doi.org/10.1038/s41386-022-01523-x
    Journal: Neuropsychopharmacology
    E-pub date: 1 Mar 2023
    Authors: C Langley, S Armand, Q Luo, G Savulich, T Segerberg, A Søndergaard, EB Pedersen, N Svart, O Overgaard-Hansen, A Johansen, C Borgsted, RN Cardinal, TW Robbins, DS Stenbæk, GM Knudsen, BJ Sahakian

    Effect of lysergic acid diethylamide (LSD) on reinforcement learning in humans.

    DOI: http://doi.org/10.1017/S0033291722002963
    Journal: Psychol Med
    E-pub date: 22 Nov 2022
    Authors: JW Kanen, Q Luo, M Rostami Kandroodi, RN Cardinal, TW Robbins, DJ Nutt, RL Carhart-Harris, HEM den Ouden

    Prefrontal Cortex Activation and Stopping Performance Underlie the Beneficial Effects of Atomoxetine on Response Inhibition in Healthy Volunteers and Those With Cocaine Use Disorder.

    DOI: http://doi.org/10.1016/j.bpsc.2021.08.010
    Journal: Biol Psychiatry Cogn Neurosci Neuroimaging
    E-pub date: 1 Nov 2022
    Authors: P Zhukovsky, S Morein-Zamir, H Ziauddeen, E Fernandez-Egea, C Meng, R Regenthal, BJ Sahakian, ET Bullmore, TW Robbins, JW Dalley, KD Ersche

    Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease.

    DOI: http://doi.org/10.1093/brain/awab142
    Journal: Brain
    E-pub date: 4 Sep 2021
    Authors: C O'Callaghan, FH Hezemans, R Ye, C Rua, PS Jones, AG Murley, N Holland, R Regenthal, KA Tsvetanov, N Wolpe, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

    Locus Coeruleus Integrity from 7T MRI Relates to Apathy and Cognition in Parkinson’s Disease and Progressive Supranuclear Palsy

    DOI: http://doi.org/10.1101/2021.04.19.21255762
    Journal:
    E-pub date: 1 Aug 2021
    Authors: R Ye, C O’Callaghan, C Rua, F Hezemans, N Holland, M Malpetti, S Jones, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

    Noradrenergic deficits contribute to apathy in Parkinson’s disease through the precision of expected outcomes

    DOI: http://doi.org/10.1101/2021.07.04.21259922
    Journal:
    E-pub date: 1 Aug 2021
    Authors: F Hezemans, N Wolpe, C O’Callaghan, R Ye, C Rua, S Jones, A Murley, N Holland, R Regenthal, K Tsvetanov, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

    Reduced locus coeruleus integrity linked to response inhibition deficits in parkinsonian disorders

    DOI: http://doi.org/10.1101/2021.10.14.21264996
    Journal:
    E-pub date: 1 Aug 2021
    Authors: R Ye, F Hezemans, C O’Callaghan, K Tsvetanov, C Rua, S Jones, N Holland, M Malpetti, A Murley, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

    Atomoxetine partially restores loss sensitivity in cocaine use disorder

    DOI: http://doi.org/10.1016/j.euroneuro.2021.10.016
    Journal:
    E-pub date: 1 Aug 2021
    Authors: L Cincikas, RN Cardinal, H Ziauddeen, E Fernandez-Egea, R Regenthal, BJ Sahakian, TW Robbins, KD Ersche

    Harnessing temperament to elucidate the complexities of serotonin function

    DOI: http://doi.org/10.31234/osf.io/gvmuy
    Journal:
    E-pub date: 18 Jul 2021
    Authors: JW Kanen, TW Robbins, IN Trofimova

    Reduced Glutamate Turnover in the Putamen Is Linked With Automatic Habits in Human Cocaine Addiction.

    DOI: http://doi.org/10.1016/j.biopsych.2020.12.009
    Journal: Biol Psychiatry
    E-pub date: 15 May 2021
    Authors: KD Ersche, TV Lim, AG Murley, C Rua, MM Vaghi, TL White, GB Williams, TW Robbins

    Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease

    DOI: http://doi.org/10.1101/2020.09.03.20176800
    Journal:
    E-pub date: 1 Aug 2020
    Authors: C O’Callaghan, F Hezemans, R Ye, C Rua, S Jones, A Murley, N Holland, R Regenthal, K Tsvetanov, N Wolpe, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

    Effect of tryptophan depletion on conditioned threat memory expression: role of intolerance of uncertainty

    DOI: http://doi.org/10.1101/2020.04.26.062505
    Journal:
    E-pub date: 1 Aug 2020
    Authors: J Kanen, F Arntz, R Yellowlees, D Christmas, A Price, A Apergis-Schoute, B Sahakian, R Cardinal, T Robbins

    Brain networks underlying vulnerability and resilience to drug addiction.

    DOI: http://doi.org/10.1073/pnas.2002509117
    Journal: Proc Natl Acad Sci U S A
    E-pub date: 30 Jun 2020
    Authors: KD Ersche, C Meng, H Ziauddeen, J Stochl, GB Williams, ET Bullmore, TW Robbins

    Probabilistic reversal learning under acute tryptophan depletion in healthy humans: a conventional analysis.

    DOI: http://doi.org/10.1177/0269881120907991
    Journal: J Psychopharmacol
    E-pub date: 1 May 2020
    Authors: JW Kanen, FE Arntz, R Yellowlees, RN Cardinal, A Price, DM Christmas, BJ Sahakian, AM Apergis-Schoute, TW Robbins

    Impulsivity and compulsivity are differentially associated with automaticity and routine on the Creature of Habit Scale.

    DOI: http://doi.org/10.1016/j.paid.2019.07.003
    Journal: Pers Individ Dif
    E-pub date: 1 Nov 2019
    Authors: KD Ersche, LHE Ward, T-V Lim, RJ Lumsden, SJ Sawiak, TW Robbins, J Stochl

    Dopamine D2-like receptor stimulation blocks negative feedback in visual and spatial reversal learning in the rat: behavioural and computational evidence.

    DOI: http://doi.org/10.1007/s00213-019-05296-y
    Journal: Psychopharmacology (Berl)
    E-pub date: 31 Aug 2019
    Authors: J Alsiö, BU Phillips, J Sala-Bayo, SRO Nilsson, TC Calafat-Pla, A Rizwand, JM Plumbridge, L López-Cruz, JW Dalley, RN Cardinal, AC Mar, TW Robbins

    Computational psychopharmacology: a translational and pragmatic approach.

    DOI: http://doi.org/10.1007/s00213-019-05302-3
    Journal: Psychopharmacology (Berl)
    E-pub date: 31 Aug 2019
    Authors: TW Robbins, RN Cardinal

    Noradrenergic modulation of stopping impulsivity in cocaine use disorder

    DOI: http://doi.org/10.1016/j.euroneuro.2018.11.317
    Journal: EUROPEAN NEUROPSYCHOPHARMACOLOGY
    E-pub date: 1 Aug 2019
    Authors: R Rodrigues, S Morein-Zamir, C Meng, H Ziauddeen, E Fernandez-Egea, R Regenthal, BJ Sahakian, ET Bullmore, TW Robbins, KD Ersche

    Atomoxetine and citalopram alter brain network organization in Parkinson’s disease.

    DOI: http://doi.org/10.1093/braincomms/fcz013
    Journal: Brain Commun
    E-pub date: 1 Aug 2019
    Authors: RJ Borchert, T Rittman, CL Rae, L Passamonti, SP Jones, D Vatansever, P Vázquez Rodríguez, Z Ye, C Nombela, LE Hughes, TW Robbins, JB Rowe

    Dopaminergic modulation of reinforcement learning in stimulant drug addiction

    DOI: http://doi.org/10.1016/j.euroneuro.2019.09.191
    Journal: EUROPEAN NEUROPSYCHOPHARMACOLOGY
    E-pub date: 1 Aug 2019
    Authors: TV Lim, RN Cardinal, C Meng, GK Murray, KJ Craig, S Abbott, SS Shabbir, J Suckling, BJ Sahakian, ET Bullmore, TW Robbins, KD Ersche

    Serotonin depletion amplifies distinct human social emotions as a function of individual differences in personality

    DOI: http://doi.org/10.1101/789669
    Journal:
    E-pub date: 1 Aug 2019
    Authors: J Kanen, F Arntz, R Yellowlees, R Cardinal, A Price, D Christmas, A Apergis-Schoute, B Sahakian, T Robbins

    Deconstructing appetitive learning in cocaine addiction using hierarchical Bayesian modelling

    DOI: http://doi.org/10.1016/j.euroneuro.2018.11.323
    Journal:
    E-pub date: 1 Aug 2019
    Authors: TV Lim, RN Cardinal, PS Jones, TW Robbins, KD Ersche

    Impaired awareness of action-outcome contingency and causality during healthy ageing and following ventromedial prefrontal cortex lesions.

    DOI: http://doi.org/10.1016/j.neuropsychologia.2018.01.021
    Journal: Neuropsychologia
    E-pub date: 1 May 2019
    Authors: C O'Callaghan, MM Vaghi, B Brummerloh, RN Cardinal, TW Robbins

    Action-Outcome Knowledge Dissociates From Behavior in Obsessive-Compulsive Disorder Following Contingency Degradation.

    DOI: http://doi.org/10.1016/j.bpsc.2018.09.014
    Journal: Biol Psychiatry Cogn Neurosci Neuroimaging
    E-pub date: 1 Feb 2019
    Authors: MM Vaghi, RN Cardinal, AM Apergis-Schoute, NA Fineberg, A Sule, TW Robbins

    Reorganization of cortical oscillatory dynamics underlying disinhibition in frontotemporal dementia.

    DOI: http://doi.org/10.1093/brain/awy176
    Journal: Brain
    E-pub date: 1 Aug 2018
    Authors: LE Hughes, T Rittman, TW Robbins, JB Rowe

    White matter change with apathy and impulsivity in frontotemporal lobar degeneration syndromes.

    DOI: http://doi.org/10.1212/WNL.0000000000005175
    Journal: Neurology
    E-pub date: 20 Mar 2018
    Authors: CJ Lansdall, ITS Coyle-Gilchrist, PS Jones, P Vázquez Rodríguez, A Wilcox, E Wehmann, KM Dick, TW Robbins, JB Rowe

    Evidence for a Long-Lasting Compulsive Alcohol Seeking Phenotype in Rats.

    DOI: http://doi.org/10.1038/npp.2017.105
    Journal: Neuropsychopharmacology
    E-pub date: 1 Mar 2018
    Authors: C Giuliano, Y Peña-Oliver, CR Goodlett, RN Cardinal, TW Robbins, ET Bullmore, D Belin, BJ Everitt

    Stability of mild cognitive impairment in newly diagnosed Parkinson’s disease.

    DOI: http://doi.org/10.1136/jnnp-2016-315099
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 31 Aug 2017
    Authors: RA Lawson, AJ Yarnall, GW Duncan, DP Breen, TK Khoo, CH Williams-Gray, RA Barker, DJ Burn, ICICLE-PD study group

    Atomoxetine effects on attentional bias to drug-related cues in cocaine dependent individuals.

    DOI: http://doi.org/10.1007/s00213-017-4643-4
    Journal: Psychopharmacology (Berl)
    E-pub date: 31 Aug 2017
    Authors: L Passamonti, M Luijten, H Ziauddeen, ITS Coyle-Gilchrist, T Rittman, SAE Brain, R Regenthal, IHA Franken, BJ Sahakian, ET Bullmore, TW Robbins, KD Ersche

    Prediction of cognition in Parkinson’s disease with a clinical-genetic score: a longitudinal analysis of nine cohorts.

    DOI: http://doi.org/10.1016/S1474-4422(17)30122-9
    Journal: Lancet Neurol
    E-pub date: 31 Aug 2017
    Authors: G Liu, JJ Locascio, J-C Corvol, B Boot, Z Liao, K Page, D Franco, K Burke, IE Jansen, A Trisini-Lipsanopoulos, S Winder-Rhodes, CM Tanner, AE Lang, S Eberly, A Elbaz, A Brice, G Mangone, B Ravina, I Shoulson, F Cormier-Dequaire, P Heutink, JJ van Hilten, RA Barker, CH Williams-Gray, J Marinus, CR Scherzer, HBS, CamPaIGN, PICNICS, PROPARK, PSG, DIGPD, PDBP

    SLC6A2 genotype variation and the modulatory effects of atomoxetine on inhibitory control in individuals with and without cocaine use disorder

    DOI: http://doi.org/10.1016/S0924-977X(17)31865-5
    Journal: EUROPEAN NEUROPSYCHOPHARMACOLOGY
    E-pub date: 1 Aug 2017
    Authors: AN Le, H Ziauddeen, E Fernandez-Egea, R Regenthal, BJ Sahakian, ET Bullmore, TW Robbins, KD Ersche

    Atomoxetine restores the response inhibition network in Parkinson’s disease.

    DOI: http://doi.org/10.1093/brain/aww138
    Journal: Brain
    E-pub date: 31 Aug 2016
    Authors: CL Rae, C Nombela, PV Rodríguez, Z Ye, LE Hughes, PS Jones, T Ham, T Rittman, I Coyle-Gilchrist, R Regenthal, BJ Sahakian, RA Barker, TW Robbins, JB Rowe

    Abnormal Frontostriatal Activity During Unexpected Reward Receipt in Depression and Schizophrenia: Relationship to Anhedonia.

    DOI: http://doi.org/10.1038/npp.2015.370
    Journal: Neuropsychopharmacology
    E-pub date: 1 Jul 2016
    Authors: N Segarra, A Metastasio, H Ziauddeen, J Spencer, NR Reinders, RB Dudas, G Arrondo, TW Robbins, L Clark, PC Fletcher, GK Murray

    Atomoxetine Enhances Connectivity of Prefrontal Networks in Parkinson’s Disease.

    DOI: http://doi.org/10.1038/npp.2016.18
    Journal: Neuropsychopharmacology
    E-pub date: 1 Jul 2016
    Authors: RJ Borchert, T Rittman, L Passamonti, Z Ye, S Sami, SP Jones, C Nombela, P Vázquez Rodríguez, D Vatansever, CL Rae, LE Hughes, TW Robbins, JB Rowe

    Atomoxetine Enhances Connectivity of Prefrontal Networks in Parkinson’s Disease.

    DOI: http://doi.org/10.1038/npp.2016.46
    Journal: Neuropsychopharmacology
    E-pub date: 1 Jul 2016
    Authors: RJ Borchert, T Rittman, L Passamonti, Z Ye, S Sami, SP Jones, C Nombela, PV Rodríguez, D Vatansever, CL Rae, LE Hughes, TW Robbins, JB Rowe

    Carrots and sticks fail to change behavior in cocaine addiction.

    DOI: http://doi.org/10.1126/science.aaf3700
    Journal: Science
    E-pub date: 17 Jun 2016
    Authors: KD Ersche, CM Gillan, PS Jones, GB Williams, LHE Ward, M Luijten, S de Wit, BJ Sahakian, ET Bullmore, TW Robbins

    Predicting beneficial effects of atomoxetine and citalopram on response inhibition in Parkinson’s disease with clinical and neuroimaging measures.

    DOI: http://doi.org/10.1002/hbm.23087
    Journal: Hum Brain Mapp
    E-pub date: 1 Mar 2016
    Authors: Z Ye, CL Rae, C Nombela, T Ham, T Rittman, PS Jones, PV Rodríguez, I Coyle-Gilchrist, R Regenthal, E Altena, CR Housden, H Maxwell, BJ Sahakian, RA Barker, TW Robbins, JB Rowe

    Fronto-striatal circuits in response-inhibition: Relevance to addiction.

    DOI: http://doi.org/10.1016/j.brainres.2014.09.012
    Journal: Brain Res
    E-pub date: 2 Dec 2015
    Authors: S Morein-Zamir, TW Robbins

    Role of Central Serotonin in Anticipation of Rewarding and Punishing Outcomes: Effects of Selective Amygdala or Orbitofrontal 5-HT Depletion.

    DOI: http://doi.org/10.1093/cercor/bhu102
    Journal: Cereb Cortex
    E-pub date: 1 Sep 2015
    Authors: R Rygula, HF Clarke, RN Cardinal, GJ Cockcroft, J Xia, JW Dalley, TW Robbins, AC Roberts

    Reduction in ventral striatal activity when anticipating a reward in depression and schizophrenia: a replicated cross-diagnostic finding.

    DOI: http://doi.org/10.3389/fpsyg.2015.01280
    Journal: Front Psychol
    E-pub date: 1 Aug 2015
    Authors: G Arrondo, N Segarra, A Metastasio, H Ziauddeen, J Spencer, NR Reinders, RB Dudas, TW Robbins, PC Fletcher, GK Murray

    Atomoxetine reduces attentional bias to cocaine-related cues irrespective of norepinephrine transporter gene polymorphism

    DOI: http://doi.org/10.1016/S0924-977X(15)30881-6
    Journal: EUROPEAN NEUROPSYCHOPHARMACOLOGY
    E-pub date: 1 Aug 2015
    Authors: CH Popham, M Luijten, H Ziauddeen, SAE Brain, R Regenthal, IH Franken, BJ Sahakian, ET Bullmore, TW Robbins, KE Ersche

    Investigating ‘waiting impulsivity’ in cocaine addiction: are the effects of atomoxetine mediated by genotype?

    DOI: http://doi.org/10.1016/S0924-977X(15)30875-0
    Journal: EUROPEAN NEUROPSYCHOPHARMACOLOGY
    E-pub date: 1 Aug 2015
    Authors: MI Pollard, H Ziauddeen, IT Coyle-Gilchrist, T Rittman, R Regenthal, S Abbott, BJ Sahakian, ET Bullmore, TW Robbins, KD Ersche

    Improving response inhibition systems in frontotemporal dementia with citalopram.

    DOI: http://doi.org/10.1093/brain/awv133
    Journal: Brain
    E-pub date: 1 Jul 2015
    Authors: LE Hughes, T Rittman, R Regenthal, TW Robbins, JB Rowe

    Dissociable rate-dependent effects of oral methylphenidate on impulsivity and D2/3 receptor availability in the striatum.

    DOI: http://doi.org/10.1523/JNEUROSCI.3890-14.2015
    Journal: J Neurosci
    E-pub date: 4 Mar 2015
    Authors: D Caprioli, B Jupp, YT Hong, SJ Sawiak, V Ferrari, L Wharton, DJ Williamson, C McNabb, D Berry, FI Aigbirhio, TW Robbins, TD Fryer, JW Dalley

    Multiple modes of impulsivity in Parkinson’s disease.

    DOI: http://doi.org/10.1371/journal.pone.0085747
    Journal: PLoS One
    E-pub date: 1 Aug 2014
    Authors: C Nombela, T Rittman, TW Robbins, JB Rowe

    Orbitofrontal dopamine depletion upregulates caudate dopamine and alters behavior via changes in reinforcement sensitivity.

    DOI: http://doi.org/10.1523/JNEUROSCI.0718-14.2014
    Journal: J Neurosci
    E-pub date: 28 May 2014
    Authors: HF Clarke, RN Cardinal, R Rygula, YT Hong, TD Fryer, SJ Sawiak, V Ferrari, G Cockcroft, FI Aigbirhio, TW Robbins, AC Roberts

    Counterfactual processing of economic action-outcome alternatives in obsessive-compulsive disorder: further evidence of impaired goal-directed behavior.

    DOI: http://doi.org/10.1016/j.biopsych.2013.01.018
    Journal: Biological Psychiatry
    E-pub date: 15 Apr 2014
    Authors: CM Gillan, S Morein-Zamir, M Kaser, NA Fineberg, A Sule, BJ Sahakian, RN Cardinal, TW Robbins

    Prefrontal hypoactivity associated with impaired inhibition in stimulant-dependent individuals but evidence for hyperactivation in their unaffected siblings.

    DOI: http://doi.org/10.1038/npp.2013.90
    Journal: Neuropsychopharmacology
    E-pub date: 1 Sep 2013
    Authors: S Morein-Zamir, P Simon Jones, ET Bullmore, TW Robbins, KD Ersche

    Investigation of attentional bias in obsessive compulsive disorder with and without depression in visual search.

    DOI: http://doi.org/10.1371/journal.pone.0080118
    Journal: PLoS One
    E-pub date: 1 Aug 2013
    Authors: S Morein-Zamir, M Papmeyer, A Durieux, NA Fineberg, BJ Sahakian, TW Robbins

    Baseline-dependent effects of cocaine pre-exposure on impulsivity and D2/3 receptor availability in the rat striatum: possible relevance to the attention-deficit hyperactivity syndrome.

    DOI: http://doi.org/10.1038/npp.2013.44
    Journal: Neuropsychopharmacology
    E-pub date: 1 Jul 2013
    Authors: D Caprioli, YT Hong, SJ Sawiak, V Ferrari, DJ Williamson, B Jupp, T Adrian Carpenter, FI Aigbirhio, BJ Everitt, TW Robbins, TD Fryer, JW Dalley

    Punishment promotes response control deficits in obsessive-compulsive disorder: evidence from a motivational go/no-go task.

    DOI: http://doi.org/10.1017/S0033291712001018
    Journal: Psychol Med
    E-pub date: 1 Feb 2013
    Authors: S Morein-Zamir, M Papmeyer, CM Gillan, MJ Crockett, NA Fineberg, BJ Sahakian, TW Robbins

    A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment.

    DOI: http://doi.org/10.1093/brain/awt263
    Journal: Brain
    E-pub date: 1 Jan 2013
    Authors: N del Campo, TD Fryer, YT Hong, R Smith, L Brichard, J Acosta-Cabronero, SR Chamberlain, R Tait, D Izquierdo, R Regenthal, J Dowson, J Suckling, J-C Baron, FI Aigbirhio, TW Robbins, BJ Sahakian, U Müller

    Serotonin modulates the effects of Pavlovian aversive predictions on response vigor.

    DOI: http://doi.org/10.1038/npp.2012.75
    Journal: Neuropsychopharmacology
    E-pub date: 1 Sep 2012
    Authors: MJ Crockett, L Clark, AM Apergis-Schoute, S Morein-Zamir, TW Robbins

    Abnormal brain structure implicated in stimulant drug addiction.

    DOI: http://doi.org/10.1126/science.1214463
    Journal: Science
    E-pub date: 3 Feb 2012
    Authors: KD Ersche, PS Jones, GB Williams, AJ Turton, TW Robbins, ET Bullmore

    The natural history of treated Parkinson’s disease in an incident, community based cohort.

    DOI: http://doi.org/10.1136/jnnp.2011.240366
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Oct 2011
    Authors: JR Evans, SL Mason, CH Williams-Gray, T Foltynie, C Brayne, TW Robbins, RA Barker

    Disruption in the balance between goal-directed behavior and habit learning in obsessive-compulsive disorder.

    DOI: http://doi.org/10.1176/appi.ajp.2011.10071062
    Journal: Am J Psychiatry
    E-pub date: 1 Jul 2011
    Authors: CM Gillan, M Papmeyer, S Morein-Zamir, BJ Sahakian, NA Fineberg, TW Robbins, S de Wit

    Abnormal structure of frontostriatal brain systems is associated with aspects of impulsivity and compulsivity in cocaine dependence.

    DOI: http://doi.org/10.1093/brain/awr138
    Journal: Brain
    E-pub date: 1 Jul 2011
    Authors: KD Ersche, A Barnes, PS Jones, S Morein-Zamir, TW Robbins, ET Bullmore

    Hippocampal dysfunction in patients with mild cognitive impairment: a functional neuroimaging study of a visuospatial paired associates learning task.

    DOI: http://doi.org/10.1016/j.neuropsychologia.2011.03.037
    Journal: Neuropsychologia
    E-pub date: 1 Jun 2011
    Authors: M de Rover, VA Pironti, JA McCabe, J Acosta-Cabronero, FS Arana, S Morein-Zamir, JR Hodges, TW Robbins, PC Fletcher, PJ Nestor, BJ Sahakian

    Dopamine, but not serotonin, regulates reversal learning in the marmoset caudate nucleus.

    DOI: http://doi.org/10.1523/JNEUROSCI.5066-10.2011
    Journal: J Neurosci
    E-pub date: 16 Mar 2011
    Authors: HF Clarke, GJ Hill, TW Robbins, AC Roberts

    Differential contributions of the primate ventrolateral prefrontal and orbitofrontal cortex to serial reversal learning.

    DOI: http://doi.org/10.1523/JNEUROSCI.2631-10.2010
    Journal: J Neurosci
    E-pub date: 27 Oct 2010
    Authors: R Rygula, SC Walker, HF Clarke, TW Robbins, AC Roberts

    Impaired visuospatial associative memory and attention in obsessive compulsive disorder but no evidence for differential dopaminergic modulation.

    DOI: http://doi.org/10.1007/s00213-010-1963-z
    Journal: Psychopharmacology (Berl)
    E-pub date: 1 Oct 2010
    Authors: S Morein-Zamir, KJ Craig, KD Ersche, S Abbott, U Muller, NA Fineberg, ET Bullmore, BJ Sahakian, TW Robbins

    The role of dopamine in sustained attention: Imaging the effects of methylphenidate in ADHD patients and healthy controls

    DOI: http://doi.org/10.1016/j.neuroimage.2010.04.082
    Journal: NEUROIMAGE
    E-pub date: 31 Aug 2010
    Authors: N del Campo, T Fryer, Y Hong, D Izquierdo, R Smith, L Brichard, S Chamberlain, JC Baron, F Aigbirhio, T Robbins, B Sahakian, U Muller

    Inhibition of thoughts and actions in obsessive-compulsive disorder: extending the endophenotype?

    DOI: http://doi.org/10.1017/S003329170999033X
    Journal: Psychol Med
    E-pub date: 1 Feb 2010
    Authors: S Morein-Zamir, NA Fineberg, TW Robbins, BJ Sahakian

    Neurochemical modulation of orbitofrontal cortex function

    DOI: http://doi.org/10.1093/acprof:oso/9780198565741.003.0016
    Journal:
    E-pub date: 1 Feb 2010
    Authors: TW Robbins, L Clark, H Clarke, AC Roberts

    Modelling human drug abuse and addiction with dedicated small animal positron emission tomography.

    DOI: http://doi.org/10.1016/j.neuropharm.2008.05.029
    Journal: Neuropharmacology
    E-pub date: 1 Aug 2009
    Authors: JW Dalley, TD Fryer, FI Aigbirhio, L Brichard, HK Richards, YT Hong, J-C Baron, BJ Everitt, TW Robbins

    Dopamine release in dissociable striatal subregions predicts the different effects of oral methylphenidate on reversal learning and spatial working memory.

    DOI: http://doi.org/10.1523/JNEUROSCI.3266-08.2009
    Journal: J Neurosci
    E-pub date: 15 Apr 2009
    Authors: PL Clatworthy, SJG Lewis, L Brichard, YT Hong, D Izquierdo, L Clark, R Cools, FI Aigbirhio, J-C Baron, TD Fryer, TW Robbins

    Catechol O-methyltransferase Val158Met genotype influences frontoparietal activity during planning in patients with Parkinson’s disease.

    DOI: http://doi.org/10.1523/JNEUROSCI.0774-07.2007
    Journal: J Neurosci
    E-pub date: 2 May 2007
    Authors: CH Williams-Gray, A Hampshire, TW Robbins, AM Owen, RA Barker

    Lack of deleterious effects of buspirone on cognition in healthy male volunteers.

    DOI: http://doi.org/10.1177/0269881107068066
    Journal: J Psychopharmacol
    E-pub date: 1 Mar 2007
    Authors: SR Chamberlain, U Müller, JB Deakin, PR Corlett, J Dowson, RN Cardinal, MRF Aitken, TW Robbins, BJ Sahakian

    Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specific.

    DOI: http://doi.org/10.1093/cercor/bhj120
    Journal: Cereb Cortex
    E-pub date: 1 Jan 2007
    Authors: HF Clarke, SC Walker, JW Dalley, TW Robbins, AC Roberts

    Differences in orbitofrontal activation during decision-making between methadone-maintained opiate users, heroin users and healthy volunteers.

    DOI: http://doi.org/10.1007/s00213-006-0515-z
    Journal: Psychopharmacology (Berl)
    E-pub date: 1 Oct 2006
    Authors: KD Ersche, PC Fletcher, JP Roiser, TD Fryer, M London, TW Robbins, BJ Sahakian

    Chapter 3 Neuroscience of Drugs and Addiction

    DOI: http://doi.org/10.1016/B978-012370624-9/50006-2
    Journal:
    E-pub date: 29 Sep 2006
    Authors: T Robbins, RN Cardinal, P DiCiano, PW Halligan, K Hellemans, J Lee, BJ Everitt

    Saccadic latency distributions in Parkinson’s disease and the effects of L-dopa.

    DOI: http://doi.org/10.1007/s00221-006-0412-z
    Journal: Exp Brain Res
    E-pub date: 1 Sep 2006
    Authors: AW Michell, Z Xu, D Fritz, SJG Lewis, T Foltynie, CH Williams-Gray, TW Robbins, RHS Carpenter, RA Barker

    II.1 Cognitive dysfunction in early Parkinson’s Disease

    DOI: http://doi.org/10.1016/s1353-8020(07)70018-4
    Journal: Parkinsonism & Related Disorders
    E-pub date: 1 May 2006
    Authors: C Williams-Gray, RA Barker, R Swainson, TW Robbins

    Double dissociation between serotonergic and dopaminergic modulation of medial prefrontal and orbitofrontal cortex during a test of impulsive choice.

    DOI: http://doi.org/10.1093/cercor/bhi088
    Journal: Cereb Cortex
    E-pub date: 1 Jan 2006
    Authors: CA Winstanley, DEH Theobald, JW Dalley, RN Cardinal, TW Robbins

    Prefrontal serotonin depletion affects reversal learning but not attentional set shifting.

    DOI: http://doi.org/10.1523/JNEUROSCI.3690-04.2005
    Journal: J Neurosci
    E-pub date: 12 Jan 2005
    Authors: HF Clarke, SC Walker, HS Crofts, JW Dalley, TW Robbins, AC Roberts

    Cortical cholinergic function and deficits in visual attentional performance in rats following 192 IgG-saporin-induced lesions of the medial prefrontal cortex.

    DOI: http://doi.org/10.1093/cercor/bhh052
    Journal: Cereb Cortex
    E-pub date: 31 Aug 2004
    Authors: JW Dalley, DE Theobald, P Bouger, Y Chudasama, RN Cardinal, TW Robbins

    Limbic corticostriatal systems and delayed reinforcement.

    DOI: http://doi.org/10.1196/annals.1308.004
    Journal: Ann N Y Acad Sci
    E-pub date: 1 Jun 2004
    Authors: RN Cardinal, CA Winstanley, TW Robbins, BJ Everitt

    Nucleus accumbens dopamine depletion impairs both acquisition and performance of appetitive Pavlovian approach behaviour: implications for mesoaccumbens dopamine function.

    DOI: http://doi.org/10.1016/s0166-4328(02)00291-7
    Journal: Behav Brain Res
    E-pub date: 2 Dec 2002
    Authors: JA Parkinson, JW Dalley, RN Cardinal, A Bamford, B Fehnert, G Lachenal, N Rudarakanchana, KM Halkerston, TW Robbins, BJ Everitt

    Local analysis of behaviour in the adjusting-delay task for assessing choice of delayed reinforcement.

    DOI: http://doi.org/10.1016/s0893-6080(02)00053-9
    Journal: Neural Netw
    E-pub date: 1 Aug 2002
    Authors: RN Cardinal, N Daw, TW Robbins, BJ Everitt

    Distinct changes in cortical acetylcholine and noradrenaline efflux during contingent and noncontingent performance of a visual attentional task.

    DOI: http://doi.org/10.1523/JNEUROSCI.21-13-04908.2001
    Journal: J Neurosci
    E-pub date: 1 Jul 2001
    Authors: JW Dalley, J McGaughy, MT O'Connell, RN Cardinal, L Levita, TW Robbins

    Decision making and neuropsychiatry.

    DOI: http://doi.org/10.1016/s1364-6613(00)01650-8
    Journal: Trends Cogn Sci
    E-pub date: 1 Jun 2001
    Authors: S Rahman, B J Sahakia, R N Cardinal, R Rogers, T Robbins