College Clare Hall

Department

School

Clinical Medicine

Institute

UK Dementia Research Institute at University of Cambridge

Research Theme Beyond the Neuron Neurons, Circuits and Networks

Research Focus

Keywords

11C-Carbon

Alzheimer's Disease

Brain Stimulation

Neurodegenerative Dementia

Clinical Neurosciences

Clinical Conditions

Alzheimer's disease

Equipment & Techniques

Positron Emission Tomography (PET)

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Dr Emad Sidhom MBBCh, ABPsych, MRCPsych

(he/him/his)

University Position

Clinical Research Associate

Interests

I am interested in neurodegenerative disorders, in particular Alzheimer's Disease. I work to understand the pathological mechanisms underlying neurodegenerative processes. I aim to search for the failure of synaptic repair and modify the unfolded protein response in the endoplasmic reticulum. The aim is to achieve a safe neuroprotective, disease modifying agent to slow down the progress of neurocognitive disorders. Electroconvulsive Therapy (ECT) and other forms of neuromodulation in psychiatry is my other area of clinical interest which include research on the low pulse amplitude (< 800 mA), ultra-brief pulse (<0.5 ms) unilateral (ECT) usage to minimise the cognitive side effects of ECT while retaining its efficacy. As well as, optimising titration schedules and algorithms of ECT dosing strategies, and understanding the mechanism of action of ECT, and the mechanism by which ECT causes adverse event in order to provide safe and effective targeted delivery of ECT.

Collaborators

Cambridge

Ben Underwood

Key Publications

Publications

Predicting patients with dementia most at risk of needing psychiatric in-patient or enhanced community care using routinely collected clinical data: retrospective multi-site cohort study.

DOI: http://doi.org/10.1192/bjp.2024.14
Journal: Br J Psychiatry
E-pub date: 1 Jun 2024
Authors: SR London, S Chen, E Sidhom, JR Lewis, E Wolverson, RN Cardinal, D Roalf, C Mueller, BR Underwood

195. Predicting Patients With Dementia Most at Risk of Needing Psychiatric Inpatient or Enhanced Community Care Using Routinely Collected Clinical Data

DOI: http://doi.org/10.1016/j.biopsych.2023.02.435
Journal: Biological Psychiatry
E-pub date: 1 May 2023
Authors: S London, S Chen, E Sidhom, J Lewis, R Cardinal, D Roalf, B Underwood

The epidemiology and clinical features of personality disorders in later life; a study of secondary care data.

DOI: http://doi.org/10.1002/gps.5837
Journal: Int J Geriatr Psychiatry
E-pub date: 1 Dec 2022
Authors: N Treagust, E Sidhom, J Lewis, C Denman, O Knutson, BR Underwood

Trazodone and patient outcomes in dementia-Limitations of naturalistic cohort data.

DOI: http://doi.org/10.1002/gps.5777
Journal: Int J Geriatr Psychiatry
E-pub date: 31 Aug 2022
Authors: E Sidhom, MS Padilla, J Lewis, S White, JT O'Brien, GR Mallucci, BR Underwood

Targeting the Unfolded Protein Response as a Disease-Modifying Pathway in Dementia

DOI: http://doi.org/10.3390/ijms23042021
Journal: International Journal of Molecular Sciences
E-pub date: 11 Feb 2022
Authors: E Sidhom, JT O’Brien, AJ Butcher, HL Smith, GR Mallucci, BR Underwood

Patient and clinician experience of providing remote memory assessment services.

DOI: http://doi.org/10.1002/gps.5664
Journal: Int J Geriatr Psychiatry
E-pub date: 5 Dec 2021
Authors: A Aftab, E Sidhom, A Forrest, N Judge, BR Underwood, K Harkness, DJ Blackburn

Challenges and opportunities for conducting a vaccine trial during the COVID-19 pandemic in the United Kingdom.

DOI: http://doi.org/10.1177/17407745211024764
Journal: Clin Trials
E-pub date: 1 Oct 2021
Authors: ME Török, BR Underwood, M Toshner, C Waddington, E Sidhom, K Sharrocks, R Bousfield, C Summers, C Saunders, Z McIntyre, H Morris, J Piper, G Calderon, S Dennis, T Assari, AM de Rotrou, A Shaw, J Bradley, J O'Brien, RC Rintoul, I Smith, E Bullmore, K Chatterjee, Cambridge COVID Vaccine Trial Team

Providing memory assessment services during COVID-19.

DOI: http://doi.org/10.1080/13607863.2020.1830946
Journal: Aging Ment Health
E-pub date: 31 Aug 2021
Authors: BR Underwood, A Thompsell, E Sidhom, A Burns

The Nomenclature of Electroconvulsive Therapy.

DOI: http://doi.org/10.1097/YCT.0000000000000735
Journal: J ECT
E-pub date: 1 Jun 2021
Authors: E Sidhom, MH Omar

Case report: delayed response after electroconvulsive therapy in a patient with major depressive disorder.

DOI: http://doi.org/10.1186/s12888-021-03053-0
Journal: BMC Psychiatry
E-pub date: 21 Jan 2021
Authors: F Chen, E Sidhom, S Yang, E Ruiz-Mendoza, J Essem

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.

DOI: http://doi.org/10.1016/S0140-6736(20)32661-1
Journal: Lancet
E-pub date: 9 Jan 2021
Authors: M Voysey, SAC Clemens, SA Madhi, LY Weckx, PM Folegatti, PK Aley, B Angus, VL Baillie, SL Barnabas, QE Bhorat, S Bibi, C Briner, P Cicconi, AM Collins, R Colin-Jones, CL Cutland, TC Darton, K Dheda, CJA Duncan, KRW Emary, KJ Ewer, L Fairlie, SN Faust, S Feng, DM Ferreira, A Finn, AL Goodman, CM Green, CA Green, PT Heath, C Hill, H Hill, I Hirsch, SHC Hodgson, A Izu, S Jackson, D Jenkin, CCD Joe, S Kerridge, A Koen, G Kwatra, R Lazarus, AM Lawrie, A Lelliott, V Libri, PJ Lillie, R Mallory, AVA Mendes, EP Milan, AM Minassian, A McGregor, H Morrison, YF Mujadidi, A Nana, PJ O'Reilly, SD Padayachee, A Pittella, E Plested, KM Pollock, MN Ramasamy, S Rhead, AV Schwarzbold, N Singh, A Smith, R Song, MD Snape, E Sprinz, RK Sutherland, R Tarrant, EC Thomson, ME Török, M Toshner, DPJ Turner, J Vekemans, TL Villafana, MEE Watson, CJ Williams, AD Douglas, AVS Hill, T Lambe, SC Gilbert, AJ Pollard, Oxford COVID Vaccine Trial Group

The Depiction of ECT in Egyptian Media

DOI: http://doi.org/10.26717/bjstr.2020.30.005011
Journal: Biomedical Journal of Scientific & Technical Research
E-pub date: 29 Sep 2020
Authors: E Sidhom

The application of stratified medicine to dementia care

DOI: http://doi.org/10.1192/bja.2020.28
Journal: BJPsych Advances
E-pub date: 1 Jul 2020
Authors: E Sidhom, J O'Brien, BR Underwood

Feasibility, safety, and preliminary efficacy of Low Amplitude Seizure Therapy (LAP-ST): A proof of concept clinical trial in man.

DOI: http://doi.org/10.1016/j.jad.2017.06.022
Journal: J Affect Disord
E-pub date: 1 Nov 2017
Authors: NA Youssef, E Sidhom

A Proof of concept clinical trial of feasibility course of low Amplitude Seizure Therapy (LAP-ST) in man: Less cognitive side effects with retention of efficacy

DOI: http://doi.org/10.1016/j.brs.2017.01.084
Journal: Brain Stimulation
E-pub date: 1 Mar 2017
Authors: NA Youssef, E Sidhom