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Research Theme Lifelong Brain Development and Brain Ageing Neurons, Circuits and Networks Adaptive Brain Computations
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Professor James B. Rowe

University Position
Professor

Interests

Dementia and Neurodegeneration have devastating consequences. My work aims to protect brain function in those at risk of dementia, and restore brain function in those with symptoms. My program has four pillars: 1. to define cognitive processes that are affected by dementia and ageing, and individual differences in cognition. 2. to determine mechanisms of individual differences, and prognosis, in terms of underlying cognitive processes (cognitive models); genetics; neural circuits and connectivity (MEG, EEG, fMRI or DWI); neurochemistry; and neuropathology (in vivo PET; and post mortem). 3. to predict the trajectory of brain function across the lifespan (CamCAN), in people at risk of dementia (eg. GENFI, PROSPECT, ICICLE-PD, D&F-Phenotyping studies), and those with symptoms (eg. PiPPIN). 4. to use new drugs to protect the brain, or restore brain function, in experimental medicines studies using precision-biomarkers in precisely-characterised clinical populations.

Associated News Items

Key Publications

Accurate digital quantification of tau pathology in progressive supranuclear palsy.

DOI: http://doi.org/10.1186/s40478-023-01674-y
Journal: Acta Neuropathol Commun
E-pub date: 9 Nov 2023
Authors: T Pansuwan, A Quaegebeur, SS Kaalund, E Hidari, M Briggs, JB Rowe, T Rittman

A robust harmonization approach for cognitive data from multiple aging and dementia cohorts.

DOI: http://doi.org/10.1002/dad2.12453
Journal: Alzheimers Dement (Amst)
E-pub date: 1 Aug 2023
Authors: J Giorgio, A Tanna, M Malpetti, SR White, J Wang, S Baker, S Landau, T Tanaka, C Chen, JB Rowe, J O'Brien, J Fripp, M Breakspear, W Jagust, Z Kourtzi, Alzheimer's Disease Neuroimaging Initiative, Australian Imaging Biomarkers and Lifestyle flagship study

Identifying healthy individuals with Alzheimer’s disease neuroimaging phenotypes in the UK Biobank.

DOI: http://doi.org/10.1038/s43856-023-00313-w
Journal: Commun Med (Lond)
E-pub date: 20 Jul 2023
Authors: T Azevedo, RAI Bethlehem, DJ Whiteside, N Swaddiwudhipong, JB Rowe, P Lió, T Rittman, Alzheimer’s Disease Neuroimaging Initiative

Temporal lobe perceptual predictions for speech are instantiated in motor cortex and reconciled by inferior frontal cortex.

DOI: http://doi.org/10.1016/j.celrep.2023.112422
Journal: Cell Rep
E-pub date: 30 May 2023
Authors: TE Cope, E Sohoglu, KA Peterson, PS Jones, C Rua, L Passamonti, W Sedley, B Post, J Coebergh, CR Butler, P Garrard, K Abdel-Aziz, M Husain, TD Griffiths, K Patterson, MH Davis, JB Rowe

Pre-diagnostic cognitive and functional impairment in multiple sporadic neurodegenerative diseases.

DOI: http://doi.org/10.1002/alz.12802
Journal: Alzheimers Dement
E-pub date: 1 May 2023
Authors: N Swaddiwudhipong, DJ Whiteside, FH Hezemans, D Street, JB Rowe, T Rittman

Differential levels of plasma biomarkers of neurodegeneration in Lewy body dementia, Alzheimer’s disease, frontotemporal dementia and progressive supranuclear palsy.

DOI: http://doi.org/10.1136/jnnp-2021-327788
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Jun 2022
Authors: L Chouliaras, A Thomas, M Malpetti, P Donaghy, J Kane, E Mak, G Savulich, MA Prats-Sedano, AJ Heslegrave, H Zetterberg, L Su, JB Rowe, JT O'Brien

In vivo neuroinflammation and cerebral small vessel disease in mild cognitive impairment and Alzheimer’s disease.

DOI: http://doi.org/10.1136/jnnp-2020-323894
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 11 Sep 2020
Authors: A Low, E Mak, M Malpetti, L Passamonti, N Nicastro, JD Stefaniak, G Savulich, L Chouliaras, L Su, JB Rowe, HS Markus, JT O'Brien

Multi-centre, multi-vendor reproducibility of 7T QSM and R2* in the human brain: results from the UK7T study

DOI: http://doi.org/10.1101/2020.04.22.055624
Journal:
E-pub date: 1 Aug 2020
Authors: C Rua, W Clarke, I Driver, O Mougin, A Morgan, S Clare, S Francis, K Muir, R Wise, A Carpenter, G Williams, J Rowe, R Bowtell, C Rodgers

Inflammation and cerebral small vessel disease: A systematic review.

DOI: http://doi.org/10.1016/j.arr.2019.100916
Journal: Ageing Res Rev
E-pub date: 31 Aug 2019
Authors: A Low, E Mak, JB Rowe, HS Markus, JT O'Brien

Evidence for causal top-down frontal contributions to predictive processes in speech perception.

DOI: http://doi.org/10.1038/s41467-017-01958-7
Journal: Nat Commun
E-pub date: 18 Dec 2017
Authors: TE Cope, E Sohoglu, W Sedley, K Patterson, PS Jones, J Wiggins, C Dawson, M Grube, RP Carlyon, TD Griffiths, MH Davis, JB Rowe

Serum immune markers and disease progression in an incident Parkinson’s disease cohort (ICICLE-PD).

DOI: http://doi.org/10.1002/mds.26563
Journal: Mov Disord
E-pub date: 1 Jul 2016
Authors: CH Williams-Gray, R Wijeyekoon, AJ Yarnall, RA Lawson, DP Breen, JR Evans, GA Cummins, GW Duncan, TK Khoo, DJ Burn, RA Barker, ICICLE-PD study group

Publications

Pharmacological and pupillary evidence for the noradrenergic contribution to reinforcement learning in Parkinson’s disease

DOI: http://doi.org/10.21203/rs.3.rs-4361233/v1
Journal:
E-pub date: 1 Aug 2024
Authors: C O'Callaghan, F Hezemans, N Subramaniam, R Ye, K Tsvetanov, A Murley, N Holland, I Orlando, R Regenthal, R Baker, C Williams-Gray, L Passamonti, T Robbins, J Rowe

Differential Synaptic Loss in β‐Amyloid Positive Versus β‐Amyloid Negative Corticobasal Syndrome

DOI: http://doi.org/10.1002/mds.29814
Journal: Mov Disord
E-pub date: 1 Jul 2024
Authors: N Holland, G Savulich, PS Jones, DJ Whiteside, D Street, P Swann, M Naessens, M Malpetti, YT Hong, TD Fryer, T Rittman, E Mulroy, FI Aigbirhio, KP Bhatia, JT O'Brien, JB Rowe

Multisystem pathology in McLeod syndrome.

DOI: http://doi.org/10.1111/neup.12935
Journal: Neuropathology
E-pub date: 1 Apr 2024
Authors: KR Schon, DG O'Donovan, M Briggs, JB Rowe, L Wijesekera, PF Chinnery, J van den Ameele

Synaptic density affects clinical severity via network dysfunction in syndromes associated with frontotemporal lobar degeneration.

DOI: http://doi.org/10.1038/s41467-023-44307-7
Journal: Nat Commun
E-pub date: 20 Dec 2023
Authors: DJ Whiteside, N Holland, KA Tsvetanov, E Mak, M Malpetti, G Savulich, PS Jones, M Naessens, MA Rouse, TD Fryer, YT Hong, FI Aigbirhio, E Mulroy, KP Bhatia, T Rittman, JT O'Brien, JB Rowe

Structural correlates of survival in progressive supranuclear palsy.

DOI: http://doi.org/10.1016/j.parkreldis.2023.105866
Journal: Parkinsonism Relat Disord
E-pub date: 1 Nov 2023
Authors: D Street, WR Bevan-Jones, M Malpetti, PS Jones, L Passamonti, BC Ghosh, T Rittman, IT Coyle-Gilchrist, K Allinson, CE Dawson, JB Rowe

Locus coeruleus integrity is linked to response inhibition deficits in Parkinson’s disease and progressive supranuclear palsy.

DOI: http://doi.org/10.1523/JNEUROSCI.0289-22.2023
Journal: J Neurosci
E-pub date: 18 Oct 2023
Authors: R Ye, FH Hezemans, C O'Callaghan, KA Tsvetanov, C Rua, PS Jones, N Holland, M Malpetti, AG Murley, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

Characterization and super-resolution imaging of small tau aggregates in human samples

DOI: http://doi.org/10.1101/2023.06.12.544575
Journal:
E-pub date: 1 Aug 2023
Authors: D Böken, D Cox, M Burke, J Lam, T Katsinelos, J Danial, W McEwan, J Rowe, D Klenerman

Quantitative susceptibility mapping at 7 Tesla in COVID-19: mechanistic and outcome associations

DOI: http://doi.org/10.1101/2023.11.22.23298899
Journal:
E-pub date: 1 Aug 2023
Authors: C Rua, B Raman, CT Rodgers, VFJ Newcombe, A Manktelow, DA Chatfield, SJ Sawcer, JG Outtrim, VC Lupson, EA Stamatakis, GB Williams, WT Clarke, L Qiu, M Ezra, R McDonald, S Clare, M Cassar, S Neubauer, KD Ersche, ET Bullmore, DK Menon, K Pattinson, JB Rowe

Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia.

DOI: http://doi.org/10.1093/brain/awad078
Journal: Brain
E-pub date: 1 Aug 2023
Authors: M Malpetti, TE Cope, D Street, PS Jones, FH Hezemans, E Mak, KA Tsvetanov, T Rittman, WR Bevan-Jones, K Patterson, L Passamonti, TD Fryer, YT Hong, FI Aigbirhio, JT O'Brien, JB Rowe

Network connectivity and structural correlates of survival in progressive supranuclear palsy and corticobasal syndrome.

DOI: http://doi.org/10.1002/hbm.26342
Journal: Hum Brain Mapp
E-pub date: 1 Aug 2023
Authors: DJ Whiteside, D Street, AG Murley, PS Jones, M Malpetti, BCP Ghosh, I Coyle-Gilchrist, A Gerhard, MT Hu, JC Klein, PN Leigh, A Church, DJ Burn, HR Morris, JB Rowe, T Rittman

Neurochemistry-enriched dynamic causal models of magnetoencephalography, using magnetic resonance spectroscopy.

DOI: http://doi.org/10.1016/j.neuroimage.2023.120193
Journal: Neuroimage
E-pub date: 1 Aug 2023
Authors: A Jafarian, LE Hughes, NE Adams, JH Lanskey, M Naessens, MA Rouse, AG Murley, KJ Friston, JB Rowe

Progression of atypical parkinsonian syndromes: PROSPECT-M-UK study implications for clinical trials.

DOI: http://doi.org/10.1093/brain/awad105
Journal: Brain
E-pub date: 1 Aug 2023
Authors: D Street, E Jabbari, A Costantini, PS Jones, N Holland, T Rittman, MT Jensen, V Chelban, YY Goh, T Guo, AJ Heslegrave, F Roncaroli, JC Klein, O Ansorge, KSJ Allinson, Z Jaunmuktane, T Revesz, TT Warner, AJ Lees, H Zetterberg, LL Russell, M Bocchetta, JD Rohrer, DJ Burn, N Pavese, A Gerhard, C Kobylecki, PN Leigh, A Church, MTM Hu, H Houlden, H Morris, JB Rowe

Longitudinal Synaptic Loss in Primary Tauopathies: An In Vivo [11 C]UCB-J Positron Emission Tomography Study.

DOI: http://doi.org/10.1002/mds.29421
Journal: Mov Disord
E-pub date: 1 Jul 2023
Authors: N Holland, PS Jones, G Savulich, M Naessens, M Malpetti, DJ Whiteside, D Street, P Swann, YT Hong, TD Fryer, T Rittman, E Mulroy, FI Aigbirhio, KP Bhatia, JT O'Brien, JB Rowe

Syndromes associated with frontotemporal lobar degeneration change response patterns on visual analogue scales.

DOI: http://doi.org/10.1038/s41598-023-35758-5
Journal: Sci Rep
E-pub date: 2 Jun 2023
Authors: RS Williams, NE Adams, LE Hughes, MA Rouse, AG Murley, M Naessens, D Street, N Holland, JB Rowe

Neurophysiological consequences of synapse loss in progressive supranuclear palsy.

DOI: http://doi.org/10.1093/brain/awac471
Journal: Brain
E-pub date: 1 Jun 2023
Authors: NE Adams, A Jafarian, A Perry, MA Rouse, AD Shaw, AG Murley, TE Cope, WR Bevan-Jones, L Passamonti, D Street, N Holland, D Nesbitt, LE Hughes, KJ Friston, JB Rowe

Temporal dynamics predict symptom onset and cognitive decline in familial frontotemporal dementia.

DOI: http://doi.org/10.1002/alz.12824
Journal: Alzheimers Dement
E-pub date: 1 May 2023
Authors: DJ Whiteside, M Malpetti, PS Jones, BCP Ghosh, I Coyle-Gilchrist, JC van Swieten, H Seelaar, L Jiskoot, B Borroni, R Sanchez-Valle, F Moreno, R Laforce, C Graff, M Synofzik, D Galimberti, M Masellis, MC Tartaglia, E Finger, R Vandenberghe, A de Mendonça, F Tagliavini, CR Butler, I Santana, IL Ber, A Gerhard, S Ducharme, J Levin, A Danek, M Otto, S Sorbi, F Pasquier, A Bouzigues, LL Russell, JD Rohrer, JB Rowe, T Rittman, GENFI consortium

APOEε4 associates with microglial activation independently of Aβ plaques and tau tangles.

DOI: http://doi.org/10.1126/sciadv.ade1474
Journal: Sci Adv
E-pub date: 5 Apr 2023
Authors: JP Ferrari-Souza, FZ Lussier, DT Leffa, J Therriault, C Tissot, B Bellaver, PCL Ferreira, M Malpetti, Y-T Wang, G Povala, AL Benedet, NJ Ashton, M Chamoun, S Servaes, G Bezgin, MS Kang, J Stevenson, N Rahmouni, V Pallen, NM Poltronetti, JT O'Brien, JB Rowe, AD Cohen, OL Lopez, DL Tudorascu, TK Karikari, WE Klunk, VL Villemagne, J-P Soucy, S Gauthier, DO Souza, H Zetterberg, K Blennow, ER Zimmer, P Rosa-Neto, TA Pascoal

Cytosolic antibody receptor TRIM21 is required for effective tau immunotherapy in mouse models.

DOI: http://doi.org/10.1126/science.abn1366
Journal: Science
E-pub date: 31 Mar 2023
Authors: AS Mukadam, LVC Miller, AE Smith, M Vaysburd, SA Sakya, S Sanford, S Keeling, BJ Tuck, T Katsinelos, C Green, L Skov, SS Kaalund, S Foss, K Mayes, K O'Connell, M Wing, C Knox, J Banbury, E Avezov, JB Rowe, M Goedert, JT Andersen, LC James, WA McEwan

Incidence of Syndromes Associated With Frontotemporal Lobar Degeneration in 9 European Countries.

DOI: http://doi.org/10.1001/jamaneurol.2022.5128
Journal: JAMA Neurol
E-pub date: 1 Mar 2023
Authors: G Logroscino, M Piccininni, C Graff, O Hardiman, AC Ludolph, F Moreno, M Otto, AM Remes, JB Rowe, H Seelaar, E Solje, E Stefanova, L Traykov, V Jelic, MT Rydell, N Pender, S Anderl-Straub, M Barandiaran, A Gabilondo, J Krüger, AG Murley, T Rittman, EL van der Ende, JC van Swieten, P Hartikainen, GM Stojmenovic, S Mehrabian, L Benussi, A Alberici, MT Dell'Abate, C Zecca, B Borroni, FRONTIERS group

Synaptic Loss in Frontotemporal Dementia Revealed by [11 C]UCB-J Positron Emission Tomography.

DOI: http://doi.org/10.1002/ana.26543
Journal: Ann Neurol
E-pub date: 1 Jan 2023
Authors: M Malpetti, PS Jones, TE Cope, N Holland, M Naessens, MA Rouse, T Rittman, G Savulich, DJ Whiteside, D Street, TD Fryer, YT Hong, S Milicevic Sephton, FI Aigbirhio, JT O Brien, JB Rowe

Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses.

DOI: http://doi.org/10.1093/brain/awac321
Journal: Brain
E-pub date: 21 Nov 2022
Authors: EJ Needham, AL Ren, RJ Digby, EJ Norton, S Ebrahimi, JG Outtrim, DA Chatfield, AE Manktelow, MM Leibowitz, VFJ Newcombe, R Doffinger, G Barcenas-Morales, C Fonseca, MJ Taussig, RM Burnstein, RJ Samanta, C Dunai, N Sithole, NJ Ashton, H Zetterberg, M Gisslén, A Edén, E Marklund, PJM Openshaw, J Dunning, MJ Griffiths, J Cavanagh, G Breen, SR Irani, A Elmer, N Kingston, C Summers, JR Bradley, LS Taams, BD Michael, ET Bullmore, KGC Smith, PA Lyons, AJ Coles, DK Menon, Cambridge NeuroCOVID Group, CITIID-NIHR COVID-19 BioResource Collaboration, Cambridge NIHR Clinical Research Facility

Brain correlates of action word memory revealed by fMRI.

DOI: http://doi.org/10.1038/s41598-022-19416-w
Journal: Sci Rep
E-pub date: 26 Sep 2022
Authors: Z Shebani, F Carota, O Hauk, JB Rowe, LW Barsalou, R Tomasello, F Pulvermüller

A multi-site, multi-participant magnetoencephalography resting-state dataset to study dementia: The BioFIND dataset.

DOI: http://doi.org/10.1016/j.neuroimage.2022.119344
Journal: Neuroimage
E-pub date: 1 Sep 2022
Authors: D Vaghari, R Bruna, LE Hughes, D Nesbitt, R Tibon, JB Rowe, F Maestu, RN Henson

Locus Coeruleus Integrity from 7 T MRI Relates to Apathy and Cognition in Parkinsonian Disorders.

DOI: http://doi.org/10.1002/mds.29072
Journal: Mov Disord
E-pub date: 31 Aug 2022
Authors: R Ye, C O'Callaghan, C Rua, FH Hezemans, N Holland, M Malpetti, PS Jones, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, J Rowe

The neurophysiological effect of NMDA-R antagonism of frontotemporal lobar degeneration is conditional on individual GABA concentration.

DOI: http://doi.org/10.1038/s41398-022-02114-6
Journal: Transl Psychiatry
E-pub date: 27 Aug 2022
Authors: A Perry, LE Hughes, N Adams, M Naessens, AG Murley, MA Rouse, D Street, PS Jones, TE Cope, E Kocagoncu, JB Rowe

Parkinson’s disease impairs cortical sensori-motor decision-making cascades

DOI: http://doi.org/10.1101/2022.10.26.22281571
Journal:
E-pub date: 1 Aug 2022
Authors: A Tomassini, TE Cope, J Zhang, JB Rowe

A modified Camel and Cactus Test detects presymptomatic semantic impairment in genetic frontotemporal dementia within the GENFI cohort.

DOI: http://doi.org/10.1080/23279095.2020.1716357
Journal: Appl Neuropsychol Adult
E-pub date: 1 Aug 2022
Authors: K Moore, R Convery, M Bocchetta, M Neason, DM Cash, C Greaves, LL Russell, MTM Clarke, G Peakman, J van Swieten, L Jiskoot, F Moreno, M Barandiaran, R Sanchez-Valle, B Borroni, R Laforce, M-C Doré, M Masellis, MC Tartaglia, C Graff, D Galimberti, JB Rowe, E Finger, M Synofzik, H-O Karnath, R Vandenberghe, A de Mendonça, C Maruta, F Tagliavini, I Santana, S Ducharme, C Butler, A Gerhard, J Levin, A Danek, M Otto, JD Warren, JD Rohrer, Genetic FTD Initiative, GENFI*

Synaptic loss in behavioural variant frontotemporal dementia revealed by [11C]UCB-J PET

DOI: http://doi.org/10.1101/2022.01.30.22270123
Journal:
E-pub date: 1 Aug 2022
Authors: M Malpetti, S Jones, T Cope, N Holland, M Naessens, M Rouse, G Savulich, T Fryer, Y Hong, SM Sephton, F Aigbirhio, J O’Brien, J Rowe

Neurophysiological consequences of synapse loss in progressive supranuclear palsy

DOI: http://doi.org/10.1101/2022.06.22.22276697
Journal:
E-pub date: 1 Aug 2022
Authors: N Adams, A Jafarian, A Perry, M Rouse, A Shaw, A Murley, T Cope, R Bevan-Jones, L Passamonti, D Street, N Holland, D Nesbitt, L Hughes, K Friston, J Rowe

Hospitalisation for COVID-19 predicts long lasting cerebrovascular impairment: A prospective observational cohort study

DOI: http://doi.org/10.1101/2022.02.01.22270235
Journal:
E-pub date: 1 Aug 2022
Authors: K Tsvetanov, L Spindler, E Stamatakis, VFJ Newcombe, V Lupson, D Chatfield, A Manktelow, J Outtrim, A Elmer, N Kingston, J Bradley, E Bullmore, J Rowe, D Menon, The Cambridge NeuroCOVID Group, The NIHR COVID-19 BioResource, The Cambridge NIHR Clinical Research Facility, The CITIID-NIHR BioResource COVID-19 Collaboration

Neurochemistry-enriched dynamic causal models of magnetoencephalography, using magnetic resonance spectroscopy

DOI: http://doi.org/10.1101/2022.06.17.493881
Journal:
E-pub date: 1 Aug 2022
Authors: A Jafarian, L Hughes, N Adams, J Lanskey, M Naessens, M Rouse, A Murley, K Friston, J Rowe

Pre-Diagnostic Cognitive and Functional Impairment in Multiple Sporadic Neurodegenerative Diseases

DOI: http://doi.org/10.1101/2022.04.05.22273468
Journal:
E-pub date: 1 Aug 2022
Authors: N Swaddiwudhipong, D Whiteside, F Hezemans, D Street, J Rowe, T Rittman

Hospitalisation for COVID-19 predicts long lasting cerebrovascular impairment: A prospective observational cohort study.

DOI: http://doi.org/10.1016/j.nicl.2022.103253
Journal: Neuroimage Clin
E-pub date: 1 Aug 2022
Authors: KA Tsvetanov, LRB Spindler, EA Stamatakis, VFJ Newcombe, VC Lupson, DA Chatfield, AE Manktelow, JG Outtrim, A Elmer, N Kingston, JR Bradley, ET Bullmore, JB Rowe, DK Menon, Cambridge NeuroCOVID Group, NIHR COVID-19 BioResource, Cambridge NIHR Clinical Research Facility, CITIID-NIHR BioResource COVID-19 Collaboration

In Vivo 18F-Flortaucipir PET Does Not Accurately Support the Staging of Progressive Supranuclear Palsy.

DOI: http://doi.org/10.2967/jnumed.121.262985
Journal: J Nucl Med
E-pub date: 1 Jul 2022
Authors: M Malpetti, SS Kaalund, KA Tsvetanov, T Rittman, M Briggs, KSJ Allinson, L Passamonti, N Holland, PS Jones, TD Fryer, YT Hong, A Kouli, WR Bevan-Jones, E Mak, G Savulich, MG Spillantini, FI Aigbirhio, CH Williams-Gray, JT O'Brien, JB Rowe

Heteroplasmic mitochondrial DNA mutations in frontotemporal lobar degeneration.

DOI: http://doi.org/10.1007/s00401-022-02423-6
Journal: Acta Neuropathol
E-pub date: 1 Jun 2022
Authors: Y Nie, A Murley, Z Golder, JB Rowe, K Allinson, PF Chinnery

Atomoxetine and citalopram alter brain network organisation in Parkinson’s disease

DOI: http://doi.org/10.1136/jnnp-2022-abn.18
Journal: Journal of Neurology, Neurosurgery & Psychiatry
E-pub date: 1 Jun 2022
Authors: R Borchert, T Rittman, C Rae, L Passamonti, S Jones, D Vatansever, PVZ Rodríguez, Z Ye, J Rowe

A synergistic core for human brain evolution and cognition.

DOI: http://doi.org/10.1038/s41593-022-01070-0
Journal: Nat Neurosci
E-pub date: 1 Jun 2022
Authors: AI Luppi, PAM Mediano, FE Rosas, N Holland, TD Fryer, JT O'Brien, JB Rowe, DK Menon, D Bor, EA Stamatakis

Noradrenergic deficits contribute to apathy in Parkinson’s disease through the precision of expected outcomes.

DOI: http://doi.org/10.1371/journal.pcbi.1010079
Journal: PLoS Comput Biol
E-pub date: 1 May 2022
Authors: FH Hezemans, N Wolpe, C O'Callaghan, R Ye, C Rua, PS Jones, AG Murley, N Holland, R Regenthal, KA Tsvetanov, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

Causal Evidence for the Multiple Demand Network in Change Detection: Auditory Mismatch Magnetoencephalography across Focal Neurodegenerative Diseases.

DOI: http://doi.org/10.1523/JNEUROSCI.1622-21.2022
Journal: J Neurosci
E-pub date: 13 Apr 2022
Authors: TE Cope, LE Hughes, HN Phillips, NE Adams, A Jafarian, D Nesbitt, M Assem, A Woolgar, J Duncan, JB Rowe

Are the UK genetic testing criteria for dementia too exclusive?

DOI: http://doi.org/10.1007/s00415-021-10867-1
Journal: J Neurol
E-pub date: 1 Apr 2022
Authors: A Christodoulidou, GE McKenna, ST Holden, JB Rowe, TE Cope

Molecular pathology and synaptic loss in primary tauopathies: A [18F]AV-1451 and [11C]UCB-J PET study

DOI: http://doi.org/10.1093/brain/awab282
Journal: Brain
E-pub date: 29 Mar 2022
Authors: N Holland, M Malpetti, T Rittman, E Mak, L Passamonti, S Kaalund, F Hezemans, P Jones, G Savulich, Y Hong, T Fryer, F Aigbirhio, J O'Brien, J Rowe

Proton magnetic resonance spectroscopy in frontotemporal lobar degeneration-related syndromes.

DOI: http://doi.org/10.1016/j.neurobiolaging.2021.10.012
Journal: Neurobiol Aging
E-pub date: 1 Mar 2022
Authors: AG Murley, KA Tsvetanov, MA Rouse, PS Jones, K Sværke, W Li, A Carpenter, JB Rowe

Dynamic targeting enables domain-general inhibitory control over action and thought by the prefrontal cortex.

DOI: http://doi.org/10.1038/s41467-021-27926-w
Journal: Nat Commun
E-pub date: 12 Jan 2022
Authors: D Apšvalka, CS Ferreira, TW Schmitz, JB Rowe, MC Anderson

Microglial activation and atrophy in frontal cortex predict executive dysfunction in frontotemporal dementia

DOI: http://doi.org/10.1002/alz.055456
Journal: Alzheimer's & Dementia
E-pub date: 1 Dec 2021
Authors: M Malpetti, PS Jones, FH Hezemans, E Mak, D Street, L Passamonti, T Rittman, TE Cope, WR Bevan‐Jones, K Patterson, TD Fryer, YT Hong, FI Aigbirho, JT O'Brien, JB Rowe

Rate‐limiting processes of tau aggregate accumulation in Alzheimer’s disease

DOI: http://doi.org/10.1002/alz.051680
Journal: Alzheimer's & Dementia
E-pub date: 1 Dec 2021
Authors: G Meisl, Y Zuo, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, T Knowles, D Klenerman

Co-Occurrence of Apathy and Impulsivity in Progressive Supranuclear Palsy.

DOI: http://doi.org/10.1002/mdc3.13339
Journal: Mov Disord Clin Pract
E-pub date: 1 Nov 2021
Authors: ZQ Kok, AG Murley, T Rittman, J Rowe, L Passamonti

Altered network stability in progressive supranuclear palsy.

DOI: http://doi.org/10.1016/j.neurobiolaging.2021.07.007
Journal: Neurobiol Aging
E-pub date: 1 Nov 2021
Authors: DJ Whiteside, PS Jones, BCP Ghosh, I Coyle-Gilchrist, A Gerhard, MT Hu, JC Klein, PN Leigh, A Church, DJ Burn, HR Morris, JB Rowe, T Rittman

In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease.

DOI: http://doi.org/10.1126/sciadv.abh1448
Journal: Sci Adv
E-pub date: 29 Oct 2021
Authors: G Meisl, E Hidari, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, TPJ Knowles, D Klenerman

Progressive supranuclear palsy: diagnosis and management.

DOI: http://doi.org/10.1136/practneurol-2020-002794
Journal: Pract Neurol
E-pub date: 1 Oct 2021
Authors: JB Rowe, N Holland, T Rittman

Altered structural connectivity networks in dementia with lewy bodies.

DOI: http://doi.org/10.1007/s11682-020-00444-x
Journal: Brain Imaging Behav
E-pub date: 1 Oct 2021
Authors: N Nicastro, E Mak, A Surendranathan, T Rittman, JB Rowe, JT O'Brien

Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease.

DOI: http://doi.org/10.1093/brain/awab142
Journal: Brain
E-pub date: 4 Sep 2021
Authors: C O'Callaghan, FH Hezemans, R Ye, C Rua, PS Jones, AG Murley, N Holland, R Regenthal, KA Tsvetanov, N Wolpe, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

GABAergic cortical network physiology in frontotemporal lobar degeneration.

DOI: http://doi.org/10.1093/brain/awab097
Journal: Brain
E-pub date: 17 Aug 2021
Authors: NE Adams, LE Hughes, MA Rouse, HN Phillips, AD Shaw, AG Murley, TE Cope, WR Bevan-Jones, L Passamonti, D Street, N Holland, D Nesbitt, K Friston, JB Rowe

A multi-site, multi-participant magnetoencephalography resting-state dataset to study dementia: The BioFIND dataset

DOI: http://doi.org/10.1101/2021.05.19.21257330
Journal:
E-pub date: 1 Aug 2021
Authors: D Vaghari, R Bruna, L Hughes, D Nesbitt, R Tibon, J Rowe, F Maestu, R Henson

Noradrenergic deficits contribute to apathy in Parkinson’s disease through the precision of expected outcomes

DOI: http://doi.org/10.1101/2021.07.04.21259922
Journal:
E-pub date: 1 Aug 2021
Authors: F Hezemans, N Wolpe, C O’Callaghan, R Ye, C Rua, S Jones, A Murley, N Holland, R Regenthal, K Tsvetanov, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

Substantia nigra ferric overload and neuromelanin loss in Parkinson’s disease measured with 7T MRI

DOI: http://doi.org/10.1101/2021.04.13.21255416
Journal:
E-pub date: 1 Aug 2021
Authors: C Rua, C O’Callaghan, R Ye, F Hezemans, L Passamonti, S Jones, G Williams, C Rodgers, J Rowe

Impairment of episodic memory in genetic frontotemporal dementia: A GENFI study.

DOI: http://doi.org/10.1002/dad2.12185
Journal: Alzheimers Dement (Amst)
E-pub date: 1 Aug 2021
Authors: JM Poos, LL Russell, G Peakman, M Bocchetta, CV Greaves, LC Jiskoot, EL van der Ende, H Seelaar, JM Papma, E van den Berg, YAL Pijnenburg, B Borroni, R Sanchez-Valle, F Moreno, R Laforce, C Graff, M Synofzik, D Galimberti, JB Rowe, M Masellis, C Tartaglia, E Finger, R Vandenberghe, A de Medonça, F Tagliavini, CR Butler, I Santana, IL Ber, A Gerhard, S Ducharme, J Levin, A Danek, M Otto, S Sorbi, F Pasquier, JC van Swieten, JD Rohrer, Genetic FTD Initiative, GENF

Differential early subcortical involvement in genetic FTD within the GENFI cohort.

DOI: http://doi.org/10.1016/j.nicl.2021.102646
Journal: Neuroimage Clin
E-pub date: 1 Aug 2021
Authors: M Bocchetta, EG Todd, G Peakman, DM Cash, RS Convery, LL Russell, DL Thomas, J Eugenio Iglesias, JC van Swieten, LC Jiskoot, H Seelaar, B Borroni, D Galimberti, R Sanchez-Valle, R Laforce, F Moreno, M Synofzik, C Graff, M Masellis, M Carmela Tartaglia, JB Rowe, R Vandenberghe, E Finger, F Tagliavini, A de Mendonça, I Santana, CR Butler, S Ducharme, A Gerhard, A Danek, J Levin, M Otto, S Sorbi, I Le Ber, F Pasquier, JD Rohrer, Genetic Frontotemporal dementia Initiative (GENFI)

Disease-related cortical thinning in presymptomatic granulin mutation carriers.

DOI: http://doi.org/10.1016/j.nicl.2020.102540
Journal: Neuroimage Clin
E-pub date: 1 Aug 2021
Authors: S Borrego-Écija, R Sala-Llonch, J van Swieten, B Borroni, F Moreno, M Masellis, C Tartaglia, C Graff, D Galimberti, R Laforce, JB Rowe, E Finger, R Vandenberghe, F Tagliavini, A de Mendonça, I Santana, M Synofzik, S Ducharme, J Levin, A Danek, A Gerhard, M Otto, C Butler, G Frisoni, S Sorbi, C Heller, M Bocchetta, DM Cash, RS Convery, KM Moore, JD Rohrer, R Sanchez-Valle, Genetic FTD Initiative GENFI

[18F]-AV-1451 binding in the substantia nigra as a marker of neuromelanin in Lewy body diseases.

DOI: http://doi.org/10.1093/braincomms/fcab177
Journal: Brain Commun
E-pub date: 1 Aug 2021
Authors: E Mak, A Kouli, N Holland, N Nicastro, G Savulich, A Surendranathan, M Malpetti, R Manavaki, YT Hong, TD Fryer, F Aigbirhio, JB Rowe, JT O'Brien, CH Williams-Gray

Locus Coeruleus Integrity from 7T MRI Relates to Apathy and Cognition in Parkinson’s Disease and Progressive Supranuclear Palsy

DOI: http://doi.org/10.1101/2021.04.19.21255762
Journal:
E-pub date: 1 Aug 2021
Authors: R Ye, C O’Callaghan, C Rua, F Hezemans, N Holland, M Malpetti, S Jones, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

Reduced locus coeruleus integrity linked to response inhibition deficits in parkinsonian disorders

DOI: http://doi.org/10.1101/2021.10.14.21264996
Journal:
E-pub date: 1 Aug 2021
Authors: R Ye, F Hezemans, C O’Callaghan, K Tsvetanov, C Rua, S Jones, N Holland, M Malpetti, A Murley, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

Looking beneath the surface: the importance of subcortical structures in frontotemporal dementia.

DOI: http://doi.org/10.1093/braincomms/fcab158
Journal: Brain Commun
E-pub date: 1 Aug 2021
Authors: M Bocchetta, M Malpetti, EG Todd, JB Rowe, JD Rohrer

Validation of the new pathology staging system for progressive supranuclear palsy

DOI: http://doi.org/10.1101/2021.01.18.21250017
Journal:
E-pub date: 1 Aug 2021
Authors: M Briggs, KSJ Allinson, M Malpetti, MG Spillantini, JB Rowe, SS Kaalund

Clinical progression of progressive supranuclear palsy: impact of trials bias and phenotype variants.

DOI: http://doi.org/10.1093/braincomms/fcab206
Journal: Brain Commun
E-pub date: 1 Aug 2021
Authors: D Street, M Malpetti, T Rittman, BCP Ghosh, AG Murley, I Coyle-Gilchrist, L Passamonti, JB Rowe

Proton magnetic resonance spectroscopy in frontotemporal lobar degeneration-related syndromes

DOI: http://doi.org/10.1101/2021.01.11.21249589
Journal:
E-pub date: 1 Aug 2021
Authors: A Murley, K Tsvetanov, M Rouse, S Jones, K Sværke, W Li, A Carpenter, J Rowe

Co-occurrence of apathy and impulsivity in progressive supranuclear palsy

DOI: http://doi.org/10.1101/2021.02.26.21252350
Journal:
E-pub date: 1 Aug 2021
Authors: ZQ Kok, A Murley, T Rittman, J Rowe, L Passamonti

Prodromal Progressive Supranuclear Palsy: insights from the UK Biobank

DOI: http://doi.org/10.1101/2021.05.06.21256759
Journal:
E-pub date: 1 Aug 2021
Authors: D Street, D Whiteside, T Rittman, J Rowe

Predicting loss of independence and mortality in frontotemporal lobar degeneration syndromes.

DOI: http://doi.org/10.1136/jnnp-2020-324903
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Jul 2021
Authors: AG Murley, MA Rouse, ITS Coyle-Gilchrist, PS Jones, W Li, J Wiggins, C Lansdall, P Vázquez Rodríguez, A Wilcox, K Patterson, JB Rowe

Synaptic density in carriers of C9orf72 mutations: a [11 C]UCB-J PET study.

DOI: http://doi.org/10.1002/acn3.51407
Journal: Ann Clin Transl Neurol
E-pub date: 1 Jul 2021
Authors: M Malpetti, N Holland, PS Jones, R Ye, TE Cope, TD Fryer, YT Hong, G Savulich, T Rittman, L Passamonti, E Mak, FI Aigbirhio, JT O'Brien, JB Rowe

Neuroinflammation predicts disease progression in progressive supranuclear palsy.

DOI: http://doi.org/10.1136/jnnp-2020-325549
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Jul 2021
Authors: M Malpetti, L Passamonti, PS Jones, D Street, T Rittman, TD Fryer, YT Hong, P Vàsquez Rodriguez, WR Bevan-Jones, FI Aigbirhio, JT O'Brien, JB Rowe

Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes.

DOI: http://doi.org/10.1002/alz.12252
Journal: Alzheimers Dement
E-pub date: 1 Jun 2021
Authors: M Malpetti, PS Jones, KA Tsvetanov, T Rittman, JC van Swieten, B Borroni, R Sanchez-Valle, F Moreno, R Laforce, C Graff, M Synofzik, D Galimberti, M Masellis, MC Tartaglia, E Finger, R Vandenberghe, A de Mendonça, F Tagliavini, I Santana, S Ducharme, CR Butler, A Gerhard, J Levin, A Danek, M Otto, GB Frisoni, R Ghidoni, S Sorbi, C Heller, EG Todd, M Bocchetta, DM Cash, RS Convery, G Peakman, KM Moore, JD Rohrer, RA Kievit, JB Rowe, Genetic FTD Initiative (GENFI)

In vivo coupling of dendritic complexity with presynaptic density in primary tauopathies.

DOI: http://doi.org/10.1016/j.neurobiolaging.2021.01.016
Journal: Neurobiol Aging
E-pub date: 1 May 2021
Authors: E Mak, N Holland, PS Jones, G Savulich, A Low, M Malpetti, SS Kaalund, L Passamonti, T Rittman, R Romero-Garcia, R Manavaki, GB Williams, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

Validation of the new pathology staging system for progressive supranuclear palsy.

DOI: http://doi.org/10.1007/s00401-021-02298-z
Journal: Acta Neuropathol
E-pub date: 1 May 2021
Authors: M Briggs, KSJ Allinson, M Malpetti, MG Spillantini, JB Rowe, SS Kaalund

Imaging tau burden in dementia with Lewy bodies using [18F]-AV1451 positron emission tomography.

DOI: http://doi.org/10.1016/j.neurobiolaging.2020.11.006
Journal: Neurobiol Aging
E-pub date: 1 May 2021
Authors: E Mak, N Nicastro, M Malpetti, G Savulich, A Surendranathan, N Holland, L Passamonti, PS Jones, SF Carter, L Su, YT Hong, TD Fryer, GB Williams, F Aigbirhio, JB Rowe, JT O'Brien

Advances in neuroimaging to support translational medicine in dementia.

DOI: http://doi.org/10.1136/jnnp-2019-322402
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Mar 2021
Authors: TE Cope, RS Weil, E Düzel, BC Dickerson, JB Rowe

Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia.

DOI: http://doi.org/10.1002/alz.12209
Journal: Alzheimers Dement
E-pub date: 1 Mar 2021
Authors: KA Tsvetanov, S Gazzina, PS Jones, J van Swieten, B Borroni, R Sanchez-Valle, F Moreno, R Laforce, C Graff, M Synofzik, D Galimberti, M Masellis, MC Tartaglia, E Finger, R Vandenberghe, A de Mendonça, F Tagliavini, I Santana, S Ducharme, C Butler, A Gerhard, A Danek, J Levin, M Otto, G Frisoni, R Ghidoni, S Sorbi, JD Rohrer, JB Rowe, Genetic FTD Initiative, GENFI

In vivo PET imaging of neuroinflammation in familial frontotemporal dementia.

DOI: http://doi.org/10.1136/jnnp-2020-323698
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Mar 2021
Authors: M Malpetti, T Rittman, PS Jones, TE Cope, L Passamonti, WR Bevan-Jones, K Patterson, TD Fryer, YT Hong, FI Aigbirhio, JT O'Brien, JB Rowe

Relationship between tau, neuroinflammation and atrophy in Alzheimer’s disease: The NIMROD study

DOI: http://doi.org/10.1016/j.inffus.2020.10.006
Journal: Information Fusion
E-pub date: 1 Mar 2021
Authors: L Su, A Surendranathan, Y Huang, WR Bevan-Jones, L Passamonti, YT Hong, R Arnold, PV Rodríguez, Y Wang, E Mak, TD Fryer, F Aigbirhio, JB Rowe, JT O'Brien

An in vivo probabilistic atlas of the human locus coeruleus at ultra-high field.

DOI: http://doi.org/10.1016/j.neuroimage.2020.117487
Journal: Neuroimage
E-pub date: 15 Jan 2021
Authors: R Ye, C Rua, C O'Callaghan, PS Jones, FH Hezemans, SS Kaalund, KA Tsvetanov, CT Rodgers, G Williams, L Passamonti, JB Rowe

Progression of Behavioral Disturbances and Neuropsychiatric Symptoms in Patients With Genetic Frontotemporal Dementia.

DOI: http://doi.org/10.1001/jamanetworkopen.2020.30194
Journal: JAMA Netw Open
E-pub date: 4 Jan 2021
Authors: A Benussi, E Premi, S Gazzina, C Brattini, E Bonomi, A Alberici, L Jiskoot, JC van Swieten, R Sanchez-Valle, F Moreno, R Laforce, C Graff, M Synofzik, D Galimberti, M Masellis, C Tartaglia, JB Rowe, E Finger, R Vandenberghe, A de Mendonça, F Tagliavini, I Santana, S Ducharme, CR Butler, A Gerhard, J Levin, A Danek, M Otto, G Frisoni, R Ghidoni, S Sorbi, I Le Ber, F Pasquier, G Peakman, E Todd, M Bocchetta, JD Rohrer, B Borroni, Genetic FTD Initiative (GENFI)

Neuroanatomical substrates of generalized brain dysfunction in COVID-19.

DOI: http://doi.org/10.1007/s00134-020-06241-w
Journal: Intensive Care Med
E-pub date: 1 Jan 2021
Authors: VFJ Newcombe, LRB Spindler, T Das, S Winzeck, K Allinson, EA Stamatakis, DK Menon, Cambridge NeuroCovid Imaging Collaborators

C9orf72, age at onset, and ancestry help discriminate behavioral from language variants in FTLD cohorts.

DOI: http://doi.org/10.1212/WNL.0000000000010914
Journal: Neurology
E-pub date: 15 Dec 2020
Authors: B Costa, C Manzoni, M Bernal-Quiros, DA Kia, M Aguilar, I Alvarez, V Alvarez, O Andreassen, M Anfossi, S Bagnoli, L Benussi, L Bernardi, G Binetti, D Blackburn, M Boada, B Borroni, L Bowns, G Bråthen, AC Bruni, H-H Chiang, J Clarimon, S Colville, ME Conidi, TE Cope, C Cruchaga, C Cupidi, ME Di Battista, J Diehl-Schmid, M Diez-Fairen, O Dols-Icardo, E Durante, D Flisar, F Frangipane, D Galimberti, M Gallo, M Gallucci, R Ghidoni, C Graff, JH Grafman, M Grossman, J Hardy, I Hernández, GJT Holloway, ED Huey, I Illán-Gala, A Karydas, B Khoshnood, MG Kramberger, M Kristiansen, PA Lewis, A Lleó, GK Madhan, R Maletta, A Maver, M Menendez-Gonzalez, G Milan, B Miller, MO Mol, P Momeni, S Moreno-Grau, CM Morris, B Nacmias, C Nilsson, V Novelli, L Öijerstedt, A Padovani, S Pal, Y Panchbhaya, P Pastor, B Peterlin, I Piaceri, S Pickering-Brown, YAL Pijnenburg, AA Puca, I Rainero, A Rendina, AMT Richardson, E Rogaeva, B Rogelj, S Rollinson, G Rossi, C Rossmeier, JB Rowe, E Rubino, A Ruiz, R Sanchez-Valle, SB Sando, AF Santillo, J Saxon, E Scarpini, M Serpente, N Smirne, S Sorbi, E Suh, F Tagliavini, JC Thompson, JQ Trojanowski, VM Van Deerlin, J Van der Zee, C Van Broeckhoven, J van Rooij, JC Van Swieten, A Veronesi, E Vitale, ML Waldö, C Woodward, J Yokoyama, V Escott-Price, JM Polke, R Ferrari, International FTD-Genetics Consortium

GABA and glutamate deficits from frontotemporal lobar degeneration are associated with disinhibition.

DOI: http://doi.org/10.1093/brain/awaa305
Journal: Brain
E-pub date: 5 Dec 2020
Authors: AG Murley, MA Rouse, PS Jones, R Ye, FH Hezemans, C O'Callaghan, P Frangou, Z Kourtzi, C Rua, TA Carpenter, CT Rodgers, JB Rowe

Social cognition impairment in genetic frontotemporal dementia within the GENFI cohort.

DOI: http://doi.org/10.1016/j.cortex.2020.08.023
Journal: Cortex
E-pub date: 1 Dec 2020
Authors: LL Russell, CV Greaves, M Bocchetta, J Nicholas, RS Convery, K Moore, DM Cash, J van Swieten, L Jiskoot, F Moreno, R Sanchez-Valle, B Borroni, R Laforce, M Masellis, MC Tartaglia, C Graff, E Rotondo, D Galimberti, JB Rowe, E Finger, M Synofzik, R Vandenberghe, A de Mendonça, F Tagliavini, I Santana, S Ducharme, C Butler, A Gerhard, J Levin, A Danek, M Otto, JD Warren, JD Rohrer, Genetic FTD Initiative, GENFI

Abnormal pain perception is associated with thalamo-cortico-striatal atrophy in C9orf72 expansion carriers in the GENFI cohort.

DOI: http://doi.org/10.1136/jnnp-2020-323279
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Dec 2020
Authors: RS Convery, M Bocchetta, CV Greaves, KM Moore, DM Cash, J Van Swieten, F Moreno, R Sánchez-Valle, B Borroni, R Laforce, M Masellis, MC Tartaglia, C Graff, D Galimberti, JB Rowe, E Finger, M Synofzik, R Vandenberghe, A de Mendonca, F Tagliavini, I Santana, S Ducharme, C Butler, A Gerhard, J Levin, A Danek, M Otto, JD Warren, JD Rohrer, Genetic FTD Initiative (GENFI)

Trajectory of apathy, cognition and neural correlates in the decades before symptoms in frontotemporal dementia

DOI: http://doi.org/10.1002/alz.041821
Journal: Alzheimer's & Dementia
E-pub date: 1 Dec 2020
Authors: M Malpetti, RA Kievit, PS Jones, T Rittman, KA Tsvetanov, JC van Swieten, B Borroni, D Galimberti, R Sanchez‐Valle, R Laforce, F Moreno, M Synofzik, C Graff, M Masellis, C Tartaglia, R Vandenberghe, E Finger, F Tagliavini, A de Mendonca, I Santana, C Butler, S Ducharme, A Gerhard, A Danek, J Levin, M Otto, GB Frisoni, R Ghidoni, C Heller, E Todd, M Bocchetta, RS Convery, G Peakman, KM Moore, JD Rohrer, JB Rowe

A cross‐cohort cognitive composite for tracking changes in pre‐clinical and prodromal Alzheimer’s disease

DOI: http://doi.org/10.1002/alz.037928
Journal: Alzheimer's & Dementia
E-pub date: 1 Dec 2020
Authors: J Giorgio, A Tanna, WJ Jagust, SL Baker, SM Landau, T Tanaka, CP Chen, A Reilhac, M Malpetti, JB Rowe, JT O'Brien, Z Kourtzi

Multimodal imaging markers of tau, neuroinflammation and atrophy to predict clinical progression in progressive supranuclear palsy

DOI: http://doi.org/10.1002/alz.044724
Journal: Alzheimer's & Dementia
E-pub date: 1 Dec 2020
Authors: M Malpetti, L Passamonti, PS Jones, T Rittman, TD Fryer, YT Hong, D Street, PV Rodríguez, WR Bevan‐Jones, FI Aigbirhio, JT O'Brien, JB Rowe

The prognostic role of microglia and tau PET in Alzheimer’s disease

DOI: http://doi.org/10.1002/alz.039817
Journal: Alzheimer's & Dementia
E-pub date: 1 Dec 2020
Authors: M Malpetti, RA Kievit, L Passamonti, PS Jones, KA Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan‐Jones, L Su, YT Hong, TD Fryer, FI Aigbirho, JT O'Brien, JB Rowe

Neuroinflammation and Tau Colocalize in vivo in Progressive Supranuclear Palsy.

DOI: http://doi.org/10.1002/ana.25911
Journal: Ann Neurol
E-pub date: 1 Dec 2020
Authors: M Malpetti, L Passamonti, T Rittman, PS Jones, P Vázquez Rodríguez, WR Bevan-Jones, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

Synaptic Loss in Primary Tauopathies Revealed by [11 C]UCB-J Positron Emission Tomography.

DOI: http://doi.org/10.1002/mds.28188
Journal: Mov Disord
E-pub date: 1 Oct 2020
Authors: N Holland, PS Jones, G Savulich, JK Wiggins, YT Hong, TD Fryer, R Manavaki, SM Sephton, I Boros, M Malpetti, FH Hezemans, FI Aigbirhio, JP Coles, J O'Brien, JB Rowe

Gray matter changes related to microglial activation in Alzheimer’s disease.

DOI: http://doi.org/10.1016/j.neurobiolaging.2020.06.010
Journal: Neurobiol Aging
E-pub date: 1 Oct 2020
Authors: N Nicastro, M Malpetti, E Mak, GB Williams, WR Bevan-Jones, SF Carter, L Passamonti, TD Fryer, YT Hong, FI Aigbirhio, JB Rowe, JT O'Brien

Metabolomic changes associated with frontotemporal lobar degeneration syndromes.

DOI: http://doi.org/10.1007/s00415-020-09824-1
Journal: J Neurol
E-pub date: 31 Aug 2020
Authors: AG Murley, PS Jones, I Coyle Gilchrist, L Bowns, J Wiggins, KA Tsvetanov, JB Rowe

Peak Width of Skeletonized Mean Diffusivity as a Marker of Diffuse Cerebrovascular Damage.

DOI: http://doi.org/10.3389/fnins.2020.00238
Journal: Front Neurosci
E-pub date: 1 Aug 2020
Authors: A Low, E Mak, JD Stefaniak, M Malpetti, N Nicastro, G Savulich, L Chouliaras, HS Markus, JB Rowe, JT O'Brien

Cortical Complexity Analyses and Their Cognitive Correlate in Alzheimer’s Disease and Frontotemporal Dementia.

DOI: http://doi.org/10.3233/JAD-200246
Journal: J Alzheimers Dis
E-pub date: 1 Aug 2020
Authors: N Nicastro, M Malpetti, TE Cope, WR Bevan-Jones, E Mak, L Passamonti, JB Rowe, JT O'Brien

Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease

DOI: http://doi.org/10.1101/2020.09.03.20176800
Journal:
E-pub date: 1 Aug 2020
Authors: C O’Callaghan, F Hezemans, R Ye, C Rua, S Jones, A Murley, N Holland, R Regenthal, K Tsvetanov, N Wolpe, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

Neuroinflammation predicts disease progression in progressive supranuclear palsy

DOI: http://doi.org/10.1101/2020.05.19.20106393
Journal:
E-pub date: 1 Aug 2020
Authors: M Malpetti, L Passamonti, S Jones, D Street, T Rittman, T Fryer, Y Hong, P Vasquez-Rodriguez, WR Bevan-Jones, F Aigbirhio, J O'Brien, J Rowe

In vivo PET imaging of neuroinflammation in familial frontotemporal dementia

DOI: http://doi.org/10.1101/2020.05.11.20098046
Journal:
E-pub date: 1 Aug 2020
Authors: M Malpetti, T Rittman, S Jones, T Cope, L Passamonti, R Bevan-Jones, K Patterson, T Fryer, Y Hong, F Aigbirhio, J O’Brien, J Rowe

Synaptic loss in primary tauopathies revealed by [11C]UCB-J positron emission tomography

DOI: http://doi.org/10.1101/2020.01.24.20018697
Journal:
E-pub date: 1 Aug 2020
Authors: N Holland, S Jones, G Savulich, J Wiggins, Y Hong, T Fryer, R Manavaki, SM Sephton, I Boros, M Malpetti, F Hezemans, F Aigbirhio, J Coles, J O’Brien, J Rowe

A synergistic core for human brain evolution and cognition

DOI: http://doi.org/10.1101/2020.09.22.308981
Journal:
E-pub date: 1 Aug 2020
Authors: A Luppi, PAM Mediano, F Rosas, N Holland, T Fryer, J O’Brien, J Rowe, D Menon, D Bor, E Stamatakis

Amplification, not spreading limits rate of tau aggregate accumulation in Alzheimer’s disease

DOI: http://doi.org/10.1101/2020.11.16.384727
Journal:
E-pub date: 1 Aug 2020
Authors: G Meisl, Y Zuo, K Allinson, T Rittman, S DeVos, J Sanchez, C Xu, K Duff, K Johnson, J Rowe, B Hyman, T Knowles, D Klenerman

Towards accurate and unbiased imaging-based differentiation of Parkinson’s disease, progressive supranuclear palsy and corticobasal syndrome.

DOI: http://doi.org/10.1093/braincomms/fcaa051
Journal: Brain Commun
E-pub date: 1 Aug 2020
Authors: MM Correia, T Rittman, CL Barnes, IT Coyle-Gilchrist, B Ghosh, LE Hughes, JB Rowe

11C-UCB-J synaptic PET and multimodal imaging in dementia with Lewy bodies.

DOI: http://doi.org/10.1186/s41824-020-00093-9
Journal: Eur J Hybrid Imaging
E-pub date: 1 Aug 2020
Authors: N Nicastro, N Holland, G Savulich, SF Carter, E Mak, YT Hong, S Milicevic Sephton, TD Fryer, FI Aigbirhio, JB Rowe, JT O'Brien

Correlation of microglial activation with white matter changes in dementia with Lewy bodies.

DOI: http://doi.org/10.1016/j.nicl.2020.102200
Journal: Neuroimage Clin
E-pub date: 1 Aug 2020
Authors: N Nicastro, E Mak, GB Williams, A Surendranathan, WR Bevan-Jones, L Passamonti, P Vàzquez Rodrìguez, L Su, R Arnold, TD Fryer, YT Hong, FI Aigbirhio, JB Rowe, JT O'Brien

Faster Cortical Thinning and Surface Area Loss in Presymptomatic and Symptomatic C9orf72 Repeat Expansion Adult Carriers.

DOI: http://doi.org/10.1002/ana.25748
Journal: Ann Neurol
E-pub date: 1 Jul 2020
Authors: G Le Blanc, V Jetté Pomerleau, J McCarthy, B Borroni, J van Swieten, D Galimberti, R Sanchez-Valle, R LaForce, F Moreno, M Synofzik, C Graff, M Masellis, MC Tartaglia, JB Rowe, R Vandenberghe, E Finger, F Tagliavini, A de Mendonça, I Santana, C Butler, A Gerhard, A Danek, J Levin, M Otto, G Frisoni, S Sorbi, JD Rohrer, S Ducharme, Genetic Frontotemporal Dementia Initiative (GENFI)

Anterior temporal lobe is necessary for efficient lateralised processing of spoken word identity.

DOI: http://doi.org/10.1016/j.cortex.2019.12.025
Journal: Cortex
E-pub date: 1 May 2020
Authors: TE Cope, Y Shtyrov, LJ MacGregor, R Holland, F Pulvermüller, JB Rowe, K Patterson

Redefining the multidimensional clinical phenotypes of frontotemporal lobar degeneration syndromes.

DOI: http://doi.org/10.1093/brain/awaa097
Journal: Brain
E-pub date: 1 May 2020
Authors: AG Murley, I Coyle-Gilchrist, MA Rouse, PS Jones, W Li, J Wiggins, C Lansdall, PV Rodríguez, A Wilcox, KA Tsvetanov, K Patterson, MA Lambon Ralph, JB Rowe

Microglial activation and tau burden predict cognitive decline in Alzheimer’s disease.

DOI: http://doi.org/10.1093/brain/awaa088
Journal: Brain
E-pub date: 1 May 2020
Authors: M Malpetti, RA Kievit, L Passamonti, PS Jones, KA Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia.

DOI: http://doi.org/10.1136/jnnp-2019-321954
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Mar 2020
Authors: C Heller, MS Foiani, K Moore, R Convery, M Bocchetta, M Neason, DM Cash, D Thomas, CV Greaves, IO Woollacott, R Shafei, JC Van Swieten, F Moreno, R Sanchez-Valle, B Borroni, R Laforce, M Masellis, MC Tartaglia, C Graff, D Galimberti, JB Rowe, E Finger, M Synofzik, R Vandenberghe, A de Mendonca, F Tagliavini, I Santana, S Ducharme, CR Butler, A Gerhard, J Levin, A Danek, G Frisoni, S Sorbi, M Otto, AJ Heslegrave, H Zetterberg, JD Rohrer, GENFI

Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.

DOI: http://doi.org/10.1093/brain/awaa033
Journal: Brain
E-pub date: 1 Mar 2020
Authors: WR Bevan-Jones, TE Cope, PS Jones, SS Kaalund, L Passamonti, K Allinson, O Green, YT Hong, TD Fryer, R Arnold, JP Coles, FI Aigbirhio, AJ Larner, K Patterson, JT O'Brien, JB Rowe

GABA-ergic Dynamics in Human Frontotemporal Networks Confirmed by Pharmaco-Magnetoencephalography.

DOI: http://doi.org/10.1523/JNEUROSCI.1689-19.2019
Journal: J Neurosci
E-pub date: 19 Feb 2020
Authors: NE Adams, LE Hughes, HN Phillips, AD Shaw, AG Murley, D Nesbitt, TE Cope, WR Bevan-Jones, L Passamonti, JB Rowe

Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study.

DOI: http://doi.org/10.1016/S1474-4422(19)30394-1
Journal: Lancet Neurol
E-pub date: 1 Feb 2020
Authors: KM Moore, J Nicholas, M Grossman, CT McMillan, DJ Irwin, L Massimo, VM Van Deerlin, JD Warren, NC Fox, MN Rossor, S Mead, M Bocchetta, BF Boeve, DS Knopman, NR Graff-Radford, LK Forsberg, R Rademakers, ZK Wszolek, JC van Swieten, LC Jiskoot, LH Meeter, EG Dopper, JM Papma, JS Snowden, J Saxon, M Jones, S Pickering-Brown, I Le Ber, A Camuzat, A Brice, P Caroppo, R Ghidoni, M Pievani, L Benussi, G Binetti, BC Dickerson, D Lucente, S Krivensky, C Graff, L Öijerstedt, M Fallström, H Thonberg, N Ghoshal, JC Morris, B Borroni, A Benussi, A Padovani, D Galimberti, E Scarpini, GG Fumagalli, IR Mackenzie, G-YR Hsiung, P Sengdy, AL Boxer, H Rosen, JB Taylor, M Synofzik, C Wilke, P Sulzer, JR Hodges, G Halliday, J Kwok, R Sanchez-Valle, A Lladó, S Borrego-Ecija, I Santana, MR Almeida, M Tábuas-Pereira, F Moreno, M Barandiaran, B Indakoetxea, J Levin, A Danek, JB Rowe, TE Cope, M Otto, S Anderl-Straub, A de Mendonça, C Maruta, M Masellis, SE Black, P Couratier, G Lautrette, ED Huey, S Sorbi, B Nacmias, R Laforce, M-PL Tremblay, R Vandenberghe, PV Damme, EJ Rogalski, S Weintraub, A Gerhard, CU Onyike, S Ducharme, SG Papageorgiou, ASL Ng, A Brodtmann, E Finger, R Guerreiro, J Bras, JD Rohrer, FTD Prevention Initiative

18F-AV1451 PET imaging and multimodal MRI changes in progressive supranuclear palsy.

DOI: http://doi.org/10.1007/s00415-019-09566-9
Journal: J Neurol
E-pub date: 1 Feb 2020
Authors: N Nicastro, PV Rodriguez, M Malpetti, WR Bevan-Jones, P Simon Jones, L Passamonti, FI Aigbirhio, JT O'Brien, JB Rowe

Falls in Progressive Supranuclear Palsy.

DOI: http://doi.org/10.1002/mdc3.12879
Journal: Mov Disord Clin Pract
E-pub date: 1 Jan 2020
Authors: FS Brown, JB Rowe, L Passamonti, T Rittman

Asymmetrical atrophy of thalamic subnuclei in Alzheimer’s disease and amyloid-positive mild cognitive impairment is associated with key clinical features.

DOI: http://doi.org/10.1016/j.dadm.2019.08.001
Journal: Alzheimers Dement (Amst)
E-pub date: 1 Dec 2019
Authors: A Low, E Mak, M Malpetti, L Chouliaras, N Nicastro, L Su, N Holland, T Rittman, PV Rodríguez, L Passamonti, WR Bevan-Jones, PS Jones, JB Rowe, JT O'Brien

Serum neurofilament light chain in genetic frontotemporal dementia: a longitudinal, multicentre cohort study.

DOI: http://doi.org/10.1016/S1474-4422(19)30354-0
Journal: Lancet Neurol
E-pub date: 1 Dec 2019
Authors: EL van der Ende, LH Meeter, JM Poos, JL Panman, LC Jiskoot, EGP Dopper, JM Papma, FJ de Jong, IMW Verberk, C Teunissen, D Rizopoulos, C Heller, RS Convery, KM Moore, M Bocchetta, M Neason, DM Cash, B Borroni, D Galimberti, R Sanchez-Valle, R Laforce, F Moreno, M Synofzik, C Graff, M Masellis, M Carmela Tartaglia, JB Rowe, R Vandenberghe, E Finger, F Tagliavini, A de Mendonça, I Santana, C Butler, S Ducharme, A Gerhard, A Danek, J Levin, M Otto, GB Frisoni, S Cappa, YAL Pijnenburg, JD Rohrer, JC van Swieten, Genetic Frontotemporal dementia Initiative (GENFI)

Test Your Memory (TYM test): diagnostic evaluation of patients with non-Alzheimer dementias.

DOI: http://doi.org/10.1007/s00415-019-09447-1
Journal: J Neurol
E-pub date: 1 Oct 2019
Authors: J Brown, J Wiggins, CJ Lansdall, K Dawson, T Rittman, JB Rowe

Perceptual and conceptual processing of visual objects across the adult lifespan.

DOI: http://doi.org/10.1038/s41598-019-50254-5
Journal: Sci Rep
E-pub date: 24 Sep 2019
Authors: R Bruffaerts, LK Tyler, M Shafto, KA Tsvetanov, Cambridge Centre for Ageing and Neuroscience, A Clarke

Test Your Memory (TYM) and Test Your Memory for Mild Cognitive Impairment (TYM-MCI): A Review and Update Including Results of Using the TYM Test in a General Neurology Clinic and Using a Telephone Version of the TYM Test.

DOI: http://doi.org/10.3390/diagnostics9030116
Journal: Diagnostics (Basel)
E-pub date: 8 Sep 2019
Authors: JM Brown, J Wiggins, K Dawson, T Rittman, JB Rowe

Cortical complexity analyses and their cognitive correlate in Alzheimer’s disease and frontotemporal dementia

DOI: http://doi.org/10.1101/19013466
Journal:
E-pub date: 1 Aug 2019
Authors: N Nicastro, M Malpetti, T Cope, WR Bevan-Jones, E Mak, L Passamonti, J Rowe, J O’brien

White matter hyperintensities in progranulin-associated frontotemporal dementia: A longitudinal GENFI study.

DOI: http://doi.org/10.1016/j.nicl.2019.102077
Journal: Neuroimage Clin
E-pub date: 1 Aug 2019
Authors: CH Sudre, M Bocchetta, C Heller, R Convery, M Neason, KM Moore, DM Cash, DL Thomas, IOC Woollacott, M Foiani, A Heslegrave, R Shafei, C Greaves, J van Swieten, F Moreno, R Sanchez-Valle, B Borroni, R Laforce, M Masellis, MC Tartaglia, C Graff, D Galimberti, JB Rowe, E Finger, M Synofzik, R Vandenberghe, A de Mendonça, F Tagliavini, I Santana, S Ducharme, C Butler, A Gerhard, J Levin, A Danek, GB Frisoni, S Sorbi, M Otto, H Zetterberg, S Ourselin, MJ Cardoso, JD Rohrer, On behalf of, GENFI

Neuroinflammation and protein aggregation co-localize across the frontotemporal dementia spectrum.: weak correlations were observed between our cohorts of controls for each ligand (supplementary figure 1)

DOI: http://doi.org/10.1101/525642
Journal:
E-pub date: 1 Aug 2019
Authors: WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, Y Hong, T Fryer, R Arnold, J Coles, F Aigbirhio, A Larner, K Patterson, J O'Brien, J Rowe

GABA-ergic dynamics in human frontotemporal networks confirmed by pharmaco-magnetoencephalography

DOI: http://doi.org/10.1101/803924
Journal:
E-pub date: 1 Aug 2019
Authors: N Adams, L Hughes, H Phillips, A Shaw, A Murley, T Cope, R Bevan-Jones, L Passamonti, J Rowe

18F-AV1451 PET imaging and white matter changes in progressive supranuclear palsy

DOI: http://doi.org/10.1101/19000596
Journal:
E-pub date: 1 Aug 2019
Authors: N Nicastro, P Vazquez Rodriguez, M Malpetti, WR Bevan-Jones, S Jones, L Passamonti, F Aigbirhio, J O’brien, J Rowe

PET markers of tau and neuroinflammation are co-localized in progressive supranuclear palsy

DOI: http://doi.org/10.1101/19010702
Journal:
E-pub date: 1 Aug 2019
Authors: M Malpetti, L Passamonti, T Rittman, S Jones, P Vázquez Rodríguez, R Bevan-Jones, Y Hong, T Fryer, F Aigbirhio, J O’Brien, J Rowe

Microglial activation and tau burden predict cognitive decline in Alzheimer’s Disease

DOI: http://doi.org/10.1101/19011189
Journal:
E-pub date: 1 Aug 2019
Authors: M Malpetti, R Kievit, L Passamonti, S Jones, K Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, Y Hong, T Fryer, F Aigbirhio, J O'Brien, J Rowe

Atomoxetine and citalopram alter brain network organization in Parkinson’s disease.

DOI: http://doi.org/10.1093/braincomms/fcz013
Journal: Brain Commun
E-pub date: 1 Aug 2019
Authors: RJ Borchert, T Rittman, CL Rae, L Passamonti, SP Jones, D Vatansever, P Vázquez Rodríguez, Z Ye, C Nombela, LE Hughes, TW Robbins, JB Rowe

O4‐03‐06: LONGITUDINAL ASSOCIATION BETWEEN APATHY AND COGNITIVE DECLINE IN PRE‐ AND POST‐SYMPTOMATIC GENETIC FRONTOTEMPORAL DEMENTIA

DOI: http://doi.org/10.1016/j.jalz.2019.06.4757
Journal: Alzheimer's & Dementia
E-pub date: 1 Jul 2019
Authors: M Malpetti, RA Kievit, PS Jones, T Rittman, KA Tsvetanov, JC van Swieten, B Borroni, D Galimberti, R Sanchez-Valle, R Laforce, F Moreno, M Synofzik, C Graff, M Masellis, C Tartaglia, R Vandenberghe, E Finger, F Tagliavini, A Mendonca, I Santana, CR Butler, S Ducharme, A Gerhard, A Danek, J Levin, M Otto, GB Frisoni, S Cappa, C Heller, RS Convery, KM Dick, JD Rohrer, JB Rowe

Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia.

DOI: http://doi.org/10.1016/j.neurobiolaging.2018.12.009
Journal: Neurobiol Aging
E-pub date: 1 May 2019
Authors: T Rittman, R Borchert, S Jones, J van Swieten, B Borroni, D Galimberti, M Masellis, MC Tartaglia, C Graff, F Tagliavini, GB Frisoni, R Laforce, E Finger, A Mendonça, S Sorbi, JD Rohrer, JB Rowe, Genetic Frontotemporal Dementia Initiative (GENFI)

The inner fluctuations of the brain in presymptomatic Frontotemporal Dementia: The chronnectome fingerprint.

DOI: http://doi.org/10.1016/j.neuroimage.2019.01.080
Journal: Neuroimage
E-pub date: 1 Apr 2019
Authors: E Premi, VD Calhoun, M Diano, S Gazzina, M Cosseddu, A Alberici, S Archetti, D Paternicò, R Gasparotti, J van Swieten, D Galimberti, R Sanchez-Valle, R Laforce, F Moreno, M Synofzik, C Graff, M Masellis, MC Tartaglia, J Rowe, R Vandenberghe, E Finger, F Tagliavini, A de Mendonça, I Santana, C Butler, S Ducharme, A Gerhard, A Danek, J Levin, M Otto, G Frisoni, S Cappa, S Sorbi, A Padovani, JD Rohrer, B Borroni, Genetic FTD Initiative, GENFI

In vivo evidence for pre-symptomatic neuroinflammation in a MAPT mutation carrier.

DOI: http://doi.org/10.1002/acn3.683
Journal: Ann Clin Transl Neurol
E-pub date: 1 Feb 2019
Authors: WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, YT Hong, T Fryer, R Arnold, JP Coles, FI Aigbirhio, JT O'Brien, JB Rowe

Meta-analytic Evidence for the Plurality of Mechanisms in Transdiagnostic Structural MRI Studies of Hallucination Status.

DOI: http://doi.org/10.1016/j.eclinm.2019.01.012
Journal: EClinicalMedicine
E-pub date: 1 Feb 2019
Authors: CPE Rollins, JR Garrison, JS Simons, JB Rowe, C O'Callaghan, GK Murray, J Suckling

Early microglial activation and peripheral inflammation in dementia with Lewy bodies.

DOI: http://doi.org/10.1093/brain/awy265
Journal: Brain
E-pub date: 1 Dec 2018
Authors: A Surendranathan, L Su, E Mak, L Passamonti, YT Hong, R Arnold, P Vázquez Rodríguez, WR Bevan-Jones, SAE Brain, TD Fryer, FI Aigbirhio, JB Rowe, JT O'Brien

[18F]AV-1451 binding is increased in frontotemporal dementia due to C9orf72 expansion.

DOI: http://doi.org/10.1002/acn3.631
Journal: Ann Clin Transl Neurol
E-pub date: 1 Oct 2018
Authors: RW Bevan-Jones, TE Cope, SP Jones, L Passamonti, YT Hong, T Fryer, R Arnold, JP Coles, FA Aigbirhio, K Patterson, JT O'Brien, JB Rowe

[18F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia.

DOI: http://doi.org/10.1136/jnnp-2017-316402
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Oct 2018
Authors: WR Bevan-Jones, TE Cope, PS Jones, L Passamonti, YT Hong, TD Fryer, R Arnold, KSJ Allinson, JP Coles, FI Aigbirhio, K Patterson, JT O'Brien, JB Rowe

In vivo coupling of tau pathology and cortical thinning in Alzheimer’s disease.

DOI: http://doi.org/10.1016/j.dadm.2018.08.005
Journal: Alzheimers Dement (Amst)
E-pub date: 1 Aug 2018
Authors: E Mak, RAI Bethlehem, R Romero-Garcia, S Cervenka, T Rittman, S Gabel, A Surendranathan, RW Bevan-Jones, L Passamonti, P Vázquez Rodríguez, L Su, R Arnold, GB Williams, YT Hong, TD Fryer, FI Aigbirhio, JB Rowe, JT O'Brien

Neurophysiological signatures of Alzheimer’s disease and frontotemporal lobar degeneration: pathology versus phenotype.

DOI: http://doi.org/10.1093/brain/awy180
Journal: Brain
E-pub date: 1 Aug 2018
Authors: S Sami, N Williams, LE Hughes, TE Cope, T Rittman, ITS Coyle-Gilchrist, RN Henson, JB Rowe

Reorganization of cortical oscillatory dynamics underlying disinhibition in frontotemporal dementia.

DOI: http://doi.org/10.1093/brain/awy176
Journal: Brain
E-pub date: 1 Aug 2018
Authors: LE Hughes, T Rittman, TW Robbins, JB Rowe

[11C]PK11195 binding in Alzheimer disease and progressive supranuclear palsy.

DOI: http://doi.org/10.1212/WNL.0000000000005610
Journal: Neurology
E-pub date: 29 May 2018
Authors: L Passamonti, PV Rodríguez, YT Hong, KSJ Allinson, WR Bevan-Jones, D Williamson, PS Jones, R Arnold, RJ Borchert, A Surendranathan, E Mak, L Su, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

Monitoring the past and choosing the future: the prefrontal cortical influences on voluntary action.

DOI: http://doi.org/10.1038/s41598-018-25127-y
Journal: Sci Rep
E-pub date: 8 May 2018
Authors: HN Phillips, TE Cope, LE Hughes, J Zhang, JB Rowe

White matter change with apathy and impulsivity in frontotemporal lobar degeneration syndromes.

DOI: http://doi.org/10.1212/WNL.0000000000005175
Journal: Neurology
E-pub date: 20 Mar 2018
Authors: CJ Lansdall, ITS Coyle-Gilchrist, PS Jones, P Vázquez Rodríguez, A Wilcox, E Wehmann, KM Dick, TW Robbins, JB Rowe

Tau burden and the functional connectome in Alzheimer’s disease and progressive supranuclear palsy.

DOI: http://doi.org/10.1093/brain/awx347
Journal: Brain
E-pub date: 1 Feb 2018
Authors: TE Cope, T Rittman, RJ Borchert, PS Jones, D Vatansever, K Allinson, L Passamonti, P Vazquez Rodriguez, WR Bevan-Jones, JT O'Brien, JB Rowe

An open-label study to assess the feasibility and tolerability of rilmenidine for the treatment of Huntington’s disease.

DOI: http://doi.org/10.1007/s00415-017-8647-0
Journal: J Neurol
E-pub date: 1 Dec 2017
Authors: BR Underwood, ZW Green-Thompson, PJ Pugh, SE Lazic, SL Mason, J Griffin, PS Jones, JB Rowe, DC Rubinsztein, RA Barker

Artificial grammar learning in vascular and progressive non-fluent aphasias.

DOI: http://doi.org/10.1016/j.neuropsychologia.2017.08.022
Journal: Neuropsychologia
E-pub date: 1 Sep 2017
Authors: TE Cope, B Wilson, H Robson, R Drinkall, L Dean, M Grube, PS Jones, K Patterson, TD Griffiths, JB Rowe, CI Petkov

Stability of mild cognitive impairment in newly diagnosed Parkinson’s disease.

DOI: http://doi.org/10.1136/jnnp-2016-315099
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 31 Aug 2017
Authors: RA Lawson, AJ Yarnall, GW Duncan, DP Breen, TK Khoo, CH Williams-Gray, RA Barker, DJ Burn, ICICLE-PD study group

The role of high-field magnetic resonance imaging in parkinsonian disorders: Pushing the boundaries forward.

DOI: http://doi.org/10.1002/mds.26968
Journal: Mov Disord
E-pub date: 1 Apr 2017
Authors: S Lehericy, DE Vaillancourt, K Seppi, O Monchi, I Rektorova, A Antonini, MJ McKeown, M Masellis, D Berg, JB Rowe, SJG Lewis, CH Williams-Gray, A Tessitore, HR Siebner, International Parkinson and Movement Disorder Society (IPMDS)-Neuroimaging Study Group

18F-AV-1451 positron emission tomography in Alzheimer’s disease and progressive supranuclear palsy.

DOI: http://doi.org/10.1093/brain/aww340
Journal: Brain
E-pub date: 1 Mar 2017
Authors: L Passamonti, P Vázquez Rodríguez, YT Hong, KSJ Allinson, D Williamson, RJ Borchert, S Sami, TE Cope, WR Bevan-Jones, PS Jones, R Arnold, A Surendranathan, E Mak, L Su, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

Neuroimaging of Inflammation in Memory and Related Other Disorders (NIMROD) study protocol: a deep phenotyping cohort study of the role of brain inflammation in dementia, depression and other neurological illnesses.

DOI: http://doi.org/10.1136/bmjopen-2016-013187
Journal: BMJ Open
E-pub date: 7 Jan 2017
Authors: WR Bevan-Jones, A Surendranathan, L Passamonti, P Vázquez Rodríguez, R Arnold, E Mak, L Su, JP Coles, TD Fryer, YT Hong, G Williams, F Aigbirhio, JB Rowe, JT O'Brien

[18F]AV-1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation.

DOI: http://doi.org/10.1002/acn3.366
Journal: Ann Clin Transl Neurol
E-pub date: 1 Dec 2016
Authors: WR Bevan Jones, TE Cope, L Passamonti, TD Fryer, YT Hong, F Aigbirhio, JJ Kril, SL Forrest, K Allinson, JP Coles, P Simon Jones, MG Spillantini, JR Hodges, JT O'Brien, JB Rowe

Managing cognition in progressive supranuclear palsy.

DOI: http://doi.org/10.2217/nmt-2016-0027
Journal: Neurodegener Dis Manag
E-pub date: 1 Dec 2016
Authors: T Rittman, IT Coyle-Gilchrist, JB Rowe

Regional expression of the MAPT gene is associated with loss of hubs in brain networks and cognitive impairment in Parkinson disease and progressive supranuclear palsy.

DOI: http://doi.org/10.1016/j.neurobiolaging.2016.09.001
Journal: Neurobiol Aging
E-pub date: 1 Dec 2016
Authors: T Rittman, M Rubinov, PE Vértes, AX Patel, CE Ginestet, BCP Ghosh, RA Barker, MG Spillantini, ET Bullmore, JB Rowe

Neuroinflammatory and morphological changes in late-life depression: the NIMROD study.

DOI: http://doi.org/10.1192/bjp.bp.116.190165
Journal: BRITISH JOURNAL OF PSYCHIATRY
E-pub date: 1 Dec 2016
Authors: L Su, YO Faluyi, YT Hong, TD Fryer, E Mak, S Gabel, L Hayes, S Soteriades, GB Williams, R Arnold, L Passamonti, PV Rodríguez, A Surendranathan, RW Bevan-Jones, J Coles, F Aigbirhio, JB Rowe, JT O'Brien

Atomoxetine restores the response inhibition network in Parkinson’s disease.

DOI: http://doi.org/10.1093/brain/aww138
Journal: Brain
E-pub date: 31 Aug 2016
Authors: CL Rae, C Nombela, PV Rodríguez, Z Ye, LE Hughes, PS Jones, T Ham, T Rittman, I Coyle-Gilchrist, R Regenthal, BJ Sahakian, RA Barker, TW Robbins, JB Rowe

Hypothalamic volume loss is associated with reduced melatonin output in Parkinson’s disease.

DOI: http://doi.org/10.1002/mds.26592
Journal: Mov Disord
E-pub date: 1 Jul 2016
Authors: DP Breen, C Nombela, R Vuono, PS Jones, K Fisher, DJ Burn, DJ Brooks, AB Reddy, JB Rowe, RA Barker

Atomoxetine Enhances Connectivity of Prefrontal Networks in Parkinson’s Disease.

DOI: http://doi.org/10.1038/npp.2016.18
Journal: Neuropsychopharmacology
E-pub date: 1 Jul 2016
Authors: RJ Borchert, T Rittman, L Passamonti, Z Ye, S Sami, SP Jones, C Nombela, P Vázquez Rodríguez, D Vatansever, CL Rae, LE Hughes, TW Robbins, JB Rowe

Atomoxetine Enhances Connectivity of Prefrontal Networks in Parkinson’s Disease.

DOI: http://doi.org/10.1038/npp.2016.46
Journal: Neuropsychopharmacology
E-pub date: 1 Jul 2016
Authors: RJ Borchert, T Rittman, L Passamonti, Z Ye, S Sami, SP Jones, C Nombela, PV Rodríguez, D Vatansever, CL Rae, LE Hughes, TW Robbins, JB Rowe

Cognitive decline and quality of life in incident Parkinson’s disease: The role of attention.

DOI: http://doi.org/10.1016/j.parkreldis.2016.04.009
Journal: Parkinsonism Relat Disord
E-pub date: 1 Jun 2016
Authors: RA Lawson, AJ Yarnall, GW Duncan, DP Breen, TK Khoo, CH Williams-Gray, RA Barker, D Collerton, J-P Taylor, DJ Burn, ICICLE-PD study group

The basal ganglia in cognitive disorders

DOI: http://doi.org/10.1093/med/9780199655946.003.0007
Journal:
E-pub date: 1 Jun 2016
Authors: J Rowe, T Rittman

Predicting beneficial effects of atomoxetine and citalopram on response inhibition in Parkinson’s disease with clinical and neuroimaging measures.

DOI: http://doi.org/10.1002/hbm.23087
Journal: Hum Brain Mapp
E-pub date: 1 Mar 2016
Authors: Z Ye, CL Rae, C Nombela, T Ham, T Rittman, PS Jones, PV Rodríguez, I Coyle-Gilchrist, R Regenthal, E Altena, CR Housden, H Maxwell, BJ Sahakian, RA Barker, TW Robbins, JB Rowe

Improving response inhibition systems in frontotemporal dementia with citalopram.

DOI: http://doi.org/10.1093/brain/awv133
Journal: Brain
E-pub date: 1 Jul 2015
Authors: LE Hughes, T Rittman, R Regenthal, TW Robbins, JB Rowe

Distinct aspects of frontal lobe structure mediate age-related differences in fluid intelligence and multitasking.

DOI: http://doi.org/10.1038/ncomms6658
Journal: Nat Commun
E-pub date: 18 Dec 2014
Authors: RA Kievit, SW Davis, DJ Mitchell, JR Taylor, J Duncan, Cam-CAN Research Team, RNA Henson, Cam-CAN Research Team

Validation of the new consensus criteria for the diagnosis of corticobasal degeneration.

DOI: http://doi.org/10.1136/jnnp-2013-307035
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 31 Aug 2014
Authors: SK Alexander, T Rittman, JH Xuereb, TH Bak, JR Hodges, JB Rowe

Multiple modes of impulsivity in Parkinson’s disease.

DOI: http://doi.org/10.1371/journal.pone.0085747
Journal: PLoS One
E-pub date: 1 Aug 2014
Authors: C Nombela, T Rittman, TW Robbins, JB Rowe

Direct gaze elicits atypical activation of the theory-of-mind network in autism spectrum conditions.

DOI: http://doi.org/10.1093/cercor/bht003
Journal: Cereb Cortex
E-pub date: 1 Jun 2014
Authors: EAH von dem Hagen, RS Stoyanova, JB Rowe, S Baron-Cohen, AJ Calder

The medial frontal-prefrontal network for altered awareness and control of action in corticobasal syndrome.

DOI: http://doi.org/10.1093/brain/awt302
Journal: Brain
E-pub date: 1 Jan 2014
Authors: N Wolpe, JW Moore, CL Rae, T Rittman, E Altena, P Haggard, JB Rowe

The Addenbrooke’s Cognitive Examination for the differential diagnosis and longitudinal assessment of patients with parkinsonian disorders.

DOI: http://doi.org/10.1136/jnnp-2012-303618
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 May 2013
Authors: T Rittman, BC Ghosh, P McColgan, DP Breen, J Evans, CH Williams-Gray, RA Barker, JB Rowe

THE UTILITY OF THE ADDENBROOKE’S COGNITIVE EXAMINATION-REVISED (ACE-R) IN PARKINSON’S DISEASE

DOI: http://doi.org/10.1136/jnnp-2011-301993.3
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
E-pub date: 1 Mar 2012
Authors: P McColgan, J Evans, DP Breen, SL Mason, B Ghosh, T Rittman, J Rowe, P Nestor, RA Barker, CH Williams-Gray

The val158met COMT polymorphism’s effect on atrophy in healthy aging and Parkinson’s disease.

DOI: http://doi.org/10.1016/j.neurobiolaging.2008.07.009
Journal: Neurobiol Aging
E-pub date: 1 Jun 2010
Authors: JB Rowe, L Hughes, CH Williams-Gray, S Bishop, S Fallon, RA Barker, AM Owen

Parkinson’s disease and dopaminergic therapy–differential effects on movement, reward and cognition.

DOI: http://doi.org/10.1093/brain/awn112
Journal: Brain
E-pub date: 31 Aug 2008
Authors: JB Rowe, L Hughes, BCP Ghosh, D Eckstein, CH Williams-Gray, S Fallon, RA Barker, AM Owen