Equipment & Techniques
I am a Sir Henry Wellcome Postdoctoral Fellow based at the UK Dementia Research Institute at the University of Cambridge. I am interested in understanding how localised protein synthesis at distal neuronal compartments, particularly axons, contributes to neural development and maintenance. Due to long distances away from the soma, distal axons are prone to intra- and/or extra-neuronal disturbances, and pathological changes in axons are frequent early manifestations of neurodegenerative disorders. Localised mRNA translation enables precise spatiotemporal control of axonal proteomes in rapid response to intracellular and environmental stimuli. My research uses various imaging techniques, in combination with RNA-Seq and proteomics, to investigate RNA localisation and local translation in axons. I sought to understand how aberrant translational activity in axons leads to prominent axonopathy, which recapitulates features of early stages of neurological diseases.