College Clare Hall
Research Focus


  • Synapse
  • Local Translation
  • RNA Localisation
  • RNA Binding Proteins
  • Stress Response
  • Clinical Conditions

  • Dementia
  • Equipment & Techniques

  • Cell culture
  • Calcium imaging
  • Immunohistochemistry
  • Microscopy
  • Back

    Dr Julie Qiaojin Lin

    University Position
    Sir Henry Wellcome Postdoctoral Fellow


    I am a Sir Henry Wellcome Postdoctoral Fellow based at the UK Dementia Research Institute at the University of Cambridge. I am interested in understanding how localised protein synthesis at distal neuronal compartments, particularly axons, contributes to neural development and maintenance. Due to long distances away from the soma, distal axons are prone to intra- and/or extra-neuronal disturbances, and pathological changes in axons are frequent early manifestations of neurodegenerative disorders. Localised mRNA translation enables precise spatiotemporal control of axonal proteomes in rapid response to intracellular and environmental stimuli. My research uses various imaging techniques, in combination with RNA-Seq and proteomics, to investigate RNA localisation and local translation in axons. I sought to understand how aberrant translational activity in axons leads to prominent axonopathy, which recapitulates features of early stages of neurological diseases.

    Key Publications

    HNRNPH1 regulates the neuroprotective cold-shock protein RBM3 expression through poison exon exclusion.

    Journal: EMBO J
    E-pub date: 17 Jul 2023
    Authors: JQ Lin, D Khuperkar, S Pavlou, S Makarchuk, N Patikas, FC Lee, JM Zbiegly, J Kang, SF Field, DM Bailey, JL Freeman, J Ule, E Metzakopian, M-D Ruepp, GR Mallucci

    Axonal mRNA translation in neurological disorders.

    Journal: RNA Biol
    E-pub date: 1 Jul 2021
    Authors: JQ Lin, FW van Tartwijk, CE Holt

    Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons.

    Journal: Cell
    E-pub date: 10 Jan 2019
    Authors: J-M Cioni, JQ Lin, AV Holtermann, M Koppers, MAH Jakobs, A Azizi, B Turner-Bridger, T Shigeoka, K Franze, WA Harris, CE Holt

    Phase Separation of FUS is Modulated by Methylation State of Cation-π Interactions and Interaction with TNPO1

    Journal: Cell
    E-pub date: 19 Apr 2018
    Authors: PH St George-Hyslop, S Qamar, G Wang, SJ Randle, FS Ruggeri, J Varela, CF Kaminski, GS Kaminski, M Vendruscolo, TPJ Knowles, D Klenerman, CE Holt, Q Lin, W meadows

    Single Molecule Translation Imaging Visualizes the Dynamics of Local β-Actin Synthesis in Retinal Axons.

    Journal: Sci Rep
    E-pub date: 6 Apr 2017
    Authors: F Ströhl, JQ Lin, RF Laine, HH-W Wong, V Urbančič, R Cagnetta, CE Holt, CF Kaminski

    ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function.

    Journal: Neuron
    E-pub date: 18 Nov 2015
    Authors: T Murakami, S Qamar, JQ Lin, GSK Schierle, E Rees, A Miyashita, AR Costa, RB Dodd, FTS Chan, CH Michel, D Kronenberg-Versteeg, Y Li, S-P Yang, Y Wakutani, W Meadows, RR Ferry, L Dong, GG Tartaglia, G Favrin, W-L Lin, DW Dickson, M Zhen, D Ron, G Schmitt-Ulms, PE Fraser, NA Shneider, C Holt, M Vendruscolo, CF Kaminski, P St George-Hyslop


    Mutation of the ALS/FTD-associated RNA-binding protein FUS alters axonal cytoskeletal organisation

    E-pub date: 1 Aug 2022
    Authors: F van Tartwijk, LCS Wunderlich, I Mela, S Makarchuk, MAH Jakobs, S Qamar, K Franze, GK Schierle, P St George-Hyslop, JQ Lin, C Holt, C Kaminski

    Live Imaging of RNA Transport and Translation in Xenopus Retinal Axons.

    Journal: Methods Mol Biol
    E-pub date: 1 Aug 2022
    Authors: JQ Lin, J-M Cioni

    The structure and global distribution of the endoplasmic reticulum network are actively regulated by lysosomes.

    Journal: Sci Adv
    E-pub date: 1 Dec 2020
    Authors: M Lu, FW van Tartwijk, JQ Lin, W Nijenhuis, P Parutto, M Fantham, CN Christensen, E Avezov, CE Holt, A Tunnacliffe, D Holcman, L Kapitein, GSK Schierle, CF Kaminski

    A waveguide imaging platform for live-cell TIRF imaging of neurons over large fields of view.

    Journal: J Biophotonics
    E-pub date: 1 Jun 2020
    Authors: IS Opstad, F Ströhl, M Fantham, C Hockings, O Vanderpoorten, FW van Tartwijk, JQ Lin, J-C Tinguely, FT Dullo, GS Kaminski-Schierle, BS Ahluwalia, CF Kaminski

    A protocol for single-molecule translation imaging in xenopus retinal ganglion cells

    E-pub date: 1 Jan 2020
    Authors: F Ströhl, JQ Lin, FW van Tartwijk, HHW Wong, CE Holt, CF Kaminski

    On-Site Ribosome Remodeling by Locally Synthesized Ribosomal Proteins in Axons.

    Journal: Cell Rep
    E-pub date: 10 Dec 2019
    Authors: T Shigeoka, M Koppers, HH-W Wong, JQ Lin, R Cagnetta, A Dwivedy, J de Freitas Nascimento, FW van Tartwijk, F Ströhl, J-M Cioni, J Schaeffer, M Carrington, CF Kaminski, H Jung, WA Harris, CE Holt

    Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons.

    Journal: Elife
    E-pub date: 20 Nov 2019
    Authors: M Koppers, R Cagnetta, T Shigeoka, LC Wunderlich, P Vallejo-Ramirez, J Qiaojin Lin, S Zhao, MA Jakobs, A Dwivedy, MS Minett, A Bellon, CF Kaminski, WA Harris, JG Flanagan, CE Holt

    Cue-Polarized Transport of β-actin mRNA Depends on 3’UTR and Microtubules in Live Growth Cones.

    Journal: Front Cell Neurosci
    E-pub date: 1 Aug 2018
    Authors: K-M Leung, B Lu, HH-W Wong, JQ Lin, B Turner-Bridger, CE Holt

    RNA Docking and Local Translation Regulate Site-Specific Axon Remodeling In Vivo.

    Journal: Neuron
    E-pub date: 16 Aug 2017
    Authors: HH-W Wong, JQ Lin, F Ströhl, CG Roque, J-M Cioni, R Cagnetta, B Turner-Bridger, RF Laine, WA Harris, CF Kaminski, CE Holt

    Dynamic Axonal Translation in Developing and Mature Visual Circuits.

    Journal: Cell
    E-pub date: 30 Jun 2016
    Authors: T Shigeoka, H Jung, J Jung, B Turner-Bridger, J Ohk, JQ Lin, PS Amieux, CE Holt

    Tumor protein Tctp regulates axon development in the embryonic visual system.

    Journal: Development
    E-pub date: 1 Apr 2016
    Authors: CG Roque, HH-W Wong, JQ Lin, CE Holt