Department

Research Theme Beyond the Neuron

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Dr Umar Sadat

University Position

Clinical Lecturer

Interests

1. Ultrasound, Computerised Tomography, Magnetic resonance imaging, Cellular Imaging of atherosclerosis 2. Role of biomechanics in pathogenesis of atherosclerotic plaques, aortic aneurysms and in aortic stent graft design & failure 3. Contrast-induced acute kidney injury

Key Publications

Publications

Study on the association of wall shear stress and vessel structural stress with atherosclerosis: An experimental animal study.

DOI: http://doi.org/10.1016/j.atherosclerosis.2021.01.017
Journal: Atherosclerosis
E-pub date: 1 Mar 2021
Authors: Z Teng, S Wang, A Tokgoz, V Taviani, J Bird, U Sadat, Y Huang, AJ Patterson, N Figg, MJ Graves, JH Gillard

Vascular Positron Emission Tomography and Restenosis in Symptomatic Peripheral Arterial Disease: A Prospective Clinical Study.

DOI: http://doi.org/10.1016/j.jcmg.2019.03.031
Journal: JACC Cardiovasc Imaging
E-pub date: 1 Apr 2020
Authors: MM Chowdhury, JM Tarkin, MS Albaghdadi, NR Evans, EPV Le, TB Berrett, U Sadat, FR Joshi, EA Warburton, JR Buscombe, PD Hayes, MR Dweck, DE Newby, JHF Rudd, PA Coughlin

Influence of overlapping pattern of multiple overlapping uncovered stents on the local mechanical environment: A patient-specific parameter study.

DOI: http://doi.org/10.1016/j.jbiomech.2017.06.048
Journal: J Biomech
E-pub date: 26 Jul 2017
Authors: S Wang, Y Zhang, J Feng, Y Huang, A Tokgoz, U Sadat, JH Gillard, Q Lu, Z Teng

Magnetic Resonance Imaging-Based Assessment of Carotid Atheroma: a Comparative Study of Patients with and without Coronary Artery Disease.

DOI: http://doi.org/10.1016/j.jstrokecerebrovasdis.2016.09.028
Journal: J Stroke Cerebrovasc Dis
E-pub date: 1 Feb 2017
Authors: A Usman, U Sadat, Z Teng, MJ Graves, JR Boyle, K Varty, PD Hayes, JH Gillard

Scan-Rescan Reproducibility of High Resolution Magnetic Resonance Imaging of Atherosclerotic Plaque in the Middle Cerebral Artery.

DOI: http://doi.org/10.1371/journal.pone.0134913
Journal: PLoS One
E-pub date: 1 Aug 2015
Authors: X Zhang, C Zhu, W Peng, B Tian, L Chen, Z Teng, J Lu, U Sadat, D Saloner, Q Liu

Management of complicated aortic aneurysms using multiple overlapping uncovered stents: mid-term outcome from a cohort study.

DOI: http://doi.org/10.1097/MD.0000000000000209
Journal: Medicine
E-pub date: 1 Dec 2014
Authors: Y Zhang, Z Teng, Q Lu, Z Zhao, J Bao, X Feng, R Feng, Z Chen, Y Huang, U Sadat, JH Gillard, Z Jing

3D high-resolution contrast enhanced MRI of carotid atheroma – a technical update

DOI: http://doi.org/10.1016/j.mri.2014.01.019
Journal: Magn Reson Imaging
E-pub date: 1 Jun 2014
Authors: C Zhu, U Sadat, AJ Patterson, Z Teng, JH Gillard, MJ Graves

The influence of computational strategy on prediction of mechanical stress in carotid atherosclerotic plaques: comparison of 2D structure-only, 3D structure-only, one-way and fully coupled fluid-structure interaction analyses.

DOI: http://doi.org/10.1016/j.jbiomech.2014.01.030
Journal: J Biomech
E-pub date: 11 Apr 2014
Authors: Y Huang, Z Teng, U Sadat, MJ Graves, MR Bennett, JH Gillard

Plaque hemorrhage in carotid artery disease: Pathogenesis, clinical and biomechanical considerations

DOI: http://doi.org/10.1016/j.jbiomech.2014.01.013
Journal: J Biomech
E-pub date: 3 Mar 2014
Authors: Z Teng, U Sadat, AJ Brown, JH Gillard

How does juxtaluminal calcium affect critical mechanical conditions in carotid atherosclerotic plaque? An exploratory study.

DOI: http://doi.org/10.1109/TBME.2013.2275078
Journal: IEEE Trans Biomed Eng
E-pub date: 1 Jan 2014
Authors: Zhongzhao Teng, Jing He, U Sadat, JR Mercer, Xiaoyan Wang, NS Bahaei, OM Thomas, JH Gillard

Intraplaque stretch in carotid atherosclerotic plaque–an effective biomechanical predictor for subsequent cerebrovascular ischemic events.

DOI: http://doi.org/10.1371/journal.pone.0061522
Journal: PLoS One
E-pub date: 1 Aug 2013
Authors: Z Teng, U Sadat, W Wang, NS Bahaei, S Chen, VE Young, MJ Graves, JH Gillard

Translational application of in vivo imaging and mechanical analysis for atherosclerotic plaque vulnerability assessment

DOI: http://doi.org/10.2174/1877613211303010002
Journal: Recent Patents on Medical Imaging
E-pub date: 11 Jun 2013
Authors: Z Teng, U Sadat

Translational application of combining magnetic resonance imaging and biomechanical analysis in carotid plaque vulnerability assessment

DOI: http://doi.org/10.2174/1877613211303010003
Journal: Recent Patents on Medical Imaging
E-pub date: 11 Jun 2013
Authors: Z Teng, U Sadat, JH Gillard

In vivo MRI-based simulation of fatigue process: a possible trigger for human carotid atherosclerotic plaque rupture.

DOI: http://doi.org/10.1186/1475-925X-12-36
Journal: Biomed Eng Online
E-pub date: 23 Apr 2013
Authors: Y Huang, Z Teng, U Sadat, J He, MJ Graves, JH Gillard

Critical mechanical conditions around neovessels in carotid atherosclerotic plaque may promote intraplaque hemorrhage

DOI: http://doi.org/10.1016/j.atherosclerosis.2012.06.015
Journal: Atherosclerosis
E-pub date: 31 Aug 2012
Authors: Z Teng, J He, AJ Degnan, S Chen, U Sadat, NS Bahaei, JHF Rudd, JH Gillard

Stress-strain profile of carotid plaque with and without juxtaluminal hemorrhage/thrombus: A possible mechanism for subsequent cerebrovascular events

DOI: http://doi.org/10.1115/SBC2011-53078
Journal: ASME 2011 Summer Bioengineering Conference, SBC 2011
E-pub date: 1 Dec 2011
Authors: Z Teng, U Sadat, JH Gillard

Characterization of healing following atherosclerotic carotid plaque rupture in acutely symptomatic patients: an exploratory study using in vivo cardiovascular magnetic resonance.

DOI: http://doi.org/10.1186/1532-429X-13-64
Journal: J Cardiovasc Magn Reson
E-pub date: 27 Oct 2011
Authors: Z Teng, AJ Degnan, U Sadat, F Wang, VE Young, MJ Graves, S Chen, JH Gillard

In vivo MRI-based 3D mechanical stress-strain profiles of carotid plaques with juxtaluminal plaque haemorrhage: an exploratory study for the mechanism of subsequent cerebrovascular events.

DOI: http://doi.org/10.1016/j.ejvs.2011.05.009
Journal: Eur J Vasc Endovasc Surg
E-pub date: 1 Oct 2011
Authors: Z Teng, U Sadat, Y Huang, VE Young, MJ Graves, J Lu, JH Gillard

Non-uniform shrinkage for obtaining computational start shape for in-vivo MRI-based plaque vulnerability assessment.

DOI: http://doi.org/10.1016/j.jbiomech.2011.06.014
Journal: J Biomech
E-pub date: 11 Aug 2011
Authors: Y Huang, Z Teng, U Sadat, S Hilborne, VE Young, MJ Graves, JH Gillard

Utility of magnetic resonance imaging-based finite element analysis for the biomechanical stress analysis of hemorrhagic and non-hemorrhagic carotid plaques.

DOI: http://doi.org/10.1253/circj.cj-10-0719
Journal: Circ J
E-pub date: 1 Aug 2011
Authors: U Sadat, Z Teng, VE Young, ZY Li, JH Gillard

Impact of plaque haemorrhage and its age on structural stresses in atherosclerotic plaques of patients with carotid artery disease: an MR imaging-based finite element simulation study.

DOI: http://doi.org/10.1007/s10554-010-9679-z
Journal: International Journal of Cardiovascular Imaging
E-pub date: 1 Mar 2011
Authors: U Sadat, Z Teng, VE Young, C Zhu, TY Tang, MJ Graves, JH Gillard

Lumen irregularity dominates the relationship between mechanical stress condition, fibrous-cap thickness, and lumen curvature in carotid atherosclerotic plaque.

DOI: http://doi.org/10.1115/1.4003439
Journal: Journal of Biomechanical Engineering
E-pub date: 4 Feb 2011
Authors: Z Teng, U Sadat, G Ji, C Zhu, VE Young, MJ Graves, JH Gillard

Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging of abdominal aortic aneurysms–a feasibility study.

DOI: http://doi.org/10.1016/j.ejvs.2010.08.022
Journal: Eur J Vasc Endovasc Surg
E-pub date: 1 Feb 2011
Authors: U Sadat, V Taviani, AJ Patterson, VE Young, MJ Graves, Z Teng, TY Tang, JH Gillard

High-resolution magnetic resonance imaging-based biomechanical stress analysis of carotid atheroma: a comparison of single transient ischaemic attack, recurrent transient ischaemic attacks, non-disabling stroke and asymptomatic patient groups.

DOI: http://doi.org/10.1016/j.ejvs.2010.09.006
Journal: Eur J Vasc Endovasc Surg
E-pub date: 1 Jan 2011
Authors: U Sadat, Z Teng, VE Young, MJ Graves, ME Gaunt, JH Gillard

Three-dimensional volumetric analysis of atherosclerotic plaques: a magnetic resonance imaging-based study of patients with moderate stenosis carotid artery disease.

DOI: http://doi.org/10.1007/s10554-010-9648-6
Journal: Int J Cardiovasc Imaging
E-pub date: 1 Dec 2010
Authors: U Sadat, Z Teng, VE Young, MJ Graves, JH Gillard

Multi-scale segmentation of carotid artery wall in MRI images

DOI: http://doi.org/10.1109/ICISE.2010.5688938
Journal: 2nd International Conference on Information Science and Engineering, ICISE2010 - Proceedings
E-pub date: 1 Dec 2010
Authors: W Fang, G Qiu, SY Chen, T Zhongzhao, U Sadat, J Gillard

Normalized wall index specific and MRI-based stress analysis of atherosclerotic carotid plaques: a study comparing acutely symptomatic and asymptomatic patients.

DOI: http://doi.org/10.1253/circj.cj-10-0305
Journal: Circ J
E-pub date: 1 Nov 2010
Authors: C Zhu, Z Teng, U Sadat, VE Young, MJ Graves, ZY Li, JH Gillard

Arterial luminal curvature and fibrous-cap thickness affect critical stress conditions within atherosclerotic plaque: an in vivo MRI-based 2D finite-element study.

DOI: http://doi.org/10.1007/s10439-010-0078-3
Journal: Ann Biomed Eng
E-pub date: 1 Oct 2010
Authors: Z Teng, U Sadat, Z Li, X Huang, C Zhu, VE Young, MJ Graves, JH Gillard

Biomechanical structural stresses of atherosclerotic plaques.

DOI: http://doi.org/10.1586/erc.10.130
Journal: Expert Rev Cardiovasc Ther
E-pub date: 1 Oct 2010
Authors: U Sadat, Z Teng, JH Gillard

Association between biomechanical structural stresses of atherosclerotic carotid plaques and subsequent ischaemic cerebrovascular events–a longitudinal in vivo magnetic resonance imaging-based finite element study.

DOI: http://doi.org/10.1016/j.ejvs.2010.07.015
Journal: European Journal of Vascular and Endovascular Surgery
E-pub date: 1 Jan 2010
Authors: U Sadat, Z Teng, VE Young, SR Walsh, ZY Li, MJ Graves, K Varty, JH Gillard