• Surgery
  • Research Theme Beyond the Neuron

    Dr Umar Sadat

    University Position
    Clinical Lecturer


    1. Ultrasound, Computerised Tomography, Magnetic resonance imaging, Cellular Imaging of atherosclerosis 2. Role of biomechanics in pathogenesis of atherosclerotic plaques, aortic aneurysms and in aortic stent graft design & failure 3. Contrast-induced acute kidney injury

    Key Publications


    Study on the association of wall shear stress and vessel structural stress with atherosclerosis: An experimental animal study.

    Journal: Atherosclerosis
    E-pub date: 1 Mar 2021
    Authors: Z Teng, S Wang, A Tokgoz, V Taviani, J Bird, U Sadat, Y Huang, AJ Patterson, N Figg, MJ Graves, JH Gillard

    Vascular Positron Emission Tomography and Restenosis in Symptomatic Peripheral Arterial Disease: A Prospective Clinical Study.

    Journal: JACC Cardiovasc Imaging
    E-pub date: 1 Apr 2020
    Authors: MM Chowdhury, JM Tarkin, MS Albaghdadi, NR Evans, EPV Le, TB Berrett, U Sadat, FR Joshi, EA Warburton, JR Buscombe, PD Hayes, MR Dweck, DE Newby, JHF Rudd, PA Coughlin

    Influence of overlapping pattern of multiple overlapping uncovered stents on the local mechanical environment: A patient-specific parameter study.

    Journal: J Biomech
    E-pub date: 26 Jul 2017
    Authors: S Wang, Y Zhang, J Feng, Y Huang, A Tokgoz, U Sadat, JH Gillard, Q Lu, Z Teng

    Magnetic Resonance Imaging-Based Assessment of Carotid Atheroma: a Comparative Study of Patients with and without Coronary Artery Disease.

    Journal: J Stroke Cerebrovasc Dis
    E-pub date: 1 Feb 2017
    Authors: A Usman, U Sadat, Z Teng, MJ Graves, JR Boyle, K Varty, PD Hayes, JH Gillard

    Scan-Rescan Reproducibility of High Resolution Magnetic Resonance Imaging of Atherosclerotic Plaque in the Middle Cerebral Artery.

    Journal: PLoS One
    E-pub date: 1 Aug 2015
    Authors: X Zhang, C Zhu, W Peng, B Tian, L Chen, Z Teng, J Lu, U Sadat, D Saloner, Q Liu

    Management of complicated aortic aneurysms using multiple overlapping uncovered stents: mid-term outcome from a cohort study.

    Journal: Medicine (Baltimore)
    E-pub date: 1 Dec 2014
    Authors: Y Zhang, Z Teng, Q Lu, Z Zhao, J Bao, X Feng, R Feng, Z Chen, Y Huang, U Sadat, JH Gillard, Z Jing

    Plaque hemorrhage in carotid artery disease: Pathogenesis, clinical and biomechanical considerations

    Journal: J Biomech
    E-pub date: 3 Mar 2014
    Authors: Z Teng, U Sadat, AJ Brown, JH Gillard

    How does juxtaluminal calcium affect critical mechanical conditions in carotid atherosclerotic plaque? An exploratory study.

    Journal: IEEE Trans Biomed Eng
    E-pub date: 1 Jan 2014
    Authors: Zhongzhao Teng, Jing He, U Sadat, JR Mercer, Xiaoyan Wang, NS Bahaei, OM Thomas, JH Gillard

    3D high-resolution contrast enhanced MRI of carotid atheroma – a technical update

    Journal: Magnetic Resonance Imaging
    E-pub date: 1 Jan 2014
    Authors: C Zhu, U Sadat, AJ Patterson, Z Teng, JH Gillard, MJ Graves

    Intraplaque stretch in carotid atherosclerotic plaque–an effective biomechanical predictor for subsequent cerebrovascular ischemic events.

    Journal: PLoS One
    E-pub date: 1 Aug 2013
    Authors: Z Teng, U Sadat, W Wang, NS Bahaei, S Chen, VE Young, MJ Graves, JH Gillard

    In vivo MRI-based simulation of fatigue process: a possible trigger for human carotid atherosclerotic plaque rupture.

    Journal: Biomed Eng Online
    E-pub date: 23 Apr 2013
    Authors: Y Huang, Z Teng, U Sadat, J He, MJ Graves, JH Gillard

    Critical mechanical conditions around neovessels in carotid atherosclerotic plaque may promote intraplaque hemorrhage

    Journal: Atherosclerosis
    E-pub date: 31 Aug 2012
    Authors: Z Teng, J He, AJ Degnan, S Chen, U Sadat, NS Bahaei, JHF Rudd, JH Gillard

    Stress-strain profile of carotid plaque with and without juxtaluminal hemorrhage/thrombus: A possible mechanism for subsequent cerebrovascular events

    Journal: ASME 2011 Summer Bioengineering Conference, SBC 2011
    E-pub date: 1 Dec 2011
    Authors: Z Teng, U Sadat, JH Gillard

    Characterization of healing following atherosclerotic carotid plaque rupture in acutely symptomatic patients: an exploratory study using in vivo cardiovascular magnetic resonance.

    Journal: J Cardiovasc Magn Reson
    E-pub date: 27 Oct 2011
    Authors: Z Teng, AJ Degnan, U Sadat, F Wang, VE Young, MJ Graves, S Chen, JH Gillard

    Non-uniform shrinkage for obtaining computational start shape for in-vivo MRI-based plaque vulnerability assessment.

    Journal: J Biomech
    E-pub date: 11 Aug 2011
    Authors: Y Huang, Z Teng, U Sadat, S Hilborne, VE Young, MJ Graves, JH Gillard

    Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging of abdominal aortic aneurysms–a feasibility study.

    Journal: Eur J Vasc Endovasc Surg
    E-pub date: 1 Feb 2011
    Authors: U Sadat, V Taviani, AJ Patterson, VE Young, MJ Graves, Z Teng, TY Tang, JH Gillard

    Multi-scale segmentation of carotid artery wall in MRI images

    Journal: 2nd International Conference on Information Science and Engineering, ICISE2010 - Proceedings
    E-pub date: 1 Dec 2010
    Authors: W Fang, G Qiu, SY Chen, T Zhongzhao, U Sadat, J Gillard

    Biomechanical structural stresses of atherosclerotic plaques.

    Journal: Expert Rev Cardiovasc Ther
    E-pub date: 1 Oct 2010
    Authors: U Sadat, Z Teng, JH Gillard

    Association between biomechanical structural stresses of atherosclerotic carotid plaques and subsequent ischaemic cerebrovascular events–a longitudinal in vivo magnetic resonance imaging-based finite element study.

    Journal: European Journal of Vascular and Endovascular Surgery
    E-pub date: 1 Jan 2010
    Authors: U Sadat, Z Teng, VE Young, SR Walsh, ZY Li, MJ Graves, K Varty, JH Gillard