EMAIL rab46@cam.ac.uk

Department

School

Clinical Medicine

Institute

John van Geest Centre for Brain Repair

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Research Theme Neurons, Circuits and Networks Lifelong Brain Development and Brain Ageing Beyond the Neuron

Other Interdiciplinary Incentives

Neuroscience

Research Focus

Keywords

Parkinson's Disease

Huntington's Disease

Human Stem Cells

Clinical Conditions

Parkinson's disease

Huntington's disease

Equipment & Techniques

Cell culture

Cross-sectional and cohort studies

Immunohistochemistry

Neuropsychological testing

Behavioural analysis

Randomised control trials

Science Culture

Industry Engagement

Open Access

Mentorship

Public Outreach

Teaching

Equality, Diversity, Inclusion and Wellbeing

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Professor Roger Barker

(he/him/his)

University Position

Professor

Professor Roger Barker is pleased to consider applications from prospective PhD students.

Interests

I work on: Clinical aspects of Parkinson's and Huntington's disease including the study of disease heterogeneity using cognitive testing, functional imaging and genetic biomarkers. Examining the value of different biomarkers to assess disease onset and progression. Evaluating and developing novel therapies for these conditions including ATMPs and especially stem cell therapies for Parkinson's Disease.. Studying the cell biology of neurodegenerative disorders.

Collaborators

Cambridge

Ben Underwood

Caroline Williams-Gray

Maria Grazia Spillantini

External

Johan Jakobsson and Malin Parmar

Elena Cattaneo

Ernest Arenas and Sten Linnarsson

Francesca Cicchetti

Key Publications

SARM1 detection in myelinating glia: sarm1/Sarm1 is dispensable for PNS and CNS myelination in zebrafish and mice.

DOI: http://doi.org/10.3389/fncel.2023.1158388
Journal: Front Cell Neurosci
E-pub date: 1 Aug 2023
Authors: SV Fazal, C Mutschler, CZ Chen, M Turmaine, C-Y Chen, Y-P Hsueh, A Ibañez-Grau, A Loreto, A Casillas-Bajo, H Cabedo, RJM Franklin, RA Barker, KR Monk, BJ Steventon, MP Coleman, JA Gomez-Sanchez, P Arthur-Farraj

B lymphocyte responses in Parkinson’s disease and their possible significance in disease progression.

DOI: http://doi.org/10.1093/braincomms/fcad060
Journal: Brain Commun
E-pub date: 1 Aug 2023
Authors: KM Scott, YT Chong, S Park, RS Wijeyekoon, S Hayat, RJ Mathews, Z Fitzpatrick, P Tyers, G Wright, J Whitby, RA Barker, MT Hu, CH Williams-Gray, MR Clatworthy

Impact of GBA1 variants on long-term clinical progression and mortality in incident Parkinson’s disease.

DOI: http://doi.org/10.1136/jnnp-2020-322857
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Jul 2020
Authors: TB Stoker, M Camacho, S Winder-Rhodes, G Liu, CR Scherzer, T Foltynie, J Evans, DP Breen, RA Barker, CH Williams-Gray

Peripheral innate immune and bacterial signals relate to clinical heterogeneity in Parkinson’s disease.

DOI: http://doi.org/10.1016/j.bbi.2020.01.018
Journal: Brain Behav Immun
E-pub date: 1 Jul 2020
Authors: RS Wijeyekoon, D Kronenberg-Versteeg, KM Scott, S Hayat, W-L Kuan, JR Evans, DP Breen, G Cummins, JL Jones, MR Clatworthy, RA Floto, RA Barker, CH Williams-Gray

Cerebrospinal Fluid Cytokines and Neurodegeneration-Associated Proteins in Parkinson’s Disease.

DOI: http://doi.org/10.1002/mds.28015
Journal: Mov Disord
E-pub date: 1 Jun 2020
Authors: RS Wijeyekoon, SF Moore, K Farrell, DP Breen, RA Barker, CH Williams-Gray

Visual hallucinations in neurological and ophthalmological disease: pathophysiology and management.

DOI: http://doi.org/10.1136/jnnp-2019-322702
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 May 2020
Authors: J O'Brien, JP Taylor, C Ballard, RA Barker, C Bradley, A Burns, D Collerton, S Dave, R Dudley, P Francis, A Gibbons, K Harris, V Lawrence, I Leroi, I McKeith, M Michaelides, C Naik, C O'Callaghan, K Olsen, M Onofrj, R Pinto, G Russell, P Swann, A Thomas, P Urwyler, RS Weil, D Ffytche

The Peripheral Inflammatory Response to Alpha-Synuclein and Endotoxin in Parkinson’s Disease.

DOI: http://doi.org/10.3389/fneur.2018.00946
Journal: Front Neurol
E-pub date: 1 Aug 2018
Authors: AJ White, RS Wijeyekoon, KM Scott, NP Gunawardana, S Hayat, IH Solim, HT McMahon, RA Barker, CH Williams-Gray

Monocyte Function in Parkinson’s Disease and the Impact of Autologous Serum on Phagocytosis.

DOI: http://doi.org/10.3389/fneur.2018.00870
Journal: Front Neurol
E-pub date: 1 Aug 2018
Authors: RS Wijeyekoon, D Kronenberg-Versteeg, KM Scott, S Hayat, JL Jones, MR Clatworthy, RA Floto, RA Barker, CH Williams-Gray

Abnormalities of age-related T cell senescence in Parkinson’s disease.

DOI: http://doi.org/10.1186/s12974-018-1206-5
Journal: J Neuroinflammation
E-pub date: 28 May 2018
Authors: CH Williams-Gray, RS Wijeyekoon, KM Scott, S Hayat, RA Barker, JL Jones

Serum immune markers and disease progression in an incident Parkinson’s disease cohort (ICICLE-PD).

DOI: http://doi.org/10.1002/mds.26563
Journal: Mov Disord
E-pub date: 1 Jul 2016
Authors: CH Williams-Gray, R Wijeyekoon, AJ Yarnall, RA Lawson, DP Breen, JR Evans, GA Cummins, GW Duncan, TK Khoo, DJ Burn, RA Barker, ICICLE-PD study group

Development and external validation of a prognostic model in newly diagnosed Parkinson disease.

DOI: http://doi.org/10.1212/WNL.0000000000002437
Journal: Neurology
E-pub date: 15 Mar 2016
Authors: DC Velseboer, RMA de Bie, L Wieske, JR Evans, SL Mason, T Foltynie, B Schmand, RJ de Haan, B Post, RA Barker, CH Williams-Gray

The CamPaIGN study of Parkinson’s disease: 10-year outlook in an incident population-based cohort.

DOI: http://doi.org/10.1136/jnnp-2013-305277
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Nov 2013
Authors: CH Williams-Gray, SL Mason, JR Evans, T Foltynie, C Brayne, TW Robbins, RA Barker

Association of the human leucocyte antigen region with susceptibility to Parkinson’s disease.

DOI: http://doi.org/10.1136/jnnp.2008.162883
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 31 Aug 2010
Authors: M Saiki, A Baker, CH Williams-Gray, T Foltynie, RS Goodman, CJ Taylor, DAS Compston, RA Barker, SJ Sawcer, A Goris

The distinct cognitive syndromes of Parkinson’s disease: 5 year follow-up of the CamPaIGN cohort.

DOI: http://doi.org/10.1093/brain/awp245
Journal: Brain
E-pub date: 1 Nov 2009
Authors: CH Williams-Gray, JR Evans, A Goris, T Foltynie, M Ban, TW Robbins, C Brayne, BS Kolachana, DR Weinberger, SJ Sawcer, RA Barker

Apolipoprotein E genotype as a risk factor for susceptibility to and dementia in Parkinson’s disease.

DOI: http://doi.org/10.1007/s00415-009-0119-8
Journal: J Neurol
E-pub date: 1 Mar 2009
Authors: CH Williams-Gray, A Goris, M Saiki, T Foltynie, DAS Compston, SJ Sawcer, RA Barker

Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson’s disease.

DOI: http://doi.org/10.1002/ana.21192
Journal: Ann Neurol
E-pub date: 31 Aug 2007
Authors: A Goris, CH Williams-Gray, GR Clark, T Foltynie, SJG Lewis, J Brown, M Ban, MG Spillantini, A Compston, DJ Burn, PF Chinnery, RA Barker, SJ Sawcer

Evolution of cognitive dysfunction in an incident Parkinson’s disease cohort.

DOI: http://doi.org/10.1093/brain/awm111
Journal: Brain
E-pub date: 1 Jul 2007
Authors: CH Williams-Gray, T Foltynie, CEG Brayne, TW Robbins, RA Barker

Publications

Genome-wide determinants of mortality and motor progression in Parkinson’s disease.

DOI: http://doi.org/10.1038/s41531-024-00729-8
Journal: NPJ Parkinsons Dis
E-pub date: 7 Jun 2024
Authors: MMX Tan, MA Lawton, MI Pollard, E Brown, R Real, AM Carrasco, S Bekadar, E Jabbari, RH Reynolds, H Iwaki, C Blauwendraat, S Kanavou, L Hubbard, N Malek, KA Grosset, N Bajaj, RA Barker, DJ Burn, C Bresner, T Foltynie, NW Wood, CH Williams-Gray, OA Andreassen, M Toft, A Elbaz, F Artaud, A Brice, J-C Corvol, J Aasly, MJ Farrer, MA Nalls, AB Singleton, NM Williams, Y Ben-Shlomo, J Hardy, MTM Hu, DG Grosset, M Shoai, L Pihlstrøm, HR Morris

Locus coeruleus integrity is linked to response inhibition deficits in Parkinson’s disease and progressive supranuclear palsy.

DOI: http://doi.org/10.1523/JNEUROSCI.0289-22.2023
Journal: J Neurosci
E-pub date: 18 Oct 2023
Authors: R Ye, FH Hezemans, C O'Callaghan, KA Tsvetanov, C Rua, PS Jones, N Holland, M Malpetti, AG Murley, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

Establishing an online resource to facilitate global collaboration and inclusion of underrepresented populations: Experience from the MJFF Global Genetic Parkinson’s Disease Project.

DOI: http://doi.org/10.1371/journal.pone.0292180
Journal: PLoS One
E-pub date: 1 Aug 2023
Authors: E-J Vollstedt, H Madoev, A Aasly, A Ahmad-Annuar, B Al-Mubarak, RN Alcalay, V Alvarez, I Amorin, G Annesi, D Arkadir, S Bardien, RA Barker, M Barkhuizen, AN Basak, V Bonifati, A Boon, L Brighina, K Brockmann, A Carmine Belin, J Carr, J Clarimon, M Cornejo-Olivas, L Correia Guedes, J-C Corvol, D Crosiers, J Damásio, P Das, P de Carvalho Aguiar, A De Rosa, J Dorszewska, S Ertan, R Ferese, J Ferreira, E Gatto, G Genç, N Giladi, P Gómez-Garre, H Hanagasi, N Hattori, F Hentati, D Hoffman-Zacharska, SN Illarioshkin, J Jankovic, S Jesús, V Kaasinen, A Kievit, P Klivenyi, V Kostic, D Koziorowski, AA Kühn, AE Lang, S-Y Lim, C-H Lin, K Lohmann, V Markovic, MH Martikainen, G Mellick, M Merello, L Milanowski, P Mir, Ö Öztop-Çakmak, MMG Pimentel, T Pulkes, A Puschmann, E Rogaeva, EM Sammler, M Skaalum Petersen, M Skorvanek, M Spitz, O Suchowersky, AH Tan, P Termsarasab, A Thaler, V Tumas, EM Valente, B van de Warrenburg, CH Williams-Gray, R-M Wu, B Zhang, A Zimprich, J Solle, S Padmanabhan, C Klein

Selective neurodegeneration generated by intravenous α-synuclein pre-formed fibril administration is not associated with endogenous α-synuclein levels in the rat brain.

DOI: http://doi.org/10.1111/bpa.13128
Journal: Brain Pathol
E-pub date: 1 May 2023
Authors: W-L Kuan, M Alfaidi, CB Horne, B Vallin, S Fox, SV Fazal, CH Williams-Gray, RA Barker

Mitochondrial haplogroups and cognitive progression in Parkinson’s disease.

DOI: http://doi.org/10.1093/brain/awac327
Journal: Brain
E-pub date: 5 Jan 2023
Authors: G Liu, C Ni, J Zhan, W Li, J Luo, Z Liao, JJ Locascio, W Xian, L Chen, Z Pei, J-C Corvol, J Maple-Grødem, MC Campbell, A Elbaz, S Lesage, A Brice, AY Hung, MA Schwarzschild, MT Hayes, A-M Wills, B Ravina, I Shoulson, P Taba, S Kõks, TG Beach, F Cormier-Dequaire, G Alves, O-B Tysnes, JS Perlmutter, P Heutink, JJ van Hilten, RA Barker, CH Williams-Gray, CR Scherzer, International Genetics of Parkinson Disease Progression (IGPP) Consortium

Locus Coeruleus Integrity from 7 T MRI Relates to Apathy and Cognition in Parkinsonian Disorders.

DOI: http://doi.org/10.1002/mds.29072
Journal: Mov Disord
E-pub date: 31 Aug 2022
Authors: R Ye, C O'Callaghan, C Rua, FH Hezemans, N Holland, M Malpetti, PS Jones, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, J Rowe

Genome-wide determinants of mortality and motor progression in Parkinson’s disease

DOI: http://doi.org/10.1101/2022.07.07.22277297
Journal:
E-pub date: 10 Jul 2022
Authors: MMX Tan, MA Lawton, MI Pollard, E Brown, R Real, A Martinez Carrasco, S Bekadar, E Jabbari, RH Reynolds, H Iwaki, C Blauwendraat, S Kanavou, L Hubbard, N Malek, KA Grosset, N Bajaj, RA Barker, DJ Burn, C Bresner, T Foltynie, NW Wood, CH Williams-Gray, OA Andreassen, M Toft, A Elbaz, F Artaud, A Brice, J-C Corvol, J Aasly, MJ Farrer, MA Nalls, AB Singleton, NM Williams, Y Ben-Shlomo, J Hardy, MTM Hu, DG Grosset, M Shoai, L Pihlstrøm, HR Morris

Noradrenergic deficits contribute to apathy in Parkinson’s disease through the precision of expected outcomes.

DOI: http://doi.org/10.1371/journal.pcbi.1010079
Journal: PLoS Comput Biol
E-pub date: 1 May 2022
Authors: FH Hezemans, N Wolpe, C O'Callaghan, R Ye, C Rua, PS Jones, AG Murley, N Holland, R Regenthal, KA Tsvetanov, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

Level I PD-MCI Using Global Cognitive Tests and the Risk for Parkinson’s Disease Dementia.

DOI: http://doi.org/10.1002/mdc3.13451
Journal: Mov Disord Clin Pract
E-pub date: 1 May 2022
Authors: JA Boel, RMA de Bie, BA Schmand, JC Dalrymple-Alford, C Marras, CH Adler, JG Goldman, AI Tröster, DJ Burn, I Litvan, GJ Geurtsen, MDS Study Group Mild Cognitive Impairment in Parkinson's Disease

Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease.

DOI: http://doi.org/10.1093/brain/awab142
Journal: Brain
E-pub date: 4 Sep 2021
Authors: C O'Callaghan, FH Hezemans, R Ye, C Rua, PS Jones, AG Murley, N Holland, R Regenthal, KA Tsvetanov, N Wolpe, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

Noradrenergic deficits contribute to apathy in Parkinson’s disease through the precision of expected outcomes

DOI: http://doi.org/10.1101/2021.07.04.21259922
Journal:
E-pub date: 1 Aug 2021
Authors: F Hezemans, N Wolpe, C O’Callaghan, R Ye, C Rua, S Jones, A Murley, N Holland, R Regenthal, K Tsvetanov, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

Locus Coeruleus Integrity from 7T MRI Relates to Apathy and Cognition in Parkinson’s Disease and Progressive Supranuclear Palsy

DOI: http://doi.org/10.1101/2021.04.19.21255762
Journal:
E-pub date: 1 Aug 2021
Authors: R Ye, C O’Callaghan, C Rua, F Hezemans, N Holland, M Malpetti, S Jones, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

Which Neuropsychological Tests? Predicting Cognitive Decline and Dementia in Parkinson’s Disease in the ICICLE-PD Cohort.

DOI: http://doi.org/10.3233/JPD-212581
Journal: J Parkinsons Dis
E-pub date: 1 Aug 2021
Authors: RA Lawson, CH Williams-Gray, M Camacho, GW Duncan, TK Khoo, DP Breen, RA Barker, L Rochester, DJ Burn, AJ Yarnall, ICICLE-PD study group

The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features.

DOI: http://doi.org/10.3389/fnagi.2021.685594
Journal: Front Aging Neurosci
E-pub date: 1 Aug 2021
Authors: WJ Griffiths, J Abdel-Khalik, SF Moore, RS Wijeyekoon, PJ Crick, E Yutuc, K Farrell, DP Breen, CH Williams-Gray, S Theofilopoulos, E Arenas, M Trupp, RA Barker, Y Wang

Reduced locus coeruleus integrity linked to response inhibition deficits in parkinsonian disorders

DOI: http://doi.org/10.1101/2021.10.14.21264996
Journal:
E-pub date: 1 Aug 2021
Authors: R Ye, F Hezemans, C O’Callaghan, K Tsvetanov, C Rua, S Jones, N Holland, M Malpetti, A Murley, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

Genome-wide survival study identifies a novel synaptic locus and polygenic score for cognitive progression in Parkinson’s disease

DOI: http://doi.org/10.1038/s41588-021-00847-6
Journal: Nat Genet
E-pub date: 1 Jun 2021
Authors: R Barker, C Williams-Gray

Early constipation predicts faster dementia onset in Parkinson’s disease.

DOI: http://doi.org/10.1038/s41531-021-00191-w
Journal: NPJ Parkinsons Dis
E-pub date: 26 May 2021
Authors: M Camacho, AD Macleod, J Maple-Grødem, JR Evans, DP Breen, G Cummins, RS Wijeyekoon, JC Greenland, G Alves, OB Tysnes, RA Lawson, RA Barker, CH Williams-Gray

Genome-Wide Association Studies of Cognitive and Motor Progression in Parkinson’s Disease.

DOI: http://doi.org/10.1002/mds.28342
Journal: Mov Disord
E-pub date: 1 Feb 2021
Authors: MMX Tan, MA Lawton, E Jabbari, RH Reynolds, H Iwaki, C Blauwendraat, S Kanavou, MI Pollard, L Hubbard, N Malek, KA Grosset, SL Marrinan, N Bajaj, RA Barker, DJ Burn, C Bresner, T Foltynie, NW Wood, CH Williams-Gray, J Hardy, MA Nalls, AB Singleton, NM Williams, Y Ben-Shlomo, MTM Hu, DG Grosset, M Shoai, HR Morris

Differences in the Presentation and Progression of Parkinson’s Disease by Sex.

DOI: http://doi.org/10.1002/mds.28312
Journal: Mov Disord
E-pub date: 1 Jan 2021
Authors: H Iwaki, C Blauwendraat, HL Leonard, MB Makarious, JJ Kim, G Liu, J Maple-Grødem, J-C Corvol, L Pihlstrøm, M van Nimwegen, L Smolensky, N Amondikar, SJ Hutten, M Frasier, K-DH Nguyen, J Rick, S Eberly, F Faghri, P Auinger, KM Scott, R Wijeyekoon, VM Van Deerlin, DG Hernandez, RJ Gibbs, AG Day-Williams, A Brice, G Alves, AJ Noyce, O-B Tysnes, JR Evans, DP Breen, K Estrada, CE Wegel, F Danjou, DK Simon, OA Andreassen, B Ravina, M Toft, P Heutink, BR Bloem, D Weintraub, RA Barker, CH Williams-Gray, BP van de Warrenburg, JJ Van Hilten, CR Scherzer, AB Singleton, MA Nalls

Parkinson’s disease and spirituality.

DOI: http://doi.org/10.3233/NRE-192947
Journal: NeuroRehabilitation
E-pub date: 1 Aug 2020
Authors: C Redfern, SL Mason, RA Barker, A Coles

Genome-wide association studies of cognitive and motor progression in Parkinson’s disease

DOI: http://doi.org/10.1101/2020.05.07.20084343
Journal:
E-pub date: 1 Aug 2020
Authors: MMX Tan, M Lawton, E Jabbari, R Reynolds, H Iwaki, C Blauwendraat, S Kanavou, M Pollard, L Hubbard, N Malek, K Grosset, S Marrinan, N Bajaj, R Barker, D Burn, C Bresner, T Foltynie, N Wood, C Williams-Gray, J Hardy, M Nalls, A Singleton, N Williams, Y Ben-Shlomo, MTM Hu, D Grosset, M Shoai, H Morris

Differences in the presentation and progression of Parkinson’s disease by sex

DOI: http://doi.org/10.1101/2020.04.08.20058370
Journal:
E-pub date: 1 Aug 2020
Authors: H Iwaki, C Blauwendraat, H Leonard, M Makarious, J Kim, G Liu, J Maple-Grødem, J-C Corvol, L Pihlstrøm, M van Nimwegen, L Smolensky, N Amondikar, S Hutten, M Frasier, K-D Nguyen, J Rick, S Eberly, F Faghri, P Auinger, K Scott, R Wijeyekoon, V Van Deerlin, D Hernandez, R Gibbs, A Day-Williams, A Brice, G Alves, A Noyce, O-B Tysnes, J Evans, D Breen, K Estrada, C Wegel, F Danjou, D Simon, O Andreassen, B Ravina, M Toft, P Heutink, B Bloem, D Weintraub, R Barker, C Williams-Gray, B van de Warrenburg, J Van Hilten, C Scherzer, A Singleton, M Nalls

Senescence and Inflammatory Markers for Predicting Clinical Progression in Parkinson’s Disease: The ICICLE-PD Study.

DOI: http://doi.org/10.3233/JPD-191724
Journal: J Parkinsons Dis
E-pub date: 1 Aug 2020
Authors: C Martin-Ruiz, CH Williams-Gray, AJ Yarnall, JJ Boucher, RA Lawson, RS Wijeyekoon, RA Barker, C Kolenda, C Parker, DJ Burn, T Von Zglinicki, G Saretzki

Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease

DOI: http://doi.org/10.1101/2020.09.03.20176800
Journal:
E-pub date: 1 Aug 2020
Authors: C O’Callaghan, F Hezemans, R Ye, C Rua, S Jones, A Murley, N Holland, R Regenthal, K Tsvetanov, N Wolpe, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

Validation of a UPDRS-/MDS-UPDRS-based definition of functional dependency for Parkinson’s disease.

DOI: http://doi.org/10.1016/j.parkreldis.2020.05.034
Journal: Parkinsonism Relat Disord
E-pub date: 1 Jul 2020
Authors: N Ramsay, AD Macleod, G Alves, M Camacho, L Forsgren, RA Lawson, J Maple-Grødem, O-B Tysnes, CH Williams-Gray, AJ Yarnall, CE Counsell, Parkinson's Incidence Cohorts Collaboration, PINE Study, CamPaIGN study, PICNICS study, NYPUM Study, ParkWest Study: ParkWest Principal investigators, Study personnel, ICICLE-PD Study

A common polymorphism in SNCA is associated with accelerated motor decline in GBA-Parkinson’s disease.

DOI: http://doi.org/10.1136/jnnp-2019-322210
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Jun 2020
Authors: TB Stoker, M Camacho, S Winder-Rhodes, G Liu, CR Scherzer, T Foltynie, RA Barker, CH Williams-Gray

Disease modification and biomarker development in Parkinson disease: Revision or reconstruction?

DOI: http://doi.org/10.1212/WNL.0000000000009107
Journal: Neurology
E-pub date: 17 Mar 2020
Authors: AJ Espay, LV Kalia, Z Gan-Or, CH Williams-Gray, PL Bedard, SM Rowe, F Morgante, A Fasano, B Stecher, MA Kauffman, MJ Farrer, CS Coffey, MA Schwarzschild, T Sherer, RB Postuma, AP Strafella, AB Singleton, RA Barker, K Kieburtz, CW Olanow, A Lozano, JH Kordower, JM Cedarbaum, P Brundin, DG Standaert, AE Lang

Progression of Neuropsychiatric Symptoms over Time in an Incident Parkinson’s Disease Cohort (ICICLE-PD).

DOI: http://doi.org/10.3390/brainsci10020078
Journal: Brain Sci
E-pub date: 2 Feb 2020
Authors: JK Dlay, GW Duncan, TK Khoo, CH Williams-Gray, DP Breen, RA Barker, DJ Burn, RA Lawson, AJ Yarnall

DJ-1 can form β-sheet structured aggregates that co-localize with pathological amyloid deposits.

DOI: http://doi.org/10.1016/j.nbd.2019.104629
Journal: Neurobiol Dis
E-pub date: 1 Feb 2020
Authors: K Solti, W-L Kuan, B Fórizs, G Kustos, J Mihály, Z Varga, B Herberth, É Moravcsik, R Kiss, M Kárpáti, A Mikes, Y Zhao, T Imre, J-C Rochet, F Aigbirhio, CH Williams-Gray, RA Barker, G Tóth

Motor complications in Parkinson’s disease: 13-year follow-up of the CamPaIGN cohort.

DOI: http://doi.org/10.1002/mds.27882
Journal: Mov Disord
E-pub date: 1 Jan 2020
Authors: H-J Kim, S Mason, T Foltynie, S Winder-Rhodes, RA Barker, CH Williams-Gray

Genomewide association study of Parkinson’s disease clinical biomarkers in 12 longitudinal patients’ cohorts.

DOI: http://doi.org/10.1002/mds.27845
Journal: Mov Disord
E-pub date: 1 Dec 2019
Authors: H Iwaki, C Blauwendraat, HL Leonard, JJ Kim, G Liu, J Maple-Grødem, J-C Corvol, L Pihlstrøm, M van Nimwegen, SJ Hutten, K-DH Nguyen, J Rick, S Eberly, F Faghri, P Auinger, KM Scott, R Wijeyekoon, VM Van Deerlin, DG Hernandez, JR Gibbs, International Parkinson's Disease Genomics Consortium, KN Chitrala, AG Day-Williams, A Brice, G Alves, AJ Noyce, O-B Tysnes, JR Evans, DP Breen, K Estrada, CE Wegel, F Danjou, DK Simon, O Andreassen, B Ravina, M Toft, P Heutink, BR Bloem, D Weintraub, RA Barker, CH Williams-Gray, BP van de Warrenburg, JJ Van Hilten, CR Scherzer, AB Singleton, MA Nalls

Genetic risk of Parkinson disease and progression:: An analysis of 13 longitudinal cohorts.

DOI: http://doi.org/10.1212/NXG.0000000000000348
Journal: Neurol Genet
E-pub date: 31 Aug 2019
Authors: H Iwaki, C Blauwendraat, HL Leonard, G Liu, J Maple-Grødem, J-C Corvol, L Pihlstrøm, M van Nimwegen, SJ Hutten, K-DH Nguyen, J Rick, S Eberly, F Faghri, P Auinger, KM Scott, R Wijeyekoon, VM Van Deerlin, DG Hernandez, AG Day-Williams, A Brice, G Alves, AJ Noyce, O-B Tysnes, JR Evans, DP Breen, K Estrada, CE Wegel, F Danjou, DK Simon, B Ravina, M Toft, P Heutink, BR Bloem, D Weintraub, RA Barker, CH Williams-Gray, BP van de Warrenburg, JJ Van Hilten, CR Scherzer, AB Singleton, MA Nalls

Genome-wide association study of Parkinson’s disease progression biomarkers in 12 longitudinal patients’ cohorts

DOI: http://doi.org/10.1101/585836
Journal:
E-pub date: 1 Aug 2019
Authors: H Iwaki, C Blauwendraat, H Leonard, J Kim, G Liu, J Maple-Grødem, J-C Corvol, L Pihlstrøm, M van Nimwegen, S Hutten, N Khanh-Dung, J Rick, S Eberly, F Faghri, P Auinger, K Scott, R Wijeyekoon, V Van Deerlin, D Hernandez, R Gibbs, KN Chitrala, A Day-Williams, A Brice, G Alves, A Noyce, O-B Tysnes, J Evans, D Breen, K Estrada, C Wegel, F Danjou, D Simon, O Andreassen, B Ravina, M Toft, P Heutink, B Bloem, D Weintraub, R Barker, C Williams-Gray, B van de Warrenburg, J Van Hilten, C Scherzer, A Singleton, M Nalls

Portrait of blood-derived extracellular vesicles in patients with Parkinson’s disease.

DOI: http://doi.org/10.1016/j.nbd.2018.11.002
Journal: Neurobiol Dis
E-pub date: 1 Apr 2019
Authors: J Lamontagne-Proulx, I St-Amour, R Labib, J Pilon, HL Denis, N Cloutier, F Roux-Dalvai, AT Vincent, SL Mason, C Williams-Gray, A-C Duchez, A Droit, S Lacroix, N Dupré, M Langlois, S Chouinard, M Panisset, RA Barker, E Boilard, F Cicchetti

The clinical heterogeneity of Parkinson’s disease and its therapeutic implications.

DOI: http://doi.org/10.1111/ejn.14094
Journal: Eur J Neurosci
E-pub date: 1 Feb 2019
Authors: JC Greenland, CH Williams-Gray, RA Barker

The motor and cognitive features of Parkinson’s disease in patients with concurrent Gaucher disease over 2 years: a case series.

DOI: http://doi.org/10.1007/s00415-018-8908-6
Journal: J Neurol
E-pub date: 31 Aug 2018
Authors: LM Collins, CH Williams-Gray, E Morris, P Deegan, TM Cox, RA Barker

An open-label study to assess the feasibility and tolerability of rilmenidine for the treatment of Huntington’s disease.

DOI: http://doi.org/10.1007/s00415-017-8647-0
Journal: J Neurol
E-pub date: 1 Dec 2017
Authors: BR Underwood, ZW Green-Thompson, PJ Pugh, SE Lazic, SL Mason, J Griffin, PS Jones, JB Rowe, DC Rubinsztein, RA Barker

Excessive burden of lysosomal storage disorder gene variants in Parkinson’s disease.

DOI: http://doi.org/10.1093/brain/awx285
Journal: Brain
E-pub date: 1 Dec 2017
Authors: LA Robak, IE Jansen, J van Rooij, AG Uitterlinden, R Kraaij, J Jankovic, International Parkinson’s Disease Genomics Consortium (IPDGC), P Heutink, JM Shulman

Associations between Lifestyle Factors and Parkinson’s Disease in an Urban Sri Lankan Clinic Study.

DOI: http://doi.org/10.3823/2516
Journal: Int Arch Med
E-pub date: 15 Sep 2017
Authors: R Wijeyekoon, V Suriyakumara, R Gamage, T Fernando, A Jayasuriya, D Amarasinghe, H Gunasekara, D Sirisena, D Amaratunga, C Muthukuda, RA Barker, C Williams-Gray, R De Silva

Parkinson disease: Defining PD subtypes – a step toward personalized management?

DOI: http://doi.org/10.1038/nrneurol.2017.98
Journal: Nat Rev Neurol
E-pub date: 31 Aug 2017
Authors: CH Williams-Gray, RA Barker

Prediction of cognition in Parkinson’s disease with a clinical-genetic score: a longitudinal analysis of nine cohorts.

DOI: http://doi.org/10.1016/S1474-4422(17)30122-9
Journal: Lancet Neurol
E-pub date: 31 Aug 2017
Authors: G Liu, JJ Locascio, J-C Corvol, B Boot, Z Liao, K Page, D Franco, K Burke, IE Jansen, A Trisini-Lipsanopoulos, S Winder-Rhodes, CM Tanner, AE Lang, S Eberly, A Elbaz, A Brice, G Mangone, B Ravina, I Shoulson, F Cormier-Dequaire, P Heutink, JJ van Hilten, RA Barker, CH Williams-Gray, J Marinus, CR Scherzer, HBS, CamPaIGN, PICNICS, PROPARK, PSG, DIGPD, PDBP

Stability of mild cognitive impairment in newly diagnosed Parkinson’s disease.

DOI: http://doi.org/10.1136/jnnp-2016-315099
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 31 Aug 2017
Authors: RA Lawson, AJ Yarnall, GW Duncan, DP Breen, TK Khoo, CH Williams-Gray, RA Barker, DJ Burn, ICICLE-PD study group

Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases.

DOI: http://doi.org/10.1001/jamaneurol.2017.0469
Journal: JAMA Neurol
E-pub date: 1 Jul 2017
Authors: A Witoelar, IE Jansen, Y Wang, RS Desikan, JR Gibbs, C Blauwendraat, WK Thompson, DG Hernandez, S Djurovic, AJ Schork, F Bettella, D Ellinghaus, A Franke, BA Lie, LK McEvoy, TH Karlsen, S Lesage, HR Morris, A Brice, NW Wood, P Heutink, J Hardy, AB Singleton, AM Dale, T Gasser, OA Andreassen, M Sharma, International Parkinson’s Disease Genomics Consortium (IPDGC), North American Brain Expression Consortium (NABEC), and United Kingdom Brain Expression Consortium (UKBEC) Investigators

No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson’s disease in nine ADHD candidate SNPs.

DOI: http://doi.org/10.1007/s12402-017-0219-8
Journal: Atten Defic Hyperact Disord
E-pub date: 1 Jun 2017
Authors: JM Geissler, International Parkinson Disease Genomics Consortium members, M Romanos, M Gerlach, D Berg, C Schulte

Discovery and functional prioritization of Parkinson’s disease candidate genes from large-scale whole exome sequencing.

DOI: http://doi.org/10.1186/s13059-017-1147-9
Journal: Genome Biol
E-pub date: 30 Jan 2017
Authors: IE Jansen, H Ye, S Heetveld, MC Lechler, H Michels, RI Seinstra, SJ Lubbe, V Drouet, S Lesage, E Majounie, JR Gibbs, MA Nalls, M Ryten, JA Botia, J Vandrovcova, J Simon-Sanchez, M Castillo-Lizardo, P Rizzu, C Blauwendraat, AK Chouhan, Y Li, P Yogi, N Amin, CM van Duijn, International Parkinson’s Disease Genetics Consortium (IPGDC), HR Morris, A Brice, AB Singleton, DC David, EA Nollen, S Jain, JM Shulman, P Heutink

Regional expression of the MAPT gene is associated with loss of hubs in brain networks and cognitive impairment in Parkinson disease and progressive supranuclear palsy.

DOI: http://doi.org/10.1016/j.neurobiolaging.2016.09.001
Journal: Neurobiol Aging
E-pub date: 1 Dec 2016
Authors: T Rittman, M Rubinov, PE Vértes, AX Patel, CE Ginestet, BCP Ghosh, RA Barker, MG Spillantini, ET Bullmore, JB Rowe

α-Synuclein pre-formed fibrils impair tight junction protein expression without affecting cerebral endothelial cell function.

DOI: http://doi.org/10.1016/j.expneurol.2016.09.003
Journal: Exp Neurol
E-pub date: 1 Nov 2016
Authors: W-L Kuan, N Bennett, X He, JN Skepper, N Martynyuk, R Wijeyekoon, PV Moghe, CH Williams-Gray, RA Barker

Specifically neuropathic Gaucher’s mutations accelerate cognitive decline in Parkinson’s.

DOI: http://doi.org/10.1002/ana.24781
Journal: Ann Neurol
E-pub date: 1 Nov 2016
Authors: G Liu, B Boot, JJ Locascio, IE Jansen, S Winder-Rhodes, S Eberly, A Elbaz, A Brice, B Ravina, JJ van Hilten, F Cormier-Dequaire, J-C Corvol, RA Barker, P Heutink, J Marinus, CH Williams-Gray, CR Scherzer, International Genetics of Parkinson Disease Progression (IGPP) Consortium

Comparative epidemiology of incident Parkinson’s disease in Cambridgeshire, UK.

DOI: http://doi.org/10.1136/jnnp-2015-312581
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Sep 2016
Authors: JR Evans, G Cummins, DP Breen, T Foltynie, SL Mason, CEG Brayne, CH Williams-Gray, RA Barker

Atomoxetine restores the response inhibition network in Parkinson’s disease.

DOI: http://doi.org/10.1093/brain/aww138
Journal: Brain
E-pub date: 31 Aug 2016
Authors: CL Rae, C Nombela, PV Rodríguez, Z Ye, LE Hughes, PS Jones, T Ham, T Rittman, I Coyle-Gilchrist, R Regenthal, BJ Sahakian, RA Barker, TW Robbins, JB Rowe

Hypothalamic volume loss is associated with reduced melatonin output in Parkinson’s disease.

DOI: http://doi.org/10.1002/mds.26592
Journal: Mov Disord
E-pub date: 1 Jul 2016
Authors: DP Breen, C Nombela, R Vuono, PS Jones, K Fisher, DJ Burn, DJ Brooks, AB Reddy, JB Rowe, RA Barker

Cognitive decline and quality of life in incident Parkinson’s disease: The role of attention.

DOI: http://doi.org/10.1016/j.parkreldis.2016.04.009
Journal: Parkinsonism Relat Disord
E-pub date: 1 Jun 2016
Authors: RA Lawson, AJ Yarnall, GW Duncan, DP Breen, TK Khoo, CH Williams-Gray, RA Barker, D Collerton, J-P Taylor, DJ Burn, ICICLE-PD study group

Deletions at 22q11.2 in idiopathic Parkinson’s disease: a combined analysis of genome-wide association data.

DOI: http://doi.org/10.1016/S1474-4422(16)00071-5
Journal: Lancet Neurol
E-pub date: 1 May 2016
Authors: KY Mok, U Sheerin, J Simón-Sánchez, A Salaka, L Chester, V Escott-Price, K Mantripragada, KM Doherty, AJ Noyce, NE Mencacci, SJ Lubbe, International Parkinson's Disease Genomics Consortium (IPDGC), CH Williams-Gray, RA Barker, KD van Dijk, HW Berendse, P Heutink, J-C Corvol, F Cormier, S Lesage, A Brice, K Brockmann, C Schulte, T Gasser, T Foltynie, P Limousin, KE Morrison, CE Clarke, S Sawcer, TT Warner, AJ Lees, HR Morris, MA Nalls, AB Singleton, J Hardy, AY Abramov, V Plagnol, NM Williams, NW Wood

The role of executive processes in working memory deficits in Parkinson’s Disease

DOI: http://doi.org/10.1515/ppb-2016-0013
Journal: Polish Psychological Bulletin
E-pub date: 1 Apr 2016
Authors: A Gruszka, D Bor, RR Barker, E Necka, AM Owen

Loss of VPS13C Function in Autosomal-Recessive Parkinsonism Causes Mitochondrial Dysfunction and Increases PINK1/Parkin-Dependent Mitophagy.

DOI: http://doi.org/10.1016/j.ajhg.2016.01.014
Journal: Am J Hum Genet
E-pub date: 3 Mar 2016
Authors: S Lesage, V Drouet, E Majounie, V Deramecourt, M Jacoupy, A Nicolas, F Cormier-Dequaire, SM Hassoun, C Pujol, S Ciura, Z Erpapazoglou, T Usenko, C-A Maurage, M Sahbatou, S Liebau, J Ding, B Bilgic, M Emre, N Erginel-Unaltuna, G Guven, F Tison, C Tranchant, M Vidailhet, J-C Corvol, P Krack, A-L Leutenegger, MA Nalls, DG Hernandez, P Heutink, JR Gibbs, J Hardy, NW Wood, T Gasser, A Durr, J-F Deleuze, M Tazir, A Destée, E Lohmann, E Kabashi, A Singleton, O Corti, A Brice, French Parkinson's Disease Genetics Study (PDG), International Parkinson's Disease Genomics Consortium (IPDGC)

Predicting beneficial effects of atomoxetine and citalopram on response inhibition in Parkinson’s disease with clinical and neuroimaging measures.

DOI: http://doi.org/10.1002/hbm.23087
Journal: Hum Brain Mapp
E-pub date: 1 Mar 2016
Authors: Z Ye, CL Rae, C Nombela, T Ham, T Rittman, PS Jones, PV Rodríguez, I Coyle-Gilchrist, R Regenthal, E Altena, CR Housden, H Maxwell, BJ Sahakian, RA Barker, TW Robbins, JB Rowe

Review: The spectrum of clinical features seen with alpha synuclein pathology.

DOI: http://doi.org/10.1111/nan.12303
Journal: Neuropathol Appl Neurobiol
E-pub date: 1 Feb 2016
Authors: RA Barker, CH Williams-Gray

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.

DOI: http://doi.org/10.1038/mp.2014.107
Journal: Mol Psychiatry
E-pub date: 1 May 2015
Authors: Coffee and Caffeine Genetics Consortium, MC Cornelis, EM Byrne, T Esko, MA Nalls, A Ganna, N Paynter, KL Monda, N Amin, K Fischer, F Renstrom, JS Ngwa, V Huikari, A Cavadino, IM Nolte, A Teumer, K Yu, P Marques-Vidal, R Rawal, A Manichaikul, MK Wojczynski, JM Vink, JH Zhao, G Burlutsky, J Lahti, V Mikkilä, RN Lemaitre, J Eriksson, SK Musani, T Tanaka, F Geller, J Luan, J Hui, R Mägi, M Dimitriou, ME Garcia, W-K Ho, MJ Wright, LM Rose, PK Magnusson, NL Pedersen, D Couper, BA Oostra, A Hofman, MA Ikram, HW Tiemeier, AG Uitterlinden, FJ van Rooij, I Barroso, I Johansson, L Xue, M Kaakinen, L Milani, C Power, H Snieder, RP Stolk, SE Baumeister, R Biffar, F Gu, F Bastardot, Z Kutalik, DR Jacobs, NG Forouhi, E Mihailov, L Lind, C Lindgren, K Michaëlsson, A Morris, M Jensen, K-T Khaw, RN Luben, JJ Wang, S Männistö, M-M Perälä, M Kähönen, T Lehtimäki, J Viikari, D Mozaffarian, K Mukamal, BM Psaty, A Döring, AC Heath, GW Montgomery, N Dahmen, T Carithers, KL Tucker, L Ferrucci, HA Boyd, M Melbye, JL Treur, D Mellström, JJ Hottenga, I Prokopenko, A Tönjes, P Deloukas, S Kanoni, M Lorentzon, DK Houston, Y Liu, J Danesh, A Rasheed, MA Mason, AB Zonderman, L Franke, BS Kristal, International Parkinson’s Disease Genomics Consortium (IPDGC), North American Brain Expression Consortium (NABEC), UK Brain Expression Consortium (UKBEC), J Karjalainen, DR Reed, H-J Westra, MK Evans, D Saleheen, TB Harris, G Dedoussis, G Curhan, M Stumvoll, J Beilby, LR Pasquale, B Feenstra, S Bandinelli, JM Ordovas, AT Chan, U Peters, C Ohlsson, C Gieger, NG Martin, M Waldenberger, DS Siscovick, O Raitakari, JG Eriksson, P Mitchell, DJ Hunter, P Kraft, EB Rimm, DI Boomsma, IB Borecki, RJ Loos, NJ Wareham, P Vollenweider, N Caporaso, HJ Grabe, ML Neuhouser, BH Wolffenbuttel, FB Hu, E Hyppönen, M-R Järvelin, LA Cupples, PW Franks, PM Ridker, CM van Duijn, G Heiss, A Metspalu, KE North, E Ingelsson, JA Nettleton, RM van Dam, DI Chasman

The pathophysiological and prognostic heterogeneity of mild cognitive impairment in Parkinson’s disease

DOI: http://doi.org/10.1093/med/9780199681648.003.0017
Journal:
E-pub date: 1 Jan 2015
Authors: SE Winder-Rhodes, RA Barker, CH Williams-Gray

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease.

DOI: http://doi.org/10.1038/ng.3043
Journal: Nat Genet
E-pub date: 1 Sep 2014
Authors: MA Nalls, N Pankratz, CM Lill, CB Do, DG Hernandez, M Saad, AL DeStefano, E Kara, J Bras, M Sharma, C Schulte, MF Keller, S Arepalli, C Letson, C Edsall, H Stefansson, X Liu, H Pliner, JH Lee, R Cheng, International Parkinson's Disease Genomics Consortium (IPDGC), Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI), 23andMe, GenePD, NeuroGenetics Research Consortium (NGRC), Hussman Institute of Human Genomics (HIHG), Ashkenazi Jewish Dataset Investigator, Cohorts for Health and Aging Research in Genetic Epidemiology (CHARGE), North American Brain Expression Consortium (NABEC), United Kingdom Brain Expression Consortium (UKBEC), Greek Parkinson's Disease Consortium, Alzheimer Genetic Analysis Group, MA Ikram, JPA Ioannidis, GM Hadjigeorgiou, JC Bis, M Martinez, JS Perlmutter, A Goate, K Marder, B Fiske, M Sutherland, G Xiromerisiou, RH Myers, LN Clark, K Stefansson, JA Hardy, P Heutink, H Chen, NW Wood, H Houlden, H Payami, A Brice, WK Scott, T Gasser, L Bertram, N Eriksson, T Foroud, AB Singleton

Which patients with Parkinson’s disease participate in clinical trials? One centre’s experiences with a new cell based therapy trial (TRANSEURO).

DOI: http://doi.org/10.3233/JPD-140432
Journal: J Parkinsons Dis
E-pub date: 1 Aug 2014
Authors: SF Moore, NV Guzman, SL Mason, CH Williams-Gray, RA Barker

Parkinson’s disease mild cognitive impairment: application and validation of the criteria.

DOI: http://doi.org/10.3233/JPD-130304
Journal: J Parkinsons Dis
E-pub date: 1 Aug 2014
Authors: GJ Geurtsen, J Hoogland, JG Goldman, BA Schmand, AI Tröster, DJ Burn, I Litvan, MDS Study Group on the Validation of PD-MCI Criteria

Mild cognitive impairment and Parkinson’s disease–something to remember.

DOI: http://doi.org/10.3233/JPD-140427
Journal: J Parkinsons Dis
E-pub date: 1 Aug 2014
Authors: RA Barker, CH Williams-Gray

The spectrum of cognitive impairment in Lewy body diseases.

DOI: http://doi.org/10.1002/mds.25866
Journal: Mov Disord
E-pub date: 15 Apr 2014
Authors: JG Goldman, C Williams-Gray, RA Barker, JE Duda, JE Galvin

Putative cortical dopamine levels affect cortical recruitment during planning.

DOI: http://doi.org/10.1016/j.neuropsychologia.2013.07.016
Journal: Neuropsychologia
E-pub date: 1 Sep 2013
Authors: SJ Fallon, A Hampshire, CH Williams-Gray, RA Barker, AM Owen

From molecule to clinic and community for neurodegeneration: research to bridge translational gaps.

DOI: http://doi.org/10.3233/JAD-2012-129006
Journal: J Alzheimers Dis
E-pub date: 1 Aug 2013
Authors: C Brayne, RA Barker, D Harold, PG Ince, GM Savva, J Williams, CH Williams-Gray, SB Wharton

The Val158Met COMT polymorphism is a modifier of the age at onset in Parkinson’s disease with a sexual dimorphism.

DOI: http://doi.org/10.1136/jnnp-2012-304475
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Jun 2013
Authors: S Klebe, J-L Golmard, MA Nalls, M Saad, AB Singleton, JM Bras, J Hardy, J Simon-Sanchez, P Heutink, G Kuhlenbäumer, R Charfi, C Klein, J Hagenah, T Gasser, I Wurster, S Lesage, D Lorenz, G Deuschl, F Durif, P Pollak, P Damier, F Tison, A Durr, P Amouyel, J-C Lambert, C Tzourio, C Maubaret, F Charbonnier-Beaupel, K Tahiri, M Vidailhet, M Martinez, A Brice, J-C Corvol, French Parkinson's Disease Genetics Study Group, International Parkinson's Disease Genomics Consortium (IPDGC)

Two-stage association study and meta-analysis of mitochondrial DNA variants in Parkinson disease.

DOI: http://doi.org/10.1212/WNL.0b013e318294b434
Journal: Neurology
E-pub date: 28 May 2013
Authors: G Hudson, M Nalls, JR Evans, DP Breen, S Winder-Rhodes, KE Morrison, HR Morris, CH Williams-Gray, RA Barker, AB Singleton, J Hardy, NE Wood, DJ Burn, PF Chinnery

The Addenbrooke’s Cognitive Examination for the differential diagnosis and longitudinal assessment of patients with parkinsonian disorders.

DOI: http://doi.org/10.1136/jnnp-2012-303618
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 May 2013
Authors: T Rittman, BC Ghosh, P McColgan, DP Breen, J Evans, CH Williams-Gray, RA Barker, JB Rowe

A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson’s disease.

DOI: http://doi.org/10.1093/hmg/dds492
Journal: Hum Mol Genet
E-pub date: 1 Mar 2013
Authors: P Holmans, V Moskvina, L Jones, M Sharma, International Parkinson's Disease Genomics Consortium, A Vedernikov, F Buchel, M Saad, JM Bras, F Bettella, N Nicolaou, J Simón-Sánchez, F Mittag, JR Gibbs, C Schulte, A Durr, R Guerreiro, D Hernandez, A Brice, H Stefánsson, K Majamaa, T Gasser, P Heutink, NW Wood, M Martinez, AB Singleton, MA Nalls, J Hardy, HR Morris, NM Williams

Excessive daytime sleepiness and its risk factors in incident Parkinson’s disease.

DOI: http://doi.org/10.1136/jnnp-2012-304097
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Feb 2013
Authors: DP Breen, CH Williams-Gray, SL Mason, T Foltynie, RA Barker

Prefrontal dopamine levels determine the balance between cognitive stability and flexibility.

DOI: http://doi.org/10.1093/cercor/bhs025
Journal: Cereb Cortex
E-pub date: 1 Feb 2013
Authors: SJ Fallon, CH Williams-Gray, RA Barker, AM Owen, A Hampshire

Glucocerebrosidase mutations influence the natural history of Parkinson’s disease in a community-based incident cohort.

DOI: http://doi.org/10.1093/brain/aws318
Journal: Brain
E-pub date: 1 Jan 2013
Authors: SE Winder-Rhodes, JR Evans, M Ban, SL Mason, CH Williams-Gray, T Foltynie, R Duran, NE Mencacci, SJ Sawcer, RA Barker

From molecule to clinic and community for neurodegeneration: Research to bridge translational gaps

DOI: http://doi.org/10.3233/978-1-61499-154-0-385
Journal: Advances in Alzheimer's Disease
E-pub date: 1 Dec 2012
Authors: C Brayne, RA Barker, D Harold, PG Ince, GM Savva, J Williams, CH Williams-Gray, SB Wharton

Using genome-wide complex trait analysis to quantify ‘missing heritability’ in Parkinson’s disease.

DOI: http://doi.org/10.1093/hmg/dds335
Journal: Hum Mol Genet
E-pub date: 15 Nov 2012
Authors: MF Keller, M Saad, J Bras, F Bettella, N Nicolaou, J Simón-Sánchez, F Mittag, F Büchel, M Sharma, JR Gibbs, C Schulte, V Moskvina, A Durr, P Holmans, LL Kilarski, R Guerreiro, DG Hernandez, A Brice, P Ylikotila, H Stefánsson, K Majamaa, HR Morris, N Williams, T Gasser, P Heutink, NW Wood, J Hardy, M Martinez, AB Singleton, MA Nalls, International Parkinson's Disease Genomics Consortium (IPDGC), Wellcome Trust Case Control Consortium 2 (WTCCC2)

Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson’s disease.

DOI: http://doi.org/10.1002/mds.25132
Journal: Mov Disord
E-pub date: 1 Oct 2012
Authors: LL Kilarski, JP Pearson, V Newsway, E Majounie, MDW Knipe, A Misbahuddin, PF Chinnery, DJ Burn, CE Clarke, M-H Marion, AJ Lewthwaite, DJ Nicholl, NW Wood, KE Morrison, CH Williams-Gray, JR Evans, SJ Sawcer, RA Barker, MM Wickremaratchi, Y Ben-Shlomo, NM Williams, HR Morris

Addenbrooke’s Cognitive Examination-Revised for mild cognitive impairment in Parkinson’s disease.

DOI: http://doi.org/10.1002/mds.25084
Journal: Movement Disorders
E-pub date: 1 Aug 2012
Authors: P McColgan, JR Evans, DP Breen, SL Mason, RA Barker, CH Williams-Gray

Diagnostic criteria for mild cognitive impairment in Parkinson’s disease: Movement Disorder Society Task Force guidelines.

DOI: http://doi.org/10.1002/mds.24893
Journal: Mov Disord
E-pub date: 1 Mar 2012
Authors: I Litvan, JG Goldman, AI Tröster, BA Schmand, D Weintraub, RC Petersen, B Mollenhauer, CH Adler, K Marder, CH Williams-Gray, D Aarsland, J Kulisevsky, MC Rodriguez-Oroz, DJ Burn, RA Barker, M Emre

LONGITUDINAL EVALUATION OF EXCESSIVE DAYTIME SLEEPINESS AND ITS RISK FACTORS IN PARKINSON’S DISEASE

DOI: http://doi.org/10.1136/jnnp-2011-301993.149
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
E-pub date: 1 Mar 2012
Authors: DP Breen, JR Evans, CH Williams-Gray, SL Mason, T Foltynie, RA Barker

THE UTILITY OF THE ADDENBROOKE’S COGNITIVE EXAMINATION-REVISED (ACE-R) IN PARKINSON’S DISEASE

DOI: http://doi.org/10.1136/jnnp-2011-301993.3
Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
E-pub date: 1 Mar 2012
Authors: P McColgan, J Evans, DP Breen, SL Mason, B Ghosh, T Rittman, J Rowe, P Nestor, RA Barker, CH Williams-Gray

Genetic and pathological links between Parkinson’s disease and the lysosomal disorder Sanfilippo syndrome.

DOI: http://doi.org/10.1002/mds.24029
Journal: Mov Disord
E-pub date: 1 Feb 2012
Authors: SE Winder-Rhodes, P Garcia-Reitböck, M Ban, JR Evans, TS Jacques, A Kemppinen, T Foltynie, CH Williams-Gray, PF Chinnery, G Hudson, DJ Burn, LM Allcock, SJ Sawcer, RA Barker, MG Spillantini

The natural history of treated Parkinson’s disease in an incident, community based cohort.

DOI: http://doi.org/10.1136/jnnp.2011.240366
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Oct 2011
Authors: JR Evans, SL Mason, CH Williams-Gray, T Foltynie, C Brayne, TW Robbins, RA Barker

The factor structure of the UPDRS as an index of disease progression in Parkinson’s disease.

DOI: http://doi.org/10.3233/JPD-2011-0002
Journal: J Parkinsons Dis
E-pub date: 1 Aug 2011
Authors: JR Evans, SL Mason, CH Williams-Gray, T Foltynie, M Trotter, RA Barker

A two-stage meta-analysis identifies several new loci for Parkinson’s disease.

DOI: http://doi.org/10.1371/journal.pgen.1002142
Journal: PLoS Genet
E-pub date: 1 Jun 2011
Authors: International Parkinson's Disease Genomics Consortium (IPDGC), Wellcome Trust Case Control Consortium 2 (WTCCC2)

Imputation of sequence variants for identification of genetic risks for Parkinson’s disease: a meta-analysis of genome-wide association studies.

DOI: http://doi.org/10.1016/S0140-6736(10)62345-8
Journal: Lancet
E-pub date: 19 Feb 2011
Authors: International Parkinson Disease Genomics Consortium, MA Nalls, V Plagnol, DG Hernandez, M Sharma, U-M Sheerin, M Saad, J Simón-Sánchez, C Schulte, S Lesage, S Sveinbjörnsdóttir, K Stefánsson, M Martinez, J Hardy, P Heutink, A Brice, T Gasser, AB Singleton, NW Wood

Mild cognitive impairment in Parkinson disease: a multicenter pooled analysis.

DOI: http://doi.org/10.1212/WNL.0b013e3181f39d0e
Journal: Neurology
E-pub date: 21 Sep 2010
Authors: D Aarsland, K Bronnick, C Williams-Gray, D Weintraub, K Marder, J Kulisevsky, D Burn, P Barone, J Pagonabarraga, L Allcock, G Santangelo, T Foltynie, C Janvin, JP Larsen, RA Barker, M Emre

The val158met COMT polymorphism’s effect on atrophy in healthy aging and Parkinson’s disease.

DOI: http://doi.org/10.1016/j.neurobiolaging.2008.07.009
Journal: Neurobiol Aging
E-pub date: 1 Jun 2010
Authors: JB Rowe, L Hughes, CH Williams-Gray, S Bishop, S Fallon, RA Barker, AM Owen

The genetics of behavior and cognition in Parkinson’s disease

DOI: http://doi.org/10.1017/CBO9781139856669.004
Journal:
E-pub date: 1 Jan 2010
Authors: CH Williams-Gray, RA Barker

BDNF val66met influences time to onset of levodopa induced dyskinesia in Parkinson’s disease.

DOI: http://doi.org/10.1136/jnnp.2008.154294
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 Feb 2009
Authors: T Foltynie, B Cheeran, CH Williams-Gray, MJ Edwards, SA Schneider, D Weinberger, JC Rothwell, RA Barker, KP Bhatia

No evidence for association between an MAOA functional polymorphism and susceptibility to Parkinson’s disease.

DOI: http://doi.org/10.1007/s00415-009-0899-x
Journal: J Neurol
E-pub date: 1 Jan 2009
Authors: C Williams-Gray, A Goris, T Foltynie, A Compston, S Sawcer, RA Barker

Parkinson’s disease and dopaminergic therapy–differential effects on movement, reward and cognition.

DOI: http://doi.org/10.1093/brain/awn112
Journal: Brain
E-pub date: 31 Aug 2008
Authors: JB Rowe, L Hughes, BCP Ghosh, D Eckstein, CH Williams-Gray, S Fallon, RA Barker, AM Owen

The Cambridge Behavioural Inventory revised.

DOI: http://doi.org/10.1590/S1980-57642009DN20200005
Journal: Dement Neuropsychol
E-pub date: 1 Aug 2008
Authors: HJ Wear, CJ Wedderburn, E Mioshi, CH Williams-Gray, SL Mason, RA Barker, JR Hodges

The utility of the Cambridge Behavioural Inventory in neurodegenerative disease.

DOI: http://doi.org/10.1136/jnnp.2007.122028
Journal: J Neurol Neurosurg Psychiatry
E-pub date: 1 May 2008
Authors: C Wedderburn, H Wear, J Brown, SJ Mason, RA Barker, J Hodges, C Williams-Gray

Attentional control in Parkinson’s disease is dependent on COMT val 158 met genotype.

DOI: http://doi.org/10.1093/brain/awm313
Journal: Brain
E-pub date: 1 Feb 2008
Authors: CH Williams-Gray, A Hampshire, RA Barker, AM Owen

Investigation of TGFB2 as a candidate gene in multiple sclerosis and Parkinson’s disease.

DOI: http://doi.org/10.1007/s00415-006-0414-6
Journal: J Neurol
E-pub date: 1 Jul 2007
Authors: A Goris, CH Williams-Gray, T Foltynie, J Brown, M Maranian, A Walton, DAS Compston, RA Barker, SJ Sawcer

Catechol O-methyltransferase Val158Met genotype influences frontoparietal activity during planning in patients with Parkinson’s disease.

DOI: http://doi.org/10.1523/JNEUROSCI.0774-07.2007
Journal: J Neurosci
E-pub date: 2 May 2007
Authors: CH Williams-Gray, A Hampshire, TW Robbins, AM Owen, RA Barker

Visual hallucinations predict increased benefits from rivastigmine in Parkinson’s disease dementia.

DOI: http://doi.org/10.1038/ncpneuro0471
Journal: Nat Clin Pract Neurol
E-pub date: 1 May 2007
Authors: CH Williams-Gray, RA Barker

Saccadic latency distributions in Parkinson’s disease and the effects of L-dopa.

DOI: http://doi.org/10.1007/s00221-006-0412-z
Journal: Exp Brain Res
E-pub date: 1 Sep 2006
Authors: AW Michell, Z Xu, D Fritz, SJG Lewis, T Foltynie, CH Williams-Gray, TW Robbins, RHS Carpenter, RA Barker

Cognitive deficits and psychosis in Parkinson’s disease: a review of pathophysiology and therapeutic options.

DOI: http://doi.org/10.2165/00023210-200620060-00004
Journal: CNS Drugs
E-pub date: 1 Aug 2006
Authors: CH Williams-Gray, T Foltynie, SJG Lewis, RA Barker

No evidence for association with Parkinson disease for 13 single-nucleotide polymorphisms identified by whole-genome association screening.

DOI: http://doi.org/10.1086/504726
Journal: Am J Hum Genet
E-pub date: 1 Jun 2006
Authors: A Goris, CH Williams-Gray, T Foltynie, DAS Compston, RA Barker, SJ Sawcer