Department

School

Research Theme Neurons, Circuits and Networks Lifelong Brain Development and Brain Ageing Beyond the Neuron

Research Focus

Keywords

Genomics

Bioinformatics

Clinical Epidemiology

Mental Health

Brain

Mental Health Services

Computational Psychiatry

Clinical Trials

Clinical Conditions

Bipolar disorder

Psychotic disorders

Schizophrenia

Depressive disorders

Equipment & Techniques

Statistical analysis

Magnetic resonance imaging (MRI)

Science Culture

Mentorship

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Professor Graham Murray MD PhD FRCPsych

(he/him/his)

University Position

Professor

Professor Graham Murray is pleased to consider applications from prospective PhD students.

Interests

I work on the causes, brain mechanisms and treatments of mental disorder. I utilize a variety of neuroscience techniques, including statistical genomics (and other 'omics), brain imaging, computational psychiatry, pharmacological and neuropsychological studies in patients and healthy volunteers. I study the relationship between cognitive development and mental illness across the lifespan, and on the mechanisms through which etiological factors (such as genetics) lead to pathophysiological disruptions in mental illness. I am interested in the research and clinical applications of risk scores, including polygenic risk scores and clinical informatic risk prediction models. I am working to try to improve the infrastructure for psychosis translational research in the UK, through jointly leading the early psychosis workstream of the Office of Life Sciences/NIHR Mental Health Mission.

Collaborators

Cambridge

Emilio Fernandez-Egea

Sarah Morgan

Michail (Mike) Mamalakis

External

Daniel Smith, Glasgow

James Walters

Jean-Francois Mangin, Paris

Key Publications

Genetic insights into human cortical organization and development through genome-wide analyses of 2,347 neuroimaging phenotypes.

DOI: http://doi.org/10.1038/s41588-023-01475-y
Journal: NATURE GENETICS
E-pub date: 1 Aug 2023
Authors: V Warrier, E-M Stauffer, QQ Huang, EM Wigdor, EAW Slob, J Seidlitz, L Ronan, SL Valk, TT Mallard, AD Grotzinger, R Romero-Garcia, S Baron-Cohen, DH Geschwind, MA Lancaster, GK Murray, MJ Gandal, A Alexander-Bloch, H Won, HC Martin, ET Bullmore, RAI Bethlehem

Predicting treatment resistance from first-episode psychosis using routinely collected clinical information.

DOI: http://doi.org/10.1038/s44220-022-00001-z
Journal: Nat Ment Health
E-pub date: 19 Jan 2023
Authors: EF Osimo, BI Perry, P Mallikarjun, M Pritchard, J Lewis, A Katunda, GK Murray, J Perez, PB Jones, RN Cardinal, OD Howes, R Upthegrove, GM Khandaker

Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population

DOI: http://doi.org/10.1101/668939
Journal:
E-pub date: 1 Aug 2019
Authors: M Montagnese, F Knolle, J Haarsma, JD Griffin, A Richards, P Vertes, B Kiddle, PC Fletcher, PB Jones, MJ Owen, P Fonagy, ET Bullmore, R Dolan, NSPN Consortium, M Moutoussis, I Goodyer, GK Murray

Publications

Associations of 2,922 genetically predicted plasma protein levels with mental illness and response to treatment

DOI: http://doi.org/10.21203/rs.3.rs-4313341/v1
Journal:
E-pub date: 1 Aug 2024
Authors: K Zhang, B Chidiac, V Zhao, S Noordeen, V Warrier, A Butterworth, BI Perry, GK Murray, EF Osimo

More must be done to reduce cardiovascular risk for patients on antipsychotic medications.

DOI: http://doi.org/10.1097/YIC.0000000000000464
Journal: Int Clin Psychopharmacol
E-pub date: 1 May 2023
Authors: EF Osimo, BI Perry, GK Murray

The psychosis metabolic risk calculator (PsyMetRiC) for young people with psychosis: International external validation and site-specific recalibration in two independent European samples.

DOI: http://doi.org/10.1016/j.lanepe.2022.100493
Journal: Lancet Reg Health Eur
E-pub date: 1 Nov 2022
Authors: BI Perry, F Vandenberghe, N Garrido-Torres, EF Osimo, M Piras, J Vazquez-Bourgon, R Upthegrove, C Grosu, VO-G De La Foz, PB Jones, N Laaboub, M Ruiz-Veguilla, J Stochl, C Dubath, M Canal-Rivero, P Mallikarjun, A Delacrétaz, N Ansermot, E Fernandez-Egea, S Crettol, F Gamma, KJ Plessen, P Conus, GM Khandaker, GK Murray, CB Eap, B Crespo-Facorro

The genetics of cortical organisation and development: a study of 2,347 neuroimaging phenotypes

DOI: http://doi.org/10.1101/2022.09.08.507084
Journal:
E-pub date: 8 Sep 2022
Authors: V Warrier, E-M Stauffer, QQ Huang, EM Wigdor, EAW Slob, J Seidlitz, L Ronan, S Valk, TT Mallard, AD Grotzinger, R Romero-Garcia, S Baron-Cohen, DH Geschwind, M Lancaster, GK Murray, MJ Gandal, A Alexander-Bloch, H Won, HC Martin, ET Bullmore, RAI Bethlehem

Investigating the relationship of COVID-19 related stress and media consumption with schizotypy, depression, and anxiety in cross-sectional surveys repeated throughout the pandemic in Germany and the UK.

DOI: http://doi.org/10.7554/eLife.75893
Journal: Elife
E-pub date: 4 Jul 2022
Authors: S Daimer, LL Mihatsch, SAS Neufeld, GK Murray, F Knolle

Precision weighting of cortical unsigned prediction error signals benefits learning, is mediated by dopamine, and is impaired in psychosis.

DOI: http://doi.org/10.1038/s41380-020-0803-8
Journal: Mol Psychiatry
E-pub date: 1 Sep 2021
Authors: J Haarsma, PC Fletcher, JD Griffin, HJ Taverne, H Ziauddeen, TJ Spencer, C Miller, T Katthagen, I Goodyer, KMJ Diederen, GK Murray

Grey and white matter micro-structure is associated with polygenic risk for schizophrenia

DOI: http://doi.org/10.1101/2021.02.06.21251073
Journal:
E-pub date: 1 Aug 2021
Authors: E-M Stauffer, RAI Bethlehem, V Warrier, G Murray, R Romero-Garcia, J Seidlitz, E Bullmore

Is the Association Between Smoking and Depression Mediated by Inflammation? A Mendelian Randomization Study

DOI: http://doi.org/10.1101/2021.02.04.21251136
Journal:
E-pub date: 1 Aug 2021
Authors: D Galan, BI Perry, V Warrier, D Easton, GM Khandaker, GK Murray

The relationship of COVID-19 related stress and media consumption with schizotypy, depression and anxiety

DOI: http://doi.org/10.1101/2021.11.26.21266896
Journal:
E-pub date: 1 Aug 2021
Authors: S Daimer, L Mihatsch, SAS Neufeld, GK Murray, F Knolle

Inflammatory and cardiometabolic markers at presentation with first episode psychosis and long-term clinical outcomes: A longitudinal study using electronic health records.

DOI: http://doi.org/10.1016/j.bbi.2020.09.011
Journal: Brain Behav Immun
E-pub date: 1 Jan 2021
Authors: EF Osimo, BI Perry, RN Cardinal, M-E Lynall, J Lewis, A Kudchadkar, GK Murray, J Perez, PB Jones, GM Khandaker

Evidence in cortical folding patterns for prenatal predispositions to hallucinations in schizophrenia.

DOI: http://doi.org/10.1038/s41398-020-01075-y
Journal: Transl Psychiatry
E-pub date: 6 Nov 2020
Authors: CPE Rollins, JR Garrison, M Arribas, A Seyedsalehi, Z Li, RCK Chan, J Yang, D Wang, P Liò, C Yan, Z-H Yi, A Cachia, R Upthegrove, B Deakin, JS Simons, GK Murray, J Suckling

Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population.

DOI: http://doi.org/10.1016/j.schres.2020.04.022
Journal: Schizophr Res
E-pub date: 31 Aug 2020
Authors: M Montagnese, F Knolle, J Haarsma, JD Griffin, A Richards, PE Vertes, B Kiddle, PC Fletcher, PB Jones, MJ Owen, P Fonagy, ET Bullmore, RJ Dolan, NSPN Consortium, M Moutoussis, IM Goodyer, GK Murray

The neurodevelopment of anomalous perception: Evidence in cortical folding patterns for prenatal predispositions to hallucinations in schizophrenia

DOI: http://doi.org/10.1101/2020.06.04.20122424
Journal:
E-pub date: 1 Aug 2020
Authors: CPE Rollins, J Garrison, M Arribas, A Seyedsalehi, Z Li, RCK Chan, J Yang, D Wang, P Lio, C Yan, Z-H Yi, A Cachia, R Upthegrove, B Deakin, J Simons, G Murray, J Suckling

Meta-analytic Evidence for the Plurality of Mechanisms in Transdiagnostic Structural MRI Studies of Hallucination Status.

DOI: http://doi.org/10.1016/j.eclinm.2019.01.012
Journal: EClinicalMedicine
E-pub date: 1 Feb 2019
Authors: CPE Rollins, JR Garrison, JS Simons, JB Rowe, C O'Callaghan, GK Murray, J Suckling

Abnormal Frontostriatal Activity During Unexpected Reward Receipt in Depression and Schizophrenia: Relationship to Anhedonia.

DOI: http://doi.org/10.1038/npp.2015.370
Journal: Neuropsychopharmacology
E-pub date: 1 Jul 2016
Authors: N Segarra, A Metastasio, H Ziauddeen, J Spencer, NR Reinders, RB Dudas, G Arrondo, TW Robbins, L Clark, PC Fletcher, GK Murray

Reduction in ventral striatal activity when anticipating a reward in depression and schizophrenia: a replicated cross-diagnostic finding.

DOI: http://doi.org/10.3389/fpsyg.2015.01280
Journal: Front Psychol
E-pub date: 1 Aug 2015
Authors: G Arrondo, N Segarra, A Metastasio, H Ziauddeen, J Spencer, NR Reinders, RB Dudas, TW Robbins, PC Fletcher, GK Murray