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EMAIL lp429@cam.ac.uk
College King's College
Department
  • Clinical Neurosciences
    • Institute
  • MS Society Cambridge Centre for Myelin Repair
    • ORCID iDClick to view ORCID profile
    Research Theme Beyond the Neuron Neurons, Circuits and Networks
    Research Focus

    Keywords

  • Immunometabolism
  • Cell Metabolism
  • Microglia
  • Macrophages
  • Inflammation & Immunity
  • Cognitive Decline

    • Clinical Conditions

  • Multiple sclerosis
  • Stroke
  • Spinal cord injury
  • Brain cancer

    • Equipment & Techniques

  • Behavioural analysis
  • Cell culture
  • Enzyme assays
  • Confocal microscopy
  • Immunohistochemistry

    • Science Culture

  • Equality, Diversity, Inclusion and Wellbeing
  • Teaching

    • Back

    Dr Luca Peruzzotti-Jametti

    (he/him/his)
    University Position
    Senior Research Associate
    Dr Luca Peruzzotti-Jametti is pleased to consider applications from prospective PhD students.

    Interests

    Research in our group is focused on the understanding of inflammation in central nervous system (CNS) diseases. Over the past years, our research in regenerative neuroimmunology led to novel experimental advanced therapeutics with neural stem cells, acellular therapeutics (e.g., extracellular vesicles), and small molecules for the treatment of ischemic stroke, spinal cord injury, and progressive multiple sclerosis (MS). Our most recent work is focusing on cellular metabolism and mitochondria to find novel ways to modulate chronic inflammation and favour CNS regeneration. To this aim, we apply unique tools to model metabolic/mitochondrial dysfunctions in vitro (using human cells and gene editing techniques) and in vivo (with animal disease models), as well as cutting edge techniques to detect metabolic changes in rodent/human cells and tissues.

    Mitochondrial exchange between CNS and immune cells

    Collaborators

    Cambridge
  • Joanne Jones
  • Stefano Pluchino
  • Ragnhildur Thora Karadottir
  • Maura Malpetti
    • External
  • Zoltan Takats
  • Alessandro Prigione
  • Joshua D. Bernstock
  • Marco Cambiaghi
  • Marie-Ève Tremblay
  • Angelo D'Alessandro
  • Bianca Silva
  • Agnes Nadjar
  • Edoardo Gaude
  • Mike Murphy
  • Irina Mohorianu
  • Sonia Fernández-Veledo

    • Associated News Items

    Key Publications

    Mitochondrial complex I activity in microglia sustains neuroinflammation

    DOI: http://doi.org/10.1038/s41586-024-07167-9
    Journal: Nature
    E-pub date: 1 Apr 2024
    Authors: S Pluchino, L Peruzzotti Jametti

    Metabolic Control of Smoldering Neuroinflammation.

    DOI: http://doi.org/10.3389/fimmu.2021.705920
    Journal: Front Immunol
    E-pub date: 1 Aug 2021
    Authors: L Peruzzotti-Jametti, CM Willis, R Hamel, G Krzak, S Pluchino

    Subcutaneous cladribine to treat multiple sclerosis: experience in 208 patients.

    DOI: http://doi.org/10.1177/17562864211057661
    Journal: Ther Adv Neurol Disord
    E-pub date: 1 Aug 2021
    Authors: K Allen-Philbey, S De Trane, Z Mao, C Álvarez-González, J Mathews, A MacDougall, A Stennett, X Zhou, O Yildiz, A Adams, L Bianchi, C Blain, C Chapman, K Chung, CS Constantinescu, C Dalton, RA Farrell, L Fisniku, H Ford, B Gran, J Hobart, Z Khaleeli, M Mattoscio, S Pavitt, O Pearson, L Peruzzotti-Jametti, A Scalfari, B Sharrack, E Silber, EC Tallantyre, S Webb, BP Turner, M Marta, S Gnanapavan, G Juliusson, G Giovannoni, D Baker, K Schmierer

    Neural stem cells traffic functional mitochondria via extracellular vesicles.

    DOI: http://doi.org/10.1371/journal.pbio.3001166
    Journal: PLoS Biol
    E-pub date: 1 Apr 2021
    Authors: L Peruzzotti-Jametti, JD Bernstock, CM Willis, G Manferrari, R Rogall, E Fernandez-Vizarra, JC Williamson, A Braga, A van den Bosch, T Leonardi, G Krzak, Á Kittel, C Benincá, N Vicario, S Tan, C Bastos, I Bicci, N Iraci, JA Smith, B Peacock, KH Muller, PJ Lehner, EI Buzas, N Faria, M Zeviani, C Frezza, A Brisson, NJ Matheson, C Viscomi, S Pluchino

    Succinate Receptor 1: An Emerging Regulator of Myeloid Cell Function in Inflammation.

    DOI: http://doi.org/10.1016/j.it.2020.11.004
    Journal: Trends Immunol
    E-pub date: 1 Jan 2021
    Authors: G Krzak, CM Willis, JA Smith, S Pluchino, L Peruzzotti-Jametti

    Targeting Mitochondrial Metabolism in Neuroinflammation: Towards a Therapy for Progressive Multiple Sclerosis.

    DOI: http://doi.org/10.1016/j.molmed.2018.07.007
    Journal: Trends Mol Med
    E-pub date: 1 Oct 2018
    Authors: L Peruzzotti-Jametti, S Pluchino

    Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation

    DOI: http://doi.org/10.1016/j.stem.2018.01.020
    Journal: Cell Stem Cell
    E-pub date: 1 Mar 2018
    Authors: L Peruzzotti-Jametti, JD Bernstock, N Vicario, ASH Costa, CK Kwok, T Leonardi, LM Booty, I Bicci, B Balzarotti, G Volpe, G Mallucci, G Manferrari, M Donegà, N Iraci, A Braga, JM Hallenbeck, MP Murphy, F Edenhofer, C Frezza, S Pluchino

    Extracellular vesicles are independent metabolic units with asparaginase activity.

    DOI: http://doi.org/10.1038/nchembio.2422
    Journal: Nat Chem Biol
    E-pub date: 1 Sep 2017
    Authors: N Iraci, E Gaude, T Leonardi, ASH Costa, C Cossetti, L Peruzzotti-Jametti, JD Bernstock, HK Saini, M Gelati, AL Vescovi, C Bastos, N Faria, LG Occhipinti, AJ Enright, C Frezza, S Pluchino

    Metabolic determinants of the immune modulatory function of neural stem cells.

    DOI: http://doi.org/10.1186/s12974-016-0667-7
    Journal: J Neuroinflammation
    E-pub date: 2 Sep 2016
    Authors: D Drago, V Basso, E Gaude, G Volpe, L Peruzzotti-Jametti, A Bachi, G Musco, A Andolfo, C Frezza, A Mondino, S Pluchino

    The role of immune cells, glia and neurons in white and gray matter pathology in multiple sclerosis.

    DOI: http://doi.org/10.1016/j.pneurobio.2015.02.003
    Journal: Prog Neurobiol
    E-pub date: 1 Apr 2015
    Authors: G Mallucci, L Peruzzotti-Jametti, JD Bernstock, S Pluchino

    Edoxaban versus warfarin in patients with atrial fibrillation.

    DOI: http://doi.org/10.1056/NEJMoa1310907
    Journal: N Engl J Med
    E-pub date: 28 Nov 2013
    Authors: RP Giugliano, CT Ruff, E Braunwald, SA Murphy, SD Wiviott, JL Halperin, AL Waldo, MD Ezekowitz, JI Weitz, J Špinar, W Ruzyllo, M Ruda, Y Koretsune, J Betcher, M Shi, LT Grip, SP Patel, I Patel, JJ Hanyok, M Mercuri, EM Antman, ENGAGE AF-TIMI 48 Investigators

    Publications

    Combination immunotherapy with vaccine and oncolytic HSV virotherapy is time dependent.

    DOI: http://doi.org/10.1158/1535-7163.MCT-23-0873
    Journal: Mol Cancer Ther
    E-pub date: 6 May 2024
    Authors: SK Totsch, AS Ishizuka, K-D Kang, SE Gary, A Rocco, AE Fan, L Zhou, PA Valdes, S Lee, J Li, L Peruzzotti-Jametti, S Blitz, CM Garliss, JM Johnston, JM Markert, GM Lynn, JD Bernstock, GK Friedman

    Cardiovascular risk factors in secondary progressive multiple sclerosis: A cross-sectional analysis from the MS-STAT2 randomized controlled trial.

    DOI: http://doi.org/10.1111/ene.15924
    Journal: Eur J Neurol
    E-pub date: 1 Sep 2023
    Authors: T Williams, N John, A Calvi, A Bianchi, F De Angelis, A Doshi, S Wright, M Shatila, MC Yiannakas, F Chowdhury, J Stutters, A Ricciardi, F Prados, D MacManus, M Braisher, J Blackstone, O Ciccarelli, CAM Gandini Wheeler-Kingshott, F Barkhof, J Chataway, UCL MS-STAT2 investigators

    Global, Regional, and National Economic Consequences of Stroke.

    DOI: http://doi.org/10.1161/STROKEAHA.123.043131
    Journal: Stroke
    E-pub date: 1 Sep 2023
    Authors: JVE Gerstl, SE Blitz, QR Qu, AG Yearley, P Lassarén, R Lindberg, S Gupta, AD Kappel, JC Vicenty-Padilla, E Gaude, KC Atchaneeyasakul, SM Desai, DR Yavagal, L Peruzzotti-Jametti, NJ Patel, MA Aziz-Sultan, R Du, TR Smith, JD Bernstock

    Time-resolved single-cell RNAseq profiling identifies a novel Fabp5+ subpopulation of inflammatory myeloid cells with delayed cytotoxic profile in chronic spinal cord injury.

    DOI: http://doi.org/10.1016/j.heliyon.2023.e18339
    Journal: Heliyon
    E-pub date: 31 Aug 2023
    Authors: R Hamel, L Peruzzotti-Jametti, K Ridley, V Testa, B Yu, D Rowitch, JC Marioni, S Pluchino

    SUMOtherapeutics for Ischemic Stroke.

    DOI: http://doi.org/10.3390/ph16050673
    Journal: Pharmaceuticals (Basel)
    E-pub date: 29 Apr 2023
    Authors: P Karandikar, JVE Gerstl, AD Kappel, S-Y Won, D Dubinski, ME Garcia-Segura, FA Gessler, AP See, L Peruzzotti-Jametti, JD Bernstock

    SUMOtherapeutics for Ischemic Stroke

    DOI: http://doi.org/10.20944/preprints202304.0094.v1
    Journal:
    E-pub date: 6 Apr 2023
    Authors: P Karandikar, J Gerstl, A Kappel, S-Y Won, D Dubinski, ME Garcia-Segura, F Gessler, AP See, L Peruzzotti Jametti, J Bernstock

    Targeting succinate metabolism to decrease brain injury upon mechanical thrombectomy treatment of ischemic stroke.

    DOI: http://doi.org/10.1016/j.redox.2023.102600
    Journal: Redox Biol
    E-pub date: 1 Feb 2023
    Authors: A Mottahedin, HA Prag, A Dannhorn, R Mair, C Schmidt, M Yang, A Sorby-Adams, JJ Lee, N Burger, D Kulaveerasingam, MM Huang, S Pluchino, L Peruzzotti-Jametti, R Goodwin, C Frezza, MP Murphy, T Krieg

    A neural stem-cell treatment for progressive multiple sclerosis.

    DOI: http://doi.org/10.1038/s41591-022-02164-9
    Journal: Nat Med
    E-pub date: 1 Jan 2023
    Authors: V Fossati, L Peruzzotti-Jametti, S Pluchino

    Small Extracellular Vesicles Secreted by Nigrostriatal Astrocytes Rescue Cell Death and Preserve Mitochondrial Function in Parkinson’s Disease.

    DOI: http://doi.org/10.1002/adhm.202201203
    Journal: Adv Healthc Mater
    E-pub date: 1 Oct 2022
    Authors: L Leggio, F L'Episcopo, A Magrì, MJ Ulloa-Navas, G Paternò, S Vivarelli, CAP Bastos, C Tirolo, N Testa, S Caniglia, P Risiglione, F Pappalardo, A Serra, P García-Tárraga, N Faria, JJ Powell, L Peruzzotti-Jametti, S Pluchino, JM García-Verdugo, A Messina, B Marchetti, N Iraci

    Soluble factors influencing the neural stem cell niche in brain physiology, inflammation, and aging.

    DOI: http://doi.org/10.1016/j.expneurol.2022.114124
    Journal: Exp Neurol
    E-pub date: 1 Sep 2022
    Authors: CM Willis, AM Nicaise, G Krzak, R-B Ionescu, V Pappa, A D'Angelo, R Agarwal, M Repollés-de-Dalmau, L Peruzzotti-Jametti, S Pluchino

    Therapy with mesenchymal stem cell transplantation in multiple sclerosis ready for prime time: Commentary.

    DOI: http://doi.org/10.1177/13524585221097958
    Journal: Mult Scler
    E-pub date: 31 Aug 2022
    Authors: L Peruzzotti-Jametti, S Pluchino

    Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73.

    DOI: http://doi.org/10.1038/s42003-021-02721-x
    Journal: Commun Biol
    E-pub date: 14 Oct 2021
    Authors: LB Jarvis, DB Rainbow, V Coppard, SK Howlett, Z Georgieva, JL Davies, HK Mullay, J Hester, T Ashmore, A Van Den Bosch, JT Grist, AJ Coles, HS Mousa, S Pluchino, KT Mahbubani, JL Griffin, K Saeb-Parsy, F Issa, L Peruzzotti-Jametti, LS Wicker, JL Jones

    Small Extracellular Vesicles Secreted by Region-specific Astrocytes Ameliorate the Mitochondrial Function in a Cellular Model of Parkinson’s Disease

    DOI: http://doi.org/10.1101/2021.04.23.441135
    Journal:
    E-pub date: 1 Aug 2021
    Authors: L Leggio, F L’Episcopo, A Magrì, MJ Ulloa-Navas, G Paternò, S Vivarelli, C Bastos, C Tirolo, N Testa, S Caniglia, P Risiglione, F Pappalardo, N Faria, L Peruzzotti-Jametti, S Pluchino, JM García-Verdugo, A Messina, B Marchetti, N Iraci

    Stem Cell Therapies for Progressive Multiple Sclerosis.

    DOI: http://doi.org/10.3389/fcell.2021.696434
    Journal: Front Cell Dev Biol
    E-pub date: 1 Aug 2021
    Authors: JA Smith, AM Nicaise, R-B Ionescu, R Hamel, L Peruzzotti-Jametti, S Pluchino

    Systematic approach to selecting licensed drugs for repurposing in the treatment of progressive multiple sclerosis.

    DOI: http://doi.org/10.1136/jnnp-2020-324286
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Mar 2021
    Authors: N Cunniffe, KA Vuong, D Ainslie, D Baker, J Beveridge, S Bickley, P Camilleri, M Craner, D Fitzgerald, AG de la Fuente, G Giovannoni, E Gray, L Hazlehurst, R Kapoor, R Kaur, D Kozlowski, B Lumicisi, D Mahad, B Neumann, A Palmer, L Peruzzotti-Jametti, S Pluchino, J Robertson, A Rothaul, L Shellard, KJ Smith, A Wilkins, A Williams, A Coles

    Promises and Limitations of Neural Stem Cell Therapies for Progressive Multiple Sclerosis.

    DOI: http://doi.org/10.1016/j.molmed.2020.04.005
    Journal: Trends Mol Med
    E-pub date: 1 Oct 2020
    Authors: S Pluchino, JA Smith, L Peruzzotti-Jametti

    Therapeutically expanded human regulatory T-cells are super- suppressive due to HIF1A induced expression of CD73.

    DOI: http://doi.org/10.21203/rs.3.rs-92789/v1
    Journal:
    E-pub date: 1 Aug 2020
    Authors: L Jarvis, D Rainbow, V Coppard, S Howlett, J Davies, H Mullay, J Hester, T Ashmore, AVD Bosch, J Grist, A Coles, H Mousa, S Pluchino, K Mahbubani, J Griffin, K Saeb-Parsy, F Issa, L Peruzzotti-Jametti, L Wicker, J Jones

    Harnessing the Neural Stem Cell Secretome for Regenerative Neuroimmunology.

    DOI: http://doi.org/10.3389/fncel.2020.590960
    Journal: Front Cell Neurosci
    E-pub date: 1 Aug 2020
    Authors: CM Willis, AM Nicaise, R Hamel, V Pappa, L Peruzzotti-Jametti, S Pluchino

    Transplantation of induced neural stem cells (iNSCs) into chronically demyelinated corpus callosum ameliorates motor deficits.

    DOI: http://doi.org/10.1186/s40478-020-00960-3
    Journal: Acta Neuropathol Commun
    E-pub date: 9 Jun 2020
    Authors: GM Sullivan, AK Knutsen, L Peruzzotti-Jametti, A Korotcov, A Bosomtwi, BJ Dardzinski, JD Bernstock, S Rizzi, F Edenhofer, S Pluchino, RC Armstrong

    The neural stem cell secretome and its role in brain repair.

    DOI: http://doi.org/10.1016/j.brainres.2019.146615
    Journal: Brain Res
    E-pub date: 15 Feb 2020
    Authors: CM Willis, AM Nicaise, L Peruzzotti-Jametti, S Pluchino

    Chapter 6 The therapeutic potential of exogenous adult stem cells for the injured central nervous system

    DOI: http://doi.org/10.1016/B978-0-12-818084-6.00006-4
    Journal:
    E-pub date: 1 Jan 2020
    Authors: JA Smith, A Braga, R Hamel, C Rutigliani, B Yu, L Peruzzotti-Jametti, S Pluchino

    Foxg1 Antagonizes Neocortical Stem Cell Progression to Astrogenesis.

    DOI: http://doi.org/10.1093/cercor/bhz031
    Journal: Cereb Cortex
    E-pub date: 17 Dec 2019
    Authors: C Falcone, M Santo, G Liuzzi, N Cannizzaro, C Grudina, E Valencic, L Peruzzotti-Jametti, S Pluchino, A Mallamaci

    Modulation of host immune responses following non-hematopoietic stem cell transplantation: Translational implications in progressive multiple sclerosis.

    DOI: http://doi.org/10.1016/j.jneuroim.2016.12.005
    Journal: J Neuroimmunol
    E-pub date: 15 Jun 2019
    Authors: G Volpe, JD Bernstock, L Peruzzotti-Jametti, S Pluchino

    SUMOylation promotes survival and integration of neural stem cell grafts in ischemic stroke.

    DOI: http://doi.org/10.1016/j.ebiom.2019.03.035
    Journal: EBioMedicine
    E-pub date: 1 Apr 2019
    Authors: JD Bernstock, L Peruzzotti-Jametti, T Leonardi, N Vicario, D Ye, Y-J Lee, D Maric, KR Johnson, Y Mou, A Van Den Bosch, M Winterbone, GK Friedman, RJM Franklin, JM Hallenbeck, S Pluchino

    Neural Stem Cell Grafts Promote Astroglia-Driven Neurorestoration in the Aged Parkinsonian Brain via Wnt/β-Catenin Signaling.

    DOI: http://doi.org/10.1002/stem.2827
    Journal: Stem Cells
    E-pub date: 31 Aug 2018
    Authors: F L'Episcopo, C Tirolo, L Peruzzotti-Jametti, MF Serapide, N Testa, S Caniglia, B Balzarotti, S Pluchino, B Marchetti

    Neural stem cells respond to extracellular succinate via SUCNR1/GPR91 to ameliorate chronic neuroinflammation

    DOI: http://doi.org/10.17863/CAM.24280
    Journal:
    E-pub date: 20 Jul 2018
    Authors: L Peruzzotti-Jametti

    Past, present and future of cell-based therapy in progressive multiple sclerosis

    DOI: http://doi.org/10.1007/978-3-319-90695-9_6
    Journal:
    E-pub date: 27 Jun 2018
    Authors: G Volpe, JD Bernstock, L Peruzzotti-Jametti, S Pluchino

    RNA Nanotherapeutics for the Amelioration of Astroglial Reactivity.

    DOI: http://doi.org/10.1016/j.omtn.2017.11.008
    Journal: Mol Ther Nucleic Acids
    E-pub date: 2 Mar 2018
    Authors: JA Smith, A Braga, J Verheyen, S Basilico, S Bandiera, C Alfaro-Cervello, L Peruzzotti-Jametti, D Shu, F Haque, P Guo, S Pluchino

    Evaluation of RGD functionalization in hybrid hydrogels as 3D neural stem cell culture systems.

    DOI: http://doi.org/10.1039/c7bm01056g
    Journal: Biomater Sci
    E-pub date: 27 Feb 2018
    Authors: E Mauri, A Sacchetti, N Vicario, L Peruzzotti-Jametti, F Rossi, S Pluchino

    Cell-based therapeutic strategies for multiple sclerosis.

    DOI: http://doi.org/10.1093/brain/awx154
    Journal: Brain
    E-pub date: 1 Nov 2017
    Authors: NJ Scolding, M Pasquini, SC Reingold, JA Cohen, International Conference on Cell-Based Therapies for Multiple Sclerosis, International Conference on Cell-Based Therapies for Multiple Sclerosis, International Conference on Cell-Based Therapies for Multiple Sclerosis

    Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming.

    DOI: http://doi.org/10.1038/s41598-017-07631-9
    Journal: Sci Rep
    E-pub date: 7 Aug 2017
    Authors: JD Bernstock, D Ye, FA Gessler, Y-J Lee, L Peruzzotti-Jametti, P Baumgarten, KR Johnson, D Maric, W Yang, D Kögel, S Pluchino, JM Hallenbeck

    Treatment Challenges of a Primary Vertebral Artery Aneurysm Causing Recurrent Ischemic Strokes.

    DOI: http://doi.org/10.1155/2017/2571630
    Journal: Case Rep Neurol Med
    E-pub date: 1 Aug 2017
    Authors: D Strambo, L Peruzzotti-Jametti, A Semerano, G Fanelli, F Simionato, R Chiesa, E Rinaldi, V Martinelli, G Comi, M Bacigaluppi, M Sessa

    Neural stem cell transplantation in ischemic stroke: A role for preconditioning and cellular engineering.

    DOI: http://doi.org/10.1177/0271678X17700432
    Journal: J Cereb Blood Flow Metab
    E-pub date: 1 Jul 2017
    Authors: JD Bernstock, L Peruzzotti-Jametti, D Ye, FA Gessler, D Maric, N Vicario, Y-J Lee, S Pluchino, JM Hallenbeck

    Interleukin-4 induced 1 (IL4I1) promotes central nervous system remyelination.

    DOI: http://doi.org/10.1093/brain/aww266
    Journal: Brain
    E-pub date: 1 Dec 2016
    Authors: S Pluchino, L Peruzzotti-Jametti

    Neural Stem Cell Transplantation Induces Stroke Recovery by Upregulating Glutamate Transporter GLT-1 in Astrocytes.

    DOI: http://doi.org/10.1523/JNEUROSCI.1643-16.2016
    Journal: J Neurosci
    E-pub date: 12 Oct 2016
    Authors: M Bacigaluppi, GL Russo, L Peruzzotti-Jametti, S Rossi, S Sandrone, E Butti, R De Ceglia, A Bergamaschi, C Motta, M Gallizioli, V Studer, E Colombo, C Farina, G Comi, LS Politi, L Muzio, C Villani, RW Invernizzi, DM Hermann, D Centonze, G Martino

    Astrocyte power fuels neurons during stroke.

    DOI: http://doi.org/10.4414/smw.2016.14374
    Journal: Swiss Med Wkly
    E-pub date: 1 Aug 2016
    Authors: S Pluchino, L Peruzzotti-Jametti, C Frezza

    A novel quantitative high-throughput screen identifies drugs that both activate SUMO conjugation via the inhibition of microRNAs 182 and 183 and facilitate neuroprotection in a model of oxygen and glucose deprivation.

    DOI: http://doi.org/10.1177/0271678X15609939
    Journal: J Cereb Blood Flow Metab
    E-pub date: 1 Feb 2016
    Authors: JD Bernstock, Y-J Lee, L Peruzzotti-Jametti, N Southall, KR Johnson, D Maric, G Volpe, J Kouznetsova, W Zheng, S Pluchino, JM Hallenbeck

    Defining minor symptoms in acute ischemic stroke.

    DOI: http://doi.org/10.1159/000375151
    Journal: Cerebrovasc Dis
    E-pub date: 1 Aug 2015
    Authors: D Strambo, AA Zambon, L Roveri, G Giacalone, G Di Maggio, L Peruzzotti-Jametti, S La Gioia, S Galantucci, G Comi, M Sessa

    Functional Magnetic Resonance Imaging of Rats with Experimental Autoimmune Encephalomyelitis Reveals Brain Cortex Remodeling.

    DOI: http://doi.org/10.1523/JNEUROSCI.0540-15.2015
    Journal: J Neurosci
    E-pub date: 8 Jul 2015
    Authors: S Tambalo, L Peruzzotti-Jametti, R Rigolio, S Fiorini, P Bontempi, G Mallucci, B Balzarotti, P Marmiroli, A Sbarbati, G Cavaletti, S Pluchino, P Marzola

    Post-ischaemic silencing of p66Shc reduces ischaemia/reperfusion brain injury and its expression correlates to clinical outcome in stroke.

    DOI: http://doi.org/10.1093/eurheartj/ehv140
    Journal: Eur Heart J
    E-pub date: 1 Jul 2015
    Authors: RD Spescha, J Klohs, A Semerano, G Giacalone, RS Derungs, MF Reiner, D Rodriguez Gutierrez, N Mendez-Carmona, M Glanzmann, G Savarese, N Kränkel, A Akhmedov, S Keller, P Mocharla, MR Kaufmann, RH Wenger, J Vogel, L Kulic, RM Nitsch, JH Beer, L Peruzzotti-Jametti, M Sessa, TF Lüscher, GG Camici

    The role of the immune system in central nervous system plasticity after acute injury.

    DOI: http://doi.org/10.1016/j.neuroscience.2014.04.036
    Journal: Neuroscience
    E-pub date: 26 Dec 2014
    Authors: L Peruzzotti-Jametti, M Donegá, E Giusto, G Mallucci, B Marchetti, S Pluchino

    Neural precursor cells in the ischemic brain – integration, cellular crosstalk, and consequences for stroke recovery.

    DOI: http://doi.org/10.3389/fncel.2014.00291
    Journal: Front Cell Neurosci
    E-pub date: 1 Aug 2014
    Authors: DM Hermann, L Peruzzotti-Jametti, J Schlechter, JD Bernstock, TR Doeppner, S Pluchino

    Injection of next-generation directly-induced neural stem cells (iNSCs) induces recovery in a mouse model of multiple sclerosis

    DOI: http://doi.org/10.1016/j.jneuroim.2014.08.520
    Journal: JOURNAL OF NEUROIMMUNOLOGY
    E-pub date: 1 Aug 2014
    Authors: L Peruzzotti-jametti, G Mallucci, G Tannahill, B Huang, YB Lakes, E Giusto, M Donega, B Balzarotti, F Edenhofer, S Pluchino

    Neural stem cell transplantation promotes post-ischemic neuronal plasticity by regulating the expression of glutamate transporters

    DOI: http://doi.org/10.1016/j.jneuroim.2014.08.506
    Journal: JOURNAL OF NEUROIMMUNOLOGY
    E-pub date: 1 Aug 2014
    Authors: M Bacigaluppi, GL Russo, L Peruzzotti-jametti, S Rossi, E Butti, R De Ceglia, C Motta, L Muzio, G Comi, D Centonze, RW Invernizzi, DM Hermann, G Martino

    Brain Repair: The Role of Endogenous and Transplanted Neural Stem Cells

    DOI: http://doi.org/10.1002/9781118406557.ch5
    Journal:
    E-pub date: 3 Jun 2014
    Authors: M Bacigaluppi, E Butti, C Laterza, D De Feo, L Peruzzotti, A Merlini, M Cusimano, G Martino

    Rewiring the ischaemic brain with human-induced pluripotent stem cell-derived cortical neurons.

    DOI: http://doi.org/10.1093/brain/awt330
    Journal: Brain
    E-pub date: 1 Dec 2013
    Authors: S Pluchino, L Peruzzotti-Jametti

    Safety and efficacy of transcranial direct current stimulation in acute experimental ischemic stroke.

    DOI: http://doi.org/10.1161/STROKEAHA.113.001687
    Journal: Stroke
    E-pub date: 1 Nov 2013
    Authors: L Peruzzotti-Jametti, M Cambiaghi, M Bacigaluppi, M Gallizioli, E Gaude, S Mari, S Sandrone, M Cursi, L Teneud, G Comi, G Musco, G Martino, L Leocani

    Emerging subspecialties in Neurology: transcranial stimulation.

    DOI: http://doi.org/10.1212/WNL.0b013e3182833d74
    Journal: Neurology
    E-pub date: 22 Jan 2013
    Authors: L Peruzzotti-Jametti, M Bacigaluppi, S Sandrone, M Cambiaghi

    Bilateral intracavernous carotid artery occlusion caused by invasive lymphocytic hypophysitis.

    DOI: http://doi.org/10.1016/j.jstrokecerebrovasdis.2012.06.003
    Journal: J Stroke Cerebrovasc Dis
    E-pub date: 1 Nov 2012
    Authors: L Peruzzotti-Jametti, D Strambo, F Sangalli, A De Bellis, G Comi, M Sessa

    Falling too Fahr.

    DOI: http://doi.org/10.1007/s00415-012-6411-z
    Journal: J Neurol
    E-pub date: 1 Jul 2012
    Authors: A Merlini, L Peruzzotti-Jametti, M Bacigaluppi, G Mantovani, A Spada, M Rodegher, G Comi

    Life-threatening bradycardia after bilateral paramedian thalamic and midbrain infarction.

    DOI: http://doi.org/10.1007/s00415-011-6043-8
    Journal: J Neurol
    E-pub date: 1 Oct 2011
    Authors: L Peruzzotti-Jametti, M Bacigaluppi, G Giacalone, D Strambo, G Comi, M Sessa

    Therapeutic stem cell plasticity orchestrates tissue plasticity.

    DOI: http://doi.org/10.1093/brain/awr115
    Journal: Brain
    E-pub date: 1 Jun 2011
    Authors: G Martino, M Bacigaluppi, L Peruzzotti-Jametti

    Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms. (vol 132, pg 2239, 2009)

    DOI: http://doi.org/10.1093/brain/awp226
    Journal: BRAIN
    E-pub date: 1 Nov 2010
    Authors: M Bacigaluppi, S Pluchino, L Peruzzotti-Jametti, E Kilic, U Kilic, G Salani, E Brambilla, MJ West, G Comi, G Martino, DM Hermann

    Giant anterior arachnoid cyst associated with syringomyelia: implications for treatment and follow-up.

    DOI: http://doi.org/10.1097/BRS.0b013e3181c8a40a
    Journal: Spine (Phila Pa 1976)
    E-pub date: 15 Apr 2010
    Authors: L Peruzzotti-Jametti, S Ferrari, LS Politi, S Snider, S Mammi, G Comi, M Comola

    Microbubbles as drug delivery systems in cerebrovascular diseases.

    DOI: http://doi.org/10.2174/157489009789152221
    Journal: Recent Pat Cardiovasc Drug Discov
    E-pub date: 1 Nov 2009
    Authors: M Spinelli, C Demitri, A Sannino, L Peruzzotti-Jametti, M Bacigaluppi, G Comi, F Corea

    Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms.

    DOI: http://doi.org/10.1093/brain/awp174
    Journal: Brain
    E-pub date: 31 Aug 2009
    Authors: M Bacigaluppi, S Pluchino, L Peruzzotti-Jametti, E Kilic, U Kilic, G Salani, E Brambilla, MJ West, G Comi, G Martino, DM Hermann