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College Christ's College
Department
  • Psychology
  • Clinical Neurosciences
    • School
  • Biological Sciences
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    Research Theme Brains and Machines Neurons, Circuits and Networks Adaptive Brain Computations
    Research Focus

    Keywords

  • Brain Networks
  • Artificial Intelligence
  • Neurodegenerative Brain Disorders
  • Dementia
  • Hallucinations

    • Clinical Conditions

  • Parkinson's disease
  • Dementia
  • Schizophrenia
  • Alzheimer's disease

    • Equipment & Techniques

  • Magnetic resonance imaging (MRI)
  • Computational modelling
  • Cross-sectional and cohort studies
  • Other

    • Science Culture

  • Women in Neuroscience
  • Mentorship
  • Open Access

    • Back

    Dr Marcella Montagnese

    (she/her/hers)
    University Position
    Junior Research Fellow

    Interests

    I am a Junior Research Fellow in Biological and Medical Sciences at Christ’s College, University of Cambridge, and a Research Associate in Neuroinformatics at the Department of Psychology and affiliate with the Department of Clinical Neurosciences. My primary research involves analyzing neuroimaging and clinical data from memory clinics at Addenbrooke’s Hospital and other NHS trusts around the UK. I use artificial intelligence (AI) and normative models (Brain Charts, Bethlehem et al., Nature, 2022) to develop individualised tools for patient stratification and prognostication. Additionally, I have been applying cutting-edge AI techniques to solve complex healthcare challenges through my involvement in the PASSIAN Project, which focuses on implementing federated learning in the NHS. The goal is to pilot a secure, scalable clinical data-sharing solution that will remove a key roadblock to developing AI implementations for real-world biomedical data. Beyond my research, I am an ambassador for the Women Techmakers Initiative powered by Google, where I actively advocate for underrepresented groups, promote open access to coding and AI resources, and foster an inclusive tech community.

    Collaborators

    Cambridge
  • Richard Bethlehem
  • Timothy Rittman
  • Sarah Morgan
  • Zoe Kourtzi
  • Guy Williams

    • Associated News Items

    Key Publications

    Robust and interpretable AI-guided marker for early dementia prediction in real-world clinical settings

    DOI: http://doi.org/10.1016/j.eclinm.2024.102725
    Journal: EClinicalMedicine
    E-pub date: 31 Aug 2024
    Authors: LY Lee, D Vaghari, MC Burkhart, P Tino, M Montagnese, Z Li, K Zühlsdorff, J Giorgio, G Williams, E Chong, C Chen, BR Underwood, T Rittman, Z Kourtzi

    Cognition, hallucination severity and hallucination-specific insight in neurodegenerative disorders and eye disease.

    DOI: http://doi.org/10.1080/13546805.2021.1960812
    Journal: Cogn Neuropsychiatry
    E-pub date: 1 Aug 2022
    Authors: M Montagnese, M Vignando, D Collerton, D Ffytche, UP Mosimann, J-P Taylor, K daSilva Morgan, P Urwyler

    A Review of Multimodal Hallucinations: Categorization, Assessment, Theoretical Perspectives, and Clinical Recommendations.

    DOI: http://doi.org/10.1093/schbul/sbaa101
    Journal: Schizophr Bull
    E-pub date: 23 Jan 2021
    Authors: M Montagnese, P Leptourgos, C Fernyhough, F Waters, F Larøi, R Jardri, S McCarthy-Jones, N Thomas, R Dudley, J-P Taylor, D Collerton, P Urwyler

    Early impacts of the COVID-19 pandemic on mental health care and on people with mental health conditions: framework synthesis of international experiences and responses.

    DOI: http://doi.org/10.1007/s00127-020-01924-7
    Journal: Soc Psychiatry Psychiatr Epidemiol
    E-pub date: 1 Jan 2021
    Authors: L Sheridan Rains, S Johnson, P Barnett, T Steare, JJ Needle, S Carr, B Lever Taylor, F Bentivegna, J Edbrooke-Childs, HR Scott, J Rees, P Shah, J Lomani, B Chipp, N Barber, Z Dedat, S Oram, N Morant, A Simpson, COVID-19 Mental Health Policy Research Unit Group

    Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population

    DOI: http://doi.org/10.1101/668939
    Journal:
    E-pub date: 1 Aug 2019
    Authors: M Montagnese, F Knolle, J Haarsma, JD Griffin, A Richards, P Vertes, B Kiddle, PC Fletcher, PB Jones, MJ Owen, P Fonagy, ET Bullmore, R Dolan, NSPN Consortium, M Moutoussis, I Goodyer, GK Murray

    Publications

    Disrupted functional brain network associated with presence of hallucinations in Parkinson’s Disease

    DOI: http://doi.org/10.1101/2024.09.30.24314594
    Journal:
    E-pub date: 30 Sep 2024
    Authors: M Montagnese, MA Mehta, D ffytche, M Firbank, RA Lawson, J-P Taylor, ET Bullmore, SE Morgan

    Octopaminergic neurons have multiple targets in Drosophila larval mushroom body calyx and can modulate behavioral odor discrimination.

    DOI: http://doi.org/10.1101/lm.052159.120
    Journal: Learn Mem
    E-pub date: 1 Feb 2021
    Authors: JYH Wong, BA Wan, T Bland, M Montagnese, AD McLachlan, CJ O'Kane, SW Zhang, LM Masuda-Nakagawa

    Cognitive and Visual Processing Performance in Parkinson’s Disease Patients With vs Without Visual Hallucinations: A Meta-Analysis

    DOI: http://doi.org/10.2139/ssrn.3745799
    Journal: SSRN Electronic Journal
    E-pub date: 9 Jan 2021
    Authors: M Montagnese, M Vignando, D ffytche, MA Mehta

    Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population.

    DOI: http://doi.org/10.1016/j.schres.2020.04.022
    Journal: Schizophr Res
    E-pub date: 31 Aug 2020
    Authors: M Montagnese, F Knolle, J Haarsma, JD Griffin, A Richards, PE Vertes, B Kiddle, PC Fletcher, PB Jones, MJ Owen, P Fonagy, ET Bullmore, RJ Dolan, NSPN Consortium, M Moutoussis, IM Goodyer, GK Murray

    Early impacts of the COVID-19 pandemic on mental health care and on people with mental health conditions: framework synthesis of international experiences and responses

    DOI: http://doi.org/10.1101/2020.06.15.20129411
    Journal:
    E-pub date: 1 Aug 2020
    Authors: LS Rains, S Johnson, P Barnett, T Steare, J Needle, S Carr, BL Taylor, F Bentivegna, J Edbrooke-Childs, HR Scott, J Rees, P Shah, J Lomani, B Chipp, N Barber, Z Dedat, S Oram, N Morant, A Simpson, COVID-19 Mental Health Policy Research Unit Group

    Octopaminergic neurons have multiple targets inDrosophilalarval mushroom body calyx and regulate behavioral odor discrimination

    DOI: http://doi.org/10.1101/295659
    Journal:
    E-pub date: 1 Aug 2018
    Authors: JY Hilary Wong, BA Wan, T Bland, M Montagnese, A McLachlan, C O’Kane, SW Zhang, L Masuda-Nakagawa