Menu

College Peterhouse
Institute
  • Neurology Unit
  • Research Focus

    Keywords

  • Dementia
  • Progressive Supranuclear Palsy
  • Frontotemporal Dementia
  • Multimodal Neuroimaging
  • Neuropathology
  • Clinical Conditions

  • Progressive supranuclear palsy
  • Dementia
  • Equipment & Techniques

  • Magnetic resonance imaging (MRI)
  • Science Culture

  • Public Engagement
  • Back

    Dr Timothy Rittman

    University Position
    Other
    Dr Timothy Rittman is pleased to consider applications from prospective PhD students.

    Interests

    My interests are to understand neurodegenerative tauopathies at the systems level, and to translate artificial intelligence algorithms into clinical practice for memory clinics.

    Key Publications

    Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia.

    DOI: http://doi.org/10.1093/brain/awad078
    Journal: Brain
    E-pub date: 1 Aug 2023
    Authors: M Malpetti, TE Cope, D Street, PS Jones, FH Hezemans, E Mak, KA Tsvetanov, T Rittman, WR Bevan-Jones, K Patterson, L Passamonti, TD Fryer, YT Hong, FI Aigbirhio, JT O'Brien, JB Rowe

    Synaptic Loss in Frontotemporal Dementia Revealed by [11 C]UCB-J Positron Emission Tomography.

    DOI: http://doi.org/10.1002/ana.26543
    Journal: Ann Neurol
    E-pub date: 1 Jan 2023
    Authors: M Malpetti, PS Jones, TE Cope, N Holland, M Naessens, MA Rouse, T Rittman, G Savulich, DJ Whiteside, D Street, TD Fryer, YT Hong, S Milicevic Sephton, FI Aigbirhio, JT O Brien, JB Rowe

    In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease.

    DOI: http://doi.org/10.1126/sciadv.abh1448
    Journal: Sci Adv
    E-pub date: 29 Oct 2021
    Authors: G Meisl, E Hidari, K Allinson, T Rittman, SL DeVos, JS Sanchez, CK Xu, KE Duff, KA Johnson, JB Rowe, BT Hyman, TPJ Knowles, D Klenerman

    Neuroinflammation predicts disease progression in progressive supranuclear palsy.

    DOI: http://doi.org/10.1136/jnnp-2020-325549
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Jul 2021
    Authors: M Malpetti, L Passamonti, PS Jones, D Street, T Rittman, TD Fryer, YT Hong, P Vàsquez Rodriguez, WR Bevan-Jones, FI Aigbirhio, JT O'Brien, JB Rowe

    Neuroinflammation and Tau Colocalize in vivo in Progressive Supranuclear Palsy.

    DOI: http://doi.org/10.1002/ana.25911
    Journal: Ann Neurol
    E-pub date: 1 Dec 2020
    Authors: M Malpetti, L Passamonti, T Rittman, PS Jones, P Vázquez Rodríguez, WR Bevan-Jones, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Microglial activation and tau burden predict cognitive decline in Alzheimer’s Disease

    DOI: http://doi.org/10.1101/19011189
    Journal:
    E-pub date: 8 Nov 2019
    Authors: M Malpetti, R Kievit, L Passamonti, S Jones, K Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, Y Hong, T Fryer, F Aigbirhio, J O'Brien, J Rowe

    Tau burden and the functional connectome in Alzheimer’s disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1093/brain/awx347
    Journal: Brain
    E-pub date: 1 Feb 2018
    Authors: TE Cope, T Rittman, RJ Borchert, PS Jones, D Vatansever, K Allinson, L Passamonti, P Vazquez Rodriguez, WR Bevan-Jones, JT O'Brien, JB Rowe

    Gene transcription profiles associated with inter-modular hubs and connection distance in human functional magnetic resonance imaging networks.

    DOI: http://doi.org/10.1098/rstb.2015.0362
    Journal: Philos Trans R Soc Lond B Biol Sci
    E-pub date: 5 Oct 2016
    Authors: PE Vértes, T Rittman, KJ Whitaker, R Romero-Garcia, F Váša, MG Kitzbichler, K Wagstyl, P Fonagy, RJ Dolan, PB Jones, IM Goodyer, NSPN Consortium, ET Bullmore

    Adolescence is associated with genomically patterned consolidation of the hubs of the human brain connectome.

    DOI: http://doi.org/10.1073/pnas.1601745113
    Journal: Proc Natl Acad Sci U S A
    E-pub date: 9 Aug 2016
    Authors: KJ Whitaker, PE Vértes, R Romero-Garcia, F Váša, M Moutoussis, G Prabhu, N Weiskopf, MF Callaghan, K Wagstyl, T Rittman, R Tait, C Ooi, J Suckling, B Inkster, P Fonagy, RJ Dolan, PB Jones, IM Goodyer, NSPN Consortium, ET Bullmore

    Publications

    Artificial intelligence for biomarker discovery in Alzheimer’s disease and dementia.

    DOI: http://doi.org/10.1002/alz.13390
    Journal: Alzheimers Dement
    E-pub date: 31 Aug 2023
    Authors: LM Winchester, EL Harshfield, L Shi, A Badhwar, AA Khleifat, N Clarke, A Dehsarvi, I Lengyel, I Lourida, CR Madan, SJ Marzi, P Proitsi, AP Rajkumar, T Rittman, E Silajdžić, S Tamburin, JM Ranson, DJ Llewellyn

    Artificial intelligence for diagnostic and prognostic neuroimaging in dementia: A systematic review.

    DOI: http://doi.org/10.1002/alz.13412
    Journal: Alzheimers Dement
    E-pub date: 10 Aug 2023
    Authors: RJ Borchert, T Azevedo, A Badhwar, J Bernal, M Betts, R Bruffaerts, MC Burkhart, I Dewachter, HM Gellersen, A Low, I Lourida, L Machado, CR Madan, M Malpetti, J Mejia, S Michopoulou, C Muñoz-Neira, J Pepys, M Peres, V Phillips, S Ramanan, S Tamburin, HM Tantiangco, L Thakur, A Tomassini, A Vipin, E Tang, D Newby, Deep Dementia Phenotyping (DEMON) Network, JM Ranson, DJ Llewellyn, M Veldsman, T Rittman

    Network connectivity and structural correlates of survival in progressive supranuclear palsy and corticobasal syndrome.

    DOI: http://doi.org/10.1002/hbm.26342
    Journal: Hum Brain Mapp
    E-pub date: 1 Aug 2023
    Authors: DJ Whiteside, D Street, AG Murley, PS Jones, M Malpetti, BCP Ghosh, I Coyle-Gilchrist, A Gerhard, MT Hu, JC Klein, PN Leigh, A Church, DJ Burn, HR Morris, JB Rowe, T Rittman

    Longitudinal Synaptic Loss in Primary Tauopathies: An In Vivo [11 C]UCB-J Positron Emission Tomography Study.

    DOI: http://doi.org/10.1002/mds.29421
    Journal: Mov Disord
    E-pub date: 1 Jul 2023
    Authors: N Holland, PS Jones, G Savulich, M Naessens, M Malpetti, DJ Whiteside, D Street, P Swann, YT Hong, TD Fryer, T Rittman, E Mulroy, FI Aigbirhio, KP Bhatia, JT O'Brien, JB Rowe

    Temporal dynamics predict symptom onset and cognitive decline in familial frontotemporal dementia.

    DOI: http://doi.org/10.1002/alz.12824
    Journal: Alzheimers Dement
    E-pub date: 1 May 2023
    Authors: DJ Whiteside, M Malpetti, PS Jones, BCP Ghosh, I Coyle-Gilchrist, JC van Swieten, H Seelaar, L Jiskoot, B Borroni, R Sanchez-Valle, F Moreno, R Laforce, C Graff, M Synofzik, D Galimberti, M Masellis, MC Tartaglia, E Finger, R Vandenberghe, A de Mendonça, F Tagliavini, CR Butler, I Santana, IL Ber, A Gerhard, S Ducharme, J Levin, A Danek, M Otto, S Sorbi, F Pasquier, A Bouzigues, LL Russell, JD Rohrer, JB Rowe, T Rittman, GENFI consortium

    A modified Camel and Cactus Test detects presymptomatic semantic impairment in genetic frontotemporal dementia within the GENFI cohort.

    DOI: http://doi.org/10.1080/23279095.2020.1716357
    Journal: Appl Neuropsychol Adult
    E-pub date: 1 Aug 2022
    Authors: K Moore, R Convery, M Bocchetta, M Neason, DM Cash, C Greaves, LL Russell, MTM Clarke, G Peakman, J van Swieten, L Jiskoot, F Moreno, M Barandiaran, R Sanchez-Valle, B Borroni, R Laforce, M-C Doré, M Masellis, MC Tartaglia, C Graff, D Galimberti, JB Rowe, E Finger, M Synofzik, H-O Karnath, R Vandenberghe, A de Mendonça, C Maruta, F Tagliavini, I Santana, S Ducharme, C Butler, A Gerhard, J Levin, A Danek, M Otto, JD Warren, JD Rohrer, Genetic FTD Initiative, GENFI*

    In Vivo 18F-Flortaucipir PET Does Not Accurately Support the Staging of Progressive Supranuclear Palsy.

    DOI: http://doi.org/10.2967/jnumed.121.262985
    Journal: J Nucl Med
    E-pub date: 1 Jul 2022
    Authors: M Malpetti, SS Kaalund, KA Tsvetanov, T Rittman, M Briggs, KSJ Allinson, L Passamonti, N Holland, PS Jones, TD Fryer, YT Hong, A Kouli, WR Bevan-Jones, E Mak, G Savulich, MG Spillantini, FI Aigbirhio, CH Williams-Gray, JT O'Brien, JB Rowe

    Brain charts for the human lifespan

    DOI: http://doi.org/10.1038/s41586-022-04554-y
    Journal: Nature
    E-pub date: 1 Apr 2022
    Authors: RAI Bethlehem, J Seidlitz, SR White, JW Vogel, KM Anderson, C Adamson, S Adler, GS Alexopoulos, E Anagnostou, A Areces-Gonzalez, DE Astle, B Auyeung, M Ayub, G Ball, S Baron-Cohen, R Beare, SA Bedford, V Benegal, F Beyer, J Bin Bae, J Blangero, M Blesa Cábez, JP Boardman, M Borzage, JF Bosch-Bayard, N Bourke, VD Calhoun, MM Chakravarty, C Chen, C Chertavian, G Chetelat, YS Chong, JH Cole, A Corvin, E Courchesne, F Crivello, VL Cropley, J Crosbie, N Crossley, M Delarue, S Desrivieres, G Devenyi, MA Di Biase, R Dolan, KA Donald, G Donohoe, K Dunlop, AD Edwards, JT Elison, CT Ellis, JA Elman, L Eyler, DA Fair, PC Fletcher, P Fonagy, CE Franz, L Galan-Garcia, A Gholipour, J Giedd, JH Gilmore, DC Glahn, I Goodyer, PE Grant, NA Groenewold, FM Gunning, RE Gur, RC Gur, CF Hammill, O Hansson, T Hedden, A Heinz, R Henson, K Heuer, J Hoare, B Holla, AJ Holmes, R Holt, H Huang, K Im, J Ipser, CR Jack, AP Jackowski, T Jia, KA Johnson, PB Jones, DT Jones, R Kahn, H Karlsson, L Karlsson, R Kawashima, EA Kelley, S Kern, K Kim, MG Kitzbichler, WS Kremen, F Lalonde, B Landeau, S Lee, J Lerch, JD Lewis, J Li, W Liao, DP Linares, C Liston, MV Lombardo, J Lv, C Lynch, TT Mallard, M Marcelis, RD Markello, B Mazoyer, P McGuire, MJ Meaney, A Mechelli, N Medic, B Misic, SE Morgan, D Mothersill, J Nigg, MQW Ong, C Ortinau, R Ossenkoppele, M Ouyang, L Palaniyappan, L Paly, PM Pan, C Pantelis, MM Park, T Paus, Z Pausova, A Pichet Binette, K Pierce, X Qian, J Qiu, A Qiu, A Raznahan, T Rittman, CK Rollins, R Romero-Garcia, L Ronan, MD Rosenberg, DH Rowitch, GA Salum, TD Satterthwaite, HL Schaare, RJ Schachar, AP Schultz, G Schumann, M Schöll, D Sharp, RT Shinohara, I Skoog, CD Smyser, RA Sperling, DJ Stein, A Stolicyn, J Suckling, G Sullivan, Y Taki, B Thyreau, R Toro, KA Tsvetanov, NB Turk-Browne, JJ Tuulari, C Tzourio, É Vachon-Presseau, MJ Valdes-Sosa, PA Valdes-Sosa, SL Valk, T van Amelsvoort, SN Vandekar, L Vasung, LW Victoria, S Villeneuve, A Villringer, PE Vértes, K Wagstyl, YS Wang, SK Warfield, V Warrier, E Westman, ML Westwater, HC Whalley, AV Witte, N Yang, BTT Yeo, HJ Yun, A Zalesky, HJ Zar, A Zettergren, JH Zhou, H Ziauddeen, A Zugman, XN Zuo, AF Alexander-Bloch, AIBL, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Repository Without Borders Investigators, ASRB, CALM Team, Cam-CAN, CCNP, 3R-BRAIN, COBRE, ENIGMA Developmental Brain Age working group, FinnBrain, Harvard Aging Brain Study, IMAGEN, KNE96, NSPN, OASIS-3, OpenPain Project, POND, The PREVENT-AD Research Group, VETSA, Bullmore, E.T

    Molecular pathology and synaptic loss in primary tauopathies: A [18F]AV-1451 and [11C]UCB-J PET study

    DOI: http://doi.org/10.1093/brain/awab282
    Journal: Brain
    E-pub date: 29 Mar 2022
    Authors: N Holland, M Malpetti, T Rittman, E Mak, L Passamonti, S Kaalund, F Hezemans, P Jones, G Savulich, Y Hong, T Fryer, F Aigbirhio, J O'Brien, J Rowe

    Microglial activation and atrophy in frontal cortex predict executive dysfunction in frontotemporal dementia

    DOI: http://doi.org/10.1002/alz.055456
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2021
    Authors: M Malpetti, PS Jones, FH Hezemans, E Mak, D Street, L Passamonti, T Rittman, TE Cope, WR Bevan‐Jones, K Patterson, TD Fryer, YT Hong, FI Aigbirho, JT O'Brien, JB Rowe

    Co-Occurrence of Apathy and Impulsivity in Progressive Supranuclear Palsy.

    DOI: http://doi.org/10.1002/mdc3.13339
    Journal: Mov Disord Clin Pract
    E-pub date: 1 Nov 2021
    Authors: ZQ Kok, AG Murley, T Rittman, J Rowe, L Passamonti

    Clinical progression of progressive supranuclear palsy: impact of trials bias and phenotype variants.

    DOI: http://doi.org/10.1093/braincomms/fcab206
    Journal: Brain Commun
    E-pub date: 1 Aug 2021
    Authors: D Street, M Malpetti, T Rittman, BCP Ghosh, AG Murley, I Coyle-Gilchrist, L Passamonti, JB Rowe

    Artificial intelligence for diagnosis and prognosis in neuroimaging for dementia; a systematic review

    DOI: http://doi.org/10.1101/2021.12.12.21267677
    Journal:
    E-pub date: 1 Aug 2021
    Authors: R Borchert, T Azevedo, A Badhwar, J Bernal, M Betts, R Bruffaerts, MC Burkhart, I Dewachter, HM Gellersen, A Low, L Machado, CR Madan, M Malpetti, J Mejia, S Michopoulou, C Muñoz-Neira, M Peres, V Phillips, S Ramanan, S Tamburin, H Tantiangco, L Thakur, A Tomassini, A Vipin, E Tang, D Newby, J Ranson, DJ Llewellyn, M Veldsman, T Rittman

    Brain charts for the human lifespan

    DOI: http://doi.org/10.1101/2021.06.08.447489
    Journal:
    E-pub date: 1 Aug 2021
    Authors: RAI Bethlehem, J Seidlitz, SR White, JW Vogel, KM Anderson, C Adamson, S Adler, GS Alexopoulos, E Anagnostou, A Areces-Gonzalez, DE Astle, B Auyeung, M Ayub, G Ball, S Baron-Cohen, R Beare, SA Bedford, V Benegal, F Beyer, J Bin Bae, J Blangero, M Blesa Cábez, JP Boardman, M Borzage, JF Bosch-Bayard, N Bourke, VD Calhoun, MM Chakravarty, C Chen, C Chertavian, G Chetelat, YS Chong, JH Cole, A Corvin, M Costantino, E Courchesne, F Crivello, VL Cropley, J Crosbie, N Crossley, M Delarue, R Delorme, S Desrivieres, G Devenyi, MA Di Biase, R Dolan, KA Donald, G Donohoe, K Dunlop, AD Edwards, JT Elison, CT Ellis, JA Elman, L Eyler, DA Fair, E Feczko, PC Fletcher, P Fonagy, CE Franz, L Galan-Garcia, A Gholipour, J Giedd, JH Gilmore, DC Glahn, I Goodyer, PE Grant, NA Groenewold, FM Gunning, RE Gur, RC Gur, CF Hammill, O Hansson, T Hedden, A Heinz, RN Henson, K Heuer, J Hoare, B Holla, AJ Holmes, R Holt, H Huang, K Im, J Ipser, CR Jack, AP Jackowski, T Jia, KA Johnson, PB Jones, DT Jones, R Kahn, H Karlsson, L Karlsson, R Kawashima, EA Kelley, S Kern, K Kim, MG Kitzbichler, WS Kremen, F Lalonde, B Landeau, S Lee, J Lerch, JD Lewis, J Li, W Liao, C Liston, MV Lombardo, J Lv, C Lynch, TT Mallard, M Marcelis, RD Markello, SR Mathias, B Mazoyer, P McGuire, MJ Meaney, A Mechelli, N Medic, B Misic, SE Morgan, D Mothersill, J Nigg, MQW Ong, C Ortinau, C Ortinau, R Ossenkoppele, M Ouyang, L Palaniyappan, L Paly, PM Pan, C Pantelis, MM Park, T Paus, Z Pausova, D Paz-Linares, A Pichet Binette, K Pierce, X Qian, J Qiu, A Qiu, A Raznahan, T Rittman, A Rodrigue, CK Rollins, R Romero-Garcia, L Ronan, MD Rosenberg, DH Rowitch, GA Salum, TD Satterthwaite, HL Schaare, RJ Schachar, AP Schultz, G Schumann, M Schöll, D Sharp, RT Shinohara, I Skoog, CD Smyser, RA Sperling, DJ Stein, A Stolicyn, J Suckling, G Sullivan, Y Taki, B Thyreau, R Toro, N Traut, KA Tsvetanov, NB Turk-Browne, JJ Tuulari, C Tzourio, É Vachon-Presseau, MJ Valdes-Sosa, PA Valdes-Sosa, SL Valk, T van Amelsvoort, SN Vandekar, L Vasung, LW Victoria, S Villeneuve, A Villringer, A Villringer, PE Vértes, K Wagstyl, YS Wang, SK Warfield, V Warrier, E Westman, ML Westwater, HC Whalley, AV Witte, N Yang, B Yeo, H Yun, A Zalesky, HJ Zar, A Zettergren, JH Zhou, H Ziauddeen, A Zugman, XN Zuo, ET Bullmore, AF Alexander-Bloch, 3R-BRAIN, AIBL, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Repository Without Borders Investigators, UMN BCP, CALM Team, Cam-CAN, CCNP, COBRE, Developing Human Connectome Project, ENIGMA Developmental Brain Age working group, FinnBrain, Harvard Aging Brain Study, IMAGEN, KNE96, The Mayo Clinic Study of Aging, NSPN, POND, The PREVENT-AD Research Group, VETSA

    Disease-related cortical thinning in presymptomatic granulin mutation carriers.

    DOI: http://doi.org/10.1016/j.nicl.2020.102540
    Journal: Neuroimage Clin
    E-pub date: 1 Aug 2021
    Authors: S Borrego-Écija, R Sala-Llonch, J van Swieten, B Borroni, F Moreno, M Masellis, C Tartaglia, C Graff, D Galimberti, R Laforce, JB Rowe, E Finger, R Vandenberghe, F Tagliavini, A de Mendonça, I Santana, M Synofzik, S Ducharme, J Levin, A Danek, A Gerhard, M Otto, C Butler, G Frisoni, S Sorbi, C Heller, M Bocchetta, DM Cash, RS Convery, KM Moore, JD Rohrer, R Sanchez-Valle, Genetic FTD Initiative GENFI

    Differential early subcortical involvement in genetic FTD within the GENFI cohort.

    DOI: http://doi.org/10.1016/j.nicl.2021.102646
    Journal: Neuroimage Clin
    E-pub date: 1 Aug 2021
    Authors: M Bocchetta, EG Todd, G Peakman, DM Cash, RS Convery, LL Russell, DL Thomas, J Eugenio Iglesias, JC van Swieten, LC Jiskoot, H Seelaar, B Borroni, D Galimberti, R Sanchez-Valle, R Laforce, F Moreno, M Synofzik, C Graff, M Masellis, M Carmela Tartaglia, JB Rowe, R Vandenberghe, E Finger, F Tagliavini, A de Mendonça, I Santana, CR Butler, S Ducharme, A Gerhard, A Danek, J Levin, M Otto, S Sorbi, I Le Ber, F Pasquier, JD Rohrer, Genetic Frontotemporal dementia Initiative (GENFI)

    Impairment of episodic memory in genetic frontotemporal dementia: A GENFI study.

    DOI: http://doi.org/10.1002/dad2.12185
    Journal: Alzheimers Dement (Amst)
    E-pub date: 1 Aug 2021
    Authors: JM Poos, LL Russell, G Peakman, M Bocchetta, CV Greaves, LC Jiskoot, EL van der Ende, H Seelaar, JM Papma, E van den Berg, YAL Pijnenburg, B Borroni, R Sanchez-Valle, F Moreno, R Laforce, C Graff, M Synofzik, D Galimberti, JB Rowe, M Masellis, C Tartaglia, E Finger, R Vandenberghe, A de Medonça, F Tagliavini, CR Butler, I Santana, IL Ber, A Gerhard, S Ducharme, J Levin, A Danek, M Otto, S Sorbi, F Pasquier, JC van Swieten, JD Rohrer, Genetic FTD Initiative, GENF

    Synaptic density in carriers of C9orf72 mutations: a [11 C]UCB-J PET study.

    DOI: http://doi.org/10.1002/acn3.51407
    Journal: Ann Clin Transl Neurol
    E-pub date: 1 Jul 2021
    Authors: M Malpetti, N Holland, PS Jones, R Ye, TE Cope, TD Fryer, YT Hong, G Savulich, T Rittman, L Passamonti, E Mak, FI Aigbirhio, JT O'Brien, JB Rowe

    Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes.

    DOI: http://doi.org/10.1002/alz.12252
    Journal: Alzheimers Dement
    E-pub date: 1 Jun 2021
    Authors: M Malpetti, PS Jones, KA Tsvetanov, T Rittman, JC van Swieten, B Borroni, R Sanchez-Valle, F Moreno, R Laforce, C Graff, M Synofzik, D Galimberti, M Masellis, MC Tartaglia, E Finger, R Vandenberghe, A de Mendonça, F Tagliavini, I Santana, S Ducharme, CR Butler, A Gerhard, J Levin, A Danek, M Otto, GB Frisoni, R Ghidoni, S Sorbi, C Heller, EG Todd, M Bocchetta, DM Cash, RS Convery, G Peakman, KM Moore, JD Rohrer, RA Kievit, JB Rowe, Genetic FTD Initiative (GENFI)

    In vivo coupling of dendritic complexity with presynaptic density in primary tauopathies.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2021.01.016
    Journal: Neurobiol Aging
    E-pub date: 1 May 2021
    Authors: E Mak, N Holland, PS Jones, G Savulich, A Low, M Malpetti, SS Kaalund, L Passamonti, T Rittman, R Romero-Garcia, R Manavaki, GB Williams, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    In vivo PET imaging of neuroinflammation in familial frontotemporal dementia.

    DOI: http://doi.org/10.1136/jnnp-2020-323698
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Mar 2021
    Authors: M Malpetti, T Rittman, PS Jones, TE Cope, L Passamonti, WR Bevan-Jones, K Patterson, TD Fryer, YT Hong, FI Aigbirhio, JT O'Brien, JB Rowe

    Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia.

    DOI: http://doi.org/10.1002/alz.12209
    Journal: Alzheimers Dement
    E-pub date: 1 Mar 2021
    Authors: KA Tsvetanov, S Gazzina, PS Jones, J van Swieten, B Borroni, R Sanchez-Valle, F Moreno, R Laforce, C Graff, M Synofzik, D Galimberti, M Masellis, MC Tartaglia, E Finger, R Vandenberghe, A de Mendonça, F Tagliavini, I Santana, S Ducharme, C Butler, A Gerhard, A Danek, J Levin, M Otto, G Frisoni, R Ghidoni, S Sorbi, JD Rohrer, JB Rowe, Genetic FTD Initiative, GENFI

    Social cognition impairment in genetic frontotemporal dementia within the GENFI cohort.

    DOI: http://doi.org/10.1016/j.cortex.2020.08.023
    Journal: Cortex
    E-pub date: 1 Dec 2020
    Authors: LL Russell, CV Greaves, M Bocchetta, J Nicholas, RS Convery, K Moore, DM Cash, J van Swieten, L Jiskoot, F Moreno, R Sanchez-Valle, B Borroni, R Laforce, M Masellis, MC Tartaglia, C Graff, E Rotondo, D Galimberti, JB Rowe, E Finger, M Synofzik, R Vandenberghe, A de Mendonça, F Tagliavini, I Santana, S Ducharme, C Butler, A Gerhard, J Levin, A Danek, M Otto, JD Warren, JD Rohrer, Genetic FTD Initiative, GENFI

    Multimodal imaging markers of tau, neuroinflammation and atrophy to predict clinical progression in progressive supranuclear palsy

    DOI: http://doi.org/10.1002/alz.044724
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2020
    Authors: M Malpetti, L Passamonti, PS Jones, T Rittman, TD Fryer, YT Hong, D Street, PV Rodríguez, WR Bevan‐Jones, FI Aigbirhio, JT O'Brien, JB Rowe

    The prognostic role of microglia and tau PET in Alzheimer’s disease

    DOI: http://doi.org/10.1002/alz.039817
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2020
    Authors: M Malpetti, RA Kievit, L Passamonti, PS Jones, KA Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan‐Jones, L Su, YT Hong, TD Fryer, FI Aigbirho, JT O'Brien, JB Rowe

    Trajectory of apathy, cognition and neural correlates in the decades before symptoms in frontotemporal dementia

    DOI: http://doi.org/10.1002/alz.041821
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2020
    Authors: M Malpetti, RA Kievit, PS Jones, T Rittman, KA Tsvetanov, JC van Swieten, B Borroni, D Galimberti, R Sanchez‐Valle, R Laforce, F Moreno, M Synofzik, C Graff, M Masellis, C Tartaglia, R Vandenberghe, E Finger, F Tagliavini, A de Mendonca, I Santana, C Butler, S Ducharme, A Gerhard, A Danek, J Levin, M Otto, GB Frisoni, R Ghidoni, C Heller, E Todd, M Bocchetta, RS Convery, G Peakman, KM Moore, JD Rohrer, JB Rowe

    In vivo PET imaging of neuroinflammation in familial frontotemporal dementia

    DOI: http://doi.org/10.1101/2020.05.11.20098046
    Journal:
    E-pub date: 1 Aug 2020
    Authors: M Malpetti, T Rittman, S Jones, T Cope, L Passamonti, R Bevan-Jones, K Patterson, T Fryer, Y Hong, F Aigbirhio, J O’Brien, J Rowe

    Neuroinflammation predicts disease progression in progressive supranuclear palsy

    DOI: http://doi.org/10.1101/2020.05.19.20106393
    Journal:
    E-pub date: 1 Aug 2020
    Authors: M Malpetti, L Passamonti, S Jones, D Street, T Rittman, T Fryer, Y Hong, P Vasquez-Rodriguez, WR Bevan-Jones, F Aigbirhio, J O'Brien, J Rowe

    Microglial activation and tau burden predict cognitive decline in Alzheimer’s disease.

    DOI: http://doi.org/10.1093/brain/awaa088
    Journal: Brain
    E-pub date: 1 May 2020
    Authors: M Malpetti, RA Kievit, L Passamonti, PS Jones, KA Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia.

    DOI: http://doi.org/10.1136/jnnp-2019-321954
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 Mar 2020
    Authors: C Heller, MS Foiani, K Moore, R Convery, M Bocchetta, M Neason, DM Cash, D Thomas, CV Greaves, IO Woollacott, R Shafei, JC Van Swieten, F Moreno, R Sanchez-Valle, B Borroni, R Laforce, M Masellis, MC Tartaglia, C Graff, D Galimberti, JB Rowe, E Finger, M Synofzik, R Vandenberghe, A de Mendonca, F Tagliavini, I Santana, S Ducharme, CR Butler, A Gerhard, J Levin, A Danek, G Frisoni, S Sorbi, M Otto, AJ Heslegrave, H Zetterberg, JD Rohrer, GENFI

    Asymmetrical atrophy of thalamic subnuclei in Alzheimer’s disease and amyloid-positive mild cognitive impairment is associated with key clinical features.

    DOI: http://doi.org/10.1016/j.dadm.2019.08.001
    Journal: Alzheimers Dement (Amst)
    E-pub date: 1 Dec 2019
    Authors: A Low, E Mak, M Malpetti, L Chouliaras, N Nicastro, L Su, N Holland, T Rittman, PV Rodríguez, L Passamonti, WR Bevan-Jones, PS Jones, JB Rowe, JT O'Brien

    Serum neurofilament light chain in genetic frontotemporal dementia: a longitudinal, multicentre cohort study.

    DOI: http://doi.org/10.1016/S1474-4422(19)30354-0
    Journal: Lancet Neurol
    E-pub date: 1 Dec 2019
    Authors: EL van der Ende, LH Meeter, JM Poos, JL Panman, LC Jiskoot, EGP Dopper, JM Papma, FJ de Jong, IMW Verberk, C Teunissen, D Rizopoulos, C Heller, RS Convery, KM Moore, M Bocchetta, M Neason, DM Cash, B Borroni, D Galimberti, R Sanchez-Valle, R Laforce, F Moreno, M Synofzik, C Graff, M Masellis, M Carmela Tartaglia, JB Rowe, R Vandenberghe, E Finger, F Tagliavini, A de Mendonça, I Santana, C Butler, S Ducharme, A Gerhard, A Danek, J Levin, M Otto, GB Frisoni, S Cappa, YAL Pijnenburg, JD Rohrer, JC van Swieten, Genetic Frontotemporal dementia Initiative (GENFI)

    PET markers of tau and neuroinflammation are co-localized in progressive supranuclear palsy

    DOI: http://doi.org/10.1101/19010702
    Journal:
    E-pub date: 2 Nov 2019
    Authors: M Malpetti, L Passamonti, T Rittman, S Jones, P Vázquez Rodríguez, R Bevan-Jones, Y Hong, T Fryer, F Aigbirhio, J O’Brien, J Rowe

    White matter hyperintensities in progranulin-associated frontotemporal dementia: A longitudinal GENFI study.

    DOI: http://doi.org/10.1016/j.nicl.2019.102077
    Journal: Neuroimage Clin
    E-pub date: 1 Aug 2019
    Authors: CH Sudre, M Bocchetta, C Heller, R Convery, M Neason, KM Moore, DM Cash, DL Thomas, IOC Woollacott, M Foiani, A Heslegrave, R Shafei, C Greaves, J van Swieten, F Moreno, R Sanchez-Valle, B Borroni, R Laforce, M Masellis, MC Tartaglia, C Graff, D Galimberti, JB Rowe, E Finger, M Synofzik, R Vandenberghe, A de Mendonça, F Tagliavini, I Santana, S Ducharme, C Butler, A Gerhard, J Levin, A Danek, GB Frisoni, S Sorbi, M Otto, H Zetterberg, S Ourselin, MJ Cardoso, JD Rohrer, On behalf of, GENFI

    O4‐03‐06: LONGITUDINAL ASSOCIATION BETWEEN APATHY AND COGNITIVE DECLINE IN PRE‐ AND POST‐SYMPTOMATIC GENETIC FRONTOTEMPORAL DEMENTIA

    DOI: http://doi.org/10.1016/j.jalz.2019.06.4757
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Jul 2019
    Authors: M Malpetti, RA Kievit, PS Jones, T Rittman, KA Tsvetanov, JC van Swieten, B Borroni, D Galimberti, R Sanchez-Valle, R Laforce, F Moreno, M Synofzik, C Graff, M Masellis, C Tartaglia, R Vandenberghe, E Finger, F Tagliavini, A Mendonca, I Santana, CR Butler, S Ducharme, A Gerhard, A Danek, J Levin, M Otto, GB Frisoni, S Cappa, C Heller, RS Convery, KM Dick, JD Rohrer, JB Rowe

    Functional network resilience to pathology in presymptomatic genetic frontotemporal dementia.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2018.12.009
    Journal: Neurobiol Aging
    E-pub date: 1 May 2019
    Authors: T Rittman, R Borchert, S Jones, J van Swieten, B Borroni, D Galimberti, M Masellis, MC Tartaglia, C Graff, F Tagliavini, GB Frisoni, R Laforce, E Finger, A Mendonça, S Sorbi, JD Rohrer, JB Rowe, Genetic Frontotemporal Dementia Initiative (GENFI)

    The inner fluctuations of the brain in presymptomatic Frontotemporal Dementia: The chronnectome fingerprint.

    DOI: http://doi.org/10.1016/j.neuroimage.2019.01.080
    Journal: Neuroimage
    E-pub date: 1 Apr 2019
    Authors: E Premi, VD Calhoun, M Diano, S Gazzina, M Cosseddu, A Alberici, S Archetti, D Paternicò, R Gasparotti, J van Swieten, D Galimberti, R Sanchez-Valle, R Laforce, F Moreno, M Synofzik, C Graff, M Masellis, MC Tartaglia, J Rowe, R Vandenberghe, E Finger, F Tagliavini, A de Mendonça, I Santana, C Butler, S Ducharme, A Gerhard, A Danek, J Levin, M Otto, G Frisoni, S Cappa, S Sorbi, A Padovani, JD Rohrer, B Borroni, Genetic FTD Initiative, GENFI

    Neurophysiological signatures of Alzheimer’s disease and frontotemporal lobar degeneration: pathology versus phenotype.

    DOI: http://doi.org/10.1093/brain/awy180
    Journal: Brain
    E-pub date: 1 Aug 2018
    Authors: S Sami, N Williams, LE Hughes, TE Cope, T Rittman, ITS Coyle-Gilchrist, RN Henson, JB Rowe

    Atomoxetine restores the response inhibition network in Parkinson’s disease.

    DOI: http://doi.org/10.1093/brain/aww138
    Journal: Brain
    E-pub date: 31 Aug 2016
    Authors: CL Rae, C Nombela, PV Rodríguez, Z Ye, LE Hughes, PS Jones, T Ham, T Rittman, I Coyle-Gilchrist, R Regenthal, BJ Sahakian, RA Barker, TW Robbins, JB Rowe

    Atomoxetine Enhances Connectivity of Prefrontal Networks in Parkinson’s Disease.

    DOI: http://doi.org/10.1038/npp.2016.18
    Journal: Neuropsychopharmacology
    E-pub date: 1 Jul 2016
    Authors: RJ Borchert, T Rittman, L Passamonti, Z Ye, S Sami, SP Jones, C Nombela, P Vázquez Rodríguez, D Vatansever, CL Rae, LE Hughes, TW Robbins, JB Rowe

    Predicting beneficial effects of atomoxetine and citalopram on response inhibition in Parkinson’s disease with clinical and neuroimaging measures.

    DOI: http://doi.org/10.1002/hbm.23087
    Journal: Hum Brain Mapp
    E-pub date: 1 Mar 2016
    Authors: Z Ye, CL Rae, C Nombela, T Ham, T Rittman, PS Jones, PV Rodríguez, I Coyle-Gilchrist, R Regenthal, E Altena, CR Housden, H Maxwell, BJ Sahakian, RA Barker, TW Robbins, JB Rowe

    The Addenbrooke’s Cognitive Examination for the differential diagnosis and longitudinal assessment of patients with parkinsonian disorders.

    DOI: http://doi.org/10.1136/jnnp-2012-303618
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 1 May 2013
    Authors: T Rittman, BC Ghosh, P McColgan, DP Breen, J Evans, CH Williams-Gray, RA Barker, JB Rowe

    THE UTILITY OF THE ADDENBROOKE’S COGNITIVE EXAMINATION-REVISED (ACE-R) IN PARKINSON’S DISEASE

    DOI: http://doi.org/10.1136/jnnp-2011-301993.3
    Journal: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
    E-pub date: 1 Mar 2012
    Authors: P McColgan, J Evans, DP Breen, SL Mason, B Ghosh, T Rittman, J Rowe, P Nestor, RA Barker, CH Williams-Gray