College Wolfson College
  • Neurology Unit
  • Research Theme Beyond the Neuron

    Other Interdiciplinary Incentives

  • Cardiovascular Disease
  • Research Focus


  • Carotid Atherosclerosis
  • Atherosclerosis
  • Stroke
  • Stroke Risk
  • Neuroinflammation
  • Frailty
  • Positron Emission Tomography
  • Magnetic Resonance Imaging
  • Clinical Conditions

  • Cerebrovascular disorders
  • Cognitive impairment
  • Stroke
  • Equipment & Techniques

  • Calcium imaging
  • Computerised tomography
  • Magnetic resonance imaging (MRI)
  • Positron Emission Tomography (PET)
  • Randomised control trials
  • Back

    Dr Nicholas Evans

    University Position
    Clinical Senior Lecturer
    Dr Nicholas Evans is pleased to consider applications from prospective PhD students.


    I am a Stroke Association Senior Clinical Lecturer in Cerebrovascular Medicine and Honorary Consultant in Stroke Medicine at Addenbrooke's Hospital. My research investigates atherosclerosis (the hardening of blood vessels as we age), how inflammation within atherosclerosis may affect the brain, and how these processes relate to an individual's overall health (in particular the amount of physiological reserve an individual has to withstand and recover from an illness - a syndrome termed 'frailty'). I lead research programmes investigating how frailty affects treatments and outcomes after stroke, imaging studies to identify carotid atherosclerotic plaques that may cause a stroke, and drug studies where we are repurposing existing drugs used in other conditions to treat atherosclerosis and stroke. My research uses Computed Tomography (CT), Positron Emission Tomography (PET), and Magnetic Resonance Imaging (MRI) to image blood vessels and the brain. This research is a collaboration between the Departments of Clinical Neurosciences, Medicine (Cardiovascular Medicine), and Radiology within the School of Clinical Medicine. Our research has been recognised by awards from the British Atherosclerosis Society, Wellcome Trust, Royal College of Physicians, British Association of Stroke Physicians, Royal Society of Medicine, and British Heart Foundation. Our work has been supported by the Stroke Association, Dunhill Medical Trust, and British Heart Foundation. I hold an honorary clinical post providing clinical care within the Stroke Department at the Cambridge University Hospitals NHS Foundation Trust and am involved in the recruitment of participants into hyper-acute stroke trials. I am an enthusiastic medical educator, leading both the Cambridge INSPIRE Programme and Student Selected Component of the Clinical Medicine course that develop an understanding of medical research and promote clinical academic careers. I am the Director of Studies in Pre-Clinical Medicine at Wolfson College.

    A PET/CT scan showing a 'hot' carotid atherosclerotic plaque.


    Key Publications

    Imaging of the carotid artery.

    Journal: Lancet Neurol
    E-pub date: 1 Jul 2022
    Authors: NR Evans, JHF Rudd, EA Warburton

    Frailty and cerebrovascular disease: Concepts and clinical implications for stroke medicine.

    Journal: Int J Stroke
    E-pub date: 1 Mar 2022
    Authors: NR Evans, OM Todd, JS Minhas, P Fearon, GW Harston, J Mant, G Mead, J Hewitt, TJ Quinn, EA Warburton

    Carotid Atheroinflammation Is Associated With Cerebral Small Vessel Disease Severity.

    Journal: Front Neurol
    E-pub date: 1 Aug 2021
    Authors: NR Evans, JM Tarkin, J Walsh, MM Chowdhury, AJ Patterson, MJ Graves, JHF Rudd, EA Warburton

    Clinical frailty independently predicts early mortality after ischaemic stroke.

    Journal: Age Ageing
    E-pub date: 1 Jul 2020
    Authors: NR Evans, J Wall, B To, SJ Wallis, R Romero-Ortuno, EA Warburton

    Dual-Tracer Positron-Emission Tomography for Identification of Culprit Carotid Plaques and Pathophysiology In Vivo.

    Journal: Circ Cardiovasc Imaging
    E-pub date: 1 Mar 2020
    Authors: NR Evans, JM Tarkin, MM Chowdhury, EPV Le, PA Coughlin, JHF Rudd, EA Warburton

    PET imaging of the neurovascular interface in cerebrovascular disease.

    Journal: Nat Rev Neurol
    E-pub date: 1 Nov 2017
    Authors: NR Evans, JM Tarkin, JR Buscombe, HS Markus, JHF Rudd, EA Warburton

    PET Imaging of Atherosclerotic Disease: Advancing Plaque Assessment from Anatomy to Pathophysiology.

    Journal: Curr Atheroscler Rep
    E-pub date: 1 Jun 2016
    Authors: NR Evans, JM Tarkin, MM Chowdhury, EA Warburton, JHF Rudd


    The contribution of competing mechanisms in stroke despite anticoagulation in patients with atrial fibrillation.

    Journal: Eur Stroke J
    E-pub date: 1 Jun 2023
    Authors: R Herlekar, A Sur Roy, S Hajiev, I Induruwa, S Agarwal, NR Evans, K Khadjooi, H Markus, E O'Brien, E Warburton, G Zachariah, JJ McCabe

    Hyperacute stroke thrombolysis via telemedicine: a multicentre study of performance, safety and clinical efficacy.

    Journal: BMJ Open
    E-pub date: 17 Jan 2022
    Authors: NR Evans, L Sibson, DJ Day, S Agarwal, R Shekhar, EA Warburton

    Atherosclerosis imaging using PET: Insights and applications.

    Journal: Br J Pharmacol
    E-pub date: 1 Jun 2021
    Authors: RS Sriranjan, JM Tarkin, NR Evans, EPV Le, MM Chowdhury, JHF Rudd

    Assessing robustness of carotid artery CT angiography radiomics in the identification of culprit lesions in cerebrovascular events.

    Journal: Sci Rep
    E-pub date: 10 Feb 2021
    Authors: EPV Le, L Rundo, JM Tarkin, NR Evans, MM Chowdhury, PA Coughlin, H Pavey, C Wall, F Zaccagna, FA Gallagher, Y Huang, R Sriranjan, A Le, JR Weir-McCall, M Roberts, FJ Gilbert, EA Warburton, C-B Schönlieb, E Sala, JHF Rudd

    Impact of stroke on outcomes following cardiac surgery: Propensity matched analysis.

    Journal: J Card Surg
    E-pub date: 1 Nov 2020
    Authors: J Karunanantham, JM Ali, NR Evans, S Webb, SR Large

    Integrated cardiovascular assessment of atherosclerosis using PET/MRI.

    Journal: Br J Radiol
    E-pub date: 1 Sep 2020
    Authors: NR Evans, JM Tarkin, EP Le, RS Sriranjan, A Corovic, EA Warburton, JH Rudd

    Vascular Positron Emission Tomography and Restenosis in Symptomatic Peripheral Arterial Disease: A Prospective Clinical Study.

    Journal: JACC Cardiovasc Imaging
    E-pub date: 1 Apr 2020
    Authors: MM Chowdhury, JM Tarkin, MS Albaghdadi, NR Evans, EPV Le, TB Berrett, U Sadat, FR Joshi, EA Warburton, JR Buscombe, PD Hayes, MR Dweck, DE Newby, JHF Rudd, PA Coughlin

    68Ga-DOTATATE PET Identifies Residual Myocardial Inflammation and Bone Marrow Activation After Myocardial Infarction.

    Journal: J Am Coll Cardiol
    E-pub date: 21 May 2019
    Authors: JM Tarkin, C Calcagno, MR Dweck, NR Evans, MM Chowdhury, D Gopalan, DE Newby, ZA Fayad, MR Bennett, JHF Rudd

    18F-FDG Uptake on PET/CT in Symptomatic versus Asymptomatic Carotid Disease: a Meta-Analysis.

    Journal: Eur J Vasc Endovasc Surg
    E-pub date: 31 Aug 2018
    Authors: MM Chowdhury, JM Tarkin, NR Evans, E Le, EA Warburton, PD Hayes, JHF Rudd, PA Coughlin

    Clinical frailty is independently associated with non-prescription of anticoagulants in older patients with atrial fibrillation.

    Journal: Geriatr Gerontol Int
    E-pub date: 1 Nov 2017
    Authors: I Induruwa, NR Evans, A Aziz, S Reddy, K Khadjooi, R Romero-Ortuno

    Molecular imaging of atherosclerosis with integrated PET imaging.

    Journal: J Nucl Cardiol
    E-pub date: 1 Jun 2017
    Authors: B Hammad, NR Evans, JHF Rudd, A Tawakol

    Detection of Atherosclerotic Inflammation by 68Ga-DOTATATE PET Compared to [18F]FDG PET Imaging.

    Journal: J Am Coll Cardiol
    E-pub date: 11 Apr 2017
    Authors: JM Tarkin, FR Joshi, NR Evans, MM Chowdhury, NL Figg, AV Shah, LT Starks, A Martin-Garrido, R Manavaki, E Yu, RE Kuc, L Grassi, R Kreuzhuber, MA Kostadima, M Frontini, PJ Kirkpatrick, PA Coughlin, D Gopalan, TD Fryer, JR Buscombe, AM Groves, WH Ouwehand, MR Bennett, EA Warburton, AP Davenport, JHF Rudd

    Internal carotid artery dissection.

    Journal: Br J Hosp Med (Lond)
    E-pub date: 2 Dec 2016
    Authors: TB Stoker, NR Evans, EA Warburton

    Imaging Atherosclerosis.

    Journal: Circ Res
    E-pub date: 19 Feb 2016
    Authors: JM Tarkin, MR Dweck, NR Evans, RAP Takx, AJ Brown, A Tawakol, ZA Fayad, JHF Rudd

    Running, ischaemic stroke and carotid artery dissection.

    Journal: QJM
    E-pub date: 1 Dec 2015
    Authors: NR Evans, V Harper, DJ Scoffings, EA Warburton