Other Interdiciplinary Incentives
Keywords
Clinical Conditions
Equipment & Techniques
Science Culture
My lab is focused on regeneration and protection of the injured or diseased central nervous system. We study fundamental neuronal cell biology and develop gene therapy candidates for eye disease or spinal cord injury. Our work investigates developmentally regulated axon transport mechanisms that limit the delivery of regenerative proteins and organelles. We find that overcoming these transport limitations can increase regenerative ability. We use fluorescence microscopy, live cell imaging, molecular and cellular techniques to study neuronal and axonal signalling and trafficking pathways, and combine these studies with models of CNS injury and disease. These studies are identifying neuroprotective genes that stimulate axon regeneration in the spinal cord and optic nerve.
Satellite Golgi in Axons and Dendrites
