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College Wolfson College
Department
  • Medicine
    • School
  • Clinical Medicine
    • Institute
  • Wolfson Brain Imaging Centre
  • Division of Anaesthesia
    • ORCID iDClick to view ORCID profile
    Research Theme Brains and Machines Lifelong Brain Development and Brain Ageing Neurons, Circuits and Networks
    Research Focus

    Keywords

  • Brain Imaging
  • Brain Injury
  • Coma
  • Course & Outcome
  • Trajectories
  • Neurotrauma
  • Trauma
  • Traumatic Brain Injury
  • MRI

    • Clinical Conditions

  • Traumatic brain injury

    • Equipment & Techniques

  • Magnetic resonance imaging (MRI)
  • Neuropsychological testing

    • Back

    Virginia Newcombe

    University Position
    Honorary Consultant
    Dr Virginia Newcombe is pleased to consider applications from prospective PhD students.

    Interests

    My research focuses on the use of MR imaging as a biomarker in traumatic brain injury (TBI). I am particularly interested in prediction of outcome after TBI and how acute management influences the long-term outcomes of patients. My projects, which are based in the Emergency Department and Neurosciences Critical Care Unit, encompass the entire spectrum of TBI from mild to severe.

    Collaborators

    Cambridge
  • David Menon
  • Guy Williams
  • Marta Morgado Correia
  • Peter Hutchinson
  • Jonathan Coles
  • Angelos Kolias
  • Adel Helmy

    • Key Publications

    Acute thalamic connectivity precedes chronic post-concussive symptoms in mild traumatic brain injury.

    DOI: http://doi.org/10.1093/brain/awad056
    Journal: Brain
    E-pub date: 1 Aug 2023
    Authors: RE Woodrow, S Winzeck, AI Luppi, IR Kelleher-Unger, LRB Spindler, JTL Wilson, VFJ Newcombe, JP Coles, CENTER-TBI MRI Substudy Participants and Investigators, DK Menon, EA Stamatakis

    Serum biomarkers identify critically ill traumatic brain injury patients for MRI

    DOI: http://doi.org/10.1186/s13054-022-04250-3
    Journal: Critical Care
    E-pub date: 29 Nov 2022
    Authors: S Richter, S Winzeck, E Czeiter, K Amrein, EN Kornaropoulos, J Verheyden, G Sugar, Z Yang, K Wang, AIR Maas, E Steyerberg, A Büki, VFJ Newcombe, DK Menon, K Amrein, N Andelic, L Andreassen, A Anke, P Azouvi, B Bellander, H Benali, A Buki, A Caccioppola, E Calappi, M Carbonara, G Citerio, H Clusmann, M Coburn, J Coles, M Correia, E Czeiter, V De Keyser, V Degos, B Depreitere, L Eikenes, E Ezer, K Foks, S Frisvold, D Galanaud, A Ghuysen, B Glocker, A Haberg, I Haitsma, E Helseth, PJ Hutchinson, E Kornaropoulos, N Kovács, A Kowark, S Laureys, D Ledoux, H Lingsma, AIR Maas, G Manley, DK Menon, T Menovsky, B Misset, V Muraleedharan, I Nakken, V Newcombe, W Nordhøy, J Nyirádi, F Ortolano, PM Parizel, V Perlbarg, P Persona, W Peul, JP Posti, L Puybasset, S Richter, C Roe, O Roise, R Rossaint, S Rossi, D Rueckert, T Skandsen, A Sorinola, E Stamatakis, EW Steyerberg, N Stocchetti, R Takala, V Tamás, O Tenovuo, Z Vámos, G Van der Steen, W Van Hecke, TV Vyvere, J Verheyden, A Vik, V Volovici, LT Westlye, G Williams, S Winzeck, P Ylén, T Zoerle

    Metabolic derangements are associated with impaired glucose delivery following traumatic brain injury.

    DOI: http://doi.org/10.1093/brain/awab255
    Journal: Brain
    E-pub date: 16 Dec 2021
    Authors: J Hermanides, YT Hong, M Trivedi, J Outtrim, F Aigbirhio, PJ Nestor, M Guilfoyle, S Winzeck, VFJ Newcombe, T Das, MM Correia, KLH Carpenter, PJA Hutchinson, AK Gupta, TD Fryer, JD Pickard, DK Menon, JP Coles

    Neuroanatomical Substrates and Symptoms Associated With Magnetic Resonance Imaging of Patients With Mild Traumatic Brain Injury.

    DOI: http://doi.org/10.1001/jamanetworkopen.2021.0994
    Journal: JAMA Netw Open
    E-pub date: 1 Mar 2021
    Authors: S Richter, S Winzeck, EN Kornaropoulos, T Das, T Vande Vyvere, J Verheyden, GB Williams, MM Correia, DK Menon, VFJ Newcombe, Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Magnetic Resonance Imaging (CENTER-TBI MRI) Substudy Participants and Investigators

    Handling of Missing Outcome Data in Traumatic Brain Injury Research: A Systematic Review.

    DOI: http://doi.org/10.1089/neu.2018.6216
    Journal: J Neurotrauma
    E-pub date: 1 Oct 2019
    Authors: S Richter, S Stevenson, T Newman, L Wilson, DK Menon, AIR Maas, D Nieboer, H Lingsma, EW Steyerberg, VFJ Newcombe

    Pathophysiologic Mechanisms of Cerebral Ischemia and Diffusion Hypoxia in Traumatic Brain Injury.

    DOI: http://doi.org/10.1001/jamaneurol.2016.0091
    Journal: JAMA Neurol
    E-pub date: 1 May 2016
    Authors: TV Veenith, EL Carter, T Geeraerts, J Grossac, VFJ Newcombe, J Outtrim, GS Gee, V Lupson, R Smith, FI Aigbirhio, TD Fryer, YT Hong, DK Menon, JP Coles

    Publications

    Brain MRI changes in degenerative cervical myelopathy: a systematic review.

    DOI: http://doi.org/10.1016/j.ebiom.2023.104915
    Journal: EBioMedicine
    E-pub date: 1 Jan 2024
    Authors: A Rafati Fard, OD Mowforth, M Yuan, S Myrtle, KS Lee, A Banerjee, M Khan, MR Kotter, VFJ Newcombe, EA Stamatakis, BM Davies

    Fluid biomarkers and neuroimaging in mild traumatic brain injury: current uses and potential future directions for clinical use in emergency medicine.

    DOI: http://doi.org/10.1136/emermed-2023-213111
    Journal: Emerg Med J
    E-pub date: 1 Sep 2023
    Authors: V Newcombe, S Richter, DP Whitehouse, BM Bloom, F Lecky

    Serum lipidome associates with neuroimaging features in patients with traumatic brain injury

    DOI: http://doi.org/10.1101/2023.03.14.23287262
    Journal:
    E-pub date: 1 Aug 2023
    Authors: I Thomas, VFJ Newcombe, AM Dickens, S Richter, JP Posti, AIR Maas, O Tenovuo, T Hyötyläinen, A Büki, DK Menon, M Orešič

    Use of Support Vector Machines Approach via ComBat Harmonized Diffusion Tensor Imaging for the Diagnosis and Prognosis of Mild Traumatic Brain Injury: A CENTER-TBI Study.

    DOI: http://doi.org/10.1089/neu.2022.0365
    Journal: J Neurotrauma
    E-pub date: 1 Jul 2023
    Authors: M Siqueira Pinto, S Winzeck, EN Kornaropoulos, S Richter, R Paolella, MM Correia, B Glocker, G Williams, A Vik, JP Posti, A Haberg, J Stenberg, P-J Guns, AJ den Dekker, DK Menon, J Sijbers, P Van Dyck, VFJ Newcombe

    Validation of cross-sectional and longitudinal ComBat harmonization methods for magnetic resonance imaging data on a travelling subject cohort.

    DOI: http://doi.org/10.1016/j.ynirp.2022.100136
    Journal: Neuroimage Rep
    E-pub date: 1 Dec 2022
    Authors: S Richter, S Winzeck, MM Correia, EN Kornaropoulos, A Manktelow, J Outtrim, D Chatfield, JP Posti, O Tenovuo, GB Williams, DK Menon, VFJ Newcombe

    Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses.

    DOI: http://doi.org/10.1093/brain/awac321
    Journal: Brain
    E-pub date: 6 Sep 2022
    Authors: EJ Needham, AL Ren, RJ Digby, EJ Norton, S Ebrahimi, JG Outtrim, DA Chatfield, AE Manktelow, MM Leibowitz, VFJ Newcombe, R Doffinger, G Barcenas-Morales, C Fonseca, MJ Taussig, RM Burnstein, RJ Samanta, C Dunai, N Sithole, NJ Ashton, H Zetterberg, M Gisslén, A Edén, E Marklund, PJM Openshaw, J Dunning, MJ Griffiths, J Cavanagh, G Breen, SR Irani, A Elmer, N Kingston, C Summers, JR Bradley, LS Taams, BD Michael, ET Bullmore, KGC Smith, PA Lyons, AJ Coles, DK Menon, Cambridge NeuroCOVID Group, CITIID-NIHR COVID-19 BioResource Collaboration, Cambridge NIHR Clinical Research Facility

    Hospitalisation for COVID-19 predicts long lasting cerebrovascular impairment: A prospective observational cohort study.

    DOI: http://doi.org/10.1016/j.nicl.2022.103253
    Journal: Neuroimage Clin
    E-pub date: 1 Aug 2022
    Authors: KA Tsvetanov, LRB Spindler, EA Stamatakis, VFJ Newcombe, VC Lupson, DA Chatfield, AE Manktelow, JG Outtrim, A Elmer, N Kingston, JR Bradley, ET Bullmore, JB Rowe, DK Menon, Cambridge NeuroCOVID Group, NIHR COVID-19 BioResource, Cambridge NIHR Clinical Research Facility, CITIID-NIHR BioResource COVID-19 Collaboration

    Hospitalisation for COVID-19 predicts long lasting cerebrovascular impairment: A prospective observational cohort study

    DOI: http://doi.org/10.1101/2022.02.01.22270235
    Journal:
    E-pub date: 1 Aug 2022
    Authors: K Tsvetanov, L Spindler, E Stamatakis, VFJ Newcombe, V Lupson, D Chatfield, A Manktelow, J Outtrim, A Elmer, N Kingston, J Bradley, E Bullmore, J Rowe, D Menon, The Cambridge NeuroCOVID Group, The NIHR COVID-19 BioResource, The Cambridge NIHR Clinical Research Facility, The CITIID-NIHR BioResource COVID-19 Collaboration

    Journal update monthly top five.

    DOI: http://doi.org/10.1136/emermed-2021-212197
    Journal: Emerg Med J
    E-pub date: 1 Jan 2022
    Authors: L Barrett, T Adams, DP Whitehouse, S Richter, AA Boyle, V Newcombe

    Brain Injury in COVID-19 is Associated with Autoinflammation and Autoimmunity

    DOI: http://doi.org/10.1101/2021.12.03.21266112
    Journal:
    E-pub date: 1 Aug 2021
    Authors: EJ Needham, AL Ren, RJ Digby, JG Outtrim, DA Chatfield, AE Manktelow, VFJ Newcombe, R Doffinger, G Barcenas-Morales, C Fonseca, MJ Taussig, RM Burnstein, C Dunai, N Sithole, NJ Ashton, H Zetterberg, M Gisslen, A Edén, E Marklund, MJ Griffiths, J Cavanagh, G Breen, SR Irani, A Elmer, N Kingston, JR Bradley, LS Taams, BD Michael, ET Bullmore, KGC Smith, PA Lyons, AJC Coles, DK Menon, the Cambridge NeuroCOVID Group, the NIHR COVID-19 BioResource, Cambridge NIHR Clinical Research Facility

    Outcome Prediction after Moderate and Severe Traumatic Brain Injury: External Validation of Two Established Prognostic Models in 1742 European Patients.

    DOI: http://doi.org/10.1089/neu.2020.7300
    Journal: J Neurotrauma
    E-pub date: 15 May 2021
    Authors: SA Dijkland, IRAR Helmrich, D Nieboer, M van der Jagt, DWJ Dippel, DK Menon, N Stocchetti, AIR Maas, HF Lingsma, EW Steyerberg, CENTER-TBI Participants and Investigators

    Neuroanatomical substrates of generalized brain dysfunction in COVID-19.

    DOI: http://doi.org/10.1007/s00134-020-06241-w
    Journal: Intensive Care Med
    E-pub date: 1 Jan 2021
    Authors: VFJ Newcombe, LRB Spindler, T Das, S Winzeck, K Allinson, EA Stamatakis, DK Menon, Cambridge NeuroCovid Imaging Collaborators

    Understanding the relationship between cognitive performance and function in daily life after traumatic brain injury.

    DOI: http://doi.org/10.1136/jnnp-2020-324492
    Journal: J Neurol Neurosurg Psychiatry
    E-pub date: 2 Dec 2020
    Authors: L Wilson, L Horton, K Kunzmann, BJ Sahakian, VF Newcombe, EA Stamatakis, N von Steinbuechel, K Cunitz, A Covic, A Maas, D Van Praag, D Menon, CENTER-TBI participants and investigators

    Study Design Features Associated with Patient Attrition in Studies of Traumatic Brain Injury: A Systematic Review.

    DOI: http://doi.org/10.1089/neu.2020.7000
    Journal: J Neurotrauma
    E-pub date: 1 Sep 2020
    Authors: S Richter, S Stevenson, T Newman, L Wilson, AIR Maas, D Nieboer, H Lingsma, EW Steyerberg, VFJ Newcombe

    Depression following traumatic brain injury is characterised by dominant and recurring brain loops in self-referential areas

    DOI: http://doi.org/10.1101/2020.08.14.20175000
    Journal:
    E-pub date: 1 Aug 2020
    Authors: I Pappas, L Moreno-López, E Carroll, A Manktelow, J Outtrim, J Coles, V Newcombe, B Sahakian, D Menon, E Stamatakis

    Blood biomarkers on admission in acute traumatic brain injury: Relations to severity, CT findings and care path in the CENTER-TBI study.

    DOI: http://doi.org/10.1016/j.ebiom.2020.102785
    Journal: EBioMedicine
    E-pub date: 1 Jun 2020
    Authors: E Czeiter, K Amrein, BY Gravesteijn, F Lecky, DK Menon, S Mondello, VFJ Newcombe, S Richter, EW Steyerberg, TV Vyvere, J Verheyden, H Xu, Z Yang, AIR Maas, KKW Wang, A Büki, CENTER-TBI Participants and Investigators

    Validation of the short form of the International Crowding Measure in Emergency Departments: an international study.

    DOI: http://doi.org/10.1097/MEJ.0000000000000579
    Journal: Eur J Emerg Med
    E-pub date: 1 Dec 2019
    Authors: A Boyle, P Atkinson, C Basaure Verdejo, E Chan, R Clouston, P Gilligan, K Grewal, I Higginson, P Liston, V Newcombe, V Norton, S Richter, G Stoica, A Wakai

    Neural correlates of visual memory in patients with diffuse axonal injury.

    DOI: http://doi.org/10.1080/02699052.2017.1341998
    Journal: Brain Inj
    E-pub date: 1 Aug 2017
    Authors: J Lauer, L Moreno-López, A Manktelow, EL Carroll, JG Outtrim, JP Coles, VF Newcombe, BJ Sahakian, DK Menon, EA Stamatakis

    VALIDATION OF THE SHORT FORM OF THE INTERNATIONAL CROWDING MEASURE IN EMERGENCY DEPARTMENTS (ICMED): INTERNATIONAL STUDY

    DOI: http://doi.org/10.1136/emermed-2016-206402.12
    Journal: Emergency Medicine Journal
    E-pub date: 1 Dec 2016
    Authors: A Boyle, S Richter, P Atkinson, R Clouston, G Stoica, C Basaure Verdejo, A Wakai, E Chan, K Grewal, P Gilligan, I Higginson, P Liston, V Newcombe, V Norton

    Dynamic Changes in White Matter Abnormalities Correlate With Late Improvement and Deterioration Following TBI: A Diffusion Tensor Imaging Study.

    DOI: http://doi.org/10.1177/1545968315584004
    Journal: Neurorehabil Neural Repair
    E-pub date: 1 Jan 2016
    Authors: VFJ Newcombe, MM Correia, C Ledig, MG Abate, JG Outtrim, D Chatfield, T Geeraerts, AE Manktelow, E Garyfallidis, JD Pickard, BJ Sahakian, PJA Hutchinson, D Rueckert, JP Coles, GB Williams, DK Menon

    Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI): a prospective longitudinal observational study.

    DOI: http://doi.org/10.1227/NEU.0000000000000575
    Journal: Neurosurgery
    E-pub date: 1 Jan 2015
    Authors: AIR Maas, DK Menon, EW Steyerberg, G Citerio, F Lecky, GT Manley, S Hill, V Legrand, A Sorgner, CENTER-TBI Participants and Investigators

    Microstructural basis of contusion expansion in traumatic brain injury: insights from diffusion tensor imaging.

    DOI: http://doi.org/10.1038/jcbfm.2013.11
    Journal: Journal of Cerebral Blood Flow and Metabolism
    E-pub date: 1 Jun 2013
    Authors: VFJ Newcombe, GB Williams, JG Outtrim, D Chatfield, M Gulia Abate, T Geeraerts, A Manktelow, H Room, L Mariappen, PJ Hutchinson, JP Coles, DK Menon