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College Wolfson College
Department
  • Medicine
    • School
  • Clinical Medicine
    • Institute
  • Wolfson Brain Imaging Centre
  • Division of Anaesthesia
    • Research Theme Brains and Machines Lifelong Brain Development and Brain Ageing Neurons, Circuits and Networks
    Research Focus

    Keywords

  • Brain Imaging
  • Brain Injury
  • Coma
  • Course & Outcome
  • Trajectories
  • Neurotrauma
  • Trauma
  • Traumatic Brain Injury
  • MRI

    • Clinical Conditions

  • Traumatic brain injury

    • Equipment & Techniques

  • Magnetic resonance imaging (MRI)
  • Neuropsychological testing

    • Back

    Virginia Newcombe

    University Position
    Honorary Consultant
    Dr Virginia Newcombe is pleased to consider applications from prospective PhD students.

    Interests

    My research focuses on the use of MR imaging as a biomarker in traumatic brain injury (TBI). I am particularly interested in prediction of outcome after TBI and how acute management influences the long-term outcomes of patients. My projects, which are based in the Emergency Department and Neurosciences Critical Care Unit, encompass the entire spectrum of TBI from mild to severe.

    Collaborators

    Cambridge
  • David Menon
  • Guy Williams
  • Marta Morgado Correia
  • Peter Hutchinson
  • Jonathan Coles
  • Angelos Kolias
  • Adel Helmy

    • Key Publications

    Serum biomarkers identify critically ill traumatic brain injury patients for MRI

    DOI: http://doi.org/10.1186/s13054-022-04250-3
    Journal: Crit Care
    E-pub date: 29 Nov 2022
    Authors: S Richter, S Winzeck, E Czeiter, K Amrein, EN Kornaropoulos, J Verheyden, G Sugar, Z Yang, K Wang, AIR Maas, E Steyerberg, A Büki, VFJ Newcombe, DK Menon, K Amrein, N Andelic, L Andreassen, A Anke, P Azouvi, B Bellander, H Benali, A Buki, A Caccioppola, E Calappi, M Carbonara, G Citerio, H Clusmann, M Coburn, J Coles, M Correia, E Czeiter, V De Keyser, V Degos, B Depreitere, L Eikenes, E Ezer, K Foks, S Frisvold, D Galanaud, A Ghuysen, B Glocker, A Haberg, I Haitsma, E Helseth, PJ Hutchinson, E Kornaropoulos, N Kovács, A Kowark, S Laureys, D Ledoux, H Lingsma, AIR Maas, G Manley, DK Menon, T Menovsky, B Misset, V Muraleedharan, I Nakken, V Newcombe, W Nordhøy, J Nyirádi, F Ortolano, PM Parizel, V Perlbarg, P Persona, W Peul, JP Posti, L Puybasset, S Richter, C Roe, O Roise, R Rossaint, S Rossi, D Rueckert, T Skandsen, A Sorinola, E Stamatakis, EW Steyerberg, N Stocchetti, R Takala, V Tamás, O Tenovuo, Z Vámos, G Van der Steen, W Van Hecke, TV Vyvere, J Verheyden, A Vik, V Volovici, LT Westlye, G Williams, S Winzeck, P Ylén, T Zoerle

    Metabolic derangements are associated with impaired glucose delivery following traumatic brain injury.

    DOI: http://doi.org/10.1093/brain/awab255
    Journal: Brain
    E-pub date: 16 Dec 2021
    Authors: J Hermanides, YT Hong, M Trivedi, J Outtrim, F Aigbirhio, PJ Nestor, M Guilfoyle, S Winzeck, VFJ Newcombe, T Das, MM Correia, KLH Carpenter, PJA Hutchinson, AK Gupta, TD Fryer, JD Pickard, DK Menon, JP Coles

    Brain Injury in COVID-19 is Associated with Autoinflammation and Autoimmunity

    DOI: http://doi.org/10.1101/2021.12.03.21266112
    Journal:
    E-pub date: 1 Aug 2021
    Authors: EJ Needham, AL Ren, RJ Digby, JG Outtrim, DA Chatfield, AE Manktelow, VFJ Newcombe, R Doffinger, G Barcenas-Morales, C Fonseca, MJ Taussig, RM Burnstein, C Dunai, N Sithole, NJ Ashton, H Zetterberg, M Gisslen, A Edén, E Marklund, MJ Griffiths, J Cavanagh, G Breen, SR Irani, A Elmer, N Kingston, JR Bradley, LS Taams, BD Michael, ET Bullmore, KGC Smith, PA Lyons, AJC Coles, DK Menon, the Cambridge NeuroCOVID Group, the NIHR COVID-19 BioResource, Cambridge NIHR Clinical Research Facility

    Neuroanatomical Substrates and Symptoms Associated With Magnetic Resonance Imaging of Patients With Mild Traumatic Brain Injury.

    DOI: http://doi.org/10.1001/jamanetworkopen.2021.0994
    Journal: JAMA Netw Open
    E-pub date: 1 Mar 2021
    Authors: S Richter, S Winzeck, EN Kornaropoulos, T Das, T Vande Vyvere, J Verheyden, GB Williams, MM Correia, DK Menon, VFJ Newcombe, Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury Magnetic Resonance Imaging (CENTER-TBI MRI) Substudy Participants and Investigators

    Handling of Missing Outcome Data in Traumatic Brain Injury Research: A Systematic Review.

    DOI: http://doi.org/10.1089/neu.2018.6216
    Journal: J Neurotrauma
    E-pub date: 1 Oct 2019
    Authors: S Richter, S Stevenson, T Newman, L Wilson, DK Menon, AIR Maas, D Nieboer, H Lingsma, EW Steyerberg, VFJ Newcombe

    Pathophysiologic Mechanisms of Cerebral Ischemia and Diffusion Hypoxia in Traumatic Brain Injury.

    DOI: http://doi.org/10.1001/jamaneurol.2016.0091
    Journal: JAMA Neurol
    E-pub date: 1 May 2016
    Authors: TV Veenith, EL Carter, T Geeraerts, J Grossac, VFJ Newcombe, J Outtrim, GS Gee, V Lupson, R Smith, FI Aigbirhio, TD Fryer, YT Hong, DK Menon, JP Coles

    Publications

    Fluid biomarkers and neuroimaging in mild traumatic brain injury: current uses and potential future directions for clinical use in emergency medicine.

    DOI: http://doi.org/10.1136/emermed-2023-213111
    Journal: Emerg Med J
    E-pub date: 1 Sep 2023
    Authors: V Newcombe, S Richter, DP Whitehouse, BM Bloom, F Lecky

    Use of Support Vector Machines Approach via ComBat Harmonized Diffusion Tensor Imaging for the Diagnosis and Prognosis of Mild Traumatic Brain Injury: A CENTER-TBI Study.

    DOI: http://doi.org/10.1089/neu.2022.0365
    Journal: J Neurotrauma
    E-pub date: 1 Jul 2023
    Authors: M Siqueira Pinto, S Winzeck, EN Kornaropoulos, S Richter, R Paolella, MM Correia, B Glocker, G Williams, A Vik, JP Posti, A Haberg, J Stenberg, P-J Guns, AJ den Dekker, DK Menon, J Sijbers, P Van Dyck, VFJ Newcombe

    Serum lipidome associates with neuroimaging features in patients with traumatic brain injury

    DOI: http://doi.org/10.1101/2023.03.14.23287262
    Journal:
    E-pub date: 20 Mar 2023
    Authors: I Thomas, VFJ Newcombe, AM Dickens, S Richter, JP Posti, AIR Maas, O Tenovuo, T Hyötyläinen, A Büki, DK Menon, M Orešič

    Validation of cross-sectional and longitudinal ComBat harmonization methods for magnetic resonance imaging data on a travelling subject cohort.

    DOI: http://doi.org/10.1016/j.ynirp.2022.100136
    Journal: Neuroimage Rep
    E-pub date: 1 Dec 2022
    Authors: S Richter, S Winzeck, MM Correia, EN Kornaropoulos, A Manktelow, J Outtrim, D Chatfield, JP Posti, O Tenovuo, GB Williams, DK Menon, VFJ Newcombe

    Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses.

    DOI: http://doi.org/10.1093/brain/awac321
    Journal: Brain
    E-pub date: 21 Nov 2022
    Authors: EJ Needham, AL Ren, RJ Digby, EJ Norton, S Ebrahimi, JG Outtrim, DA Chatfield, AE Manktelow, MM Leibowitz, VFJ Newcombe, R Doffinger, G Barcenas-Morales, C Fonseca, MJ Taussig, RM Burnstein, RJ Samanta, C Dunai, N Sithole, NJ Ashton, H Zetterberg, M Gisslén, A Edén, E Marklund, PJM Openshaw, J Dunning, MJ Griffiths, J Cavanagh, G Breen, SR Irani, A Elmer, N Kingston, C Summers, JR Bradley, LS Taams, BD Michael, ET Bullmore, KGC Smith, PA Lyons, AJ Coles, DK Menon, Cambridge NeuroCOVID Group, CITIID-NIHR COVID-19 BioResource Collaboration, Cambridge NIHR Clinical Research Facility

    Journal update monthly top five.

    DOI: http://doi.org/10.1136/emermed-2021-212197
    Journal: Emerg Med J
    E-pub date: 1 Jan 2022
    Authors: L Barrett, T Adams, DP Whitehouse, S Richter, AA Boyle, V Newcombe

    Study Design Features Associated with Patient Attrition in Studies of Traumatic Brain Injury: A Systematic Review.

    DOI: http://doi.org/10.1089/neu.2020.7000
    Journal: J Neurotrauma
    E-pub date: 1 Sep 2020
    Authors: S Richter, S Stevenson, T Newman, L Wilson, AIR Maas, D Nieboer, H Lingsma, EW Steyerberg, VFJ Newcombe

    Blood biomarkers on admission in acute traumatic brain injury: Relations to severity, CT findings and care path in the CENTER-TBI study.

    DOI: http://doi.org/10.1016/j.ebiom.2020.102785
    Journal: EBioMedicine
    E-pub date: 1 Jun 2020
    Authors: E Czeiter, K Amrein, BY Gravesteijn, F Lecky, DK Menon, S Mondello, VFJ Newcombe, S Richter, EW Steyerberg, TV Vyvere, J Verheyden, H Xu, Z Yang, AIR Maas, KKW Wang, A Büki, CENTER-TBI Participants and Investigators

    Validation of the short form of the International Crowding Measure in Emergency Departments: an international study.

    DOI: http://doi.org/10.1097/MEJ.0000000000000579
    Journal: Eur J Emerg Med
    E-pub date: 1 Dec 2019
    Authors: A Boyle, P Atkinson, C Basaure Verdejo, E Chan, R Clouston, P Gilligan, K Grewal, I Higginson, P Liston, V Newcombe, V Norton, S Richter, G Stoica, A Wakai

    VALIDATION OF THE SHORT FORM OF THE INTERNATIONAL CROWDING MEASURE IN EMERGENCY DEPARTMENTS (ICMED): INTERNATIONAL STUDY

    DOI: http://doi.org/10.1136/emermed-2016-206402.12
    Journal: Emergency Medicine Journal
    E-pub date: 1 Dec 2016
    Authors: A Boyle, S Richter, P Atkinson, R Clouston, G Stoica, C Basaure Verdejo, A Wakai, E Chan, K Grewal, P Gilligan, I Higginson, P Liston, V Newcombe, V Norton

    Dynamic Changes in White Matter Abnormalities Correlate With Late Improvement and Deterioration Following TBI: A Diffusion Tensor Imaging Study.

    DOI: http://doi.org/10.1177/1545968315584004
    Journal: Neurorehabil Neural Repair
    E-pub date: 1 Jan 2016
    Authors: VFJ Newcombe, MM Correia, C Ledig, MG Abate, JG Outtrim, D Chatfield, T Geeraerts, AE Manktelow, E Garyfallidis, JD Pickard, BJ Sahakian, PJA Hutchinson, D Rueckert, JP Coles, GB Williams, DK Menon

    Microstructural basis of contusion expansion in traumatic brain injury: insights from diffusion tensor imaging.

    DOI: http://doi.org/10.1038/jcbfm.2013.11
    Journal: Journal of Cerebral Blood Flow and Metabolism
    E-pub date: 1 Jun 2013
    Authors: VFJ Newcombe, GB Williams, JG Outtrim, D Chatfield, M Gulia Abate, T Geeraerts, A Manktelow, H Room, L Mariappen, PJ Hutchinson, JP Coles, DK Menon