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EMAIL al857@cam.ac.uk
College St John's College
Department
  • Engineering
    • Institute
  • Division of Anaesthesia
  • Information Engineering
    • ORCID iDClick to view ORCID profile
    Research Theme Brains and Machines Neurons, Circuits and Networks Adaptive Brain Computations
    Research Focus

    Keywords

  • Consciousness
  • Functional Connectivity
  • Receptor
  • Artificial Neural Network
  • Complex Science & Network Analysis
  • Dynamics
  • Information
  • Pharmacology

    • Clinical Conditions

  • Traumatic brain injury

    • Equipment & Techniques

  • Magnetic resonance imaging (MRI)
  • Positron Emission Tomography (PET)

    • Back

    Dr Andrea Luppi

    University Position
    Wellcome Early Career Fellow
    Dr Andrea Luppi is pleased to consider applications from prospective PhD students.

    Interests

    My work investigates how brain function arises from the complex interplay of brain structure and dynamics. To this end, I study how pharmacological and pathological perturbations such as coma, anaesthesia and psychedelics reshape brain function across species (human, macaque, mouse) and across modalities. Working at the intersection of integrative and computational neuroscience, I combine approaches from information theory, network science and whole-brain computational modelling.

    Collaborators

    Cambridge
  • David Menon
  • Emmanuel Stamatakis
  • Daniel Bor
  • James B. Rowe
  • Elisa Galliano
  • Jascha Achterberg
  • Susanna Mierau
  • Petra Vertes
    • External
  • Bratislav Misic
  • Adrian Owen
  • Pedro Mediano
  • Fernando Rosas
  • Robin Carhart-Harris
  • Lorina Naci
  • Bechir Jarraya
  • Enrico Amico

    • Associated News Items

    Key Publications

    Information decomposition and the informational architecture of the brain.

    DOI: http://doi.org/10.1016/j.tics.2023.11.005
    Journal: Trends Cogn Sci
    E-pub date: 1 Apr 2024
    Authors: AI Luppi, FE Rosas, PAM Mediano, DK Menon, EA Stamatakis

    Acute thalamic connectivity precedes chronic post-concussive symptoms in mild traumatic brain injury.

    DOI: http://doi.org/10.1093/brain/awad056
    Journal: Brain
    E-pub date: 1 Aug 2023
    Authors: RE Woodrow, S Winzeck, AI Luppi, IR Kelleher-Unger, LRB Spindler, JTL Wilson, VFJ Newcombe, JP Coles, CENTER-TBI MRI Substudy Participants and Investigators, DK Menon, EA Stamatakis

    Ten simple rules for aspiring graduate students.

    DOI: http://doi.org/10.1371/journal.pcbi.1009276
    Journal: PLoS Comput Biol
    E-pub date: 31 Aug 2021
    Authors: AI Luppi, CC Newton, L Folsom, E Galliano, R Romero-Garcia

    Dopaminergic brainstem disconnection is common to pharmacological and pathological consciousness perturbation.

    DOI: http://doi.org/10.1073/pnas.2026289118
    Journal: Proc Natl Acad Sci U S A
    E-pub date: 27 Jul 2021
    Authors: LRB Spindler, AI Luppi, RM Adapa, MM Craig, P Coppola, ARD Peattie, AE Manktelow, P Finoia, BJ Sahakian, GB Williams, J Allanson, JD Pickard, DK Menon, EA Stamatakis

    Publications

    A Synergistic Workspace for Human Consciousness Revealed by Integrated Information Decomposition

    DOI: http://doi.org/10.7554/eLife.88173
    Journal:
    E-pub date: 18 Jul 2024
    Authors: AI Luppi, PAM Mediano, FE Rosas, J Allanson, JD Pickard, RL Carhart-Harris, GB Williams, MM Craig, P Finoia, AM Owen, L Naci, DK Menon, D Bor, EA Stamatakis

    Systematic evaluation of fMRI data-processing pipelines for consistent functional connectomics

    DOI: http://doi.org/10.1038/s41467-024-48781-5
    Journal: Nature Communications
    E-pub date: 4 Jun 2024
    Authors: AI Luppi, HM Gellersen, Z-Q Liu, ARD Peattie, AE Manktelow, R Adapa, AM Owen, L Naci, DK Menon, SI Dimitriadis, EA Stamatakis

    Oxygen and the Spark of Human Brain Evolution: Complex Interactions of Metabolism and Cortical Expansion across Development and Evolution.

    DOI: http://doi.org/10.1177/10738584221138032
    Journal: Neuroscientist
    E-pub date: 1 Apr 2024
    Authors: AI Luppi, FE Rosas, MP Noonan, PAM Mediano, ML Kringelbach, RL Carhart-Harris, EA Stamatakis, AC Vernon, FE Turkheimer

    A role for the serotonin 2A receptor in the expansion and functioning of human transmodal cortex.

    DOI: http://doi.org/10.1093/brain/awad311
    Journal: Brain
    E-pub date: 4 Jan 2024
    Authors: AI Luppi, M Girn, FE Rosas, C Timmermann, L Roseman, D Erritzoe, DJ Nutt, EA Stamatakis, RN Spreng, L Xing, WB Huttner, RL Carhart-Harris

    General anaesthesia reduces the uniqueness of brain connectivity across individuals and across species.

    DOI: http://doi.org/10.1101/2023.11.08.566332
    Journal:
    E-pub date: 13 Nov 2023
    Authors: AI Luppi, D Golkowski, A Ranft, R Ilg, D Jordan, D Bzdok, AM Owen, L Naci, EA Stamatakis, E Amico, B Misic

    Converging on consistent functional connectomics

    DOI: http://doi.org/10.1101/2023.06.23.546329
    Journal:
    E-pub date: 1 Aug 2023
    Authors: AI Luppi, HM Gellersen, Z-Q Liu, ARD Peattie, AE Manktelow, R Adapa, AM Owen, L Naci, DK Menon, SI Dimitriadis, EA Stamatakis

    A Synergistic Workspace for Human Consciousness Revealed by Integrated Information Decomposition

    DOI: http://doi.org/10.7554/elife.88173.1
    Journal:
    E-pub date: 25 Jul 2023
    Authors: AI Luppi, PAM Mediano, FE Rosas, J Allanson, JD Pickard, RL Carhart-Harris, GB Williams, MM Craig, P Finoia, AM Owen, L Naci, DK Menon, D Bor, EA Stamatakis

    Local Orchestration of Global Functional Patterns Supporting Loss and Restoration of Consciousness in the Primate Brain

    DOI: http://doi.org/10.1101/2023.06.30.547281
    Journal:
    E-pub date: 3 Jul 2023
    Authors: AI Luppi, L Uhrig, J Tasserie, CM Signorelli, E Stamatakis, A Destexhe, B Jarraya, R Cofre

    In vivo mapping of pharmacologically induced functional reorganization onto the human brain’s neurotransmitter landscape.

    DOI: http://doi.org/10.1126/sciadv.adf8332
    Journal: Sci Adv
    E-pub date: 16 Jun 2023
    Authors: AI Luppi, JY Hansen, R Adapa, RL Carhart-Harris, L Roseman, C Timmermann, D Golkowski, A Ranft, R Ilg, D Jordan, V Bonhomme, A Vanhaudenhuyse, A Demertzi, O Jaquet, MA Bahri, NLN Alnagger, P Cardone, ARD Peattie, AE Manktelow, DB de Araujo, SL Sensi, AM Owen, L Naci, DK Menon, B Misic, EA Stamatakis

    Chronic Mild Traumatic Brain Injury: Aberrant Static and Dynamic Connectomic Features Identified Through Machine Learning Model Fusion.

    DOI: http://doi.org/10.1007/s12021-022-09615-1
    Journal: Neuroinformatics
    E-pub date: 1 Apr 2023
    Authors: NJ Simos, K Manolitsi, AI Luppi, A Kagialis, M Antonakakis, M Zervakis, D Antypa, E Kavroulakis, TG Maris, A Vakis, EA Stamatakis, E Papadaki

    Reduced emergent character of neural dynamics in patients with a disrupted connectome.

    DOI: http://doi.org/10.1016/j.neuroimage.2023.119926
    Journal: Neuroimage
    E-pub date: 1 Apr 2023
    Authors: AI Luppi, PAM Mediano, FE Rosas, J Allanson, JD Pickard, GB Williams, MM Craig, P Finoia, ARD Peattie, P Coppola, DK Menon, D Bor, EA Stamatakis

    Distributed harmonic patterns of structure-function dependence orchestrate human consciousness

    DOI: http://doi.org/10.1038/s42003-023-04474-1
    Journal: Commun Biol
    E-pub date: 28 Jan 2023
    Authors: AI Luppi, J Vohryzek, ML Kringelbach, PAM Mediano, MM Craig, R Adapa, RL Carhart-Harris, L Roseman, I Pappas, ARD Peattie, AE Manktelow, BJ Sahakian, P Finoia, GB Williams, J Allanson, JD Pickard, DK Menon, S Atasoy, EA Stamatakis

    Receptor-informed network control theory links LSD and psilocybin to a flattening of the brain’s control energy landscape.

    DOI: http://doi.org/10.1038/s41467-022-33578-1
    Journal: Nat Commun
    E-pub date: 3 Oct 2022
    Authors: SP Singleton, AI Luppi, RL Carhart-Harris, J Cruzat, L Roseman, DJ Nutt, G Deco, ML Kringelbach, EA Stamatakis, A Kuceyeski

    Changes in dynamic transitions between integrated and segregated states underlie visual hallucinations in Parkinson’s disease.

    DOI: http://doi.org/10.1038/s42003-022-03903-x
    Journal: Commun Biol
    E-pub date: 8 Sep 2022
    Authors: A Zarkali, AI Luppi, EA Stamatakis, S Reeves, P McColgan, L-A Leyland, AJ Lees, RS Weil

    Reduced emergent character of neural dynamics in patients with a disrupted connectome

    DOI: http://doi.org/10.1101/2022.06.16.496445
    Journal:
    E-pub date: 1 Aug 2022
    Authors: A Luppi, PAM Mediano, F Rosas, J Allanson, J Pickard, G Williams, M Craig, P Finoia, ARD Peattie, P Coppola, D Menon, D Bor, E Stamatakis

    Mapping Pharmacologically-induced Functional Reorganisation onto the Brain’s Neurotransmitter Landscape

    DOI: http://doi.org/10.1101/2022.07.12.499688
    Journal:
    E-pub date: 13 Jul 2022
    Authors: AI Luppi, JY Hansen, R Adapa, RL Carhart-Harris, L Roseman, C Timmermann, D Golkowski, A Ranft, R Ilg, D Jordan, V Bonhomme, A Vanhaudenhuyse, A Demertzi, O Jaquet, MA Bahri, NLN Alnagger, P Cardone, ARD Peattie, AE Manktelow, DB de Araujo, SL Sensi, AM Owen, L Naci, DK Menon, B Misic, EA Stamatakis

    Network dynamics scale with levels of awareness.

    DOI: http://doi.org/10.1016/j.neuroimage.2022.119128
    Journal: Neuroimage
    E-pub date: 1 Jul 2022
    Authors: P Coppola, LRB Spindler, AI Luppi, R Adapa, L Naci, J Allanson, P Finoia, GB Williams, JD Pickard, AM Owen, DK Menon, EA Stamatakis

    Correction: Mechanisms Underlying Disorders of Consciousness: Bridging Gaps to Move Toward an Integrated Translational Science.

    DOI: http://doi.org/10.1007/s12028-022-01488-1
    Journal: Neurocrit Care
    E-pub date: 1 Jun 2022
    Authors: AI Luppi, J Cain, LRB Spindler, UJ Górska, D Toker, AE Hudson, EN Brown, MN Diringer, RD Stevens, M Massimini, MM Monti, EA Stamatakis, M Boly, Curing Coma Campaign and Its Contributing Collaborators

    A synergistic core for human brain evolution and cognition.

    DOI: http://doi.org/10.1038/s41593-022-01070-0
    Journal: Nat Neurosci
    E-pub date: 1 Jun 2022
    Authors: AI Luppi, PAM Mediano, FE Rosas, N Holland, TD Fryer, JT O'Brien, JB Rowe, DK Menon, D Bor, EA Stamatakis

    Oxygen and the Spark of Human Brain Evolution: a Complex Systems Account

    DOI: http://doi.org/10.20944/preprints202206.0002.v1
    Journal:
    E-pub date: 1 Jun 2022
    Authors: A Luppi, F Rosas, M Noonan, P Mediano, M Kringelbach, R Carhart-Harris, E Stamatakis, A Vernon, F Turkheimer

    Whole-brain modelling identifies distinct but convergent paths to unconsciousness in anaesthesia and disorders of consciousness.

    DOI: http://doi.org/10.1038/s42003-022-03330-y
    Journal: Commun Biol
    E-pub date: 20 Apr 2022
    Authors: AI Luppi, PAM Mediano, FE Rosas, J Allanson, JD Pickard, GB Williams, MM Craig, P Finoia, ARD Peattie, P Coppola, AM Owen, L Naci, DK Menon, D Bor, EA Stamatakis

    Combining network topology and information theory to construct representative brain networks.

    DOI: http://doi.org/10.1162/netn_a_00170
    Journal: Netw Neurosci
    E-pub date: 1 Aug 2021
    Authors: AI Luppi, EA Stamatakis

    Paths to Oblivion: Common Neural Mechanisms of Anaesthesia and Disorders of Consciousness

    DOI: http://doi.org/10.1101/2021.02.14.431140
    Journal:
    E-pub date: 1 Aug 2021
    Authors: A Luppi, PAM Mediano, F Rosas, J Allanson, J Pickard, G Williams, M Craig, P Finoia, ARD Peattie, P Coppola, A Owen, L Naci, D Menon, D Bor, E Stamatakis

    The Inert Brain: Explaining Neural Inertia as Post-anaesthetic Sleep Inertia.

    DOI: http://doi.org/10.3389/fnins.2021.643871
    Journal: Front Neurosci
    E-pub date: 1 Aug 2021
    Authors: AI Luppi, LRB Spindler, DK Menon, EA Stamatakis

    Network dynamics scale with levels of awareness

    DOI: http://doi.org/10.1101/2021.04.12.439452
    Journal:
    E-pub date: 1 Aug 2021
    Authors: P Coppola, LRB Spindler, A Luppi, R Adapa, L Naci, J Allanson, P Finoia, G Williams, J Pickard, A Owen, D Menon, E Stamatakis

    Preserved fractal character of structural brain networks is associated with covert consciousness after severe brain injury.

    DOI: http://doi.org/10.1016/j.nicl.2021.102682
    Journal: Neuroimage Clin
    E-pub date: 1 Aug 2021
    Authors: AI Luppi, MM Craig, P Coppola, ARD Peattie, P Finoia, GB Williams, J Allanson, JD Pickard, DK Menon, EA Stamatakis

    Searching for Consistent Brain Network Topologies Across the Garden of (Shortest) Forking Paths

    DOI: http://doi.org/10.1101/2021.07.13.452257
    Journal:
    E-pub date: 1 Aug 2021
    Authors: A Luppi, H Gellersen, A Peattie, A Manktelow, D Menon, S Dimitriadis, E Stamatakis

    What it is like to be a bit: an integrated information decomposition account of emergent mental phenomena.

    DOI: http://doi.org/10.1093/nc/niab027
    Journal: Neurosci Conscious
    E-pub date: 1 Aug 2021
    Authors: AI Luppi, PAM Mediano, FE Rosas, DJ Harrison, RL Carhart-Harris, D Bor, EA Stamatakis

    Changes in dynamic transitions between integrated and segregated states underlie visual hallucinations in Parkinson’s disease

    DOI: http://doi.org/10.1101/2021.06.21.449237
    Journal:
    E-pub date: 1 Aug 2021
    Authors: A Zarkali, A Luppi, E Stamatakis, S Reeves, P McColgan, L-A Leyland, A Lees, R Weil

    LSD and psilocybin flatten the brain’s energy landscape: insights from receptor-informed network control theory

    DOI: http://doi.org/10.1101/2021.05.14.444193
    Journal:
    E-pub date: 1 Aug 2021
    Authors: P Singleton, A Luppi, R Carhart-Harris, J Cruzat, L Roseman, D Nutt, G Deco, M Kringelbach, M Kringelbach, E Stamatakis, A Kuceyeski

    Mechanisms Underlying Disorders of Consciousness: Bridging Gaps to Move Toward an Integrated Translational Science.

    DOI: http://doi.org/10.1007/s12028-021-01281-6
    Journal: Neurocrit Care
    E-pub date: 1 Jul 2021
    Authors: AI Luppi, J Cain, LRB Spindler, UJ Górska, D Toker, AE Hudson, EN Brown, MN Diringer, RD Stevens, M Massimini, MM Monti, EA Stamatakis, M Boly, Curing Coma Campaign and Its Contributing Collaborators

    Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane.

    DOI: http://doi.org/10.1002/hbm.25405
    Journal: Hum Brain Mapp
    E-pub date: 15 Jun 2021
    Authors: AI Luppi, D Golkowski, A Ranft, R Ilg, D Jordan, DK Menon, EA Stamatakis

    LSD alters dynamic integration and segregation in the human brain.

    DOI: http://doi.org/10.1016/j.neuroimage.2020.117653
    Journal: Neuroimage
    E-pub date: 15 Feb 2021
    Authors: AI Luppi, RL Carhart-Harris, L Roseman, I Pappas, DK Menon, EA Stamatakis

    What it is like to be a bit: An Integrated Information Decomposition account of emergent mental phenomena

    DOI: http://doi.org/10.31234/osf.io/g9p3r
    Journal:
    E-pub date: 29 Jan 2021
    Authors: AI Luppi, P Mediano, F Rosas, DJ Harrison, R Carhart-Harris, D Bor, EA Stamatakis

    A synergistic core for human brain evolution and cognition

    DOI: http://doi.org/10.1101/2020.09.22.308981
    Journal:
    E-pub date: 1 Aug 2020
    Authors: A Luppi, PAM Mediano, F Rosas, N Holland, T Fryer, J O’Brien, J Rowe, D Menon, D Bor, E Stamatakis

    Distributed harmonic patterns of structure-function dependence orchestrate human consciousness

    DOI: http://doi.org/10.1101/2020.08.10.244459
    Journal:
    E-pub date: 1 Aug 2020
    Authors: A Luppi, J Vohryzek, M Kringelbach, PAM Mediano, M Craig, R Adapa, R Carhart-Harris, L Roseman, I Pappas, ARD Peattie, A Manktelow, B Sahakian, P Finoia, G Williams, J Allanson, J Pickard, D Menon, S Atasoy, E Stamatakis

    A Synergistic Workspace for Human Consciousness Revealed by Integrated Information Decomposition

    DOI: http://doi.org/10.1101/2020.11.25.398081
    Journal:
    E-pub date: 1 Aug 2020
    Authors: A Luppi, PAM Mediano, F Rosas, J Allanson, J Pickard, R Carhart-Harris, G Williams, M Craig, P Finoia, A Owen, L Naci, D Menon, D Bor, E Stamatakis

    Consciousness & Brain Functional Complexity in Propofol Anaesthesia.

    DOI: http://doi.org/10.1038/s41598-020-57695-3
    Journal: Sci Rep
    E-pub date: 23 Jan 2020
    Authors: TF Varley, AI Luppi, I Pappas, L Naci, R Adapa, AM Owen, DK Menon, EA Stamatakis

    Consciousness-specific dynamic interactions of brain integration and functional diversity.

    DOI: http://doi.org/10.1038/s41467-019-12658-9
    Journal: Nat Commun
    E-pub date: 10 Oct 2019
    Authors: AI Luppi, MM Craig, I Pappas, P Finoia, GB Williams, J Allanson, JD Pickard, AM Owen, L Naci, DK Menon, EA Stamatakis

    Consciousness & Brain Functional Complexity in Propofol Anaesthesia

    DOI: http://doi.org/10.1101/680447
    Journal:
    E-pub date: 1 Aug 2019
    Authors: TF Varley, A Luppi, I Pappas, L Naci, R Adapa, A Owen, DK Menon, EA Stamatakis