Other Interdiciplinary Incentives
Equipment & Techniques
Memory is a critical function of the brain, but little is known about the mechanisms by which memories are modified, adapted, and persist. Memories are known to 'reconsolidate' undergoing updating and strengthening following their destabilisation at retrieval. I study the neurochemical, molecular and intracellular basis of the reconsolidation process, for aversive (fear) and appetitive (addictive drug) memories. Using translationally relevant animal models of neuropsychiatric disorders, such as post-traumatic stress disorder, drug addiction and obsessive-compulsive disorder, I also focus on using this knowledge of memory reconsolidation mechanisms to develop treatments for these disorders, based on the disruption of maladaptive memories.