• Psychology
  • Other Interdiciplinary Incentives

  • SBS Neuroscience, Psychology and Behaviour theme
  • Research Focus


  • Adaptive Brain
  • Addiction
  • ADHD
  • Dopamine
  • MRI
  • Stress
  • Noradrenaline
  • Clinical Conditions

  • Addiction
  • Equipment & Techniques

  • Magnetic resonance imaging (MRI)
  • Science Culture

  • Industry Engagement
  • Back

    Professor Jeff Dalley

    University Position
    Professor Jeff Dalley is pleased to consider applications from prospective PhD students.


    Primary research interests include behavioural and cognitive neuroscience, psychopharmacology and neuromodulation of limbic cortico-striatal brain circuitry. Specific interests include behavioural and neurobiological endophenotypes and their translational application to complex psychiatric disorders, including schizophrenia, ADHD and OCD. Much of my present research involves understanding the genetic, neurodevelopmental and neurobiological bases of individual differences in behaviour, particularly in relation to pre-disposition to drug abuse and addiction. Experimental approaches include behavioural and cognitive methodologies, in-vivo fibre photometry, intra-cerebral and systemic pharmacology, targeted neural and neurochemical brain lesions, in-vivo neurophysiology, immunohistochemistry, pre-clinical magnetic resonance imaging and positron emission tomography.

    Key Publications

    Glutamate Within the Marmoset Anterior Hippocampus Interacts with Area 25 to Regulate the Behavioral and Cardiovascular Correlates of High-Trait Anxiety.

    Journal: J Neurosci
    E-pub date: 17 Apr 2019
    Authors: JL Zeredo, SKL Quah, CU Wallis, L Alexander, GJ Cockcroft, AM Santangelo, J Xia, Y Shiba, JW Dalley, RN Cardinal, AC Roberts, HF Clarke

    Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates.

    Journal: Neurosci Biobehav Rev
    E-pub date: 1 Nov 2004
    Authors: JW Dalley, RN Cardinal, TW Robbins

    Cognitive inflexibility after prefrontal serotonin depletion.

    Journal: Science
    E-pub date: 7 May 2004
    Authors: HF Clarke, JW Dalley, HS Crofts, TW Robbins, AC Roberts


    Early-life stress biases responding to negative feedback and increases amygdala volume and vulnerability to later-life stress.

    Journal: Transl Psychiatry
    E-pub date: 7 Mar 2023
    Authors: EG Dutcher, L Lopez-Cruz, EAC Pama, M-E Lynall, ICR Bevers, JA Jones, S Khan, SJ Sawiak, AL Milton, MR Clatworthy, TW Robbins, ET Bullmore, JW Dalley

    Sex-dependent effects of early life stress on reinforcement learning and limbic cortico-striatal functional connectivity.

    Journal: Neurobiol Stress
    E-pub date: 1 Jan 2023
    Authors: K Zühlsdorff, L López-Cruz, EG Dutcher, JA Jones, C Pama, S Sawiak, S Khan, AL Milton, TW Robbins, ET Bullmore, JW Dalley

    Prefrontal Cortex Activation and Stopping Performance Underlie the Beneficial Effects of Atomoxetine on Response Inhibition in Healthy Volunteers and Those With Cocaine Use Disorder.

    Journal: Biol Psychiatry Cogn Neurosci Neuroimaging
    E-pub date: 1 Nov 2022
    Authors: P Zhukovsky, S Morein-Zamir, H Ziauddeen, E Fernandez-Egea, C Meng, R Regenthal, BJ Sahakian, ET Bullmore, TW Robbins, JW Dalley, KD Ersche

    Dopamine D2-like receptor stimulation blocks negative feedback in visual and spatial reversal learning in the rat: behavioural and computational evidence.

    Journal: Psychopharmacology (Berl)
    E-pub date: 31 Aug 2019
    Authors: J Alsiö, BU Phillips, J Sala-Bayo, SRO Nilsson, TC Calafat-Pla, A Rizwand, JM Plumbridge, L López-Cruz, JW Dalley, RN Cardinal, AC Mar, TW Robbins

    Role of Central Serotonin in Anticipation of Rewarding and Punishing Outcomes: Effects of Selective Amygdala or Orbitofrontal 5-HT Depletion.

    Journal: Cereb Cortex
    E-pub date: 1 Sep 2015
    Authors: R Rygula, HF Clarke, RN Cardinal, GJ Cockcroft, J Xia, JW Dalley, TW Robbins, AC Roberts

    Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specific.

    Journal: Cereb Cortex
    E-pub date: 1 Jan 2007
    Authors: HF Clarke, SC Walker, JW Dalley, TW Robbins, AC Roberts

    Double dissociation between serotonergic and dopaminergic modulation of medial prefrontal and orbitofrontal cortex during a test of impulsive choice.

    Journal: Cereb Cortex
    E-pub date: 1 Jan 2006
    Authors: CA Winstanley, DEH Theobald, JW Dalley, RN Cardinal, TW Robbins

    Prefrontal serotonin depletion affects reversal learning but not attentional set shifting.

    Journal: J Neurosci
    E-pub date: 12 Jan 2005
    Authors: HF Clarke, SC Walker, HS Crofts, JW Dalley, TW Robbins, AC Roberts

    Cortical cholinergic function and deficits in visual attentional performance in rats following 192 IgG-saporin-induced lesions of the medial prefrontal cortex.

    Journal: Cereb Cortex
    E-pub date: 31 Aug 2004
    Authors: JW Dalley, DE Theobald, P Bouger, Y Chudasama, RN Cardinal, TW Robbins

    Nucleus accumbens dopamine depletion impairs both acquisition and performance of appetitive Pavlovian approach behaviour: implications for mesoaccumbens dopamine function.

    Journal: Behav Brain Res
    E-pub date: 2 Dec 2002
    Authors: JA Parkinson, JW Dalley, RN Cardinal, A Bamford, B Fehnert, G Lachenal, N Rudarakanchana, KM Halkerston, TW Robbins, BJ Everitt

    Distinct changes in cortical acetylcholine and noradrenaline efflux during contingent and noncontingent performance of a visual attentional task.

    Journal: J Neurosci
    E-pub date: 1 Jul 2001
    Authors: JW Dalley, J McGaughy, MT O'Connell, RN Cardinal, L Levita, TW Robbins