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Research Focus

Keywords

  • fMRI Analysis
  • Resting State fMRI
  • Resilience
  • Dementia
  • Multimodal Neuroimaging
  • Clinical Conditions

  • Dementia
  • Equipment & Techniques

  • Magnetic resonance imaging (MRI)
  • Positron Emission Tomography (PET)
  • Electroencephalography (EEG)
  • Computational modelling
  • Cross-sectional and cohort studies
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    Dr Kamen Tsvetanov

    (he/him/his)
    University Position
    Senior Research Associate
    Dr Kamen Tsvetanov is pleased to consider applications from prospective PhD students.

    Interests

    Dr. Tsvetanov is an Alzheimer's Society Dementia Research Leader Fellow in cognitive neuroscience of ageing and dementia. The central goal of his research is to obtain a better understanding of the complex relationship between human brain dynamics and cognition in in relation to genetic, vascular and comorbidity factors. He approaches this goal using a variety of methods, examining human neural dynamics at the neurophysiological, haemodynamic, and neurotransmitter levels with data-driven and generative modelling of magnetic resonance imaging and electrophysiological recordings.

    Brain areas with rich blood supply lower their vascular reactivity with ageing

    Key Publications

    Brain charts for the human lifespan

    DOI: http://doi.org/10.1101/2021.06.08.447489
    Journal:
    E-pub date: 1 Aug 2021
    Authors: RAI Bethlehem, J Seidlitz, SR White, JW Vogel, KM Anderson, C Adamson, S Adler, GS Alexopoulos, E Anagnostou, A Areces-Gonzalez, DE Astle, B Auyeung, M Ayub, G Ball, S Baron-Cohen, R Beare, SA Bedford, V Benegal, F Beyer, J Bin Bae, J Blangero, M Blesa Cábez, JP Boardman, M Borzage, JF Bosch-Bayard, N Bourke, VD Calhoun, MM Chakravarty, C Chen, C Chertavian, G Chetelat, YS Chong, JH Cole, A Corvin, M Costantino, E Courchesne, F Crivello, VL Cropley, J Crosbie, N Crossley, M Delarue, R Delorme, S Desrivieres, G Devenyi, MA Di Biase, R Dolan, KA Donald, G Donohoe, K Dunlop, AD Edwards, JT Elison, CT Ellis, JA Elman, L Eyler, DA Fair, E Feczko, PC Fletcher, P Fonagy, CE Franz, L Galan-Garcia, A Gholipour, J Giedd, JH Gilmore, DC Glahn, I Goodyer, PE Grant, NA Groenewold, FM Gunning, RE Gur, RC Gur, CF Hammill, O Hansson, T Hedden, A Heinz, RN Henson, K Heuer, J Hoare, B Holla, AJ Holmes, R Holt, H Huang, K Im, J Ipser, CR Jack, AP Jackowski, T Jia, KA Johnson, PB Jones, DT Jones, R Kahn, H Karlsson, L Karlsson, R Kawashima, EA Kelley, S Kern, K Kim, MG Kitzbichler, WS Kremen, F Lalonde, B Landeau, S Lee, J Lerch, JD Lewis, J Li, W Liao, C Liston, MV Lombardo, J Lv, C Lynch, TT Mallard, M Marcelis, RD Markello, SR Mathias, B Mazoyer, P McGuire, MJ Meaney, A Mechelli, N Medic, B Misic, SE Morgan, D Mothersill, J Nigg, MQW Ong, C Ortinau, C Ortinau, R Ossenkoppele, M Ouyang, L Palaniyappan, L Paly, PM Pan, C Pantelis, MM Park, T Paus, Z Pausova, D Paz-Linares, A Pichet Binette, K Pierce, X Qian, J Qiu, A Qiu, A Raznahan, T Rittman, A Rodrigue, CK Rollins, R Romero-Garcia, L Ronan, MD Rosenberg, DH Rowitch, GA Salum, TD Satterthwaite, HL Schaare, RJ Schachar, AP Schultz, G Schumann, M Schöll, D Sharp, RT Shinohara, I Skoog, CD Smyser, RA Sperling, DJ Stein, A Stolicyn, J Suckling, G Sullivan, Y Taki, B Thyreau, R Toro, N Traut, KA Tsvetanov, NB Turk-Browne, JJ Tuulari, C Tzourio, É Vachon-Presseau, MJ Valdes-Sosa, PA Valdes-Sosa, SL Valk, T van Amelsvoort, SN Vandekar, L Vasung, LW Victoria, S Villeneuve, A Villringer, A Villringer, PE Vértes, K Wagstyl, YS Wang, SK Warfield, V Warrier, E Westman, ML Westwater, HC Whalley, AV Witte, N Yang, B Yeo, H Yun, A Zalesky, HJ Zar, A Zettergren, JH Zhou, H Ziauddeen, A Zugman, XN Zuo, ET Bullmore, AF Alexander-Bloch, 3R-BRAIN, AIBL, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Repository Without Borders Investigators, UMN BCP, CALM Team, Cam-CAN, CCNP, COBRE, Developing Human Connectome Project, ENIGMA Developmental Brain Age working group, FinnBrain, Harvard Aging Brain Study, IMAGEN, KNE96, The Mayo Clinic Study of Aging, NSPN, POND, The PREVENT-AD Research Group, VETSA

    Publications

    Synaptic density affects clinical severity via network dysfunction in syndromes associated with frontotemporal lobar degeneration.

    DOI: http://doi.org/10.1038/s41467-023-44307-7
    Journal: Nat Commun
    E-pub date: 20 Dec 2023
    Authors: DJ Whiteside, N Holland, KA Tsvetanov, E Mak, M Malpetti, G Savulich, PS Jones, M Naessens, MA Rouse, TD Fryer, YT Hong, FI Aigbirhio, E Mulroy, KP Bhatia, T Rittman, JT O'Brien, JB Rowe

    Locus coeruleus integrity is linked to response inhibition deficits in Parkinson’s disease and progressive supranuclear palsy.

    DOI: http://doi.org/10.1523/JNEUROSCI.0289-22.2023
    Journal: J Neurosci
    E-pub date: 18 Oct 2023
    Authors: R Ye, FH Hezemans, C O'Callaghan, KA Tsvetanov, C Rua, PS Jones, N Holland, M Malpetti, AG Murley, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

    Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia.

    DOI: http://doi.org/10.1093/brain/awad078
    Journal: Brain
    E-pub date: 1 Aug 2023
    Authors: M Malpetti, TE Cope, D Street, PS Jones, FH Hezemans, E Mak, KA Tsvetanov, T Rittman, WR Bevan-Jones, K Patterson, L Passamonti, TD Fryer, YT Hong, FI Aigbirhio, JT O'Brien, JB Rowe

    Lifespan differences in visual short-term memory load-modulated functional connectivity.

    DOI: http://doi.org/10.1016/j.neuroimage.2023.119982
    Journal: Neuroimage
    E-pub date: 15 Apr 2023
    Authors: S Lugtmeijer, L Geerligs, KA Tsvetanov, DJ Mitchell, Cam-Can, KL Campbell

    Hospitalisation for COVID-19 predicts long lasting cerebrovascular impairment: A prospective observational cohort study.

    DOI: http://doi.org/10.1016/j.nicl.2022.103253
    Journal: Neuroimage Clin
    E-pub date: 1 Aug 2022
    Authors: KA Tsvetanov, LRB Spindler, EA Stamatakis, VFJ Newcombe, VC Lupson, DA Chatfield, AE Manktelow, JG Outtrim, A Elmer, N Kingston, JR Bradley, ET Bullmore, JB Rowe, DK Menon, Cambridge NeuroCOVID Group, NIHR COVID-19 BioResource, Cambridge NIHR Clinical Research Facility, CITIID-NIHR BioResource COVID-19 Collaboration

    Hospitalisation for COVID-19 predicts long lasting cerebrovascular impairment: A prospective observational cohort study

    DOI: http://doi.org/10.1101/2022.02.01.22270235
    Journal:
    E-pub date: 1 Aug 2022
    Authors: K Tsvetanov, L Spindler, E Stamatakis, VFJ Newcombe, V Lupson, D Chatfield, A Manktelow, J Outtrim, A Elmer, N Kingston, J Bradley, E Bullmore, J Rowe, D Menon, The Cambridge NeuroCOVID Group, The NIHR COVID-19 BioResource, The Cambridge NIHR Clinical Research Facility, The CITIID-NIHR BioResource COVID-19 Collaboration

    In Vivo 18F-Flortaucipir PET Does Not Accurately Support the Staging of Progressive Supranuclear Palsy.

    DOI: http://doi.org/10.2967/jnumed.121.262985
    Journal: J Nucl Med
    E-pub date: 1 Jul 2022
    Authors: M Malpetti, SS Kaalund, KA Tsvetanov, T Rittman, M Briggs, KSJ Allinson, L Passamonti, N Holland, PS Jones, TD Fryer, YT Hong, A Kouli, WR Bevan-Jones, E Mak, G Savulich, MG Spillantini, FI Aigbirhio, CH Williams-Gray, JT O'Brien, JB Rowe

    Noradrenergic deficits contribute to apathy in Parkinson’s disease through the precision of expected outcomes.

    DOI: http://doi.org/10.1371/journal.pcbi.1010079
    Journal: PLoS Comput Biol
    E-pub date: 1 May 2022
    Authors: FH Hezemans, N Wolpe, C O'Callaghan, R Ye, C Rua, PS Jones, AG Murley, N Holland, R Regenthal, KA Tsvetanov, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

    Brain charts for the human lifespan

    DOI: http://doi.org/10.1038/s41586-022-04554-y
    Journal: Nature
    E-pub date: 1 Apr 2022
    Authors: RAI Bethlehem, J Seidlitz, SR White, JW Vogel, KM Anderson, C Adamson, S Adler, GS Alexopoulos, E Anagnostou, A Areces-Gonzalez, DE Astle, B Auyeung, M Ayub, G Ball, S Baron-Cohen, R Beare, SA Bedford, V Benegal, F Beyer, J Bin Bae, J Blangero, M Blesa Cábez, JP Boardman, M Borzage, JF Bosch-Bayard, N Bourke, VD Calhoun, MM Chakravarty, C Chen, C Chertavian, G Chetelat, YS Chong, JH Cole, A Corvin, E Courchesne, F Crivello, VL Cropley, J Crosbie, N Crossley, M Delarue, S Desrivieres, G Devenyi, MA Di Biase, R Dolan, KA Donald, G Donohoe, K Dunlop, AD Edwards, JT Elison, CT Ellis, JA Elman, L Eyler, DA Fair, PC Fletcher, P Fonagy, CE Franz, L Galan-Garcia, A Gholipour, J Giedd, JH Gilmore, DC Glahn, I Goodyer, PE Grant, NA Groenewold, FM Gunning, RE Gur, RC Gur, CF Hammill, O Hansson, T Hedden, A Heinz, R Henson, K Heuer, J Hoare, B Holla, AJ Holmes, R Holt, H Huang, K Im, J Ipser, CR Jack, AP Jackowski, T Jia, KA Johnson, PB Jones, DT Jones, R Kahn, H Karlsson, L Karlsson, R Kawashima, EA Kelley, S Kern, K Kim, MG Kitzbichler, WS Kremen, F Lalonde, B Landeau, S Lee, J Lerch, JD Lewis, J Li, W Liao, DP Linares, C Liston, MV Lombardo, J Lv, C Lynch, TT Mallard, M Marcelis, RD Markello, B Mazoyer, P McGuire, MJ Meaney, A Mechelli, N Medic, B Misic, SE Morgan, D Mothersill, J Nigg, MQW Ong, C Ortinau, R Ossenkoppele, M Ouyang, L Palaniyappan, L Paly, PM Pan, C Pantelis, MM Park, T Paus, Z Pausova, A Pichet Binette, K Pierce, X Qian, J Qiu, A Qiu, A Raznahan, T Rittman, CK Rollins, R Romero-Garcia, L Ronan, MD Rosenberg, DH Rowitch, GA Salum, TD Satterthwaite, HL Schaare, RJ Schachar, AP Schultz, G Schumann, M Schöll, D Sharp, RT Shinohara, I Skoog, CD Smyser, RA Sperling, DJ Stein, A Stolicyn, J Suckling, G Sullivan, Y Taki, B Thyreau, R Toro, KA Tsvetanov, NB Turk-Browne, JJ Tuulari, C Tzourio, É Vachon-Presseau, MJ Valdes-Sosa, PA Valdes-Sosa, SL Valk, T van Amelsvoort, SN Vandekar, L Vasung, LW Victoria, S Villeneuve, A Villringer, PE Vértes, K Wagstyl, YS Wang, SK Warfield, V Warrier, E Westman, ML Westwater, HC Whalley, AV Witte, N Yang, BTT Yeo, HJ Yun, A Zalesky, HJ Zar, A Zettergren, JH Zhou, H Ziauddeen, A Zugman, XN Zuo, AF Alexander-Bloch, AIBL, Alzheimer’s Disease Neuroimaging Initiative, Alzheimer’s Disease Repository Without Borders Investigators, ASRB, CALM Team, Cam-CAN, CCNP, 3R-BRAIN, COBRE, ENIGMA Developmental Brain Age working group, FinnBrain, Harvard Aging Brain Study, IMAGEN, KNE96, NSPN, OASIS-3, OpenPain Project, POND, The PREVENT-AD Research Group, VETSA, Bullmore, E.T

    Proton magnetic resonance spectroscopy in frontotemporal lobar degeneration-related syndromes.

    DOI: http://doi.org/10.1016/j.neurobiolaging.2021.10.012
    Journal: Neurobiol Aging
    E-pub date: 1 Mar 2022
    Authors: AG Murley, KA Tsvetanov, MA Rouse, PS Jones, K Sværke, W Li, A Carpenter, JB Rowe

    Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease.

    DOI: http://doi.org/10.1093/brain/awab142
    Journal: Brain
    E-pub date: 4 Sep 2021
    Authors: C O'Callaghan, FH Hezemans, R Ye, C Rua, PS Jones, AG Murley, N Holland, R Regenthal, KA Tsvetanov, N Wolpe, RA Barker, CH Williams-Gray, TW Robbins, L Passamonti, JB Rowe

    Proton magnetic resonance spectroscopy in frontotemporal lobar degeneration-related syndromes

    DOI: http://doi.org/10.1101/2021.01.11.21249589
    Journal:
    E-pub date: 1 Aug 2021
    Authors: A Murley, K Tsvetanov, M Rouse, S Jones, K Sværke, W Li, A Carpenter, J Rowe

    Noradrenergic deficits contribute to apathy in Parkinson’s disease through the precision of expected outcomes

    DOI: http://doi.org/10.1101/2021.07.04.21259922
    Journal:
    E-pub date: 1 Aug 2021
    Authors: F Hezemans, N Wolpe, C O’Callaghan, R Ye, C Rua, S Jones, A Murley, N Holland, R Regenthal, K Tsvetanov, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

    Reduced locus coeruleus integrity linked to response inhibition deficits in parkinsonian disorders

    DOI: http://doi.org/10.1101/2021.10.14.21264996
    Journal:
    E-pub date: 1 Aug 2021
    Authors: R Ye, F Hezemans, C O’Callaghan, K Tsvetanov, C Rua, S Jones, N Holland, M Malpetti, A Murley, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

    Apathy in presymptomatic genetic frontotemporal dementia predicts cognitive decline and is driven by structural brain changes.

    DOI: http://doi.org/10.1002/alz.12252
    Journal: Alzheimers Dement
    E-pub date: 1 Jun 2021
    Authors: M Malpetti, PS Jones, KA Tsvetanov, T Rittman, JC van Swieten, B Borroni, R Sanchez-Valle, F Moreno, R Laforce, C Graff, M Synofzik, D Galimberti, M Masellis, MC Tartaglia, E Finger, R Vandenberghe, A de Mendonça, F Tagliavini, I Santana, S Ducharme, CR Butler, A Gerhard, J Levin, A Danek, M Otto, GB Frisoni, R Ghidoni, S Sorbi, C Heller, EG Todd, M Bocchetta, DM Cash, RS Convery, G Peakman, KM Moore, JD Rohrer, RA Kievit, JB Rowe, Genetic FTD Initiative (GENFI)

    Brain functional network integrity sustains cognitive function despite atrophy in presymptomatic genetic frontotemporal dementia.

    DOI: http://doi.org/10.1002/alz.12209
    Journal: Alzheimers Dement
    E-pub date: 1 Mar 2021
    Authors: KA Tsvetanov, S Gazzina, PS Jones, J van Swieten, B Borroni, R Sanchez-Valle, F Moreno, R Laforce, C Graff, M Synofzik, D Galimberti, M Masellis, MC Tartaglia, E Finger, R Vandenberghe, A de Mendonça, F Tagliavini, I Santana, S Ducharme, C Butler, A Gerhard, A Danek, J Levin, M Otto, G Frisoni, R Ghidoni, S Sorbi, JD Rohrer, JB Rowe, Genetic FTD Initiative, GENFI

    An in vivo probabilistic atlas of the human locus coeruleus at ultra-high field.

    DOI: http://doi.org/10.1016/j.neuroimage.2020.117487
    Journal: Neuroimage
    E-pub date: 15 Jan 2021
    Authors: R Ye, C Rua, C O'Callaghan, PS Jones, FH Hezemans, SS Kaalund, KA Tsvetanov, CT Rodgers, G Williams, L Passamonti, JB Rowe

    The prognostic role of microglia and tau PET in Alzheimer’s disease

    DOI: http://doi.org/10.1002/alz.039817
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2020
    Authors: M Malpetti, RA Kievit, L Passamonti, PS Jones, KA Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan‐Jones, L Su, YT Hong, TD Fryer, FI Aigbirho, JT O'Brien, JB Rowe

    Trajectory of apathy, cognition and neural correlates in the decades before symptoms in frontotemporal dementia

    DOI: http://doi.org/10.1002/alz.041821
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Dec 2020
    Authors: M Malpetti, RA Kievit, PS Jones, T Rittman, KA Tsvetanov, JC van Swieten, B Borroni, D Galimberti, R Sanchez‐Valle, R Laforce, F Moreno, M Synofzik, C Graff, M Masellis, C Tartaglia, R Vandenberghe, E Finger, F Tagliavini, A de Mendonca, I Santana, C Butler, S Ducharme, A Gerhard, A Danek, J Levin, M Otto, GB Frisoni, R Ghidoni, C Heller, E Todd, M Bocchetta, RS Convery, G Peakman, KM Moore, JD Rohrer, JB Rowe

    Metabolomic changes associated with frontotemporal lobar degeneration syndromes.

    DOI: http://doi.org/10.1007/s00415-020-09824-1
    Journal: J Neurol
    E-pub date: 31 Aug 2020
    Authors: AG Murley, PS Jones, I Coyle Gilchrist, L Bowns, J Wiggins, KA Tsvetanov, JB Rowe

    Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson’s disease

    DOI: http://doi.org/10.1101/2020.09.03.20176800
    Journal:
    E-pub date: 1 Aug 2020
    Authors: C O’Callaghan, F Hezemans, R Ye, C Rua, S Jones, A Murley, N Holland, R Regenthal, K Tsvetanov, N Wolpe, R Barker, C Williams-Gray, T Robbins, L Passamonti, J Rowe

    Redefining the multidimensional clinical phenotypes of frontotemporal lobar degeneration syndromes.

    DOI: http://doi.org/10.1093/brain/awaa097
    Journal: Brain
    E-pub date: 1 May 2020
    Authors: AG Murley, I Coyle-Gilchrist, MA Rouse, PS Jones, W Li, J Wiggins, C Lansdall, PV Rodríguez, A Wilcox, KA Tsvetanov, K Patterson, MA Lambon Ralph, JB Rowe

    Microglial activation and tau burden predict cognitive decline in Alzheimer’s disease.

    DOI: http://doi.org/10.1093/brain/awaa088
    Journal: Brain
    E-pub date: 1 May 2020
    Authors: M Malpetti, RA Kievit, L Passamonti, PS Jones, KA Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, YT Hong, TD Fryer, FI Aigbirhio, JT O'Brien, JB Rowe

    Microglial activation and tau burden predict cognitive decline in Alzheimer’s Disease

    DOI: http://doi.org/10.1101/19011189
    Journal:
    E-pub date: 8 Nov 2019
    Authors: M Malpetti, R Kievit, L Passamonti, S Jones, K Tsvetanov, T Rittman, E Mak, N Nicastro, WR Bevan-Jones, L Su, Y Hong, T Fryer, F Aigbirhio, J O'Brien, J Rowe

    Perceptual and conceptual processing of visual objects across the adult lifespan.

    DOI: http://doi.org/10.1038/s41598-019-50254-5
    Journal: Sci Rep
    E-pub date: 24 Sep 2019
    Authors: R Bruffaerts, LK Tyler, M Shafto, KA Tsvetanov, Cambridge Centre for Ageing and Neuroscience, A Clarke

    O4‐03‐06: LONGITUDINAL ASSOCIATION BETWEEN APATHY AND COGNITIVE DECLINE IN PRE‐ AND POST‐SYMPTOMATIC GENETIC FRONTOTEMPORAL DEMENTIA

    DOI: http://doi.org/10.1016/j.jalz.2019.06.4757
    Journal: Alzheimer's & Dementia
    E-pub date: 1 Jul 2019
    Authors: M Malpetti, RA Kievit, PS Jones, T Rittman, KA Tsvetanov, JC van Swieten, B Borroni, D Galimberti, R Sanchez-Valle, R Laforce, F Moreno, M Synofzik, C Graff, M Masellis, C Tartaglia, R Vandenberghe, E Finger, F Tagliavini, A Mendonca, I Santana, CR Butler, S Ducharme, A Gerhard, A Danek, J Levin, M Otto, GB Frisoni, S Cappa, C Heller, RS Convery, KM Dick, JD Rohrer, JB Rowe