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EMAIL jwd20@cam.ac.uk
College St Catharine's College
Department
  • Psychology
    • School
  • Biological Sciences
    • Institute
  • Behavioural and Clinical Neuroscience Institute
    • Click to view home page
    Research Theme Adaptive Brain Computations Neurons, Circuits and Networks Lifelong Brain Development and Brain Ageing

    Other Interdiciplinary Incentives

  • SBS Neuroscience, Psychology and Behaviour theme

    • Research Focus

    Keywords

  • Adaptive Brain
  • Addiction
  • ADHD
  • Dopamine
  • MRI
  • Stress
  • Noradrenaline

    • Clinical Conditions

  • Addiction

    • Equipment & Techniques

  • Magnetic resonance imaging (MRI)
  • FPLC/HPLC

    • Science Culture

  • Industry Engagement

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    Professor Jeff Dalley

    University Position
    Professor
    Professor Jeff Dalley is pleased to consider applications from prospective PhD students.

    Interests

    Primary research interests include behavioural and cognitive neuroscience, psychopharmacology and neuromodulation of limbic cortico-striatal brain circuitry. Specific interests include behavioural and neurobiological endophenotypes and their translational application to complex psychiatric disorders, including schizophrenia, ADHD and OCD. Much of my present research involves understanding the genetic, neurodevelopmental and neurobiological bases of individual differences in behaviour, particularly in relation to pre-disposition to drug abuse and addiction. Experimental approaches include behavioural and cognitive methodologies, in-vivo fibre photometry, intra-cerebral and systemic pharmacology, targeted neural and neurochemical brain lesions, in-vivo neurophysiology, immunohistochemistry, pre-clinical magnetic resonance imaging and positron emission tomography.

    Collaborators

    Cambridge
  • David Belin
  • Amy Milton
  • Stephen Sawiak
  • Barry Everitt
  • Trevor Robbins
  • Zoe Kourtzi
  • Rebecca Lawson

    • Key Publications

    Glutamate Within the Marmoset Anterior Hippocampus Interacts with Area 25 to Regulate the Behavioral and Cardiovascular Correlates of High-Trait Anxiety.

    DOI: http://doi.org/10.1523/JNEUROSCI.2451-18.2018
    Journal: J Neurosci
    E-pub date: 17 Apr 2019
    Authors: JL Zeredo, SKL Quah, CU Wallis, L Alexander, GJ Cockcroft, AM Santangelo, J Xia, Y Shiba, JW Dalley, RN Cardinal, AC Roberts, HF Clarke

    Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement.

    DOI: http://doi.org/10.1126/science.1137073
    Journal: Science
    E-pub date: 2 Mar 2007
    Authors: JW Dalley, TD Fryer, L Brichard, ESJ Robinson, DEH Theobald, K Lääne, Y Peña, ER Murphy, Y Shah, K Probst, I Abakumova, FI Aigbirhio, HK Richards, Y Hong, J-C Baron, BJ Everitt, TW Robbins

    Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates.

    DOI: http://doi.org/10.1016/j.neubiorev.2004.09.006
    Journal: Neurosci Biobehav Rev
    E-pub date: 1 Nov 2004
    Authors: JW Dalley, RN Cardinal, TW Robbins

    Cognitive inflexibility after prefrontal serotonin depletion.

    DOI: http://doi.org/10.1126/science.1094987
    Journal: Science
    E-pub date: 7 May 2004
    Authors: HF Clarke, JW Dalley, HS Crofts, TW Robbins, AC Roberts

    Publications

    Early-life stress biases responding to negative feedback and increases amygdala volume and vulnerability to later-life stress.

    DOI: http://doi.org/10.1038/s41398-023-02385-7
    Journal: Transl Psychiatry
    E-pub date: 7 Mar 2023
    Authors: EG Dutcher, L Lopez-Cruz, EAC Pama, M-E Lynall, ICR Bevers, JA Jones, S Khan, SJ Sawiak, AL Milton, MR Clatworthy, TW Robbins, ET Bullmore, JW Dalley

    Sex-dependent effects of early life stress on reinforcement learning and limbic cortico-striatal functional connectivity.

    DOI: http://doi.org/10.1016/j.ynstr.2022.100507
    Journal: Neurobiol Stress
    E-pub date: 1 Jan 2023
    Authors: K Zühlsdorff, L López-Cruz, EG Dutcher, JA Jones, C Pama, S Sawiak, S Khan, AL Milton, TW Robbins, ET Bullmore, JW Dalley

    Prefrontal Cortex Activation and Stopping Performance Underlie the Beneficial Effects of Atomoxetine on Response Inhibition in Healthy Volunteers and Those With Cocaine Use Disorder.

    DOI: http://doi.org/10.1016/j.bpsc.2021.08.010
    Journal: Biol Psychiatry Cogn Neurosci Neuroimaging
    E-pub date: 1 Nov 2022
    Authors: P Zhukovsky, S Morein-Zamir, H Ziauddeen, E Fernandez-Egea, C Meng, R Regenthal, BJ Sahakian, ET Bullmore, TW Robbins, JW Dalley, KD Ersche

    Dopamine D2-like receptor stimulation blocks negative feedback in visual and spatial reversal learning in the rat: behavioural and computational evidence.

    DOI: http://doi.org/10.1007/s00213-019-05296-y
    Journal: Psychopharmacology (Berl)
    E-pub date: 31 Aug 2019
    Authors: J Alsiö, BU Phillips, J Sala-Bayo, SRO Nilsson, TC Calafat-Pla, A Rizwand, JM Plumbridge, L López-Cruz, JW Dalley, RN Cardinal, AC Mar, TW Robbins

    Role of Central Serotonin in Anticipation of Rewarding and Punishing Outcomes: Effects of Selective Amygdala or Orbitofrontal 5-HT Depletion.

    DOI: http://doi.org/10.1093/cercor/bhu102
    Journal: Cereb Cortex
    E-pub date: 1 Sep 2015
    Authors: R Rygula, HF Clarke, RN Cardinal, GJ Cockcroft, J Xia, JW Dalley, TW Robbins, AC Roberts

    Dissociable rate-dependent effects of oral methylphenidate on impulsivity and D2/3 receptor availability in the striatum.

    DOI: http://doi.org/10.1523/JNEUROSCI.3890-14.2015
    Journal: J Neurosci
    E-pub date: 4 Mar 2015
    Authors: D Caprioli, B Jupp, YT Hong, SJ Sawiak, V Ferrari, L Wharton, DJ Williamson, C McNabb, D Berry, FI Aigbirhio, TW Robbins, TD Fryer, JW Dalley

    Translating positron emission tomography studies in animals to stimulant addiction: promises and pitfalls.

    DOI: http://doi.org/10.1016/j.conb.2013.04.003
    Journal: Current Opinion in Neurobiology
    E-pub date: 1 Aug 2013
    Authors: D Caprioli, TD Fryer, SJ Sawiak, FI Aigbirhio, JW Dalley

    Baseline-dependent effects of cocaine pre-exposure on impulsivity and D2/3 receptor availability in the rat striatum: possible relevance to the attention-deficit hyperactivity syndrome.

    DOI: http://doi.org/10.1038/npp.2013.44
    Journal: Neuropsychopharmacology
    E-pub date: 1 Jul 2013
    Authors: D Caprioli, YT Hong, SJ Sawiak, V Ferrari, DJ Williamson, B Jupp, T Adrian Carpenter, FI Aigbirhio, BJ Everitt, TW Robbins, TD Fryer, JW Dalley

    Synthesis and evaluation of 18F-FE-PEO in rodents: an 18F-labeled full agonist for opioid receptor imaging.

    DOI: http://doi.org/10.2967/jnumed.112.108688
    Journal: J Nucl Med
    E-pub date: 1 Feb 2013
    Authors: PJ Riss, YT Hong, J Marton, D Caprioli, DJ Williamson, V Ferrari, N Saigal, BL Roth, G Henriksen, TD Fryer, JW Dalley, FI Aigbirhio

    Applications of positron emission tomography in animal models of neurological and neuropsychiatric disorders.

    DOI: http://doi.org/10.1016/j.neubiorev.2012.01.009
    Journal: Neuroscience and Biobehavioral Reviews
    E-pub date: 1 Apr 2012
    Authors: K Virdee, P Cumming, D Caprioli, B Jupp, A Rominger, FI Aigbirhio, TD Fryer, PJ Riss, JW Dalley

    Validation and quantification of [18F]altanserin binding in the rat brain using blood input and reference tissue modeling.

    DOI: http://doi.org/10.1038/jcbfm.2011.94
    Journal: J Cereb Blood Flow Metab
    E-pub date: 1 Dec 2011
    Authors: PJ Riss, YT Hong, D Williamson, D Caprioli, S Sitnikov, V Ferrari, SJ Sawiak, J-C Baron, JW Dalley, TD Fryer, FI Aigbirhio

    Modelling human drug abuse and addiction with dedicated small animal positron emission tomography.

    DOI: http://doi.org/10.1016/j.neuropharm.2008.05.029
    Journal: Neuropharmacology
    E-pub date: 1 Aug 2009
    Authors: JW Dalley, TD Fryer, FI Aigbirhio, L Brichard, HK Richards, YT Hong, J-C Baron, BJ Everitt, TW Robbins

    Cognitive inflexibility after prefrontal serotonin depletion is behaviorally and neurochemically specific.

    DOI: http://doi.org/10.1093/cercor/bhj120
    Journal: Cereb Cortex
    E-pub date: 1 Jan 2007
    Authors: HF Clarke, SC Walker, JW Dalley, TW Robbins, AC Roberts

    Double dissociation between serotonergic and dopaminergic modulation of medial prefrontal and orbitofrontal cortex during a test of impulsive choice.

    DOI: http://doi.org/10.1093/cercor/bhi088
    Journal: Cereb Cortex
    E-pub date: 1 Jan 2006
    Authors: CA Winstanley, DEH Theobald, JW Dalley, RN Cardinal, TW Robbins

    Prefrontal serotonin depletion affects reversal learning but not attentional set shifting.

    DOI: http://doi.org/10.1523/JNEUROSCI.3690-04.2005
    Journal: J Neurosci
    E-pub date: 12 Jan 2005
    Authors: HF Clarke, SC Walker, HS Crofts, JW Dalley, TW Robbins, AC Roberts

    Cortical cholinergic function and deficits in visual attentional performance in rats following 192 IgG-saporin-induced lesions of the medial prefrontal cortex.

    DOI: http://doi.org/10.1093/cercor/bhh052
    Journal: Cereb Cortex
    E-pub date: 31 Aug 2004
    Authors: JW Dalley, DE Theobald, P Bouger, Y Chudasama, RN Cardinal, TW Robbins

    Nucleus accumbens dopamine depletion impairs both acquisition and performance of appetitive Pavlovian approach behaviour: implications for mesoaccumbens dopamine function.

    DOI: http://doi.org/10.1016/s0166-4328(02)00291-7
    Journal: Behav Brain Res
    E-pub date: 2 Dec 2002
    Authors: JA Parkinson, JW Dalley, RN Cardinal, A Bamford, B Fehnert, G Lachenal, N Rudarakanchana, KM Halkerston, TW Robbins, BJ Everitt

    Distinct changes in cortical acetylcholine and noradrenaline efflux during contingent and noncontingent performance of a visual attentional task.

    DOI: http://doi.org/10.1523/JNEUROSCI.21-13-04908.2001
    Journal: J Neurosci
    E-pub date: 1 Jul 2001
    Authors: JW Dalley, J McGaughy, MT O'Connell, RN Cardinal, L Levita, TW Robbins