EMAIL ef280@cam.ac.uk

Department

School

Clinical Medicine

Institute

Behavioural and Clinical Neuroscience Institute

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Research Theme Beyond the Neuron Adaptive Brain Computations

Research Focus

Keywords

Schizophrenia

Antipsychotics

Clozapine

Aetiology

Clinical Trials

Clinical Conditions

Schizophrenia

Equipment & Techniques

Neuropsychological testing

Randomised control trials

Statistical analysis

Computational modelling

Science Culture

History of Science

Philosophy of Science

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Emilio Fernandez-Egea MBBS MA (Cantab) DStat MD PhD

University Position

Associate Professor
Affiliated Member

Dr Emilio Fernandez-Egea is pleased to consider applications from prospective PhD students.

Interests

My research interests are mostly the biological and clinical aspects of chronic schizophrenia. I’m the Cambridge Psychosis Centre and Clozapine Clinic Lead for the local MH Trust (Cambridgeshire and Peterborough NHS Foundation Trust). We study all aspects of the treatment resistant schizophrenia including psychosis but mostly the non-psychotic symptoms: poor motivation, decreased emotional life, cognition and others. In our studies, we use different methods and techniques, including blood biomarkers, clinical epidemiology, computational neuroscience, as well as clinical trials with new interventions (both pharmacological and non-pharmacological). Our main lines of research are: 1) the link between metabolic abnormalities and schizophrenia, 2) the understanding of negative symptoms and, 3) uncommon antipsychotic-induced side effects (i.e. compulsive behaviour). Additionally, I am deputy editor for the British Journal of Psychiatry and Spanish Journal of Psychiatry and Mental Health.

Collaborators

Cambridge

External

Key Publications

The role of psychosis and clozapine load in excessive checking in treatment-resistant schizophrenia: longitudinal observational study.

DOI: http://doi.org/10.1192/bjp.2024.30
Journal: Br J Psychiatry
E-pub date: 1 May 2024
Authors: E Fernandez-Egea, S Chen, E Sangüesa, P Gassó, M Biria, J Plaistow, I Jarratt-Barnham, N Segarra, S Mas, M-P Ribate, CB García, NA Fineberg, Y Worbe, RN Cardinal, TW Robbins

A new era for the negative symptoms of schizophrenia.

DOI: http://doi.org/10.1192/bjp.2023.69
Journal: Br J Psychiatry
E-pub date: 1 Jul 2023
Authors: E Fernandez-Egea, A Mucci, J Lee, B Kirkpatrick

Causes of death in clozapine-treated patients in a catchment area: a 10-year retrospective case-control study.

DOI: http://doi.org/10.1016/j.euroneuro.2020.05.011
Journal: Eur Neuropsychopharmacol
E-pub date: 1 Jul 2020
Authors: E Rose, S Chen, C Turrion, C Jenkins, RN Cardinal, E Fernandez-Egea

One hundred years ago: Nijinsky and the origins of schizophrenia.

DOI: http://doi.org/10.1093/brain/awy262
Journal: Brain
E-pub date: 1 Jan 2019
Authors: E Fernandez-Egea

Metabolic profile of antipsychotic-naive individuals with non-affective psychosis.

DOI: http://doi.org/10.1192/bjp.bp.108.052605
Journal: Br J Psychiatry
E-pub date: 1 May 2009
Authors: E Fernandez-Egea, M Bernardo, T Donner, I Conget, E Parellada, A Justicia, E Esmatjes, C Garcia-Rizo, B Kirkpatrick

Is schizophrenia a syndrome of accelerated aging?

DOI: http://doi.org/10.1093/schbul/sbm140
Journal: Schizophr Bull
E-pub date: 1 Nov 2008
Authors: B Kirkpatrick, E Messias, PD Harvey, E Fernandez-Egea, CR Bowie

Publications

Clozapine ultrarapid metabolism during weak induction probably exists but requires careful diagnosis. A literature review, five new cases and a proposed definition.

DOI: http://doi.org/10.1016/j.schres.2023.05.010
Journal: Schizophr Res
E-pub date: 1 Jun 2024
Authors: G Schoretsanitis, AE Anıl Yağcıoğlu, C-J Ruan, CB Eap, E Molden, T Baptista, SR Clark, E Fernandez-Egea, SH Kim, H-Y Lane, J Leung, O Maroñas Amigo, M Motuca, I Olmos, S Every-Palmer, RM Procyshyn, C Rohde, S Satish, PFJ Schulte, E Spina, H Takeuchi, H Verdoux, CU Correll, J de Leon

Exploring low clozapine C/D ratios, inverted clozapine-norclozapine ratios and undetectable concentrations as measures of non-adherence in clozapine patients: A literature review and a case series of 17 patients from 3 studies.

DOI: http://doi.org/10.1016/j.schres.2023.07.002
Journal: Schizophr Res
E-pub date: 1 Jun 2024
Authors: C-J Ruan, I Olmos, C Ricciardi, G Schoretsanitis, PD Vincent, AE Anıl Yağcıoğlu, CB Eap, T Baptista, SR Clark, E Fernandez-Egea, SH Kim, H-Y Lane, J Leung, O Maroñas Amigo, M Motuca, S Every-Palmer, RM Procyshyn, C Rohde, S Suhas, PFJ Schulte, E Spina, H Takeuchi, H Verdoux, CU Correll, E Molden, C De Las Cuevas, J de Leon

Influence of time to clozapine prescription on the clinical outcome.

DOI: http://doi.org/10.1016/j.schres.2023.09.028
Journal: Schizophr Res
E-pub date: 1 Jun 2024
Authors: LI Muñoz-Manchado, JI Perez-Revuelta, A Banerjee, L Galindo-Guarin, M Bernardo, F González-Saiz, JM Villagrán-Moreno, E Fernández-Egea

Revealing the reporting disparity: VigiBase highlights underreporting of clozapine in other Western European countries compared to the UK.

DOI: http://doi.org/10.1016/j.schres.2023.11.010
Journal: Schizophr Res
E-pub date: 1 Jun 2024
Authors: C De Las Cuevas, EJ Sanz, JA Gross, CU Correll, H Verdoux, J Lally, R de Filippis, PFJ Schulte, E Molden, M Arrojo-Romero, AD Bostrom, G Schoretsanitis, E Fernandez-Egea, J de Leon

Eli Robins: The grandfather of DSM-III

DOI: http://doi.org/10.1016/j.euroneuro.2024.03.001
Journal: Eur Neuropsychopharmacol
E-pub date: 1 Jun 2024
Authors: B Kirkpatrick, E Fernandez-Egea

Anthropometry in antipsychotic-naïve first-episode psychosis patients: An exploratory approach to the role of environmental early life events in two independent samples.

DOI: http://doi.org/10.1016/j.schres.2024.02.020
Journal: Schizophr Res
E-pub date: 1 Apr 2024
Authors: C Garcia-Rizo, B Crespo-Facorro, C Oliveira, M Gómez-Revuelta, B Kirkpatrick, JM-V Son, LC de la Hoz, M Garriga, N Garrido-Torres, M Bernardo, E Fernandez-Egea, J Vázquez-Bourgon

Impact of Pharmacogenetic Testing on Clozapine Treatment Efficacy in Patients with Treatment-Resistant Schizophrenia

DOI: http://doi.org/10.3390/biomedicines12030597
Journal: Biomedicines
E-pub date: 7 Mar 2024
Authors: E Sangüesa, E Fernández-Egea, J Concha, CB García, MP Ribate

The influence of reward sensitivity on weight in treatment-resistant chronic schizophrenia.

DOI: http://doi.org/10.1016/j.sjpmh.2024.01.005
Journal: Span J Psychiatry Ment Health
E-pub date: 7 Feb 2024
Authors: I Jarratt Barnham, Y Saleh, M Hussain, E Fernandez-Egea

The longitudinal structure of negative symptoms in treatment resistant schizophrenia.

DOI: http://doi.org/10.1016/j.comppsych.2023.152440
Journal: Compr Psychiatry
E-pub date: 1 Jan 2024
Authors: N Wolpe, A Vituri, PB Jones, M Shahar, E Fernandez-Egea

[The structural stability of negative symptoms over time].

DOI: http://doi.org/10.1192/bjo.2023.600
Journal: BJPsych Open
E-pub date: 3 Nov 2023
Authors: N Wolpe, E Fernandez-Egea

Negative symptoms and cognitive impairment are associated with distinct motivational deficits in treatment resistant schizophrenia.

DOI: http://doi.org/10.1038/s41380-023-02232-7
Journal: Mol Psychiatry
E-pub date: 1 Nov 2023
Authors: Y Saleh, I Jarratt-Barnham, P Petitet, E Fernandez-Egea, SG Manohar, M Husain

Assessment and the concept of negative symptoms.

DOI: http://doi.org/10.1016/j.sjpmh.2023.09.006
Journal: Span J Psychiatry Ment Health
E-pub date: 29 Oct 2023
Authors: B Kirkpatrick, E Fernandez-Egea

Relationship between severe mental illness and physical multimorbidity: a meta-analysis and call for action.

DOI: http://doi.org/10.1136/bmjment-2023-300870
Journal: BMJ Ment Health
E-pub date: 1 Oct 2023
Authors: D Pizzol, M Trott, L Butler, Y Barnett, T Ford, SA Neufeld, A Ragnhildstveit, CN Parris, BR Underwood, GF López Sánchez, M Fossey, C Brayne, E Fernandez-Egea, G Fond, L Boyer, JI Shin, S Pardhan, L Smith

Eating disorders and physical multimorbidity in the English general population.

DOI: http://doi.org/10.1007/s40519-023-01600-0
Journal: Eat Weight Disord
E-pub date: 7 Sep 2023
Authors: L Smith, GF López Sánchez, E Fernandez-Egea, T Ford, C Parris, BR Underwood, L Butler, Y Barnett, M Trott, A Koyanagi

An international adult guideline for making clozapine titration safer by using six ancestry-based personalized dosing titrations, CRP, and clozapine levels

DOI: http://doi.org/10.1016/j.psiq.2023.100415
Journal: Psiquiatria Biologica
E-pub date: 1 Sep 2023
Authors: J de Leon, G Schoretsanitis, RL Smith, E Molden, A Solismaa, N Seppälä, M Kopeček, P Švancer, I Olmos, C Ricciardi, C Iglesias-Garcia, A Iglesias-Alonso, E Spina, CJ Ruan, CY Wang, G Wang, YL Tang, SK Lin, HY Lane, YS Kim, SH Kim, AP Rajkumar, DF González-Esquivel, H Jung-Cook, T Baptista, C Rohde, J Nielsen, H Verdoux, C Quiles, EJ Sanz, C De las Cuevas, D Cohen, PFJ Schulte, A Ertuğrul, AE Anıl Yağcıoğlu, N Chopra, B McCollum, C Shelton, RO Cotes, AR Kaithi, JM Kane, S Farooq, CH Ng, J Bilbily, C Hiemke, C López-Jaramillo, I McGrane, F Lana, CB Eap, M Arrojo-Romero, FŞ Rădulescu, E Seifritz, S Every-Palmer, CA Bousman, E Bebawi, R Bhattacharya, DL Kelly, Y Otsuka, J Lazary, R Torres, A Yecora, M Motuca, SKW Chan, M Zolezzi, S Ouanes, D De Berardis, S Grover, RM Procyshyn, RA Adebayo, OO Kirilochev, A Soloviev, KN Fountoulakis, A Wilkowska, WJ Cubała, M Ayub, A Silva, RM Bonelli, JM Villagrán-Moreno, B Crespo-Facorro, H Temmingh, E Decloedt, MR Pedro, H Takeuchi, M Tsukahara, G Gründer, M Sagud, A Celofiga, D Ignjatovic Ristic, BB Ortiz, H Elkis, AJ Pacheco Palha, A Llerena, E Fernandez-Egea, D Siskind, A Weizman, R Masmoudi, S Mohd Saffian, JG Leung, PF Buckley, SR Marder

Clozapine Optimization: A Delphi Consensus Guideline From the Treatment Response and Resistance in Psychosis Working Group.

DOI: http://doi.org/10.1093/schbul/sbad030
Journal: Schizophr Bull
E-pub date: 4 Jul 2023
Authors: E Wagner, D Siskind, P Falkai, O Howes, C Correll, J Lee, WG Honer, JM Kane, E Fernandez-Egea, TRE Barnes, A Hasan, TRRIP Working Group

Longitudinal effect of clozapine-associated sedation on motivation in schizophrenia: naturalistic longitudinal study.

DOI: http://doi.org/10.1192/bjp.2022.191
Journal: Br J Psychiatry
E-pub date: 1 Jul 2023
Authors: N Wolpe, S Chen, B Kirkpatrick, PB Jones, C Jenkins, RN Cardinal, E Fernandez-Egea

Author’s Reply. RE: Longitudinal effect of clozapine-associated sedation on motivation in schizophrenia: naturalistic longitudinal study.

DOI: http://doi.org/10.1192/bjp.2023.84
Journal: Br J Psychiatry
E-pub date: 1 Jul 2023
Authors: N Wolpe, S Chen, B Kirkpatrick, PB Jones, C Jenkins, RN Cardinal, E Fernandez-Egea

Clozapine-related obsessive-compulsive symptoms and their impact on wellbeing: a naturalistic longitudinal study.

DOI: http://doi.org/10.1017/S003329172100492X
Journal: Psychol Med
E-pub date: 1 May 2023
Authors: K Parkin, S Chen, M Biria, J Plaistow, H Beckwith, I Jarratt-Barnham, N Segarra, Y Worbe, NA Fineberg, RN Cardinal, TW Robbins, E Fernandez-Egea

Prefrontal Cortex Activation and Stopping Performance Underlie the Beneficial Effects of Atomoxetine on Response Inhibition in Healthy Volunteers and Those With Cocaine Use Disorder.

DOI: http://doi.org/10.1016/j.bpsc.2021.08.010
Journal: Biol Psychiatry Cogn Neurosci Neuroimaging
E-pub date: 1 Nov 2022
Authors: P Zhukovsky, S Morein-Zamir, H Ziauddeen, E Fernandez-Egea, C Meng, R Regenthal, BJ Sahakian, ET Bullmore, TW Robbins, JW Dalley, KD Ersche

The psychosis metabolic risk calculator (PsyMetRiC) for young people with psychosis: International external validation and site-specific recalibration in two independent European samples.

DOI: http://doi.org/10.1016/j.lanepe.2022.100493
Journal: Lancet Reg Health Eur
E-pub date: 1 Nov 2022
Authors: BI Perry, F Vandenberghe, N Garrido-Torres, EF Osimo, M Piras, J Vazquez-Bourgon, R Upthegrove, C Grosu, VO-G De La Foz, PB Jones, N Laaboub, M Ruiz-Veguilla, J Stochl, C Dubath, M Canal-Rivero, P Mallikarjun, A Delacrétaz, N Ansermot, E Fernandez-Egea, S Crettol, F Gamma, KJ Plessen, P Conus, GM Khandaker, GK Murray, CB Eap, B Crespo-Facorro

A clozapine’s uncharted voyage: Five years and a pandemic after the end of mandatory haematological notifications to the Spanish medicines agency

DOI: http://doi.org/10.1016/j.rpsm.2022.04.001
Journal: Revista de Psiquiatria y Salud Mental
E-pub date: 1 Oct 2022
Authors: P Andres-Olivera, C Turrion, E Fernandez-Egea, J Perez

Alterations in white matter microstructure in alcohol and alcohol-polydrug dependence: Associations with lifetime alcohol and nicotine exposure

DOI: http://doi.org/10.1111/adb.13207
Journal: Addiction Biology
E-pub date: 1 Sep 2022
Authors: K Agunbiade, L Fonville, J McGonigle, R Elliott, KD Ersche, R Flechais, C Orban, A Murphy, DG Smith, J Suckling, EM Taylor, B Deakin, TW Robbins, DJ Nutt, AR Lingford-Hughes, LM Paterson, A Lingford-Hughes, L Paterson, R Elliott, A Murphy, E Taylor, K Ersche, D Smith, L Reed, F Passetti, L Faravelli, D Erritzoe, I Mick, N Kalk, A Waldman, L Nestor, S Kuchibatla, V Boyapati, A Metastasio, Y Faluyi, E Fernandez-Egea, S Abbott, B Sahakian, V Voon, I Rabiner

Multidimensional predictors of negative symptoms in antipsychotic-naive first-episode psychosis.

DOI: http://doi.org/10.1503/jpn.210138
Journal: J Psychiatry Neurosci
E-pub date: 1 Aug 2022
Authors: A Toll, L Blanco-Hinojo, D Bergé, X Duran, I Canosa, T Legido, F Marmol, V Pérez-Solà, E Fernández-Egea, A Mané

Validation of a European Spanish adaptation of the Apathy Evaluation Scale-self-rated version (AES-S) in patients with schizophrenia.

DOI: http://doi.org/10.1016/j.rpsmen.2020.04.007
Journal: Rev Psiquiatr Salud Ment (Engl Ed)
E-pub date: 1 Aug 2022
Authors: C Martínez-Cao, L García-Álvarez, T Bobes-Bascarán, L de la Fuente-Tomás, E Fernández-Egea, Á Velasco, L González-Blanco, P Zurrón-Madera, E Fonseca-Pedrero, PA Sáiz-Martínez, MP García-Portilla, J Bobes

Defining negative symptoms remission in schizophrenia using the Brief Negative Symptom Scale.

DOI: http://doi.org/10.1016/j.rpsmen.2022.01.007
Journal: Rev Psiquiatr Salud Ment (Engl Ed)
E-pub date: 1 Aug 2022
Authors: G Rekhi, MS Ang, YH Chan, E Fernandez-Egea, B Kirkpatrick, J Lee

The effect of early life events on glucose levels in first-episode psychosis.

DOI: http://doi.org/10.3389/fendo.2022.983792
Journal: Front Endocrinol (Lausanne)
E-pub date: 1 Aug 2022
Authors: C Garcia-Rizo, B Cabrera, M Bioque, G Mezquida, A Lobo, A Gonzalez-Pinto, CM Diaz-Caneja, I Corripio, E Vieta, I Baeza, MP Garcia-Portilla, M Gutierrez-Fraile, R Rodriguez-Jimenez, M Garriga, E Fernandez-Egea, M Bernardo, PEPs GROUP

A clozapine’s uncharted voyage: Five years and a pandemic after the end of mandatory haematological notifications to the Spanish medicines agency.

DOI: http://doi.org/10.1016/j.rpsmen.2022.04.001
Journal: Rev Psiquiatr Salud Ment (Engl Ed)
E-pub date: 1 Aug 2022
Authors: P Andres-Olivera, C Turrion, E Fernandez-Egea, J Perez

Who is prescribed valproate and how carefully is this treatment reviewed in UK mental health services? Data from a clinical audit.

DOI: http://doi.org/10.1177/20451253221110016
Journal: Ther Adv Psychopharmacol
E-pub date: 1 Aug 2022
Authors: C Paton, L Citrome, E Fernandez-Egea, O Rendora, TRE Barnes

Early versus late risk factors for deficit and nondeficit schizophrenia.

DOI: http://doi.org/10.1016/j.rpsmen.2022.01.006
Journal: Rev Psiquiatr Salud Ment (Engl Ed)
E-pub date: 1 Aug 2022
Authors: S Alabaf, B Kirkpatrick, S Chen, RN Cardinal, E Fernandez-Egea

Bobby Fischer and the delusions of a king of logic.

DOI: http://doi.org/10.1093/brain/awac140
Journal: Brain
E-pub date: 3 Jun 2022
Authors: E Fernandez-Egea, TW Robbins

Is it time to change the term negative symptoms?

DOI: http://doi.org/10.1016/j.euroneuro.2022.03.004
Journal: Eur Neuropsychopharmacol
E-pub date: 1 Jun 2022
Authors: E Fernandez-Egea, N Wolpe

Two Factors, Five Factors, or Both? External Validation Studies of Negative Symptom Dimensions in Schizophrenia.

DOI: http://doi.org/10.1093/schbul/sbab148
Journal: Schizophr Bull
E-pub date: 7 May 2022
Authors: AO Ahmed, B Kirkpatrick, E Granholm, LM Rowland, PB Barker, JM Gold, RW Buchanan, T Outram, M Bernardo, M Paz García-Portilla, A Mane, E Fernandez-Egea, GP Strauss

An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels.

DOI: http://doi.org/10.1055/a-1625-6388
Journal: Pharmacopsychiatry
E-pub date: 1 Mar 2022
Authors: J de Leon, G Schoretsanitis, RL Smith, E Molden, A Solismaa, N Seppälä, M Kopeček, P Švancer, I Olmos, C Ricciardi, C Iglesias-Garcia, A Iglesias-Alonso, E Spina, C-J Ruan, C-Y Wang, G Wang, Y-L Tang, S-K Lin, H-Y Lane, YS Kim, SH Kim, AP Rajkumar, DF González-Esquivel, H Jung-Cook, T Baptista, C Rohde, J Nielsen, H Verdoux, C Quiles, EJ Sanz, C De Las Cuevas, D Cohen, PFJ Schulte, A Ertuğrul, AE Anıl Yağcıoğlu, N Chopra, B McCollum, C Shelton, RO Cotes, AR Kaithi, JM Kane, S Farooq, CH Ng, J Bilbily, C Hiemke, C López-Jaramillo, I McGrane, F Lana, CB Eap, M Arrojo-Romero, FŞ Rădulescu, E Seifritz, S Every-Palmer, CA Bousman, E Bebawi, R Bhattacharya, DL Kelly, Y Otsuka, J Lazary, R Torres, A Yecora, M Motuca, SKW Chan, M Zolezzi, S Ouanes, D De Berardis, S Grover, RM Procyshyn, RA Adebayo, OO Kirilochev, A Soloviev, KN Fountoulakis, A Wilkowska, WJ Cubała, M Ayub, A Silva, RM Bonelli, JM Villagrán-Moreno, B Crespo-Facorro, H Temmingh, E Decloedt, MR Pedro, H Takeuchi, M Tsukahara, G Gründer, M Sagud, A Celofiga, D Ignjatovic Ristic, BB Ortiz, H Elkis, AJ Pacheco Palha, A LLerena, E Fernandez-Egea, D Siskind, A Weizman, R Masmoudi, S Mohd Saffian, JG Leung, PF Buckley, SR Marder, L Citrome, O Freudenreich, CU Correll, DJ Müller

Correction: An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels.

DOI: http://doi.org/10.1055/a-1737-1527
Journal: Pharmacopsychiatry
E-pub date: 1 Mar 2022
Authors: J de Leon, G Schoretsanitis, RL Smith, E Molden, A Solismaa, N Seppälä, M Kopeček, P Švancer, I Olmos, C Ricciardi, C Iglesias-Garcia, A Iglesias-Alonso, E Spina, C-J Ruan, C-Y Wang, G Wang, Y-L Tang, S-K Lin, H-Y Lane, YS Kim, SH Kim, AP Rajkumar, DF González-Esquivel, H Jung-Cook, T Baptista, C Rohde, J Nielsen, H Verdoux, C Quiles, EJ Sanz, C De Las Cuevas, D Cohen, PFJ Schulte, A Ertuğrul, AE Anıl Yağcıoğlu, N Chopra, B McCollum, C Shelton, RO Cotes, AR Kaithi, JM Kane, S Farooq, CH Ng, J Bilbily, C Hiemke, C López-Jaramillo, I McGrane, F Lana, CB Eap, M Arrojo-Romero, FŞ Rădulescu, E Seifritz, S Every-Palmer, CA Bousman, E Bebawi, R Bhattacharya, DL Kelly, Y Otsuka, J Lazary, R Torres, A Yecora, M Motuca, SKW Chan, M Zolezzi, S Ouanes, D De Berardis, S Grover, RM Procyshyn, RA Adebayo, OO Kirilochev, A Soloviev, KN Fountoulakis, A Wilkowska, WJ Cubała, M Ayub, A Silva, RM Bonelli, JM Villagrán-Moreno, B Crespo-Facorro, H Temmingh, E Decloedt, MR Pedro, H Takeuchi, M Tsukahara, G Gründer, M Sagud, A Celofiga, D Ignjatovic Ristic, BB Ortiz, H Elkis, AJ Pacheco Palha, A LLerena, E Fernandez-Egea, D Siskind, A Weizman, R Masmoudi, S Mohd Saffian, JG Leung, PF Buckley, SR Marder, L Citrome, O Freudenreich, CU Correll, DJ Müller

Risk factors for excess deaths during lockdown among older users of secondary care mental health services without confirmed COVID-19: A retrospective cohort study.

DOI: http://doi.org/10.1002/gps.5610
Journal: Int J Geriatr Psychiatry
E-pub date: 1 Dec 2021
Authors: S Chen, PB Jones, BR Underwood, E Fernandez-Egea, P Qin, JR Lewis, RN Cardinal

The sooner the better: clinical and neural correlates of impulsive choice in Tourette disorder.

DOI: http://doi.org/10.1038/s41398-021-01691-2
Journal: Transl Psychiatry
E-pub date: 3 Nov 2021
Authors: C Atkinson-Clement, A de Liege, Y Klein, B Beranger, R Valabregue, C Delorme, E Roze, E Fernandez-Egea, A Hartmann, TW Robbins, Y Worbe

Longer-term mortality following SARS-CoV-2 infection in people with severe mental illness: retrospective case-matched study.

DOI: http://doi.org/10.1192/bjo.2021.1046
Journal: BJPsych Open
E-pub date: 1 Nov 2021
Authors: S Chen, E Fernandez-Egea, PB Jones, JR Lewis, RN Cardinal

The Effect of Clozapine on Self-reported Duration of Sleep and Its Interaction With 23 Other Medications: A 5-Year Naturalistic Study.

DOI: http://doi.org/10.1097/JCP.0000000000001432
Journal: J Clin Psychopharmacol
E-pub date: 1 Sep 2021
Authors: E Fernandez-Egea, S Chen, C Jenkins, C Turrion, SP Mitchell, DJF Dodwell, LM Mann, JB Deakin, ZH Syed, S Hafizi, J Zimbron, AS Praseedom, RN Cardinal

Difficulties in delivery and depressive symptomatology in schizophrenia.

DOI: http://doi.org/10.1016/j.rpsm.2019.12.002
Journal: Rev Psiquiatr Salud Ment (Engl Ed)
E-pub date: 1 Aug 2021
Authors: G Mezquida, E Fernández-Egea, D Treen, A Mané, D Bergé, G Savulich, L García-Álvarez, MP García-Portilla, J Bobes, M Bernardo, C García-Rizo

Mechanisms Underlying Motivational Dysfunction in Schizophrenia.

DOI: http://doi.org/10.3389/fnbeh.2021.709753
Journal: Front Behav Neurosci
E-pub date: 1 Aug 2021
Authors: Y Saleh, I Jarratt-Barnham, E Fernandez-Egea, M Husain

Waiting for Godot or the use of biomarkers in clinical practice.

DOI: http://doi.org/10.1016/j.rpsmen.2021.07.003
Journal: Rev Psiquiatr Salud Ment (Engl Ed)
E-pub date: 1 Aug 2021
Authors: E Fernández-Egea

Women Neuroscientist Disciples of Pío del Río-Hortega: the Cajal School Spreads in Europe and South America.

DOI: http://doi.org/10.3389/fnana.2021.666938
Journal: Front Neuroanat
E-pub date: 1 Aug 2021
Authors: C Nombela, E Fernández-Egea, E Giné, Y Worbe, J Del Río-Hortega Bereciartu, F de Castro

Is apathy a true trans-diagnostic construct? preliminary findings of the european study on apathy in schizophrenia

DOI: http://doi.org/10.1192/j.eurpsy.2021.160
Journal: EUROPEAN PSYCHIATRY
E-pub date: 1 Aug 2021
Authors: E Fernandez-Egea

Atomoxetine partially restores loss sensitivity in cocaine use disorder

DOI: http://doi.org/10.1016/j.euroneuro.2021.10.016
Journal:
E-pub date: 1 Aug 2021
Authors: L Cincikas, RN Cardinal, H Ziauddeen, E Fernandez-Egea, R Regenthal, BJ Sahakian, TW Robbins, KD Ersche

Waiting for Godot or the use of biomarkers in clinical practice.

DOI: http://doi.org/10.1016/j.rpsm.2021.07.003
Journal: Rev Psiquiatr Salud Ment
E-pub date: 1 Jul 2021
Authors: E Fernández-Egea

Defining negative symptoms remission in schizophrenia using the Brief Negative Symptom Scale.

DOI: http://doi.org/10.1016/j.rpsm.2021.05.003
Journal: Rev Psiquiatr Salud Ment (Engl Ed)
E-pub date: 29 May 2021
Authors: G Rekhi, MS Ang, YH Chan, E Fernandez-Egea, B Kirkpatrick, J Lee

Early versus late risk factors for deficit and nondeficit schizophrenia.

DOI: http://doi.org/10.1016/j.rpsm.2021.03.002
Journal: Rev Psiquiatr Salud Ment (Engl Ed)
E-pub date: 1 Apr 2021
Authors: S Alabaf, B Kirkpatrick, S Chen, RN Cardinal, E Fernandez-Egea

Chronic alcohol exposure differentially modulates structural and functional properties of amygdala: A cross-sectional study

DOI: http://doi.org/10.1111/adb.12980
Journal: Addiction Biology
E-pub date: 20 Nov 2020
Authors: C Orban, J McGonigle, RSA Flechais, LM Paterson, R Elliott, D Erritzoe, KD Ersche, A Murphy, LJ Nestor, F Passetti, LJ Reed, AS Ribeiro, DG Smith, J Suckling, EM Taylor, AD Waldman, VC Wing, JFW Deakin, TW Robbins, DJ Nutt, AR Lingford-Hughes, D Nutt, A Lingford-Hughes, L Paterson, J McGonigle, R Flechais, C Orban, B Deakin, R Elliott, A Murphy, E Taylor, T Robbins, K Ersche, J Suckling, D Smith, L Reed, L Faravelli, D Erritzoe, I Mick, N Kalk, A Waldman, L Nestor, S Kuchibatla, V Boyapati, A Metastasio, Y Faluyi, E Fernandez-Egea, S Abbott, B Sahakian, V Voon, I Rabiner

Cannabis use influence on peripheral brain-derived neurotrophic factor levels in antipsychotic-naïve first-episode psychosis.

DOI: http://doi.org/10.1007/s00406-020-01117-y
Journal: Eur Arch Psychiatry Clin Neurosci
E-pub date: 1 Oct 2020
Authors: A Toll, D Bergé, K Burling, L Scoriels, D Treen, C Monserrat, F Marmol, X Duran, PB Jones, V Pérez-Solà, E Fernandez-Egea, A Mané

Intra-individual variation of clozapine and norclozapine plasma levels in clinical practice.

DOI: http://doi.org/10.1016/j.rpsm.2019.03.002
Journal: Rev Psiquiatr Salud Ment (Engl Ed)
E-pub date: 1 Aug 2020
Authors: MC Turrion, J Perez, M Bernardo, E Fernandez-Egea

Sleepwalking Associated With Clozapine Treatment: 2 Cases.

DOI: http://doi.org/10.1097/JCP.0000000000001208
Journal: J Clin Psychopharmacol
E-pub date: 1 Aug 2020
Authors: NF Daniels, E Fernandez-Egea

The Medium-Term Impact of COVID-19 Lockdown on Referrals to Secondary Care Mental Health Services: A Controlled Interrupted Time Series Study.

DOI: http://doi.org/10.3389/fpsyt.2020.585915
Journal: Front Psychiatry
E-pub date: 1 Aug 2020
Authors: S Chen, R She, P Qin, A Kershenbaum, E Fernandez-Egea, JR Nelder, C Ma, J Lewis, C Wang, RN Cardinal

What happens in naive first-episode of psychosis patients initiating olanzapine treatment? Body mass index gain and improvement in negative symptomatology

DOI: http://doi.org/10.1016/j.euroneuro.2020.09.414
Journal: EUROPEAN NEUROPSYCHOPHARMACOLOGY
E-pub date: 1 Aug 2020
Authors: G Mezquida, M Garriga, S Amoretti, E Fernandez-Egea, A Meseguer, M Vazquez, V Soler-Cata, B Kirkpatrick, M Bernardo, GR Clemente

Risk Factors for Excess Deaths Among Older Adults Without Confirmed COVID-19 During Lockdown: A Retrospective Cohort Study

DOI: http://doi.org/10.2139/ssrn.3672334
Journal:
E-pub date: 1 Aug 2020
Authors: S Chen, P Jones, B Underwood, E Fernandez-Egea, P Qin, J Lewis, R Cardinal

Validation of a European Spanish adaptation of the Apathy Evaluation Scale-self-rated version (AES-S) in patients with schizophrenia.

DOI: http://doi.org/10.1016/j.rpsm.2020.04.008
Journal: Rev Psiquiatr Salud Ment (Engl Ed)
E-pub date: 4 Jun 2020
Authors: C Martínez-Cao, L García-Álvarez, T Bobes-Bascarán, L de la Fuente-Tomás, E Fernández-Egea, Á Velasco, L González-Blanco, P Zurrón-Madera, E Fonseca-Pedrero, PA Sáiz-Martínez, MP García-Portilla, J Bobes

Structural and functional abnormalities within sensori-motor and limbic networks underpin intermittent explosive symptoms in Tourette disorder.

DOI: http://doi.org/10.1016/j.jpsychires.2020.02.033
Journal: J Psychiatr Res
E-pub date: 1 Jun 2020
Authors: C Atkinson-Clement, F Sofia, E Fernandez-Egea, A de Liege, B Beranger, Y Klein, E Deniau, E Roze, A Hartmann, Y Worbe

Longitudinal effects of clozapine concentration and clozapine to N-desmethylclozapine ratio on cognition: A mediation model.

DOI: http://doi.org/10.1016/j.euroneuro.2020.01.016
Journal: Eur Neuropsychopharmacol
E-pub date: 1 Apr 2020
Authors: F Dal Santo, I Jarratt-Barnham, L González-Blanco, MP García-Portilla, J Bobes, E Fernández-Egea

Birth weight and antipsychotic induced weight gain: A prenatal programming approach in the PEPs study.

DOI: http://doi.org/10.1016/j.schres.2019.12.030
Journal: Schizophr Res
E-pub date: 1 Apr 2020
Authors: C García-Rizo, M Bioque, G Mezquida, S Amoretti, MJ Cuesta, CM Díaz-Caneja, S Mas, A Lobo, A González-Pinto, D Fraguas, I Corripio, E Vieta, I Baeza, D Bergé, E Fernandez-Egea, M Garriga, M Bernardo, PEPs GROUP

The influence of negative and affective symptoms on anhedonia self-report in schizophrenia.

DOI: http://doi.org/10.1016/j.comppsych.2020.152165
Journal: Compr Psychiatry
E-pub date: 25 Jan 2020
Authors: I Jarratt-Barnham, Y Saleh, M Husain, B Kirkpatrick, E Fernandez-Egea

Birth weight, family history of diabetes and diabetes onset in schizophrenia.

DOI: http://doi.org/10.1136/bmjdrc-2019-001036
Journal: BMJ Open Diabetes Res Care
E-pub date: 1 Jan 2020
Authors: E Fernandez-Egea, R Walker, H Ziauddeen, RN Cardinal, ET Bullmore

An Early Developmental Marker of Deficit versus Nondeficit Schizophrenia.

DOI: http://doi.org/10.1093/schbul/sbz024
Journal: Schizophr Bull
E-pub date: 24 Oct 2019
Authors: B Kirkpatrick, Ö Gürbüz Oflezer, M Delice Arslan, G Hack, E Fernandez-Egea

Naltrexone differentially modulates the neural correlates of motor impulse control in abstinent alcohol-dependent and polysubstance-dependent individuals.

DOI: http://doi.org/10.1111/ejn.14262
Journal: Eur J Neurosci
E-pub date: 31 Aug 2019
Authors: LJ Nestor, LM Paterson, A Murphy, J McGonigle, C Orban, L Reed, E Taylor, R Flechais, D Smith, ET Bullmore, KD Ersche, J Suckling, R Elliott, B Deakin, I Rabiner, A Lingford Hughes, BJ Sahakian, TW Robbins, DJ Nutt, ICCAM Consortium

Antipsychotic-induced weight gain and birth weight in psychosis: A fetal programming model.

DOI: http://doi.org/10.1016/j.jpsychires.2019.05.004
Journal: J Psychiatr Res
E-pub date: 31 Aug 2019
Authors: M Garriga, E Fernandez-Egea, A Mallorqui, L Serrano, C Oliveira, E Parellada, B Kirkpatrick, E Vieta, M Bernardo, C Garcia-Rizo

A cross sectional study of impact and clinical risk factors of antipsychotic-induced OCD.

DOI: http://doi.org/10.1016/j.euroneuro.2019.06.006
Journal: Eur Neuropsychopharmacol
E-pub date: 31 Aug 2019
Authors: M Biria, F-X Huang, Y Worbe, NA Fineberg, TW Robbins, E Fernandez-Egea

Noradrenergic modulation of stopping impulsivity in cocaine use disorder

DOI: http://doi.org/10.1016/j.euroneuro.2018.11.317
Journal: EUROPEAN NEUROPSYCHOPHARMACOLOGY
E-pub date: 1 Aug 2019
Authors: R Rodrigues, S Morein-Zamir, C Meng, H Ziauddeen, E Fernandez-Egea, R Regenthal, BJ Sahakian, ET Bullmore, TW Robbins, KD Ersche

Influence of secondary sources in the Brief Negative Symptom Scale.

DOI: http://doi.org/10.1016/j.schres.2018.10.004
Journal: SCHIZOPHRENIA RESEARCH
E-pub date: 1 Aug 2019
Authors: D Treen, G Savulich, G Mezquida, MP García-Portilla, A Toll, C García-Rizo, L García-Álvarez, D Bergé, J Bobes, M Bernardo, E Fernandez-Egea, A Mané

IDENTIFICATION AND VALIDATION OF THE FIVE-FACTOR MODEL OF NEGATIVE SYMPTOMS IN SCHIZOPHRENIA

DOI: http://doi.org/10.1093/schbul/sbz021.262
Journal: SCHIZOPHRENIA BULLETIN
E-pub date: 1 Aug 2019
Authors: A Ahmed, GP Strauss, E Fernandez-Egea, B Kirkpatrick

Cross-sectional study of diet patterns in early and chronic schizophrenia.

DOI: http://doi.org/10.1016/j.schres.2019.03.029
Journal: Schizophr Res
E-pub date: 1 Jun 2019
Authors: L Scoriels, J Zimbron, N Garcia-León, M Coll-Negre, M Giro, J Perez, PB Jones, E Fernandez-Egea

Cross-cultural Validation of the 5-Factor Structure of Negative Symptoms in Schizophrenia.

DOI: http://doi.org/10.1093/schbul/sby050
Journal: Schizophr Bull
E-pub date: 7 Mar 2019
Authors: AO Ahmed, B Kirkpatrick, S Galderisi, A Mucci, A Rossi, A Bertolino, P Rocca, M Maj, S Kaiser, M Bischof, MN Hartmann-Riemer, M Kirschner, K Schneider, MP Garcia-Portilla, A Mane, M Bernardo, E Fernandez-Egea, C Jiefeng, Y Jing, T Shuping, JM Gold, DN Allen, GP Strauss

Blood cell count in antipsychotic-naive patients with non-affective psychosis.

DOI: http://doi.org/10.1111/eip.12456
Journal: Early Interv Psychiatry
E-pub date: 1 Feb 2019
Authors: C Garcia-Rizo, M Casanovas, E Fernandez-Egea, C Oliveira, A Meseguer, B Cabrera, G Mezquida, M Bioque, B Kirkpatrick, M Bernardo

Distinct risk factors for obsessive and compulsive symptoms in chronic schizophrenia.

DOI: http://doi.org/10.1017/S003329171800017X
Journal: Psychol Med
E-pub date: 1 Dec 2018
Authors: E Fernandez-Egea, Y Worbe, M Bernardo, TW Robbins

Obstetric Phenotypes in the Heterogeneity of Schizophrenia.

DOI: http://doi.org/10.1097/NMD.0000000000000897
Journal: J Nerv Ment Dis
E-pub date: 1 Nov 2018
Authors: G Mezquida, E Fernandez-Egea, D Treen, A Mané, D Bergé, G Savulich, L Garcia-Alvarez, P García-Portilla, J Bobes, M Bernardo, C Garcia-Rizo

A CASE STUDY OF CLOZAPINE AND COGNITION: FRIEND OR FOE?

DOI: http://doi.org/10.1093/schbul/sby018.856
Journal: SCHIZOPHRENIA BULLETIN
E-pub date: 1 Aug 2018
Authors: G Mezquida, G Savulich, S Atkinson, M Bernardo, E Fernandez-Egea

DISTINCT RISK FACTORS FOR OBSESSIVE AND COMPULSIVE SYMPTOMS IN SCHIZOPHRENIA

DOI: http://doi.org/10.1093/schbul/sby018.879
Journal: SCHIZOPHRENIA BULLETIN
E-pub date: 1 Aug 2018
Authors: E Fernandez-Egea, Y Worbe, M Bernardo, TW Robbins

A Case Study of Clozapine and Cognition: Friend or Foe?

DOI: http://doi.org/10.1097/JCP.0000000000000847
Journal: J Clin Psychopharmacol
E-pub date: 1 Apr 2018
Authors: G Savulich, G Mezquida, S Atkinson, M Bernardo, E Fernandez-Egea

Inverse association between negative symptoms and body mass index in chronic schizophrenia.

DOI: http://doi.org/10.1016/j.schres.2017.04.002
Journal: Schizophr Res
E-pub date: 1 Feb 2018
Authors: G Mezquida, G Savulich, C Garcia-Rizo, MP Garcia-Portilla, A Toll, L Garcia-Alvarez, J Bobes, A Mané, M Bernardo, E Fernandez-Egea

The course of negative symptoms in first-episode schizophrenia and its predictors: A prospective two-year follow-up study.

DOI: http://doi.org/10.1016/j.schres.2017.01.047
Journal: Schizophr Res
E-pub date: 1 Nov 2017
Authors: G Mezquida, B Cabrera, M Bioque, S Amoretti, A Lobo, A González-Pinto, A Espliego, I Corripio, E Vieta, J Castro-Fornieles, D Bergé, MJ Escartí, Á Ibañez, R Penadés, AM Sánchez-Torres, M Bernardo, PEPs Group

Correspondence regarding two recent publications in npj:schizophrenia about DNAm and accelerated aging in schizophrenia.

DOI: http://doi.org/10.1038/s41537-017-0041-5
Journal: NPJ Schizophr
E-pub date: 23 Oct 2017
Authors: E Fernandez-Egea, B Kirkpatrick

SLC6A2 genotype variation and the modulatory effects of atomoxetine on inhibitory control in individuals with and without cocaine use disorder

DOI: http://doi.org/10.1016/S0924-977X(17)31865-5
Journal: EUROPEAN NEUROPSYCHOPHARMACOLOGY
E-pub date: 1 Aug 2017
Authors: AN Le, H Ziauddeen, E Fernandez-Egea, R Regenthal, BJ Sahakian, ET Bullmore, TW Robbins, KD Ersche

Reality monitoring impairment in schizophrenia reflects specific prefrontal cortex dysfunction.

DOI: http://doi.org/10.1016/j.nicl.2017.01.028
Journal: Neuroimage Clin
E-pub date: 1 Aug 2017
Authors: JR Garrison, E Fernandez-Egea, R Zaman, M Agius, JS Simons

Obstetric complications and cognitive function in schizophrenia

DOI: http://doi.org/10.1016/S0924-977X(17)31622-X
Journal: EUROPEAN NEUROPSYCHOPHARMACOLOGY
E-pub date: 1 Aug 2017
Authors: G Mezquida, E Fernandez-Egea, D Treen, A Mane, D Berge, L Garcia-Alvarez, P Garcia-Portilla, J Bobes, M Bernardo, C Garcia-Rizo

Neural basis of impaired safety signaling in Obsessive Compulsive Disorder.

DOI: http://doi.org/10.1073/pnas.1609194114
Journal: Proc Natl Acad Sci U S A
E-pub date: 21 Mar 2017
Authors: AM Apergis-Schoute, CM Gillan, NA Fineberg, E Fernandez-Egea, BJ Sahakian, TW Robbins

Metabolic syndrome or glucose challenge in first episode of psychosis?

DOI: http://doi.org/10.1016/j.eurpsy.2016.10.001
Journal: Eur Psychiatry
E-pub date: 1 Mar 2017
Authors: C Garcia-Rizo, E Fernandez-Egea, C Oliveira, A Meseguer, B Cabrera, G Mezquida, M Bioque, R Penades, E Parellada, M Bernardo, B Kirkpatrick

Visual Population Receptive Fields in People with Schizophrenia Have Reduced Inhibitory Surrounds.

DOI: http://doi.org/10.1523/JNEUROSCI.3620-15.2016
Journal: J Neurosci
E-pub date: 8 Feb 2017
Authors: EJ Anderson, MS Tibber, DS Schwarzkopf, SS Shergill, E Fernandez-Egea, G Rees, SC Dakin

Meta-analysis of glucose tolerance, insulin, and insulin resistance in antipsychotic-naïve patients with nonaffective psychosis.

DOI: http://doi.org/10.1016/j.schres.2016.09.026
Journal: Schizophr Res
E-pub date: 1 Jan 2017
Authors: AM Greenhalgh, L Gonzalez-Blanco, C Garcia-Rizo, E Fernandez-Egea, B Miller, MB Arroyo, B Kirkpatrick

Association of the brain-derived neurotrophic factor Val66Met polymorphism with negative symptoms severity, but not cognitive function, in first-episode schizophrenia spectrum disorders.

DOI: http://doi.org/10.1016/j.eurpsy.2016.04.011
Journal: Eur Psychiatry
E-pub date: 1 Oct 2016
Authors: G Mezquida, R Penadés, B Cabrera, G Savulich, A Lobo, A González-Pinto, MJ Penzol, I Corripio, E Fernandez-Egea, P Gassó, MJ Cuesta, M Bernardo, PEPs group

A systematic review and meta-analysis of randomised controlled trials of treatments for clozapine-induced obesity and metabolic syndrome.

DOI: http://doi.org/10.1016/j.euroneuro.2016.07.010
Journal: Eur Neuropsychopharmacol
E-pub date: 1 Sep 2016
Authors: J Zimbron, GM Khandaker, C Toschi, PB Jones, E Fernandez-Egea

Peripheral Immune Cell Populations Associated with Cognitive Deficits and Negative Symptoms of Treatment-Resistant Schizophrenia.

DOI: http://doi.org/10.1371/journal.pone.0155631
Journal: PLoS One
E-pub date: 1 Aug 2016
Authors: E Fernandez-Egea, PE Vértes, SM Flint, L Turner, S Mustafa, A Hatton, KGC Smith, PA Lyons, ET Bullmore

An observational study of clozapine-induced sedation and its pharmacological management

DOI: http://doi.org/10.1016/j.eurpsy.2016.01.091
Journal: EUROPEAN PSYCHIATRY
E-pub date: 1 Aug 2016
Authors: S Ramos Perdigues, A Mane Santacana, RB Sauras Quetcuti, E Fernandez-Egea

Well-being in clozapine-treated schizophrenia patients: The significance of positive symptoms.

DOI: http://doi.org/10.1016/j.comppsych.2016.04.009
Journal: Compr Psychiatry
E-pub date: 1 Jul 2016
Authors: JEH Brown, G Mezquida, E Fernandez-Egea

Prolactin concentrations in antipsychotic-naïve patients with schizophrenia and related disorders: A meta-analysis.

DOI: http://doi.org/10.1016/j.schres.2016.03.018
Journal: Schizophr Res
E-pub date: 1 Jul 2016
Authors: L González-Blanco, AMD Greenhalgh, C Garcia-Rizo, E Fernandez-Egea, BJ Miller, B Kirkpatrick

Association of birth weight and the development of antipsychotic induced adiposity in individuals with treatment resistant schizophrenia.

DOI: http://doi.org/10.1016/j.euroneuro.2016.03.008
Journal: Eur Neuropsychopharmacol
E-pub date: 1 Jun 2016
Authors: H Ziauddeen, C Garcia-Rizo, M Bernardo, B Kirkpatrick, SE Ozanne, PB Jones, E Fernandez-Egea

Valence-dependent influence of serotonin depletion on model-based choice strategy.

DOI: http://doi.org/10.1038/mp.2015.46
Journal: Mol Psychiatry
E-pub date: 1 May 2016
Authors: Y Worbe, S Palminteri, G Savulich, ND Daw, E Fernandez-Egea, TW Robbins, V Voon

Abnormal glycemic homeostasis at the onset of serious mental illnesses: A common pathway.

DOI: http://doi.org/10.1016/j.psyneuen.2016.02.001
Journal: Psychoneuroendocrinology
E-pub date: 1 May 2016
Authors: C Garcia-Rizo, B Kirkpatrick, E Fernandez-Egea, C Oliveira, M Bernardo

Impulsivity in abstinent alcohol and polydrug dependence: a multidimensional approach.

DOI: http://doi.org/10.1007/s00213-016-4245-6
Journal: Psychopharmacology (Berl)
E-pub date: 1 Apr 2016
Authors: EM Taylor, A Murphy, V Boyapati, KD Ersche, R Flechais, S Kuchibatla, J McGonigle, A Metastasio, L Nestor, C Orban, F Passetti, L Paterson, D Smith, J Suckling, R Tait, AR Lingford-Hughes, TW Robbins, DJ Nutt, JFW Deakin, R Elliott, ICCAM Platform

An observational study of clozapine induced sedation and its pharmacological management.

DOI: http://doi.org/10.1016/j.euroneuro.2015.11.006
Journal: Eur Neuropsychopharmacol
E-pub date: 1 Jan 2016
Authors: S Ramos Perdigués, R Sauras Quecuti, A Mané, L Mann, C Mundell, E Fernandez-Egea

The impact of neuroscience on society: cognitive enhancement in neuropsychiatric disorders and in healthy people.

DOI: http://doi.org/10.1098/rstb.2014.0214
Journal: Philos Trans R Soc Lond B Biol Sci
E-pub date: 19 Sep 2015
Authors: BJ Sahakian, AB Bruhl, J Cook, C Killikelly, G Savulich, T Piercy, S Hafizi, J Perez, E Fernandez-Egea, J Suckling, PB Jones

The Imperial College Cambridge Manchester (ICCAM) platform study: An experimental medicine platform for evaluating new drugs for relapse prevention in addiction. Part A: Study description.

DOI: http://doi.org/10.1177/0269881115596155
Journal: J Psychopharmacol
E-pub date: 1 Sep 2015
Authors: LM Paterson, RSA Flechais, A Murphy, LJ Reed, S Abbott, V Boyapati, R Elliott, D Erritzoe, KD Ersche, Y Faluyi, L Faravelli, E Fernandez-Egea, NJ Kalk, SS Kuchibatla, J McGonigle, A Metastasio, I Mick, L Nestor, C Orban, F Passetti, EA Rabiner, DG Smith, J Suckling, R Tait, EM Taylor, AD Waldman, TW Robbins, JFW Deakin, DJ Nutt, AR Lingford-Hughes, ICCAM Platform

The negative syndrome of schizophrenia: three -underlying components are better than two.

DOI: http://doi.org/10.1016/j.schres.2015.05.003
Journal: Schizophr Res
E-pub date: 31 Aug 2015
Authors: MP Garcia-Portilla, L Garcia-Alvarez, A Mané, C Garcia-Rizo, G Sugranyes, D Bergé, M Bernardo, E Fernández-Egea, J Bobes

Association between antipsychotic/antidepressant drug treatments and hospital admissions in schizophrenia assessed using a mental health case register.

DOI: http://doi.org/10.1038/npjschz.2015.35
Journal: NPJ Schizophr
E-pub date: 1 Aug 2015
Authors: RN Cardinal, G Savulich, LM Mann, E Fernández-Egea

Tryptophan Depletion Promotes Habitual over Goal-Directed Control of Appetitive Responding in Humans.

DOI: http://doi.org/10.1093/ijnp/pyv013
Journal: Int J Neuropsychopharmacol
E-pub date: 5 Feb 2015
Authors: Y Worbe, G Savulich, S de Wit, E Fernandez-Egea, TW Robbins

The thrifty psychiatric phenotype.

DOI: http://doi.org/10.1111/acps.12309
Journal: Acta Psychiatrica Scandinavica
E-pub date: 1 Jan 2015
Authors: C Garcia-Rizo, E Fernandez-Egea, M Bernardo, B Kirkpatrick

Spanish adaptation and validation of the Brief Negative Symptoms Scale.

DOI: http://doi.org/10.1016/j.comppsych.2014.05.024
Journal: Comprehensive Psychiatry
E-pub date: 1 Oct 2014
Authors: A Mané, C García-Rizo, MP Garcia-Portilla, D Bergé, G Sugranyes, L Garcia-Alvarez, M Bernardo, J Bobes, E Fernandez-Egea

Brain metabolism during hallucination-like auditory stimulation in schizophrenia.

DOI: http://doi.org/10.1371/journal.pone.0084987
Journal: PLoS One
E-pub date: 1 Aug 2014
Authors: G Horga, E Fernández-Egea, A Mané, M Font, KC Schatz, C Falcon, F Lomeña, M Bernardo, E Parellada

SPANISH ADAPTATION AND VALIDATION OF THE BRIEF NEGATIVE SYNDROME SCALE

DOI: http://doi.org/10.1016/S0920-9964(14)70447-5
Journal: SCHIZOPHRENIA RESEARCH
E-pub date: 1 Aug 2014
Authors: AM Santacana, C Garcia-Rizo, D Berge, MP Garcia-Portilla, L Garcia, G Sugranyes, M Bernardo, J Bobes, E Fernandez-Egea

Serotonin depletion induces ‘waiting impulsivity’ on the human four-choice serial reaction time task: cross-species translational significance.

DOI: http://doi.org/10.1038/npp.2013.351
Journal: Neuropsychopharmacology
E-pub date: 1 May 2014
Authors: Y Worbe, G Savulich, V Voon, E Fernandez-Egea, TW Robbins

Distribution of tract deficits in schizophrenia.

DOI: http://doi.org/10.1186/1471-244X-14-99
Journal: BMC Psychiatry
E-pub date: 2 Apr 2014
Authors: I Ellison-Wright, PJ Nathan, ET Bullmore, R Zaman, RB Dudas, M Agius, E Fernandez-Egea, U Müller, CM Dodds, NJ Forde, C Scanlon, A Leemans, C McDonald, DM Cannon

Schizophrenia: a systemic disorder.

DOI: http://doi.org/10.3371/CSRP.KIMI.031513
Journal: Clinical Schizophrenia and Related Psychoses
E-pub date: 1 Jan 2014
Authors: B Kirkpatrick, B Miller, C García-Rizo, E Fernandez-Egea

“Is bipolar disorder an endocrine condition?” Glucose abnormalities in bipolar disorder.

DOI: http://doi.org/10.1111/acps.12194
Journal: Acta Psychiatrica Scandinavica
E-pub date: 1 Jan 2014
Authors: C Garcia-Rizo, B Kirkpatrick, E Fernandez-Egea, C Oliveira, A Meseguer, I Grande, J Undurraga, E Vieta, M Bernardo

Cannabis use is associated with increased CCL11 plasma levels in young healthy volunteers.

DOI: http://doi.org/10.1016/j.pnpbp.2013.06.011
Journal: Prog Neuropsychopharmacol Biol Psychiatry
E-pub date: 1 Oct 2013
Authors: E Fernandez-Egea, L Scoriels, S Theegala, M Giro, SE Ozanne, K Burling, PB Jones

Oscillatory underpinnings of mismatch negativity and their relationship with cognitive function in patients with schizophrenia.

DOI: http://doi.org/10.1371/journal.pone.0083255
Journal: PLoS One
E-pub date: 1 Aug 2013
Authors: M Kaser, F Soltesz, P Lawrence, S Miller, C Dodds, R Croft, RB Dudas, R Zaman, E Fernandez-Egea, U Müller, A Dean, ET Bullmore, PJ Nathan

Corrigendum to “Inflammatory markers in antipsychotic-naïve patients with nonaffective psychosis and deficit vs. nondeficit features” [Psychiatry Res. 198 (2012) 212-215]

DOI: http://doi.org/10.1016/j.psychres.2013.08.041
Journal: PSYCHIATRY RESEARCH
E-pub date: 1 Aug 2013
Authors: C Garcia-Rizo, E Fernandez-Egea, C Oliveira, A Justicia, M Bernardo, B Kirkpatrick

Cannabis use is associated with biological markers of ageing in healthy volunteers

DOI: http://doi.org/10.1016/S0924-977X(13)70899-X
Journal: EUROPEAN NEUROPSYCHOPHARMACOLOGY
E-pub date: 1 Aug 2013
Authors: L Scoriels, S Theegala, M Giro, SE Ozanne, K Burling, PB Jones, E Fernandez-Egea

Glucose abnormalities in newly diagnosed, medication-naive patients with bipolar disorder, mania, and psychosis

DOI: http://doi.org/10.1016/S0924-977X(13)70108-1
Journal: EUROPEAN NEUROPSYCHOPHARMACOLOGY
E-pub date: 1 Aug 2013
Authors: C Garcia-Rizo, B Kirkpatrick, E Fernandez-Egea, C Oliveira, I Grande, J Undurraga, E Vieta, M Bernardo

Screening for substance use disorders in first-episode psychosis: implications for readmission.

DOI: http://doi.org/10.1016/j.schres.2013.02.031
Journal: Schizophrenia Research
E-pub date: 1 May 2013
Authors: A Batalla, C Garcia-Rizo, P Castellví, E Fernandez-Egea, M Yücel, E Parellada, B Kirkpatrick, R Martin-Santos, M Bernardo

Diabetes or prediabetes in newly diagnosed patients with nonaffective psychosis? A historical and contemporary view.

DOI: http://doi.org/10.1093/schbul/sbs134
Journal: Schizophr Bull
E-pub date: 1 Mar 2013
Authors: E Fernandez-Egea, C Garcia-Rizo, J Zimbron, B Kirkpatrick

Abnormal glucose tolerance, white blood cell count, and telomere length in newly diagnosed, antidepressant-naïve patients with depression.

DOI: http://doi.org/10.1016/j.bbi.2012.11.009
Journal: Brain, Behavior, and Immunity
E-pub date: 1 Feb 2013
Authors: C Garcia-Rizo, E Fernandez-Egea, BJ Miller, C Oliveira, A Justicia, JK Griffith, CM Heaphy, M Bernardo, B Kirkpatrick

Should obesity be a limiting factor for clozapine treatment?

DOI: http://doi.org/10.1016/j.rpsm.2012.05.005
Journal: Revista de Psiquiatria y Salud Mental
E-pub date: 1 Jan 2013
Authors: A Pons i Villanueva, A Romero, J Goti, E Fernandez-Egea, J Undurraga, X Carne, M Bernardo

Inflammatory markers in antipsychotic-naïve patients with nonaffective psychosis and deficit vs. nondeficit features.

DOI: http://doi.org/10.1016/j.psychres.2011.08.014
Journal: Psychiatry Research
E-pub date: 30 Jul 2012
Authors: C Garcia-Rizo, E Fernandez-Egea, C Oliveira, A Justicia, M Bernardo, B Kirkpatrick

Left amygdalar activation in deficit syndrome compared with non-deficit subjects with schizophrenia during the control task in a facial emotion recognition paradigm.

DOI: http://doi.org/10.1016/j.pscychresns.2011.09.016
Journal: Psychiatry Research - Neuroimaging
E-pub date: 30 Jul 2012
Authors: E Fernandez-Egea, E Parelada, G Sugranyes, G Horga, F Lomeña, C Falcon, J Pavia, M Bermardo

Use of electroconvulsive therapy in Parkinson disease with residual axial symptoms partially unresponsive to L-dopa: a pilot study.

DOI: http://doi.org/10.1097/YCT.0b013e31823c98c0
Journal: J ECT
E-pub date: 1 Jun 2012
Authors: LP Pintor, F Valldeoriola, E Fernández-Egea, R Sánchez, L Rami, E Tolosa, A Muñiz, MJ Martí, M Bernardo

Is abnormal glucose tolerance in antipsychotic-naive patients with nonaffective psychosis confounded by poor health habits?

DOI: http://doi.org/10.1093/schbul/sbq058
Journal: Schizophr Bull
E-pub date: 1 Mar 2012
Authors: B Kirkpatrick, BJ Miller, C Garcia-Rizo, E Fernandez-Egea, M Bernardo

Prolactin concentrations in newly diagnosed, antipsychotic-naïve patients with nonaffective psychosis.

DOI: http://doi.org/10.1016/j.schres.2011.07.025
Journal: Schizophr Res
E-pub date: 1 Jan 2012
Authors: C Garcia-Rizo, E Fernandez-Egea, C Oliveira, A Justicia, E Parellada, M Bernardo, B Kirkpatrick

A 4-year dopamine transporter (DAT) imaging study in neuroleptic-naive first episode schizophrenia patients.

DOI: http://doi.org/10.1016/j.pscychresns.2011.03.004
Journal: Psychiatry Res
E-pub date: 31 Oct 2011
Authors: A Mané, J Gallego, F Lomeña, JJ Mateos, E Fernandez-Egea, G Horga, A Cot, J Pavia, M Bernardo, E Parellada

Testosterone in newly diagnosed, antipsychotic-naive men with nonaffective psychosis: a test of the accelerated aging hypothesis.

DOI: http://doi.org/10.1097/PSY.0b013e318230343f
Journal: Psychosom Med
E-pub date: 1 Oct 2011
Authors: E Fernandez-Egea, C García-Rizo, B Miller, E Parellada, A Justicia, M Bernardo, B Kirkpatrick

Differential brain glucose metabolic patterns in antipsychotic-naïve first-episode schizophrenia with and without auditory verbal hallucinations.

DOI: http://doi.org/10.1503/jpn.100085
Journal: J Psychiatry Neurosci
E-pub date: 1 Sep 2011
Authors: G Horga, E Parellada, F Lomeña, E Fernández-Egea, A Mané, M Font, C Falcón, AB Konova, J Pavia, D Ros, M Bernardo

Metabolic effects of olanzapine in patients with newly diagnosed psychosis.

DOI: http://doi.org/10.1097/JCP.0b013e31820fcea3
Journal: J Clin Psychopharmacol
E-pub date: 1 Apr 2011
Authors: E Fernandez-Egea, B Miller, C Garcia-Rizo, M Bernardo, B Kirkpatrick

Spanish validation of the Brief Assessment in Cognition in Schizophrenia (BACS) in patients with schizophrenia and healthy controls.

DOI: http://doi.org/10.1016/j.eurpsy.2009.11.001
Journal: Eur Psychiatry
E-pub date: 1 Mar 2011
Authors: N Segarra, M Bernardo, F Gutierrez, A Justicia, E Fernadez-Egea, M Allas, G Safont, F Contreras, J Gascon, PA Soler-Insa, JM Menchon, C Junque, RSE Keefe

Cholesterol and triglycerides in antipsychotic-naive patients with nonaffective psychosis.

DOI: http://doi.org/10.1016/j.psychres.2010.06.001
Journal: Psychiatry Res
E-pub date: 15 Aug 2010
Authors: B Kirkpatrick, C Garcia-Rizo, K Tang, E Fernandez-Egea, M Bernardo

TESTOSTERONE IN NEWLY DIAGNOSED, ANTIPSYCHOTIC-NAIVE MEN WITH NONAFFECTIVE PSYCHOSIS: A TEST OF THE ACCELERATED AGING HYPOTHESIS

DOI: http://doi.org/10.1016/j.schres.2010.02.491
Journal: SCHIZOPHRENIA RESEARCH
E-pub date: 1 Apr 2010
Authors: E Fernandez-Egea, C Garcia-Rizo, B Miller, A Justicia, M Bernardo, B Kirkpatrick

18FDG PET study of amygdalar activity during facial emotion recognition in schizophrenia.

DOI: http://doi.org/10.1007/s00406-009-0020-6
Journal: Eur Arch Psychiatry Clin Neurosci
E-pub date: 1 Feb 2010
Authors: E Fernandez-Egea, E Parellada, F Lomeña, C Falcon, J Pavia, A Mane, G Horga, M Bernardo

Stem cell signaling in newly diagnosed, antipsychotic-naive subjects with nonaffective psychosis.

DOI: http://doi.org/10.1038/mp.2009.45
Journal: Mol Psychiatry
E-pub date: 1 Nov 2009
Authors: E Fernandez-Egea, A Bruna, C Garcia-Rizo, M Bernardo, B Kirkpatrick

Progressive gray matter changes in first episode schizophrenia: a 4-year longitudinal magnetic resonance study using VBM.

DOI: http://doi.org/10.1016/j.schres.2009.07.014
Journal: Schizophr Res
E-pub date: 1 Oct 2009
Authors: A Mané, C Falcon, JJ Mateos, E Fernandez-Egea, G Horga, F Lomeña, N Bargalló, A Prats-Galino, M Bernardo, E Parellada

Adaptation and validation of the Spanish version of the Strauss and Carpenter Prognostic Scale for Schizophrenia.

DOI: http://doi.org/10.1016/S1888-9891(09)73233-1
Journal: Revista de Psiquiatria y Salud Mental
E-pub date: 1 Oct 2009
Authors: M Ahuir, M Bernardo, E de la Serna, S Ochoa, J Carlson, G Escartín, A Gutiérrez-Zotes, J Valero, M Salamero, S Cañizares, E Fernández-Egea, J Cañete, P Gallo

Psychosis and catatonia as a first presentation of antiphospholipid syndrome.

DOI: http://doi.org/10.1192/bjp.195.3.272
Journal: Br J Psychiatry
E-pub date: 1 Sep 2009
Authors: RN Cardinal, DN Shah, CJ Edwards, GRV Hughes, E Fernández-Egea

Cannabis use and age of diagnosis of schizophrenia.

DOI: http://doi.org/10.1016/j.eurpsy.2009.01.002
Journal: Eur Psychiatry
E-pub date: 1 Jun 2009
Authors: G Sugranyes, I Flamarique, E Parellada, I Baeza, J Goti, E Fernandez-Egea, M Bernardo

A continuous emotional task activates the left amygdala in healthy volunteers: (18)FDG PET study.

DOI: http://doi.org/10.1016/j.pscychresns.2008.01.003
Journal: Psychiatry Res
E-pub date: 31 Mar 2009
Authors: E Fernandez-Egea, E Parellada, F Lomeña, C Falcon, J Pavia, A Mane, G Sugranyes, M Valdes, M Bernardo

Telomere length and pulse pressure in newly diagnosed, antipsychotic-naive patients with nonaffective psychosis.

DOI: http://doi.org/10.1093/schbul/sbn169
Journal: Schizophr Bull
E-pub date: 1 Mar 2009
Authors: E Fernandez-Egea, M Bernardo, CM Heaphy, JK Griffith, E Parellada, E Esmatjes, I Conget, L Nguyen, V George, H Stöppler, B Kirkpatrick

Differences in glucose tolerance between deficit and nondeficit schizophrenia.

DOI: http://doi.org/10.1016/j.schres.2008.09.023
Journal: Schizophr Res
E-pub date: 1 Feb 2009
Authors: B Kirkpatrick, E Fernandez-Egea, C Garcia-Rizo, M Bernardo

Fluordeoxyglucose-PET study in first-episode schizophrenic patients during the hallucinatory state, after remission and during linguistic-auditory activation.

DOI: http://doi.org/10.1097/MNM.0b013e328302cd10
Journal: Nucl Med Commun
E-pub date: 1 Oct 2008
Authors: E Parellada, F Lomena, M Font, D Pareto, F Gutierrez, M Simo, E Fernández-Egea, J Pavia, D Ros, M Bernardo

Glucose abnormalities in the siblings of people with schizophrenia.

DOI: http://doi.org/10.1016/j.schres.2008.04.017
Journal: Schizophr Res
E-pub date: 31 Aug 2008
Authors: E Fernandez-Egea, M Bernardo, E Parellada, A Justicia, C Garcia-Rizo, E Esmatjes, I Conget, B Kirkpatrick

Parental history of type 2 diabetes in patients with nonaffective psychosis.

DOI: http://doi.org/10.1016/j.schres.2007.10.002
Journal: Schizophr Res
E-pub date: 1 Jan 2008
Authors: E Fernandez-Egea, B Miller, M Bernardo, T Donner, B Kirkpatrick

[Adaptation and validation into Spanish of Schedule for the Deficit Syndrome].

DOI: http://doi.org/10.1157/13107363
Journal: Medicina Clinica
E-pub date: 16 Jun 2007
Authors: M Bernardo, E Fernández-Egea, A Torras, F Gutiérrez, M Ahuir, C Arango

[Value of screening test for syphilis in acute psychiatric inpatients].

DOI: http://doi.org/10.1157/13106941
Journal: Medicina Clinica
E-pub date: 9 Jun 2007
Authors: E Gómez-Gil, E Fernández-Egea, A Trilla, M Almela

Psychiatric disorders in temporal lobe epilepsy patients over the first year after surgical treatment.

DOI: http://doi.org/10.1016/j.seizure.2006.12.004
Journal: Seizure
E-pub date: 1 Apr 2007
Authors: L Pintor, E Bailles, E Fernández-Egea, V Sánchez-Gistau, X Torres, M Carreño, J Rumia, S Matrai, T Boget, T Raspall, A Donaire, N Bargalló, X Setoain

Lower striatal dopamine transporter binding in neuroleptic-naive schizophrenic patients is not related to antipsychotic treatment but it suggests an illness trait.

DOI: http://doi.org/10.1007/s00213-006-0570-5
Journal: Psychopharmacology (Berl)
E-pub date: 1 Apr 2007
Authors: JJ Mateos, F Lomeña, E Parellada, F Mireia, E Fernandez-Egea, J Pavia, A Prats, F Pons, M Bernardo

Palate and dentition in schizophrenia.

DOI: http://doi.org/10.1016/j.schres.2006.12.022
Journal: Schizophr Res
E-pub date: 1 Mar 2007
Authors: B Kirkpatrick, GD Hack, E Higginbottom, D Hoffacker, E Fernandez-Egea

Fertility of first-degree relatives of patients with schizophrenia: a three generation perspective.

DOI: http://doi.org/10.1016/j.schres.2006.12.002
Journal: Schizophr Res
E-pub date: 1 Mar 2007
Authors: AC Svensson, P Lichtenstein, S Sandin, CM Hultman

The role of the amygdala in facial emotion recognition in schizophrenia

DOI: http://doi.org/10.1016/s1134-5934(07)73257-8
Journal: Psiquiatria Biologica
E-pub date: 1 Jan 2007
Authors: E Fernández-Egea, EP Rodon, FL Caballero, AM Santacana, MB Arroyo

Decreased striatal dopamine transporter binding assessed with [123I] FP-CIT in first-episode schizophrenic patients with and without short-term antipsychotic-induced parkinsonism.

DOI: http://doi.org/10.1007/s00213-005-2250-2
Journal: Psychopharmacology (Berl)
E-pub date: 1 Sep 2005
Authors: JJ Mateos, F Lomeña, E Parellada, M Font, E Fernandez, J Pavia, A Prats, F Pons, M Bernardo

Psychiatric disorders, trauma, and MMPI profile in a Spanish sample of nonepileptic seizure patients.

DOI: http://doi.org/10.1016/j.genhosppsych.2004.04.003
Journal: Gen Hosp Psychiatry
E-pub date: 1 Aug 2004
Authors: E Baillés, L Pintor, E Fernandez-Egea, X Torres, S Matrai, J De Pablo, S Arroyo

Lack of sex differences in striatal dopamine D2 receptor binding in drug-naive schizophrenic patients: an IBZM-SPECT study.

DOI: http://doi.org/10.1016/j.pscychresns.2003.05.001
Journal: Psychiatry Res
E-pub date: 15 Jan 2004
Authors: E Parellada, F Lomeña, AM Catafau, M Bernardo, M Font, E Fernández-Egea, J Pavía, F Gutierrez

[Relationship between patient’s subjective stress perception and the course of inflammatory bowel disease].

DOI: http://doi.org/10.1016/s0210-5705(03)70382-3
Journal: Gastroenterol Hepatol
E-pub date: 1 Aug 2003
Authors: E Gómez-Gil, A Vidal, J Panés, J Jaén, JM Peri, E Fernández-Egea, JM Piqué

Relationship between patient’s subjective stress perception and the course of inflammatory bowel disease

DOI: http://doi.org/10.1157/13050353
Journal: Gastroenterologia y Hepatologia
E-pub date: 1 Jan 2003
Authors: E Gómez-Gil, A Vidal, J Panés, J Jaén, JM Peri, E Fernández-Egea, JM Piqué

[Serological testing and prevalence of human immunodeficiency, hepatitis B and C viruses infections amongst acute psychiatric inpatients].

DOI: http://doi.org/10.1016/s0025-7753(02)73543-4
Journal: Medicina Clinica
E-pub date: 23 Nov 2002
Authors: E Fernández-Egea, E Gómez Gil, B Corbella Santomà, M Salamero Baró, J Blanch Andreu, M Valdés Miyar

Lack of clinical relevance of routine chest radiography in acute psychiatric admissions.

DOI: http://doi.org/10.1016/s0163-8343(01)00179-7
Journal: Gen Hosp Psychiatry
E-pub date: 1 Aug 2002
Authors: E Gómez-Gil, A Trilla, B Corbella, E Fernández-Egea, P Luburich, J de Pablo, J Ferrer Raldúa, M Valdés